LOCUS       NM_001024254            4895 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus TAO kinase 3 (Taok3), mRNA.
ACCESSION   NM_001024254 XM_222216
VERSION     NM_001024254.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Raman,M., Earnest,S., Zhang,K., Zhao,Y. and Cobb,M.H.
  TITLE     TAO kinases mediate activation of p38 in response to DNA damage
  JOURNAL   EMBO J 26 (8), 2005-2014 (2007)
   PUBMED   17396146
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   Wakabayashi,T., Kosaka,J. and Oshika,T.
  TITLE     JNK inhibitory kinase is up-regulated in retinal ganglion cells
            after axotomy and enhances BimEL expression level in neuronal cells
  JOURNAL   J Neurochem 95 (2), 526-536 (2005)
   PUBMED   16092929
  REMARK    GeneRIF: JIK may contribute to axotomy-induced retinal ganglion
            cell death by up-regulating the expression of BH3-only protein
            Erratum:[J Neurochem. 2007 Jun;101(6):1723]
REFERENCE   3  (bases 1 to 4895)
  AUTHORS   Yoneda,T., Imaizumi,K., Oono,K., Yui,D., Gomi,F., Katayama,T. and
            Tohyama,M.
  TITLE     Activation of caspase-12, an endoplastic reticulum (ER) resident
            caspase, through tumor necrosis factor receptor-associated factor
            2-dependent mechanism in response to the ER stress
  JOURNAL   J Biol Chem 276 (17), 13935-13940 (2001)
   PUBMED   11278723
REFERENCE   4  (bases 1 to 4895)
  AUTHORS   Zhang,W., Chen,T., Wan,T., He,L., Li,N., Yuan,Z. and Cao,X.
  TITLE     Cloning of DPK, a novel dendritic cell-derived protein kinase
            activating the ERK1/ERK2 and JNK/SAPK pathways
  JOURNAL   Biochem Biophys Res Commun 274 (3), 872-879 (2000)
   PUBMED   10924369
REFERENCE   5  (bases 1 to 4895)
  AUTHORS   Tassi,E., Biesova,Z., Di Fiore,P.P., Gutkind,J.S. and Wong,W.T.
  TITLE     Human JIK, a novel member of the STE20 kinase family that inhibits
            JNK and is negatively regulated by epidermal growth factor
  JOURNAL   J Biol Chem 274 (47), 33287-33295 (1999)
   PUBMED   10559204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1 and AB195232.1.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001024254.3.
            
            On Mar 10, 2021 this sequence version replaced NM_001024254.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.43475.1,
                                           SRR26643286.35508.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JAXUCZ010000012.1  45134212-45134439   c
            229-322             JAXUCZ010000012.1  45122011-45122104   c
            323-421             JAXUCZ010000012.1  45066278-45066376   c
            422-638             JAXUCZ010000012.1  45054819-45055035   c
            639-710             JAXUCZ010000012.1  45049722-45049793   c
            711-812             JAXUCZ010000012.1  45048463-45048564   c
            813-858             JAXUCZ010000012.1  45044120-45044165   c
            859-955             JAXUCZ010000012.1  45042978-45043074   c
            956-1069            JAXUCZ010000012.1  45040558-45040671   c
            1070-1161           JAXUCZ010000012.1  45037843-45037934   c
            1162-1712           AB195232.1         759-1309
            1713-1847           JAXUCZ010000012.1  45008861-45008995   c
            1848-2084           JAXUCZ010000012.1  44998728-44998964   c
            2085-2213           JAXUCZ010000012.1  44997110-44997238   c
            2214-2417           JAXUCZ010000012.1  44994193-44994396   c
            2418-2657           JAXUCZ010000012.1  44985509-44985748   c
            2658-2870           JAXUCZ010000012.1  44983730-44983942   c
            2871-3053           JAXUCZ010000012.1  44976927-44977109   c
            3054-4895           JAXUCZ010000012.1  44973180-44975021   c
FEATURES             Location/Qualifiers
     source          1..4895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4895
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /note="TAO kinase 3"
                     /db_xref="GeneID:304530"
                     /db_xref="RGD:1562861"
     exon            1..228
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            229..322
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            323..421
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            422..638
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..3215
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /EC_number="2.7.11.1"
                     /note="jun kinase-inhibitory kinase; axotomy-related gene
                     357 protein; thousand and one amino acid protein 3;
                     JNK/SAPK-inhibitory kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO3"
                     /protein_id="NP_001019425.1"
                     /db_xref="GeneID:304530"
                     /db_xref="RGD:1562861"
                     /translation="MRKGVLKDPEIAELFFKEDPEELFIDLHEIGHGSFGAVYFATNA
                     HTNEVVAIKKMSYSGKQTHEKWQDILKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVME
                     YCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHFHSLIHRDIKAGNILLTEPGQ
                     VKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERK
                     PPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKIPQERPAAAELLRHDF
                     IRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEEEEDSEQG
                     SNLNREVDSLGSIHSIPSVSVSTGSRSSSVNSMQEVMDEGSPELVMMQEDEGTVNSSS
                     SMVHKKDHVFVRDEAGHGDPRPEPRPTQSVQSRALHYRNRERFATIKSASLVTRQIHE
                     HEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIEL
                     EKLAKKQVATIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEE
                     MNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDRNCRCFKRKIMTKRH
                     EVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTE
                     LENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNH
                     QLEVTPKNEHKAILKTLKEEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQAL
                     RLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKE
                     RSERIKTLLERQERETETFDMESLRMGFGNLVTLDFPKEDYR"
     exon            639..710
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            711..812
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            813..858
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            859..955
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1069
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1161
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1255
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1337
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1505
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1712
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1847
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2084
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2213
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2417
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2657
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2870
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3053
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..4895
                     /gene="Taok3"
                     /gene_synonym="JIK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgctcc gcgcagtcgg gtgcgattgg tcacccctgg cggagccgca cctcggacag
       61 cagcagcgaa ggcagcctag ggtcctgcgt ggagagtgag gcgcaacggg gactcgcggg
      121 cggaggctgc gcgtggggac ccagcacgcg aagacccagc acgagagcga ctccgggcac
      181 cagtgagagg aggcggcggc gccggggccg cggctgacaa gcgctgagac ttaccgtacg
      241 tgagcttcaa acagaagaca ccgtagatct gaaggctaaa atgtgaagac gacctgactg
      301 ctcttcatgc tcaagaaacc cggcgcatcc taagtgcggg agaccgggac tgtaagtgag
      361 gagacactgc tgctacaatg cccctgagcc gtgctgtggg gtttgagcca tgcatccaaa
      421 gggactgaag gtctataaga ataaaaattg tagtcaatga gagagacaga gggactgggt
      481 cgtcaaacag cagcgtgcct gctgccacac tggccaccat gcgtaaagga gtgctgaagg
      541 accccgagat tgccgagctg ttcttcaagg aggaccccga agagctcttt atcgacctgc
      601 atgaaatcgg acatggcagc tttggagccg tgtacttcgc aactaatgcg cacaccaacg
      661 aggtggttgc tattaagaaa atgtcctaca gtgggaagca gacccacgag aaatggcaag
      721 atatcctgaa ggaagttcga ttcctccagc agctgaagca cccgaacacc atcgagtaca
      781 aaggctgtta tttaaaggag cacaccgctt ggttggtgat ggagtactgc ttaggttcag
      841 cctctgactt gttagaagtt cataagaaac cacttcagga agtagagatt gctgctatca
      901 cccatggtgc cttgcagggg ctggcctacc tccactttca ctccctgatt cacagggaca
      961 ttaaagcagg gaatatcctc ctcacagagc caggccaggt gaagctggct gacttcgggt
     1021 ccgcttccat ggcttctcct gccaactcct tcgtggggac tccttactgg atggccccag
     1081 aggtgatctt agccatggac gaagggcagt acgacgggaa agttgacatc tggtcactcg
     1141 gcatcacctg catagagctg gcggagcgga agccccccct cttcaacatg aacgccatga
     1201 gcgccctcta ccacatcgct cagaatgact cccccacgct gcagtccaga gaatggacag
     1261 actccttcag gagattcgtt gattactgct tgcacaaaat acctcaggaa cgaccagccg
     1321 cggcggaact gttgcggcac gacttcattc ggagggagcg gccgccgagg gtcctcattg
     1381 acctcataca gaggacgaaa gatgctgtcc gagagctgga caacctgcag tacaggaaaa
     1441 tgaagaagat cctcttccag gagactcgga acggacccct gaatgagtca caagaagagg
     1501 aagaagacag tgagcaagga agcaacctga accgagaggt ggacagtctg gggagcatcc
     1561 actccatccc cagcgtgtca gtgagcacgg gcagccggag cagcagcgtg aacagcatgc
     1621 aggaggtcat ggacgagggc agccctgagc tcgtcatgat gcaggaggat gaaggcacag
     1681 tcaactccag ctcctctatg gtacacaaga aggatcatgt attcgtaagg gatgaggcgg
     1741 gccacggcga tcccaggcct gagccgcggc ctacccagtc agttcagagc cgggccctcc
     1801 actatcggaa ccgagagcgc tttgccacga tcaaatccgc gtctttggtt acacggcaga
     1861 tccacgagca tgagcaggag aacgagctgc gggaacagat gtcaggttat aagcggatgc
     1921 ggcgccagca ccagaagcag ctgatcgccc tggagaacaa gctgaaggct gagatggatg
     1981 agcaccgcct caagctccag aaggaggtgg agacgcatgc caacaactcg tccatcgagc
     2041 tggagaagct ggccaagaag caagtggcta ccatagaaaa ggaggcaaag gtagccgcag
     2101 cggatgagaa gaagttccag cagcagatcc tggcccagca gaagaaggac ttgacaactt
     2161 tcttagaaag tcagaagaag cagtacaaga tttgtaagga gaaaataaaa gaggaaatga
     2221 acgaggacca tagcacaccc aagaaggaga agcaggagcg catatcgaag cataaagaga
     2281 acctgcagca cacgcaggcc gaggaggaag cccacctgct cacgcaacag aggctgtact
     2341 acgacagaaa ctgccgctgc ttcaagcgga aaataatgac caagcgccac gaggtggaac
     2401 agcagaacat tcgggaggaa ctaaataaaa agaggaccca gaaagaaatg gagcacgcca
     2461 tgctgatccg gcatgatgaa tccacccgag agctcgagta cagacagctg cacacactgc
     2521 agaagctccg catggacctg atccggttac agcaccagac tgagctggag aaccagctgg
     2581 agtacaataa gaggcgggag cgggagctgc accggaagca cgtcatggag cttcggcaac
     2641 agccgaaaaa cttaaaggcc atggaaatgc aaattaaaaa gcagtttcag gacacttgca
     2701 aagtacagac caaacagtac aaagcactca aaaaccacca gttggaagtc actccaaaga
     2761 atgagcacaa agcaatccta aagacactga aggaggagca gacgaggaag ctggccatct
     2821 tggccgagca gtatgaacag agtataaacg agatgatggc ctctcaagcg ttacggctag
     2881 acgaggcgca agaggcagaa tgccaggcct tgagactaca gctccagcag gagatggagc
     2941 tgctcaacgc ctaccagagc aaaatcaaga tgcaaacgga ggcccagcac gagcgcgagc
     3001 tgcagaagct agagcagagg gtgtccctgc gcagagcgca tcttgagcag aagattgaag
     3061 aggagctggc cgccctgcag aaggaacgca gtgagaggat caagactctc ctggaaagac
     3121 aagagcgaga gaccgagact tttgacatgg agagcctcag aatggggttt gggaatttgg
     3181 tgacattaga ttttcctaag gaggactata gatgagatta aatttttttg ccatttacaa
     3241 aaaaaaaatg aaaaaagaaa acaaaaaaat tcagaccctg cgaaactaca ttccccatct
     3301 taacgggcgc tgctctcact tcacactgtc tccctctctt cctctcttct ctctctctct
     3361 ctctctctct ctctctctct ctctctctct ctcccctccc tccctccctc cctccccaac
     3421 cttccctctc ctctttcccc cctctctctc ctctctcttc tctccctctc cctgtctccc
     3481 tctctccctc ttctctctcc ccctctccct tccccctctc ctctctccct ccctcttctc
     3541 tccctccccc ttctctcctt cccttcctcc tctccctctc tctctctcac ttcccctctc
     3601 tcctccctct ctcttccccc tctctccctc tctctccctc ctctaccccc tctcttcctc
     3661 cctctcttcc cccctctctc cctctttctt tctctctccc cctctctctc cccctctctc
     3721 tctcttcctc tctttctctc tctctccccc tcccccctac cctttctctc ttccctcccc
     3781 ctctctctcc ctgacaccgt gttgcactag tgcctgttga ttcttactcc atcaggggcc
     3841 ctttcctccc cccgtgtcaa ctttcagtgc tggccgagac ccggccgccc ctgccgtcca
     3901 ccacctgcat cgcggtgctg atgcggttcg gatgttctgc tgaaaacctc ggaggtggtt
     3961 ttagggtctg tcaaccaaca aacggcgatg gaacacagat ggatgttgct ttgagcaatc
     4021 cctcgttgtc accaaccagt gaaagtaaag caaaaaaaac cgaaaacaag caaataccta
     4081 aagaaaccta aataacaaac acatggcaag ggggagagag acacaatccg cagccttaca
     4141 ccttaaccag ctgctgcata actttatttt attttatttt tttggtattt attcatcagg
     4201 aattaaaaaa acaaagtttt attaaagatt gaaaatttga tacattttac aggaactaat
     4261 tgtgatgtac atatgaagtg gtaacattat tactattttg gggccggggt gggtgggtgg
     4321 ggtgaagaga tctcgtggtt tttaagaacc tgccggcaag agtttgcctt gccgtcagcc
     4381 tggtctactg tatcccagca tcctctgctg ttgcagacgg tgcgagtaca cttaaggagc
     4441 tcacagaatc ccagtagcac aaaattgggc tttggcaaat catgtatttt gtgtatagag
     4501 ggaatctaag gagaggaatt gcttattttc atattgtatt ttaactgttt ctctgatcaa
     4561 aattttttta cttcctcctc ctgttcctcc ccgcccccac gcccacctcc cgcttcagtc
     4621 tctggagttc aatgtcttct ctgtccaatc atctgtttat ttctccttcc cctacccacg
     4681 ctccctatct gtggtcataa atactgcatt attcatcctt tcaaactgtg tattttctta
     4741 caataaaaaa tgatgaagag aaaaaggctt cactcctttt gcatgcactt aaaaaaaaaa
     4801 cttaaaaaag aaaacatttt tcaggttccg aggaagagca tgattaactg tcagggcttt
     4861 taattatatt tgtaaataaa agtgttcgtc acatc
//
