LOCUS       NM_001164073            2113 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus TRAF family member-associated NFKB activator
            (Tank), transcript variant 2, mRNA.
ACCESSION   NM_001164073
VERSION     NM_001164073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Wang,W., Huang,X., Xin,H.B., Fu,M., Xue,A. and Wu,Z.H.
  TITLE     TRAF Family Member-associated NF-kappaB Activator (TANK) Inhibits
            Genotoxic Nuclear Factor kappaB Activation by Facilitating
            Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase
  JOURNAL   J Biol Chem 290 (21), 13372-13385 (2015)
   PUBMED   25861989
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Igwe,O.J.
  TITLE     Modulation of peripheral inflammation in sensory ganglia by nuclear
            factor (kappa)B decoy oligodeoxynucleotide: involvement of SRC
            kinase pathway
  JOURNAL   Neurosci Lett 381 (1-2), 114-119 (2005)
   PUBMED   15882800
  REMARK    GeneRIF: The present results indicate that the wild-type ODN decoy
            may act as a competitor for NF(kappa)B binding to its cognate
            recognition sequence as well as a modulator of c-Src activity in
            the DRG.
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Chariot,A., Leonardi,A., Muller,J., Bonif,M., Brown,K. and
            Siebenlist,U.
  TITLE     Association of the adaptor TANK with the I kappa B kinase (IKK)
            regulator NEMO connects IKK complexes with IKK epsilon and TBK1
            kinases
  JOURNAL   J Biol Chem 277 (40), 37029-37036 (2002)
   PUBMED   12133833
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   5  (bases 1 to 2113)
  AUTHORS   Rothe,M., Xiong,J., Shu,H.B., Williamson,K., Goddard,A. and
            Goeddel,D.V.
  TITLE     I-TRAF is a novel TRAF-interacting protein that regulates
            TRAF-mediated signal transduction
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8241-8246 (1996)
   PUBMED   8710854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 13, 2021 this sequence version replaced NM_001164073.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, and uses an alternate in-frame splice site in
            the central coding region, compared to variant 1. The resulting
            isoform (2) lacks one internal residue, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129086.1, SRR26643292.12571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000003.1  66522837-66522992
            157-304             JAXUCZ010000003.1  66558144-66558291
            305-413             JAXUCZ010000003.1  66571511-66571619
            414-532             JAXUCZ010000003.1  66573417-66573535
            533-603             JAXUCZ010000003.1  66588383-66588453
            604-719             JAXUCZ010000003.1  66589027-66589142
            720-1270            JAXUCZ010000003.1  66594380-66594930
            1271-2113           JAXUCZ010000003.1  66598022-66598864
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..2113
                     /gene="Tank"
                     /note="TRAF family member-associated NFKB activator"
                     /db_xref="GeneID:252961"
                     /db_xref="RGD:628859"
     exon            1..156
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            157..304
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1447
                     /gene="Tank"
                     /note="isoform 2 is encoded by transcript variant 2; TRAF
                     family member-associated Nf-kappa B activator; TRAF
                     interacting protein TANK; TRAF family member-associated
                     NF-kappa-B activator"
                     /codon_start=1
                     /product="TRAF family member-associated NF-kappa-B
                     activator isoform 2"
                     /protein_id="NP_001157545.1"
                     /db_xref="GeneID:252961"
                     /db_xref="RGD:628859"
                     /translation="MDKNIGEQLNRAYEAFRQACMDRDSAVRELQQKTENYEQRIREQ
                     QEQLSFQQTLIDRLKSQLRLVDSSRDNTCDYVPLLEDSDRRKNNLTLDEPHDKVKLGT
                     LRDKQSKVRRQEVSSGKETSKDLSIPLHHERDNIEKTFWDLKEEFHRICLLAKAQKDH
                     LSKLNIPDIATDTQCSVPIQCTDKTEKQEALFKPQAKDDINRGMSCVTSVTPRGLGRD
                     EEDTSFESLSKFNVKFPPVDSDSTFLHSTPETPSILAPSTPEAVCQDKFNVEVRDSPG
                     NLVKTEETLFEIQGINPITSAIQNLKTTDKTKPSNLRAPCLPAGDHNVFYVNTFPLQD
                     PPDAPFPSLDSPGKAVRGPQQPLWKPFPNQDTDLVVPSGSDSVLLKPQVCEFCQELFP
                     PSLTSRGDFLRHLNTHFNGET"
     exon            305..413
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            414..532
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            533..603
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            604..719
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1270
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2113
                     /gene="Tank"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtggaa gtccccagtt ccttccacac aagggagagc tcaggacagt ttgggcagca
       61 tctggtagag cctgtgcaaa cggtttccag aatgtgtccg tgcctgtctt taaagagaca
      121 cagtcagtga aggaaaactt gtcacctgga gaagagagct ggcattcgta ccatccttta
      181 tagtgatgct acaggacaaa gaggaatgga taaaaacatt ggcgagcaac tcaatagagc
      241 atatgaagcc ttccgacagg catgcatgga tagagattca gcagtaagag agctgcagca
      301 gaagactgag aactatgaac aaagaatacg cgagcaacag gaacagctgt catttcaaca
      361 aactctcatt gacaggctaa agtcacagct acgtcttgtg gattctagtc gagataacac
      421 ttgtgactat gtacctttgc ttgaagacag tgacagaagg aagaataatt tgacccttga
      481 tgaaccacat gataaagtga aactaggaac actgagagat aagcaatcaa aggtgagaag
      541 acaagaagtt tcttctggaa aagagacctc aaaggatctc agcatccctt tgcatcatga
      601 aagggataat atagagaaga ctttctggga ccttaaagaa gaatttcata ggatatgctt
      661 actagcaaaa gcacagaaag accacttaag caaacttaat ataccagata ttgcaactga
      721 cacacagtgt tctgtgccta tacagtgtac cgataaaaca gaaaaacaag aagcgctgtt
      781 taagccccag gctaaagatg atataaatag aggtatgtcg tgcgtcacat ctgtcacacc
      841 aagaggactg ggccgggatg aggaagatac ctcttttgaa tcgctttcta aattcaatgt
      901 caagtttccg cctgtggaca gtgactctac ttttctacat agcactccag agaccccgag
      961 catccttgct ccctccacac ctgaggcagt gtgccaggac aagtttaatg tggaagtcag
     1021 agacagccca ggaaacttgg ttaaaacaga agaaacttta tttgaaattc agggaattaa
     1081 ccccataact tcagctatac aaaaccttaa aacaactgac aaaacaaaac cctcaaatct
     1141 tagagctccg tgtttgccag ctggagacca taatgtgttc tatgtaaata cgttcccact
     1201 tcaagacccg cctgacgcac cttttccctc actggattcc ccaggaaagg ctgtccgagg
     1261 accacagcag cccctttgga agccttttcc taaccaagac actgacttag tggtaccaag
     1321 tggttcagac tcagtactcc ttaaacctca agtgtgtgag ttctgtcaag agcttttccc
     1381 accatccctt acatccagag gggatttcct ccggcatctt aatacacact ttaatggaga
     1441 gacttaaatc acatttgaaa acagacatat catgttctct gtgatggttt tgagtttgta
     1501 atgctagaga atgcttgctt gtaagctaaa tttaaggttg tgtataaaag aaattcattg
     1561 tcacagctat ttgaattttt ctctaaagtt gttactctat cttttaagag atcattttgt
     1621 atataaaaaa ctataattca ttatattata ttattcatgt ttatactata atttccagat
     1681 ttcaaaatta cgcatgtgac ctacagagtt atgtaatcat aatttatgtt ctaaatggct
     1741 aagtttattg tttgactctc acgaaatcta ttaaatttgg ttatatcaaa tgtttatagg
     1801 gtattcaaat ttcatttgaa tttttaatta tactacaggt aatattcctt taaaatatgt
     1861 ttgtaactta cagataatag cagacaatat gatcaaagta aatatcaaat caatcattag
     1921 ttgcccagtg aaaattattt aaacatttta gatcattttt taaataatac acatggtttt
     1981 aatttttact atgtgtataa aatgcatgat tgagtgatta ttattaaata ttaaaagttc
     2041 cttatgtcat gattattgaa agtgttcttt gtttctgagg taaataaatc acatttgggg
     2101 agggttcata aaa
//
