LOCUS       NM_173327              12158 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus TAO kinase 1 (Taok1), mRNA.
ACCESSION   NM_173327 XM_039085331
VERSION     NM_173327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12158)
  AUTHORS   Li J, Liu Z, Wang L, Xu H and Wang Y.
  TITLE     Thousand and one kinase 1 protects MCAO-induced cerebral ischemic
            stroke in rats by decreasing apoptosis and pro-inflammatory factors
  JOURNAL   Biosci Rep 39 (10) (2019)
   PUBMED   31652447
  REMARK    GeneRIF: Thousand and one kinase 1 protects MCAO-induced cerebral
            ischemic stroke in rats by decreasing apoptosis and
            pro-inflammatory factors.
REFERENCE   2  (bases 1 to 12158)
  AUTHORS   Sun Y, Chiu TT, Foley KP, Bilan PJ and Klip A.
  TITLE     Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in
            insulin-stimulated muscle cells
  JOURNAL   Mol Biol Cell 25 (7), 1159-1170 (2014)
   PUBMED   24478457
REFERENCE   3  (bases 1 to 12158)
  AUTHORS   Patel M, Cai Q, Ding D, Salvi R, Hu Z and Hu BH.
  TITLE     The miR-183/Taok1 target pair is implicated in cochlear responses
            to acoustic trauma
  JOURNAL   PLoS One 8 (3), e58471 (2013)
   PUBMED   23472202
  REMARK    GeneRIF: Inhibition of miR-183 in cochlear organotypic culture
            leads to upregulation of Taok1. Exposure to noise caused a
            significant upregulation of Taok1.
REFERENCE   4  (bases 1 to 12158)
  AUTHORS   Cuadrado A and Nebreda AR.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   5  (bases 1 to 12158)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 12158)
  AUTHORS   Raman M, Earnest S, Zhang K, Zhao Y and Cobb MH.
  TITLE     TAO kinases mediate activation of p38 in response to DNA damage
  JOURNAL   EMBO J 26 (8), 2005-2014 (2007)
   PUBMED   17396146
REFERENCE   7  (bases 1 to 12158)
  AUTHORS   Zihni C, Mitsopoulos C, Tavares IA, Ridley AJ and Morris JD.
  TITLE     Prostate-derived sterile 20-like kinase 2 (PSK2) regulates
            apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1
  JOURNAL   J Biol Chem 281 (11), 7317-7323 (2006)
   PUBMED   16407310
REFERENCE   8  (bases 1 to 12158)
  AUTHORS   Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J and
            Mandelkow EM.
  TITLE     MARKK, a Ste20-like kinase, activates the polarity-inducing kinase
            MARK/PAR-1
  JOURNAL   EMBO J 22 (19), 5090-5101 (2003)
   PUBMED   14517247
REFERENCE   9  (bases 1 to 12158)
  AUTHORS   Mitsopoulos C, Zihni C, Garg R, Ridley AJ and Morris JD.
  TITLE     The prostate-derived sterile 20-like kinase (PSK) regulates
            microtubule organization and stability
  JOURNAL   J Biol Chem 278 (20), 18085-18091 (2003)
   PUBMED   12639963
REFERENCE   10 (bases 1 to 12158)
  AUTHORS   Hutchison M, Berman KS and Cobb MH.
  TITLE     Isolation of TAO1, a protein kinase that activates MEKs in
            stress-activated protein kinase cascades
  JOURNAL   J Biol Chem 273 (44), 28625-28632 (1998)
   PUBMED   9786855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_173327.3.
            
            On or before Jul 19, 2021 this sequence version replaced
            XM_039085331.1, NM_173327.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JACYVU010000220.1  19290012-19290094   c
            84-174              JACYVU010000220.1  19288255-19288345   c
            175-237             JACYVU010000220.1  19284267-19284329   c
            238-459             JACYVU010000220.1  19258088-19258309   c
            460-531             JACYVU010000220.1  19254159-19254230   c
            532-633             JACYVU010000220.1  19249099-19249200   c
            634-679             JACYVU010000220.1  19248223-19248268   c
            680-776             JACYVU010000220.1  19246846-19246942   c
            777-890             JACYVU010000220.1  19244882-19244995   c
            891-982             JACYVU010000220.1  19243309-19243400   c
            983-1076            JACYVU010000220.1  19236062-19236155   c
            1077-1158           JACYVU010000220.1  19234133-19234214   c
            1159-1326           JACYVU010000220.1  19230886-19231053   c
            1327-1530           JACYVU010000220.1  19230383-19230586   c
            1531-1665           JACYVU010000220.1  19226173-19226307   c
            1666-1902           JACYVU010000220.1  19221064-19221300   c
            1903-2031           JACYVU010000220.1  19218493-19218621   c
            2032-2235           JACYVU010000220.1  19216662-19216865   c
            2236-2475           JACYVU010000220.1  19212556-19212795   c
            2476-2688           JACYVU010000220.1  19210097-19210309   c
            2689-2871           JACYVU010000220.1  19208965-19209147   c
            2872-12158          JACYVU010000220.1  19197930-19207216   c
FEATURES             Location/Qualifiers
     source          1..12158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..12158
                     /gene="Taok1"
                     /note="TAO kinase 1"
                     /db_xref="GeneID:286993"
                     /db_xref="RGD:708455"
     exon            1..83
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            84..174
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..237
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..459
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..3333
                     /gene="Taok1"
                     /EC_number="2.7.11.1"
                     /function="activates MEKs in stress-activated protein
                     kinase cascades"
                     /note="thousand and one amino acid protein 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TAO1"
                     /protein_id="NP_775449.2"
                     /db_xref="GeneID:286993"
                     /db_xref="RGD:708455"
                     /translation="MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYF
                     ARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAW
                     LVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLT
                     EPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIEL
                     AERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELL
                     KHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEE
                     QDHGGGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMS
                     NSSVIHLKPEEENYQEEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQ
                     MQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFA
                     AEMEKLIKKHQASMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQL
                     KEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLL
                     GRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQH
                     QTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKAL
                     RNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAEC
                     QVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLAL
                     QNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNP
                     TGGSGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSIGVRNSPQALRRT
                     ASGGRTEQGMSRSTSVTSQISNGSHMSYT"
     exon            460..531
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..633
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..679
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..776
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..890
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..982
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1076
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1158
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1326
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1530
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1665
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1902
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2031
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2235
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2475
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2688
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2871
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..12158
                     /gene="Taok1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctcctc gctctccagc gctgaggcca acggagcgct ccaggggtct gcgccggtct
       61 gcccccgacc tgccggcgaa gggtccaggc tggtttaact gtgtagctga ggataacttc
      121 aaactcctga aatcctgata actctgtctc cagcctccaa gtctagaatt acaggtttct
      181 gaacttgttc atggctggat ttttaaaaaa tatattcaag atttcctgtt atgaaatttt
      241 atgccagtgt ggcttcattc atacagatga accaagcttt gggatagcag tataaaatta
      301 gaatcagaca gctgactgct cagcaggatg ccatcaacta acagagcagg cagtctaaag
      361 gaccctgaaa tcgcagagct cttcttcaaa gaagatccgg aaaaactctt cacagatctc
      421 agagaaatcg gccatgggag ctttggagca gtttattttg cacgagatgt gcgtactaat
      481 gaagtggtgg ccatcaagaa aatgtcttat agtggaaagc agtctactga gaaatggcag
      541 gatattatta aggaagtcaa gtttctacaa agaataaaac atcccaacag tatagaatac
      601 aaaggctgct atttacgtga acacacagca tggcttgtaa tggaatattg tttaggatct
      661 gcttcggatt tactagaagt tcataaaaag ccattacaag aagtggaaat agcagcaatt
      721 acacatggtg ctctccaggg attagcttat ttacattctc ataccatgat ccatagagat
      781 atcaaagcag gaaatatcct tctgacagaa ccaggccaag tgaaacttgc tgactttgga
      841 tctgcttcca tggcctcccc tgccaattct tttgtgggaa caccatattg gatggcccca
      901 gaagtaattt tagccatgga tgaaggacaa tatgatggca aagttgatgt atggtctctt
      961 ggaataacat gtattgaatt agccgagagg aagcctcctt tatttaatat gaatgcaatg
     1021 agtgccttat atcacatagc ccaaaatgaa tcccctacac tacagtctaa tgaatggtct
     1081 gattattttc gaaactttgt agattcttgc ctccagaaaa tccctcaaga tcgccctaca
     1141 tcagaggaac ttttaaagca catgtttgtt cttcgagagc gccctgaaac agtgttaata
     1201 gatcttattc aaaggacaaa ggatgcagta agagagctgg acaatctaca atatcgaaag
     1261 atgaagaaac tccttttcca ggaggcacat aatggaccag cagtagaagc acaggaagaa
     1321 gaggaggagc aagatcatgg tggtggccgg acaggaacag taaatagtgt tggaagcaat
     1381 cagtctatcc ccagtatgtc tatcagtgcc agtagccaaa gcagcagtgt taatagtctt
     1441 ccagatgcat cggatgacaa gagtgagcta gacatgatgg agggagacca tacagtgatg
     1501 tctaacagtt ctgtcatcca cttaaaacct gaggaggaaa attaccaaga agaaggagat
     1561 cctagaacaa gagcatcaga tccacagtct ccacctcaag tgtctcgtca caaatcacat
     1621 tatcgtaata gagaacactt tgcaactata cgaacagcat cactggttac aagacagatg
     1681 caagaacatg agcaggactc tgaacttaga gaacagatgt ctggttataa gcggatgagg
     1741 cgacagcatc agaagcagct gatgactctg gaaaataaac tgaaggcaga aatggacgaa
     1801 catcggctca gattagacaa agatcttgaa actcagcgca acaatttcgc tgcagaaatg
     1861 gagaaactta ttaagaaaca ccaagcttct atggaaaaag aggctaaagt gatggccaac
     1921 gaggagaaaa aattccaaca acacattcag gctcaacaga agaaagaact gaatagcttt
     1981 ttggagtctc aaaaaagaga atataaactt cgaaaagagc agcttaagga ggagctgaat
     2041 gaaaaccaga gcacacctaa aaaagaaaag caggaatggc tttcaaagca gaaggagaat
     2101 attcaacatt ttcaggcaga agaagaagct aatcttcttc gacgtcaaag gcagtatcta
     2161 gagctagaat gtcgtcgctt caaaagaaga atgttacttg gtcggcataa cttggaacag
     2221 gaccttgtca gggaggagtt aaacaaaagg cagactcaga aggacttaga acatgcaatg
     2281 ttactgcgac agcatgaatc catgcaagaa ctggagtttc gccacctcaa cactattcag
     2341 aagatgcgct gtgagttgat cagactgcaa catcaaactg agcttactaa ccagctggaa
     2401 tacaataaga gaagggaacg ggaactaaga cggaaacatg tcatggaagt tcgacagcag
     2461 cctaagagtt tgaagtctaa agaactccaa ataaaaaagc agtttcagga tacctgcaaa
     2521 attcaaacca gacagtacaa agcattaagg aatcacctac tggagactac accaaagagt
     2581 gagcacaaag ctgttctgaa aagactcaag gaggaacaga ctcggaagtt agccatcttg
     2641 gctgagcagt atgatcatag cattaatgaa atgctctcca cacaagctct gcgtttggat
     2701 gaagcacagg aagcagaatg ccaggttttg aagatgcagc tacagcagga actggagctg
     2761 ttgaatgcat atcagagcaa aatcaagatg caggctgagg cccaacatga tcgagagctt
     2821 cgagagctgg aacaaagggt ctcccttcgg agagcactct tagaacagaa gattgaagaa
     2881 gagatgttgg ctttgcagaa tgaacgcaca gaacgaatac gtagcctgct cgagcgccag
     2941 gccagagaaa ttgaagcttt tgactctgaa agcatgagat taggttttag taacatggtc
     3001 ctttctaatc tctcccctga ggcattcagc cacagctacc caggagcttc tagctggtct
     3061 cacaatccta ctgggggttc aggacctcac tggggtcatc ccatgggtgg cacaccacaa
     3121 gcttggggtc atccgatgca aggcggaccc caaccatggg gtcacccctc agggccaatg
     3181 caaggggtac ctcgaggtag cagtatagga gtccgcaata gcccccaggc tctgaggcgg
     3241 acagcttctg ggggacggac ggaacagggc atgagcagaa gcacgagtgt cacttcacaa
     3301 atatccaatg ggtcacacat gtcttacaca taataattga aagtggcaat tccgctggag
     3361 ctgtctgcca aaagaaactg cctacagaca tcagcacagc agcctcctca cttgggtact
     3421 accgggtgga agctgtgcat atggtatatt ttattcgtct ttgtaaagcg ttatgttttg
     3481 tgtttactaa ttgggatgtc atagtatttg gctgccgggg gtttttgtgg ttggcttttt
     3541 gtttctttgt ttttaacttt tggaaaaatt ttaaagtggg aaatagataa ctatttcatg
     3601 tatgtggcaa aaaaaattgg ctttatagaa ggggtattat ctgaacaata taaaaataaa
     3661 atgaagcaaa ctaatctgga tcatcacttt agggtatcca cagcctaaga aatttgttgg
     3721 aagatgtaaa gccttccttc atattccaaa ttctgtgagt cactgacagc aggcagtatc
     3781 catgctgaaa cacattctta ctgaaatata cctccattcc tcaccagtgt gctttcttta
     3841 tctatggatt gatctgattt ctcaacctca tttggactaa aaaacagaag gacatgaaca
     3901 ttaaacgatt gcatttacct tttcagtggt agaaaatcac ttagttcttt gctaagtgct
     3961 tcagaaactt gtcagatttc gtaggtcgta taagatggac ttgcttacag agatataagc
     4021 tgtgtggcta ttgcactaac aacctgtgag cttgcagagg agaaactaga gggccagatg
     4081 ggcccctgag agttcctgtg gtagatagga atgttcagca gggagaagga ggtaaagcct
     4141 gtattgcctg acattgtgtt tttgtgctat atctcgtctg accccgtcta taagacccca
     4201 aacagtacct ttgctctgta taaaaccaag acatagccaa cacaaagcca atgccagagg
     4261 cattgaatga tgccatattg tgaacagcca tctagtagaa tattcatcac actacataga
     4321 catgatttta ttatcccctt tttagctttg ggattccatg tttacaagta gcagtagttg
     4381 attatttaaa tagttgccac caggagtcac tgagccaatg actaccagct gctgactaat
     4441 cttcacactg tagttgcttc atttgcaggt cttctgtgct taattgctgt ttttgttgcc
     4501 gtagtacctt acaaattctt aattcattga gagttagtga ccatccgggt ccatgttaat
     4561 atcacataat agcaaattcc ctttcagaag tttctagctt tagtgctaaa atactactga
     4621 gaaagaaact aggtagtttg agtgaaagaa aacaacaaaa attgaaaata atatgcagtg
     4681 gtcaggtacc actaatattt ggggagtgtg ttttgtctgt tcttcaatga aggatcaacc
     4741 cagtgttctg catcagtgtt agttaatgtc ccatggtttg tgtggagctt gagttggtgg
     4801 tagaccgggg ccagagacca gagttttttg ttttttgttt tagtaagtta ttgtcctgct
     4861 ccctttccag ttgtcttgaa gagctcttgc tactaactct gggtcctgct tttcatttat
     4921 gtagacagta agcattctct taatcacaat tagaacaaac tcgtgaccaa attgttatct
     4981 acgatggaag ttcttggttt gcttaaccac attctatgtc ttgtccaggt atgtgagtcc
     5041 agtctccatg acttaccccc ttcaaaagct tctgacactg gtttgaggat ttctaacact
     5101 aaataaaaga aaaattagat caggatgtgg tagcaaatgc ctataatccc agcatttggg
     5161 aggcaggggt aggaaggaat ctcaggttca aggctgcctt caggtgtctc caaaaaaaaa
     5221 aaaaaaaaaa gaaggaacaa aagaaaggta aatgctatag tataagtcct ttaaaaatct
     5281 agtggaaggt taatggtagt tacacatttc taagcagggt tttaaacata ttccccatta
     5341 gtttttaggt aaacatggac aagttataac taatgaaaag ggcctttaga tttgtttttt
     5401 gttttttttg ttttttttcc ccattcaaaa tatcattaaa gagtttcaaa caaattgaaa
     5461 attctgtgtt tggagaaaat aaaggaaatc tttagagttt agtagactat tcaaaactgt
     5521 aaaataatat ctttaaaaac cattccggca accatctgtt cccagagggt ttgattgaga
     5581 aagcagatca ggtgtgtgta agacatctct tcaaactcca aactatgacc agaaacactt
     5641 tatcatcacc cattgtgagc atcacttggt caaatttact gagtccattt tgatcataat
     5701 gcccgcatac tagtgtgatt aaacactgac tgtcctgtcc agtaagaatt tctgcctcat
     5761 ctaatcgtgt ggcaccctat cttttcatgt tgttcattat acctgaattg taccatcagt
     5821 ttagttaaga tgcatgtagt ttgcacagtg attaaagtga acaggttatg tttataacaa
     5881 ctctagagga accatggaca cagcaggaat tgtcacagta aaaactggta gcaggaaaat
     5941 ttgaaagggt ttgaaatgcc ctgaatgggg caagtacttt atagagaaaa aatgcaaaaa
     6001 tgtcaacatt tgaccagatg aacactacct cctccccagt tactggtatt cactcatgtg
     6061 tgtgtttaag aaaatgaacg catggagaac ttgtgtagca caccagaagt tgtggatcta
     6121 tatctggtat ccagaaccta cagggaaatg tttctttttc tccctttttc ggggtcagca
     6181 ttttaaaaat gcaaagcctc atatgttgag acattttagg ggttggggat ttagctcagt
     6241 ggtagagcgc ttgcctagga agcgcaaggc cctgggttca gtccccagct ccggaaaaaa
     6301 agaaccaaaa aaaaaaaaaa aaagacattt tatttctaat tagattccct gccctttgca
     6361 cataactttt cttctaaact gagttctaac cctaaatttt gacatcagaa agtgtttgca
     6421 ctgtataaac aacgttagct gaaagcatgt ttatttttaa aagagctcct gctcttctgc
     6481 acatttccat atctagagat gaaaactcct gaatttgaag tcacacgcac aggtggaata
     6541 cagcctgaag tcaaggcctt gctagtaaat gaatctttgt ccatagttac gatttctggc
     6601 tgcctggaca tcaagtaaac ataacactaa agaagctgga gatcacatcc tgctactaac
     6661 aatttttctg tgcatccttt tcaaaaattg aaaattttta gatcacaagg cagaatttag
     6721 taattttatg cttctgtaaa tgtctagcat tttaaactaa gtacattgtt ttggacactg
     6781 gaataatatg atttattttc acctgtaaag atgacttcat tgtacttgaa cacctttgca
     6841 tttctccatt tgtgccattt acaagtggaa ataaattgta ttataccatg atctactggt
     6901 gttttaaaac tgttacatgt gcacattttg ggtatagcta ttttcatttg tatgtatata
     6961 ttgtatatac atatgagtgt ttatatgttt gtatagatgg atggatataa ctcattttaa
     7021 acatgtctgc cagggctcaa gttttattgt tgtcccccac ctctcccgcc ccatgttaca
     7081 gcaagagtga gtactctggg ttgatactta tggaaggtga tgagtagata cattctctct
     7141 atccctttag cacttgtatg cctgaggaga aagttaaatc aactatgaaa ccataagtta
     7201 caatgcagta aaagtgtgct agggaaggag ccagttattc tttgagtttg ttttacaatg
     7261 caactaaaat tacaagctgc agagagaaat gaactctgca atgaacactg gtagtaattg
     7321 ttctgcagag gttaagagag ccactgagtc acagtcttca cggacttagg gtctcttagt
     7381 gttggtccca tgatcctcat ttgcttttta tccctaatac taatagtcat gtttattgtc
     7441 gagggtcaag actgccaagc aaagaattac aactaaaaca caaccgaggc tctcctcagc
     7501 tgtaaaatga gcaggagatg atcacccagg gaaggtagac tggtttgaag ggctgcctcc
     7561 ttttgactta ccttcttgct aacagtaagt tctttgtgca ccttctaccc cttctgattc
     7621 aatactgttc aagcagagat ttggtctgac acaacatgcc ttcttagttt tgcttctttt
     7681 ctctcgagac atgtatcctt tctgatggag taattgatgt ttagccaagg ctggcctcaa
     7741 attcctagca gtctttctgt aagcctctca agtactggga ttataggcat gagctaccat
     7801 gccaatagcc acagcaaccc attctttttg gaggttttat agttttgcat ttgtctcatg
     7861 ttcagaatgt gaagtgtcct aatgtgtatt aaagtcagaa aataatatat ttaagggcta
     7921 ctaagtgtga atctgctata atgatggaag aaatagtctt aaggagcatt gggctgtcat
     7981 ctttgagctg cttatcaaaa tacagatcat tattgaatat aaacaaattc tgttttattt
     8041 tgtccctaat aacagaagtc tcccttccat ggttttagca ttgccttttt aaaaaggcac
     8101 tcaccctgag ttgttacaaa ctggaaattt ctcaccctca gattccttaa aggatgaaga
     8161 gtgtgctgtc cactcagcat atgtgcctct tgtatgcaag gactactgat ggaagtctgt
     8221 tttgctgtgt ctggttatgt tgtctgcact tttatgaaat cactacagta gatctacgtt
     8281 ggaaataact attaatttgt aaagaaaatt ttattaaaca ctgtagaaaa agtgaagctg
     8341 agaactcttc cttttgtgca tttatgtttc ctactgaatt ctggtagccc acttttaaag
     8401 ttatattggc ttttttctcc tctttgatta tattcagatt tccagacaag tgctggcctt
     8461 cagatgataa gcataagtaa tatgcatcat atctgcctgt tgcaggcttc tgaaacctgc
     8521 actgccctcc atgcaaaaat aagtatctta ggagatagac gcagagagca gaacccgggg
     8581 agccatgtac tatgtcacca tctgttactg tttccagcaa tccaaactga agtccgtgca
     8641 tgcgcgcgtg catgcgtgcg tgcgtgcgtg cgtgtgtgcg tgtgtgtgtg ttgggggttt
     8701 tgttttgctt tgcttttaaa tatacaaggg gttcttcttt aatacaggaa aaggttagtc
     8761 ctctccagca ggatgcccac tggatataat attaacatct gtaggtagtt ggaagtgtag
     8821 agagaagaga aggtaagact tctcaatgaa tgaaaaaggg tgtcttgatg atcaagaatc
     8881 tccccccccc cccccaaagt acgggtaatt caacctgcac agtttccttt cactcgtagt
     8941 ttaacaatta tgagtgaaaa atcatgtaat tatctgtaaa tatgtagcta acaaattgac
     9001 ctagtttctg tactagtttc tggttttgta ctaaagttta taggtctgtg ccagctagag
     9061 aggagttgct gccattgcta gttgtgcttc tggcatataa ccctgagacc atcctaggtg
     9121 acattttaga attaatgcct aaatgttgtt aaatggggaa atggagctta atcattggtc
     9181 aggtttgaaa tcttttgaag ctaagtaatt ttatttaata tgattacatg tcgtcagtca
     9241 tgagtgaggt gtagggagtc ttcctccccc agtggccatg tttacagagt gttgtctata
     9301 aagtgcaagt gtgttaatgt ttatgtaaat tatgcaggtg ataactttat ggtttgggac
     9361 tgttcatggg ctcttttaac tgcattttca aatgaaatga actttgctta ttgctggcac
     9421 attgatccca tttctggaac atttcctact tccagaattc cgtatgttcc tcagacatta
     9481 cccccacgta acctcccttc ctctgatatg ccttgtagct aagatttaaa agactgttga
     9541 acatagatga ggggagtgca tttcttaaaa atccatgaac cctcaattgt atgctttcag
     9601 tattgtgtta tatgtttcta tggcaacttt gaagtcagtg gtttagaaat gaggtaccaa
     9661 tgttaatgaa aagtatgtac tctttgcttt tgcatggctt ggcttagtat ccaaggtata
     9721 ttagagccac tggaaagcat gaagaccagt tatatggaaa caggtttctc tcagtggcac
     9781 attttgcttt ttcttagccc tcaaatacat tgcctcggca tgaacattat tgttaatata
     9841 aattgcacat ggtcatcgag cgaattataa aattttgaaa agatgcagct gcccaatatt
     9901 tacagtctct atctcaagta acagcgtagg tattggaacc cttctagccc ttcttggggt
     9961 caaacaggta tgtcggttat caaggcattg gctacccctg gggtattgcc acgctgttgt
    10021 cttttgctgc ctgttcattc cacatgtgct gttccttgca cttcatactc ttccaagaaa
    10081 ctatcaccct ttcttcctat tttatttgtc gtttatttca caataaatgg gaattgtgcc
    10141 tatttagatc gcccctccag ttaagtacac atgtaatcca agccagagac aagatggaaa
    10201 aacttttttt tttttcaaat tcacttggcc agtaatttat ctaacaaacg ttttaccaca
    10261 ttatcttgac acttgataga agagcctatt aggagtcaca gtggtttgtt tcatagagta
    10321 aaacccaagt gaggagggat gtgtggggtt tccatcggaa aataattttg ttcttggttt
    10381 actctttatg attcttctct gctagtttag aataggttaa tttttttatt ttttttttat
    10441 ttagggaaat ttttacaaaa ataatggtct gatgtaaata ccattttaaa gtacagtgca
    10501 cataactccc taggctattc caacctactt gtaaatgctt tagagttttt aaattaacac
    10561 ttctgttgct aaatactatt tatgtaagtc tgaaaaggtt tttaacccat ataaaacatt
    10621 taaatgatgc aggttgttat gagcaagtta gctttgagaa cccctcttta gtgtatgaaa
    10681 aaagcctaac atgcattagt gaggttggag agactatgag aaatatgtat agtgtatatt
    10741 ttaaacagct ttgcttgtat tgtgaagatt taagaacaaa cttgagattt ttaaagttaa
    10801 ctattaacac agttttaaca taagttatcc cactgggttt gaaagcatct tgaatgtata
    10861 acccttctgt aacccaggtt ggtctttgct tttactgaac caccaaacgt tatttatatt
    10921 tttagtttta tgtactcatt tctttttgtt ttcctcaaac agcatgttgt tgttgttggg
    10981 gttttttgtt tttgttttga tttttttttt ttgcacatat agaaattttt taaaagaagg
    11041 aaattaatac atggtttttc tctagatttt cttcacttca gtctttgtac taacctctta
    11101 aaagccatgg cattccattg ctttatttgt gcaaatgcca ggggtggttt ttatttttat
    11161 ttttgctatt tacctagaga gagagagaga gagagagaga gagagagaga gagagacaat
    11221 gcttcagtca attgcttttt tatttaaaat ttaaaggaaa aaaaaagaaa aaaaaaagct
    11281 gtaaccttat catttctgag tagaccattg agagaaatgc acacctgtca gcccaggacc
    11341 agctttggtg gctaaaggga atattttaac ttcacaagat aagatgttct gtacaaaatg
    11401 tggtatatgt tatccacagt ctgtttcagt tattcccata agtcaggtcc agataaatga
    11461 gggttatcag ctaactgata tgttatcatt gaggttcgtc aatgaatttg tacatttcta
    11521 gttccctttg gtgaagggaa aaatgatgat tttgcaagac ctagattttg gcttggtttc
    11581 ttgcctcctt ttttggcagc cttcatcttt tcctaaagcc cttgagcctg tagggttttc
    11641 atagtggaca aaggacttaa atggtctttt aaaactggga tagtttttgg ggaaagggca
    11701 agagattatc atattgaaca tatagtatcc taatactttt aacagtggat aattttgagt
    11761 aaacccagtc ctttcaattt ttagattaaa catgcccaca gtggaggctt accaaaggtt
    11821 gcaatgagga ggaagcctct ccctctctgt cagcccagct ggtaaagggg actgtgcaga
    11881 tgtgcatttt cctttcggta gaaatggtcc gcagcactaa ctggtaagga ttattgtaca
    11941 gtatattgtc agtattcttc tggttcagca taccttatag ttcgtatata acctgtatta
    12001 attgtataga ttgtgcattt aaagctgtta ccaagttgtc agaaccttaa gaacgaaaac
    12061 aggtcatatg taatattttg tttgtaagta tcctttgtat catagcaaag gaaatgttta
    12121 aaagatcaac tgtaataaaa gtaattttag tacacaga
//
