LOCUS       NM_001002854            5819 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tetratricopeptide repeat, ankyrin repeat and
            coiled-coil containing 1 (Tanc1), mRNA.
ACCESSION   NM_001002854 XM_229944
VERSION     NM_001002854.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5819)
  AUTHORS   Avirneni-Vadlamudi,U., Galindo,K.A., Endicott,T.R., Paulson,V.,
            Cameron,S. and Galindo,R.L.
  TITLE     Drosophila and mammalian models uncover a role for the myoblast
            fusion gene TANC1 in rhabdomyosarcoma
  JOURNAL   J Clin Invest 122 (1), 403-407 (2012)
   PUBMED   22182840
REFERENCE   2  (bases 1 to 5819)
  AUTHORS   Han,S., Nam,J., Li,Y., Kim,S., Cho,S.H., Cho,Y.S., Choi,S.Y.,
            Choi,J., Han,K., Kim,Y., Na,M., Kim,H., Bae,Y.C., Choi,S.Y. and
            Kim,E.
  TITLE     Regulation of dendritic spines, spatial memory, and embryonic
            development by the TANC family of PSD-95-interacting proteins
  JOURNAL   J Neurosci 30 (45), 15102-15112 (2010)
   PUBMED   21068316
REFERENCE   3  (bases 1 to 5819)
  AUTHORS   Nonaka,H., Takei,K., Umikawa,M., Oshiro,M., Kuninaka,K.,
            Bayarjargal,M., Asato,T., Yamashiro,Y., Uechi,Y., Endo,S.,
            Suzuki,T. and Kariya,K.I.
  TITLE     MINK is a Rap2 effector for phosphorylation of the postsynaptic
            scaffold protein TANC1
  JOURNAL   Biochem Biophys Res Commun 377 (2), 573-578 (2008)
   PUBMED   18930710
REFERENCE   4  (bases 1 to 5819)
  AUTHORS   Suzuki,T., Li,W., Zhang,J.P., Tian,Q.B., Sakagami,H., Usuda,N.,
            Kondo,H., Fujii,T. and Endo,S.
  TITLE     A novel scaffold protein, TANC, possibly a rat homolog of
            Drosophila rolling pebbles (rols), forms a multiprotein complex
            with various postsynaptic density proteins
  JOURNAL   Eur J Neurosci 21 (2), 339-350 (2005)
   PUBMED   15673434
  REMARK    GeneRIF: TANC protein may work as a postsynaptic scaffold component
            by forming a multiprotein complex with various postsynaptic density
            proteins.
            Erratum:[Eur J Neurosci. 2005 Feb;21(3):825. Usada, Nobuteru
            [corrected to Usuda, Nobuteru]]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB098072.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001002854.2.
            
            On Aug 30, 2004 this sequence version replaced XM_229944.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB098072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5819
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..5819
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /note="tetratricopeptide repeat, ankyrin repeat and
                     coiled-coil containing 1"
                     /db_xref="GeneID:311055"
                     /db_xref="RGD:1302949"
     exon            1..103
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            104..183
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..5672
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /note="TPR domain, ankyrin-repeat and
                     coiled-coil-containing; TPR domain, ankyrin-repeat and
                     coiled-coil domain-containing protein 1"
                     /codon_start=1
                     /product="protein TANC1"
                     /protein_id="NP_001002854.1"
                     /db_xref="GeneID:311055"
                     /db_xref="RGD:1302949"
                     /translation="MLKAVLKKSREGVKGSKKEAGGDFGSETPTLSSSGDSPVNSLST
                     TEDTYRVSLAKGVSMSLPSSPLLPRQSHLTQSRANKKSPGPVRKPKYVESPRVPGDPV
                     MIPFREGSKPAEPIETEAKVDNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNE
                     AMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLES
                     KDSGIIATITSSSENDDRSGSSLEWNRDGSLRLGVQKGVLHDRRLDNCSPVAEEETTG
                     SAESVLPKAESSAGDGPVPYSQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLR
                     TSIRLPWHSTAGARFAPYKPQEILLKPLLFEVPSITTDSVFVGRDWLFQQIEENLRNT
                     ELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRMRQVASSSPSSSLKTSDPTHDLPG
                     TPLLSPSSSTSALSAARTPPGPGTVDSQRPREDAVKYLASRVVAYHYCQADNTYTCLV
                     PEFVHSIATLLCRSHQLAAYRDLLIREPQLQSMLNLRSCVQDPVAAFKRGILEPLTNL
                     RNEQKIPEEEYIILIDGLNEAEFHKPDHGDTLSSFITKIIPKFPPWLKLIVTVRADFQ
                     EIISTLPFVKLSLDDFPGNQDIHSDLHAYVQHRVHSSQDILSNISLNGKADAALIGKV
                     SSRLVLRNLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSA
                     FDRALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQKMEALSCFLIKKRDK
                     TRMFCHPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESKLNRQQTVELGHHI
                     LKAHIFKGLSKKTGVSSSHPQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGA
                     NVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMK
                     LVCLLTKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQA
                     LQQALTAAASMGHSAVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKLEICELL
                     LERGAAVSRANRRGVPPLFCAARQGHWQVVQLLLDRGCDVNPNDKQGRTPLMVAACEG
                     HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTP
                     LDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGN
                     AAWAMATFKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGPGEDMRP
                     FNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLA
                     ALADLQEAVKLCPTNQEIKRLLARVEEECKQLQRNQQQKQQAPLPAPPNDSDNDEEAP
                     ASSLKDHFPIEEAEEEDTSSQEESISPTPRSQPPPSVPSPYIRNLQEGLQSKGRPASP
                     QSWAGISKSLRETVAQPGLVMQPTKQAQIVKTNQHLGSGQSSMRNSNTKVQVSSQNPP
                     PSPMPGRVSAAPAVSRNQHLEGTGPFSTGTGCGHFGDRLGPSQSLQLQRGESGTAYPL
                     PSKVKAAERLLAHASVAVDMALPSQGGPVSCSDVRHPASLSSSGSSGSPSSSVKMSSS
                     TSSLTSSSSVSDGFKAQGPDCRIRDRGTTQVQGGTAEHRPRNTPFMGIMDKIARFQQQ
                     VNPPSRSWHCPVTEGLLTNTATAAGLQTNSEKPALKPGGYCSQAKPCSVPPLGMGVHN
                     GAQVKELEENKCQVPALCQDNRKTKGVPHLYPEGVSKQPLHVSTEAHRSHLTSAKPKR
                     SFIESNV"
     exon            184..372
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            373..477
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            478..608
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            609..795
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1059
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1161
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1443
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1595
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1827
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1994
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2602
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2711
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2834
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3071
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..3257
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3336
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3470
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3594
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3770
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3771..3903
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..3995
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4142
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4243
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..5819
                     /gene="Tanc1"
                     /gene_synonym="Tanc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagtgttgg gcacgacgta caggaaaagg acaggagaga gaactgagac ttaaggacca
       61 ccgcgcagag tttcctctgt gaacgagaag ataacagaga cagagacaaa agagtgttga
      121 aaatgttgaa ggctgtgctg aagaagagcc gagagggagt aaagggaagc aagaaggaag
      181 caggaggtga ctttggctca gagacgccca ccttgtcctc cagtggtgac tctcctgtga
      241 acagtttgtc cacaacagag gacacctacc gtgtgagctt ggccaaaggg gtctccatgt
      301 ctcttccttc atcacctttg ctgcctcgac aatctcacct gacacagtca agggcgaaca
      361 aaaagtctcc aggtcccgtc aggaagccca agtatgtgga aagccccagg gtaccaggag
      421 atccagttat gattcccttc agagaagggt ccaagcccgc agagcccatc gagactgaag
      481 caaaggtgga taatgaaccg agctgctctc cagcagcaca ggaactgttg acaagactgg
      541 gatttttact gggagagggg atcccaagtg ccacacacat aaccatcgaa gacaaaaatg
      601 aagccatgtg cacagccctg agtcaaggca tcagtccttg ctccacactg acaagcagca
      661 ccgcctctcc cagcacagat agcccctgct caaccttgaa tagctgtgtc agcaagacgg
      721 cagccaacaa aagcccctgt gagaccatta gcagccctag ttccaccctg gagagcaagg
      781 acagtggaat tatagccaca attaccagtt catcggaaaa tgatgaccgg agtggctcca
      841 gtctggaatg gaatagagat ggaagcctga ggttaggggt tcagaaggga gtgcttcatg
      901 accgaaggct ggataactgt tccccagtgg cagaagagga gactactggg tcggcggaga
      961 gcgtactgcc caaggcggaa tcctcagctg gagatggtcc ggtcccttat tctcagagct
     1021 caggctcgct aataatgcca cggcccaact cagttgcagc gacaagttct accaaattgg
     1081 aagacttgag ctatttagac ggacagagaa atgctcctct ccggacgtcg attagattgc
     1141 cctggcacag tacggctgga gcacggtttg ctccctacaa accacaggag attttgttga
     1201 agcccttgct tttcgaagtg ccaagcatca cgaccgactc tgtgtttgtg ggaagagatt
     1261 ggctctttca acagatagaa gagaacttga ggaacacaga actggcagaa aacagaggag
     1321 cagtggtggt gggaaatgta gggtttggga agacagccat catttccaag ttggtggcac
     1381 tgagctgtca tggaagccgc atgagacagg tagcatccag cagccccagt tcatctctca
     1441 aaacctcaga tcccacccat gaccttcccg gtactccgtt actttcacca agttcttcca
     1501 caagcgctct cagtgcggcc agaacacctc ccgggcccgg tactgttgac agccagagac
     1561 caagagagga tgcggtgaaa tacctcgcct ctagggtggt ggcctaccat tactgccagg
     1621 cagacaacac gtacacgtgt ctggtacctg agtttgtgca cagcattgca actttgctgt
     1681 gccggtccca ccagctggct gcctaccgag accttctgat cagggagccc cagctacaga
     1741 gcatgctgaa cctccgctcc tgtgtgcagg atcctgtggc tgctttcaag aggggcatcc
     1801 tggagccact tacaaaccta agaaacgagc agaaaattcc agaagaggaa tacatcatct
     1861 tgatagatgg cttgaatgaa gccgaatttc ataagcctga tcacggggac acgctgtctt
     1921 cattcattac caaaatcatt cctaagttcc ccccctggct gaagttgatc gtgaccgtga
     1981 gagcagattt tcaggaaatc atcagcacgc tgccttttgt caagctttcc ttagacgact
     2041 tcccaggcaa ccaggacatc cacagcgacc tgcacgcata cgtccagcac agggtccaca
     2101 gcagtcagga catcctcagc aacatctccc tgaacggcaa ggccgacgcc gccctcatcg
     2161 gcaaagtcag cagccgcctg gtgctgcgga accttggctc ctacctgtac ctcaagctca
     2221 cgctggacct cttccagcgg ggccacctgg tcataaagag cgccagctac aaggtggtgc
     2281 ctgtgtctct gtctgaactc tatttgctgc agtgcaacat gaagttcatg acccagtctg
     2341 ccttcgaccg agcccttccc attttgaacg tggccctcgc gtccctccac cccatgacgg
     2401 atgagcagat attccaggcg atcaacgccg gccacatcca aggcgagcag ggctgggagg
     2461 actttcagca gaagatggag gccctctctt gcttcctcat taagaagaga gacaaaaccc
     2521 ggatgttctg ccacccgtcc ttcagagagt ggctggtgtg gagagcggat ggcgaaagca
     2581 cagccttcct gtgtgagccc aggaatggac acgctctact ggcgttcatg ttttctcgac
     2641 aggaaagcaa gctgaaccgc cagcagaccg tggagcttgg ccaccacatc ctgaaggcac
     2701 acattttcaa gggcctcagt aagaagactg gagtctcctc aagccatccg caggccctgt
     2761 ggattggcta cagcacagag gggctgtctg ctgccctggc ttctctcagg aatctctaca
     2821 ctcccaatgt aaaggtgagc cggctcctga tcttgggagg ggccaacgtg aactacagga
     2881 cagaagtgtt aaacaacgcc cccatcctgt gcgtccagtc tcaccttggc catgaggaag
     2941 ttgtcacgct cctgctggaa tttggcgcct gcctggacgg gatgtcggag aatggaatga
     3001 acgcactgtg ttacgcagct gctgccggcc acatgaagct ggtgtgtttg ctgaccaaga
     3061 agggggcaag ggtggaccac ttggataaga agggccagtg tgcactcgtc cacagcgcgc
     3121 tgaggggcca cagtgacatt ctccagtacc tactgaactg tgagtggtcg gcaggccctc
     3181 cgcagcctgg caccctgagg aagagccaag ccctgcagca ggcactgaca gcagccgcca
     3241 gcatgggcca cagcgcggtc gtccagtcct tgctgggaat ggcagaggaa catgaaatcg
     3301 aggtcaatgg caccgacaca ttgtggggag aaacagcgct gactgccgcg gctgggagag
     3361 gaaagctgga gatctgcgag cttctgctgg agcgtggagc ggccgtgtct cgggccaaca
     3421 ggagaggggt accccctctg ttttgtgcag cccgccaggg gcattggcag gtcgtgcaat
     3481 tgcttttgga tcggggctgt gacgtgaacc cgaatgacaa gcagggtcgg acacctctca
     3541 tggtggctgc ctgtgaagga cacctgagca ccgtggaatt tctcctctcc aaaggtgctg
     3601 ctctttcttc cctggacaaa gagggcctgt cggcattgag ctgggcttgt ctgaagggtc
     3661 acagggcagt ggtccagtat ctggtcgaag aaggagcaga aatagaccaa acagacaaaa
     3721 atggccgtac tcccttggac ctggccgcct tctatggtga tgcagagact gtgctgtacc
     3781 tggtggagaa aggagccgtg atagaacacg tggaccacag tgggatgcgc cccctggaca
     3841 gagccatcgg ttgccgaaac accgctgtag tggttacact gctgagaaaa ggagccaaac
     3901 taggaaatgc cgcttgggcg atggccactt tcaaacctga tattctgatc atacttttac
     3961 agaaattgat ggaggaagga aatgtgatgt acaagaaagg gaagatgaag gaggcagccc
     4021 agaggtacca gtatgcctta cggaagttcc ctcgggaagg acccggagaa gacatgaggc
     4081 cattcaatga gctgagagtc tccctctatc tcaacctgtc gagatgccga aggaaaacca
     4141 atgactttgg cttggcagaa gaatttgctt caaaggctct ggaactgaaa ccgaaatcct
     4201 atgaagcctt ttatgcccgg gcaagagcaa aaaggaacag caggcagttc ctggctgctc
     4261 tggctgacct gcaggaggct gtgaaactct gtcccaccaa tcaggaaatc aagcggcttt
     4321 tggcccgtgt tgaagaagag tgtaaacaac tccagaggaa ccagcagcaa aaacagcagg
     4381 cacccctgcc ggctccaccc aatgactctg ataatgatga ggaagcccca gcctctagtc
     4441 taaaagacca cttccccatt gaggaggcag aggaggaaga cacctcttca caagaagagt
     4501 ccatttcccc gactcccaga tcccagccac caccatctgt cccttcccca tatatccgca
     4561 accttcaaga gggattacag tccaaaggca ggccagcgtc cccacagagc tgggcaggaa
     4621 tcagtaagtc cctgagagag actgtagctc agccaggttt ggttatgcag ccgaccaaac
     4681 aggcgcagat cgtgaagacc aatcaacatc taggttctgg gcaatccagc atgaggaaca
     4741 gtaacaccaa agtacaggtc tcttctcaga accctccccc aagcccaatg ccaggtagag
     4801 tatctgcagc ccctgccgtg agcagaaacc agcatttaga gggaacgggt cccttcagta
     4861 caggaactgg ttgtggtcac ttcggggatc ggctgggccc cagccagagc ctccagctgc
     4921 agcgcggtga gagcggcact gcgtatcctc tcccgagcaa agtcaaagca gccgagaggc
     4981 tcctggctca cgcctctgtg gctgtggaca tggcccttcc gagccagggt ggaccagtga
     5041 gctgcagcga tgtgcggcac ccagcttccc tcagcagctc cggctcgtcc ggctctccat
     5101 ccagcagcgt aaagatgtcg agctccacca gtagcttgac ttcaagcagt agcgtttcag
     5161 acggattcaa ggcccaagga ccagactgta gaatcagaga cagaggtaca actcaggtgc
     5221 agggtggcac tgccgaacac aggccccgca acactccatt catgggcatc atggacaaga
     5281 tcgccaggtt ccagcagcaa gtcaaccctc cgagccgctc ctggcactgc ccggtgacag
     5341 agggactact gacaaacaca gccactgcag ccggcctgca gactaactct gagaaacccg
     5401 ccctcaagcc cggaggatat tgtagccaag ccaagccgtg ttcagttccc cccctgggca
     5461 tgggtgtcca caatggggct caggtgaagg agctggaaga aaataagtgc caagttccag
     5521 ccctctgtca agacaacagg aaaactaagg gtgtgcccca tctctacccg gaaggcgtct
     5581 ctaagcagcc gcttcatgtc agtacggaag cccacaggag ccacctcact tcagcgaaac
     5641 caaagcgatc gttcatagag tccaatgtgt gagccttaag caacccctgt gtagaatctg
     5701 gagtgcagtc tgttggctcg tggtgataaa taatgtcttt ttttcataat aaaaattacc
     5761 tgttagccat attttccacc tcttgggtgg atctgatgcc attgacatat taaaactgt
//
