LOCUS       NM_138894               1466 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus trafficking regulator and scaffold protein
            tamalin (Tamalin), mRNA.
ACCESSION   NM_138894
VERSION     NM_138894.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Chiu,S.L., Diering,G.H., Ye,B., Takamiya,K., Chen,C.M., Jiang,Y.,
            Niranjan,T., Schwartz,C.E., Wang,T. and Huganir,R.L.
  TITLE     GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal
            Recycling of AMPA Receptors
  JOURNAL   Neuron 93 (6), 1405-1419 (2017)
   PUBMED   28285821
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Peng,H.Y., Chen,G.D., Hsieh,M.C., Lai,C.Y., Huang,Y.P. and Lin,T.B.
  TITLE     Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's
            adjuvant-induced inflammatory pain via regulating dorsal horn
            GluR1-containing AMPA receptor trafficking in rats
  JOURNAL   Pain 153 (12), 2380-2392 (2012)
   PUBMED   22980744
  REMARK    GeneRIF: Our results suggest that spinal SGK1 phosphorylation,
            which subsequently triggers the GRASP-1/Rab4 cascade, plays a
            pivotal role in CFA-induced inflammatory pain by regulating
            GluR1-containing AMPAR recycling in the dorsal horn.
REFERENCE   3  (bases 1 to 1466)
  AUTHORS   Mo,J., Choi,S., Ahn,P.G., Sun,W., Lee,H.W. and Kim,H.
  TITLE     PDZ-scaffold protein, Tamalin promotes dendritic outgrowth and
            arborization in rat hippocampal neuron
  JOURNAL   Biochem Biophys Res Commun 422 (2), 250-255 (2012)
   PUBMED   22569042
  REMARK    GeneRIF: These results suggest that Tamalin is responsible for
            neuronal dendritic development via regulation of
            EFA6A/Arf6-mediated cytoskeleton dynamics.
REFERENCE   4  (bases 1 to 1466)
  AUTHORS   Sugi,T., Oyama,T., Muto,T., Nakanishi,S., Morikawa,K. and
            Jingami,H.
  TITLE     Crystal structures of autoinhibitory PDZ domain of Tamalin:
            implications for metabotropic glutamate receptor trafficking
            regulation
  JOURNAL   EMBO J 26 (8), 2192-2205 (2007)
   PUBMED   17396155
REFERENCE   5  (bases 1 to 1466)
  AUTHORS   Hirose,M., Kitano,J., Nakajima,Y., Moriyoshi,K., Yanagi,S.,
            Yamamura,H., Muto,T., Jingami,H. and Nakanishi,S.
  TITLE     Phosphorylation and recruitment of Syk by immunoreceptor
            tyrosine-based activation motif-based phosphorylation of tamalin
  JOURNAL   J Biol Chem 279 (31), 32308-32315 (2004)
   PUBMED   15173175
  REMARK    GeneRIF: tamalin is a novel signaling molecule that possesses a PDZ
            domain and a PDZ binding motif and mediates Syk signaling in an
            ITAM-based fashion
REFERENCE   6  (bases 1 to 1466)
  AUTHORS   Kitano,J., Yamazaki,Y., Kimura,K., Masukado,T., Nakajima,Y. and
            Nakanishi,S.
  TITLE     Tamalin is a scaffold protein that interacts with multiple neuronal
            proteins in distinct modes of protein-protein association
  JOURNAL   J Biol Chem 278 (17), 14762-14768 (2003)
   PUBMED   12586822
  REMARK    GeneRIF: Tamalin interacts with multiple neuronal proteins and
            several scaffold proteins in the brain through its distinct
            evolutionarily-conserved protein-binding domains; and tamalin mRNA
            is developmentally up-regulated at the postnatal period.
REFERENCE   7  (bases 1 to 1466)
  AUTHORS   Kitano,J., Kimura,K., Yamazaki,Y., Soda,T., Shigemoto,R.,
            Nakajima,Y. and Nakanishi,S.
  TITLE     Tamalin, a PDZ domain-containing protein, links a protein complex
            formation of group 1 metabotropic glutamate receptors and the
            guanine nucleotide exchange factor cytohesins
  JOURNAL   J Neurosci 22 (4), 1280-1289 (2002)
   PUBMED   11850456
REFERENCE   8  (bases 1 to 1466)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF374272.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF374272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1466
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="trafficking regulator and scaffold protein tamalin"
                     /db_xref="GeneID:192254"
                     /db_xref="RGD:70554"
     exon            1..303
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1245
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /note="GRP1-associated scaffold protein; GRP1 (general
                     receptor for phosphoinositides 1)-associated scaffold
                     protein; PSD-95 PDZ domain-containing protein; 95 kDa
                     postsynaptic density protein discs-large ZO-1
                     domain-containing protein; Grp1 (general receptor for
                     phosphoinositides)-associated scaffold protein; general
                     receptor for phosphoinositides 1 associated scaffold
                     protein"
                     /codon_start=1
                     /product="general receptor for phosphoinositides
                     1-associated scaffold protein"
                     /protein_id="NP_620249.1"
                     /db_xref="GeneID:192254"
                     /db_xref="RGD:70554"
                     /translation="MTLRRLRKLQQKEEATAAPDLAGRAPDSEAARAAPTPSGPPAAA
                     APPGAPGDELYAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNFTQSPEQQRKVLT
                     LEKGDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGL
                     NVEGIRHREIVDIIKASGNVLRLETLYGTSIRKAELEARLQYLKQTLYEKWGEYRSLM
                     VQEQRLVHGLVVKDPSIYDTLESVRSCLYGAGLLPGSLPFGPLLAAPGGARGGSRRAK
                     GDTDDAVYHTCFFGGAEPQALPPPPPPARAPGPGSAETPASVLCPAPRATLSRSASVR
                     CAGPGGGGGGGAPGALWTEAREQALCGAGLRKTKYRSFRRRLLKFIPGLNRSLEEEES
                     QL"
     exon            304..353
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            354..408
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            409..511
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            512..605
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            606..672
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            673..739
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1466
                     /gene="Tamalin"
                     /gene_synonym="Grasp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgccaacc ccatctaccg gagtgagtgc ggcctccgag gggcgccgga cgccggagcc
       61 atgacccttc gccgactcag gaagctgcag cagaaggagg aggcgacggc cgcgccggac
      121 ctcgctggcc gggctcccga ctccgaagcc gctcgcgctg cgccgacccc ctccggcccc
      181 ccggctgccg ccgctccgcc aggagccccc ggggacgagc tgtacgcagc attggaggac
      241 tatcaccctg cggagctgta ccgcgcgctc gccgtgtccg ggggcaccct gccccgccga
      301 aagggctcag gattccgttg gaagaatttt actcagagtc ctgaacaaca acggaaggtt
      361 ctgactttgg agaagggaga caaccagacc tttggcttcg agatccagac ttatggcctt
      421 caccaccgag aagagcagcg tgtggagatg gtgacctttg tctgccgagt tcacgagtcc
      481 agccctgccc agctggctgg gctcacgcct ggggacacca tcgccagtgt caatggtctc
      541 aacgtggaag gcatccggca ccgggagatt gtggatatca tcaaagcatc tggcaacgtt
      601 ctcagactgg aaaccctgta tgggacgtcc attcggaagg cagaactgga ggcacgactg
      661 cagtacctta agcaaaccct gtatgagaag tggggcgaat acaggtcgct tatggtacag
      721 gagcagcggc tagtgcacgg cctggtggtg aaggacccaa gcatctatga cacactggag
      781 tccgtgcgct cctgcctcta cggcgcaggc ctgcttcccg gctcgctgcc ctttgggcct
      841 ctgctcgcag cgcctggggg tgcccgcggg ggctcacggc gggccaaagg ggacacggac
      901 gacgccgtgt atcacacgtg cttctttggg ggcgccgagc cgcaggcgct gccgccccca
      961 ccgccccccg cgcgcgcgcc aggcccgggc tccgccgaga ctccggcgtc cgtgctgtgt
     1021 cccgcacccc gtgccacgct cagccgcagc gccagtgtgc ggtgcgcggg cccaggcggg
     1081 ggcggcggcg ggggcgcgcc aggagccctc tggactgagg cccgtgagca ggccctgtgc
     1141 ggcgccggtc tacgtaagac caagtaccgc agcttccgca ggcggctgct caaattcatc
     1201 cccggactca accgctccct ggaggaagag gagagccagc tgtaggggtg cgggtgggca
     1261 ggtgggaagt atttatttat ttattcatcg taacagccag tgcaaaaagt aggggcagta
     1321 ggggcggtcc aaggactcca ggagcccaaa gcagcaggag agggtccttg ctagctctgg
     1381 tccttctggt ctggttcact gcttgtctgc tggggggaaa aagggcgctg agctgctttc
     1441 tgccctcctc taaacgacag caggaa
//
