LOCUS       NM_022702               4298 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TAO kinase 2 (Taok2), mRNA.
ACCESSION   NM_022702
VERSION     NM_022702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Yadav,S., Oses-Prieto,J.A., Peters,C.J., Zhou,J., Pleasure,S.J.,
            Burlingame,A.L., Jan,L.Y. and Jan,Y.N.
  TITLE     TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine
            Maturation through Septin7 Phosphorylation
  JOURNAL   Neuron 93 (2), 379-393 (2017)
   PUBMED   28065648
  REMARK    GeneRIF: TAOK2 directly phosphorylates the cytoskeletal GTPase
            Septin7, at an evolutionary conserved residue. This phosphorylation
            induces translocation of Septin7 to the spine, where it associates
            with and stabilizes the scaffolding protein PSD95, promoting
            dendritic spine maturation.
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   de Anda,F.C., Rosario,A.L., Durak,O., Tran,T., Graff,J.,
            Meletis,K., Rei,D., Soda,T., Madabhushi,R., Ginty,D.D.,
            Kolodkin,A.L. and Tsai,L.H.
  TITLE     Autism spectrum disorder susceptibility gene TAOK2 affects basal
            dendrite formation in the neocortex
  JOURNAL   Nat Neurosci 15 (7), 1022-1031 (2012)
   PUBMED   22683681
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Yasuda,S., Tanaka,H., Sugiura,H., Okamura,K., Sakaguchi,T.,
            Tran,U., Takemiya,T., Mizoguchi,A., Yagita,Y., Sakurai,T., De
            Robertis,E.M. and Yamagata,K.
  TITLE     Activity-induced protocadherin arcadlin regulates dendritic spine
            number by triggering N-cadherin endocytosis via TAO2beta and p38
            MAP kinases
  JOURNAL   Neuron 56 (3), 456-471 (2007)
   PUBMED   17988630
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Zhou,T.J., Sun,L.G., Gao,Y. and Goldsmith,E.J.
  TITLE     Crystal structure of the MAP3K TAO2 kinase domain bound by an
            inhibitor staurosporine
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 38 (6), 385-392 (2006)
   PUBMED   16761096
  REMARK    GeneRIF: this analysis of atomic details for TAO2-staurosporine
            interactions explains the relatively low potency of staurosporine
            against TAO2
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Zhou,T., Raman,M., Gao,Y., Earnest,S., Chen,Z., Machius,M.,
            Cobb,M.H. and Goldsmith,E.J.
  TITLE     Crystal structure of the TAO2 kinase domain: activation and
            specificity of a Ste20p MAP3K
  JOURNAL   Structure 12 (10), 1891-1900 (2004)
   PUBMED   15458637
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Chen,Z. and Cobb,M.H.
  TITLE     Regulation of stress-responsive mitogen-activated protein (MAP)
            kinase pathways by TAO2
  JOURNAL   J Biol Chem 276 (19), 16070-16075 (2001)
   PUBMED   11279118
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Moore,T.M., Garg,R., Johnson,C., Coptcoat,M.J., Ridley,A.J. and
            Morris,J.D.
  TITLE     PSK, a novel STE20-like kinase derived from prostatic carcinoma
            that activates the c-Jun N-terminal kinase mitogen-activated
            protein kinase pathway and regulates actin cytoskeletal
            organization
  JOURNAL   J Biol Chem 275 (6), 4311-4322 (2000)
   PUBMED   10660600
REFERENCE   10 (bases 1 to 4298)
  AUTHORS   Chen,Z., Hutchison,M. and Cobb,M.H.
  TITLE     Isolation of the protein kinase TAO2 and identification of its
            mitogen-activated protein kinase/extracellular signal-regulated
            kinase kinase binding domain
  JOURNAL   J Biol Chem 274 (40), 28803-28807 (1999)
   PUBMED   10497253
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF140556.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF140556.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..4298
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /note="TAO kinase 2"
                     /db_xref="GeneID:64666"
                     /db_xref="RGD:621590"
     exon            1..157
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            158..324
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..3900
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /EC_number="2.7.11.1"
                     /note="serine-threonine kinase; thousand and one amino
                     acid protein 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO2"
                     /protein_id="NP_073193.1"
                     /db_xref="GeneID:64666"
                     /db_xref="RGD:621590"
                     /translation="MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYF
                     ARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAW
                     LVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLS
                     EPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL
                     AERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLL
                     KHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEE
                     AEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEE
                     EEGPESREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTS
                     TSSSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQL
                     LALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKF
                     QQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQ
                     CQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALL
                     LRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQ
                     QPKSLKVRAGQLPMGLPATGALGPLSTGTLSEEQPCSSGQEAILGQRMLGEEEEAVPE
                     RMILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDWDISKEMKESRVPSLAS
                     QERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIG
                     TPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFAVGSSSGLLPLLL
                     LLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFLLLAQGTALGA
                     VLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMRRGISRLWL
                     RVLLRLSPMVFRALQGCAAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPRTTQHPL
                     ALLARVWALCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQ
                     RRLGLSASRQLPPGTVAGRRSQTRRALPPWR"
     exon            325..396
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            397..498
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..544
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..641
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..755
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..847
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..941
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1023
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1191
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1458
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1620
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1986
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2190
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..4290
                     /gene="Taok2"
                     /gene_synonym="Tao2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggaggct tcccgggccc gcccctcagg aagggcgaaa gctgaggaag aggtggcgag
       61 ggggaaggtc tccttgcccc tctccccgct tgtcagagca actggagtac cccaggcgga
      121 agcggaggcg ctggggcacc atagtgaccc ctaccaggca agatcccaat ttcagggccc
      181 ccaggggcca tcatgccagc tgggggccgg gccgggagcc tgaaggaccc tgatgtagct
      241 gagctcttct tcaaagatga ccctgagaag cttttctctg acctccggga aattggccat
      301 ggcagttttg gagctgtgta ctttgcccgg gatgtccgga acagtgaggt ggtggccatc
      361 aagaagatgt cctatagtgg gaagcaatca aatgagaaat ggcaggatat catcaaggag
      421 gtgcggttct tacagaagct acggcatcct aataccattc agtaccgggg ctgttacctg
      481 agggagcaca cagcttggct ggtgatggag tattgcctgg gttcagcttc tgatcttctc
      541 gaagtgcaca agaagccgct gcaggaggta gagattgcag ctgtgaccca tggtgcgctt
      601 cagggcctgg cctatctaca ttcacacaac atgatccata gagatgtgaa ggctgggaac
      661 atcttgctgt cagaaccagg cttggtgaaa ctgggggact ttggctccgc atccatcatg
      721 gcacctgcca actcatttgt gggcactcca tactggatgg ctccagaggt gatcctagcc
      781 atggatgagg gacaatatga tggcaaagtg gatgtctggt ccttggggat aacctgtatt
      841 gagctagcgg agcggaagcc accactgttt aacatgaatg caatgagtgc cttataccac
      901 attgcacaga atgaatcccc tgctctccag tcaggacact ggtctgagta cttccggaat
      961 tttgttgact cctgtcttca gaaaatccct caagacagac caacctcaga ggttcttttg
     1021 aagcaccgct ttgtgctccg ggagcggcca cccacagtca tcatggacct aattcagagg
     1081 accaaggatg ctgtacggga actagataac ctgcagtacc gaaagatgaa gaagatacta
     1141 ttccaagagg cacccaatgg ccctggtgct gaggccccag aggaagagga ggaagcagaa
     1201 ccttacatgc accgagcagg gacactgacc agtctagaga gtagccattc agtgcccagc
     1261 atgtccatca gcgcctccag ccaaagcagc tcagtcaaca gcctagcaga tgcctcagat
     1321 aatgaagaag aggaggagga ggaagaggaa gaagaagagg aggaggaaga agaaggccct
     1381 gaatcccgag agatggccat gatgcaggag ggggagcata cagtcacttc ccacagctcc
     1441 atcatccacc ggctgccggg ctcagacaac ctatatgatg atccctacca gccagagatg
     1501 accccaggtc cactccaacc acctgcagcc cctcccacct ccacctcctc ctcttctgct
     1561 cgccgcagag cttattgccg caaccgagac cactttgcca ccatccgtac tgcctccctg
     1621 gtcagccgtc agatccagga gcatgagcag gactcggccc tgcgggagca actaagtggc
     1681 tacaagcgga tgcggcgtca gcaccagaag caactgctgg ccctggagtc ccgtctgagg
     1741 ggtgaacgtg aggagcacag tgggcggttg cagcgtgaac tcgaggcaca gcgggctggc
     1801 tttgggactg aggctgagaa gctggcccgg aggcaccagg ccattggtga gaaggaagca
     1861 cgagctgctc aggctgagga gcggaagttc cagcagcaca tcttggggca gcagaagaag
     1921 gaactggctg ccctgctgga ggcacagaag cgaacctata agcttcggaa ggagcagttg
     1981 aaagaggagc tccaggagaa ccctagcaca cccaaacgag agaaggctga gtggctgttg
     2041 aggcagaaag agcagttgca acagtgccag gcagaggagg aggcagggct actgcggagg
     2101 caacgccagt actttgagct tcagtgtcgc caatacaagc gcaagatgct actggctcgg
     2161 cacagcctag accaggacct gcttcgagag gacttgaata agaaacagac acagaaggac
     2221 ttggagtgtg ctctgctgtt acggcagcat gaggctaccc gagagctgga gctacgacag
     2281 ctccaggctg tccagcgcac acgtgctgaa ctcacccgcc ttcagcacca gacagagcta
     2341 ggcaaccagt tggagtacaa caagcgacgg gagcaagagt tgcggcagaa gcacgcggcc
     2401 caggttcgcc agcagcccaa gagcctcaaa gtacgtgcag gccagctacc catgggcctc
     2461 cctgctaccg gggctctggg accactcagc acaggcaccc ttagtgaaga gcagccctgc
     2521 tcatctggcc aggaggcaat cctgggccaa aggatgctgg gagaggagga ggaagcagtg
     2581 ccagagagaa tgattctggg aaaggaaggg actactttgg agccagagga gcagaggatt
     2641 ctgggggaag aaatgggaac ctttagttcc agcccacaaa aacataggag tctggttaat
     2701 gaggaagatt gggatatatc taaagaaatg aaggagagta gagtcccatc cctggcatcc
     2761 caggagagaa atattattgg ccaggaagag gctggggcat ggaatctgtg ggagaaggag
     2821 catggaaacc ttgtggatat ggagttcaag cttggctggg tccagggtcc agttctgact
     2881 ccagtgcctg aggaggaaga ggaggaggaa gaggagggag gggctccaat tggaaccccc
     2941 agggaccctg gagatggctg tccttcccca gatatccccc cagagccacc tccatcacat
     3001 ctgagacagt accctgctag ccagcttcct ggattcttgt ctcatggcct cctgactggc
     3061 ctctcctttg cagtggggtc ctcctctggc ctcttgcccc tactacttct gctgctactc
     3121 ccattgctgg cagcccaggg tggaggtggc ttgcaggcag cactgctggc ccttgaggta
     3181 ggactagtgg gcctgggggc ctcctacctg ttcctttgta cagctctaca cctgccaccc
     3241 agtctgttct tactcctggc tcagggcact gcactggggg ctgtccttag cctgagctgg
     3301 cgcagaggcc ttatgggtgt gcctctgggc cttggggctg cctggctcct agcttggccc
     3361 agcctggctt tacctctggc agctatggcg gctgggggca aatgggtacg gcagcaaggc
     3421 ccccagatgc gtcggggcat ctctcgactc tggttgcggg ttctgctacg cctgtcaccc
     3481 atggtctttc gggccctaca gggctgtgcg gctgtgggag accgggggct gtttgccctg
     3541 taccctaaga ccaataagaa tggtttccga agtcgactgc ctgtcccttg gccccgtcag
     3601 ggaaatcctc gcactacaca gcacccacta gctctgttag caagagtttg ggctctgtgc
     3661 aagggctgga actggcgcct agcacgggct agccatagat tagcttcttg tttgcccccc
     3721 tgggctgttc atatactagc tagctggggc ctgcttaagg gtgaaaggcc cagtcggatc
     3781 cctcggctgc taccgcgaag ccaacgccgt cttgggctct cagcttcccg acagctacca
     3841 ccagggactg tagctgggcg gagatctcag acccgcaggg ccctgcctcc ctggaggtaa
     3901 ccagttctaa ccctccaccc aaatttaggg cattgagcac tttatctccc atgactcagt
     3961 aaagtctctc cagtcccttg gcctctcctc cccttctgac ctttcttcct cagtatgttt
     4021 ccccaggtcc aatcccagcc ccagatgtag atttctagac aggcagcctc ctctactgtg
     4081 gagtccagaa tgacactctt gtgttttccc cagtccccta agttattgct gtcccctgct
     4141 gtgtgtgtgc tcatcctcac cctcatcggc tcaggcctgg ggccaggggt ggcagggagg
     4201 gaagtcatgg gggttttccc tctttgattt tgtttttctg tctcccttcc aacctgtccc
     4261 cttcccctcc accaaaagag aaaaaaaaaa aaaaaaaa
//
