LOCUS       NM_001107958            4225 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TAL bHLH transcription factor 1, erythroid
            differentiation factor (Tal1), mRNA.
ACCESSION   NM_001107958 XM_001069740 XM_006238616 XM_233430
VERSION     NM_001107958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4225)
  AUTHORS   Maruyama,K., Uematsu,S., Kondo,T., Takeuchi,O., Martino,M.M.,
            Kawasaki,T. and Akira,S.
  TITLE     Strawberry notch homologue 2 regulates osteoclast fusion by
            enhancing the expression of DC-STAMP
  JOURNAL   J Exp Med 210 (10), 1947-1960 (2013)
   PUBMED   23980096
REFERENCE   2  (bases 1 to 4225)
  AUTHORS   Tallack,M.R., Magor,G.W., Dartigues,B., Sun,L., Huang,S.,
            Fittock,J.M., Fry,S.V., Glazov,E.A., Bailey,T.L. and Perkins,A.C.
  TITLE     Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq
  JOURNAL   Genome Res 22 (12), 2385-2398 (2012)
   PUBMED   22835905
REFERENCE   3  (bases 1 to 4225)
  AUTHORS   Khalid,A.M., Asano,A., Hosaka,Y.Z., Ohta,M., Ohyama,K. and
            Yamano,Y.
  TITLE     Rat stem-cell leukemia gene expression increased during testis
            maturation
  JOURNAL   Biosci Biotechnol Biochem 76 (11), 2118-2123 (2012)
   PUBMED   23132581
  REMARK    GeneRIF: TAL-1 may be involved in cell division, morphological
            changes, and the development of spermatogenic cells in the normal
            rat testis
REFERENCE   4  (bases 1 to 4225)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   5  (bases 1 to 4225)
  AUTHORS   Dey,S., Curtis,D.J., Jane,S.M. and Brandt,S.J.
  TITLE     The TAL1/SCL transcription factor regulates cell cycle progression
            and proliferation in differentiating murine bone marrow monocyte
            precursors
  JOURNAL   Mol Cell Biol 30 (9), 2181-2192 (2010)
   PUBMED   20194619
REFERENCE   6  (bases 1 to 4225)
  AUTHORS   Robb,L., Lyons,I., Li,R., Hartley,L., Kontgen,F., Harvey,R.P.,
            Metcalf,D. and Begley,C.G.
  TITLE     Absence of yolk sac hematopoiesis from mice with a targeted
            disruption of the scl gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7075-7079 (1995)
   PUBMED   7624372
REFERENCE   7  (bases 1 to 4225)
  AUTHORS   Shivdasani,R.A., Mayer,E.L. and Orkin,S.H.
  TITLE     Absence of blood formation in mice lacking the T-cell leukaemia
            oncoprotein tal-1/SCL
  JOURNAL   Nature 373 (6513), 432-434 (1995)
   PUBMED   7830794
REFERENCE   8  (bases 1 to 4225)
  AUTHORS   Mouthon,M.A., Bernard,O., Mitjavila,M.T., Romeo,P.H.,
            Vainchenker,W. and Mathieu-Mahul,D.
  TITLE     Expression of tal-1 and GATA-binding proteins during human
            hematopoiesis
  JOURNAL   Blood 81 (3), 647-655 (1993)
   PUBMED   7678994
REFERENCE   9  (bases 1 to 4225)
  AUTHORS   Aplan,P.D., Nakahara,K., Orkin,S.H. and Kirsch,I.R.
  TITLE     The SCL gene product: a positive regulator of erythroid
            differentiation
  JOURNAL   EMBO J 11 (11), 4073-4081 (1992)
   PUBMED   1396592
REFERENCE   10 (bases 1 to 4225)
  AUTHORS   Aplan,P.D., Lombardi,D.P., Reaman,G.H., Sather,H.N., Hammond,G.D.
            and Kirsch,I.R.
  TITLE     Involvement of the putative hematopoietic transcription factor SCL
            in T-cell acute lymphoblastic leukemia
  JOURNAL   Blood 79 (5), 1327-1333 (1992)
   PUBMED   1311214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Dec 13, 2013 this sequence version replaced
            XM_006238616.1, NM_001107958.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7512.1,
                                           SRR26643285.20054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               JAXUCZ010000005.1  133824464-133824734
            272-420             JAXUCZ010000005.1  133826313-133826461
            421-867             JAXUCZ010000005.1  133829657-133830103
            868-962             JAXUCZ010000005.1  133831213-133831307
            963-4225            JAXUCZ010000005.1  133834475-133837737
FEATURES             Location/Qualifiers
     source          1..4225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..4225
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /note="TAL bHLH transcription factor 1, erythroid
                     differentiation factor"
                     /db_xref="GeneID:313507"
                     /db_xref="RGD:1306748"
     exon            1..271
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..420
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..867
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1411
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /note="T-cell acute lymphocytic leukemia 1"
                     /codon_start=1
                     /product="T-cell acute lymphocytic leukemia protein 1"
                     /protein_id="NP_001101428.2"
                     /db_xref="GeneID:313507"
                     /db_xref="RGD:1306748"
                     /translation="MTERPPSEAARSDPQLEGQEAAEARMAPPHLVLLNGVTKETNRA
                     APAETPVIELGARSSAGGGPAGGGGAARDLKGRDAVATEARHRVPTTELCRPPGPAPA
                     PAPASAPAELPGDGRMVQLSPPALAAPAGPGRALLYSLSQPLASLGSGFFGEPDAFPM
                     FTNNNRVKRRPSPYEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHP
                     PDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKPGKDPMVGAGGGGAGGGIPPE
                     DLLQDVLSPNSSCGSSLDGAASPDSYTEEPTPKHTPRSLHPALLPAADGAGPR"
     exon            868..962
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..4225
                     /gene="Tal1"
                     /gene_synonym="Tal-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtccacatg ggggcgggga gcgggatttc acattttatt ccaaattatg atgtattcgg
       61 gagccagtgt tggctcggat ggatggacag agccgagtag gcggcagctc tgtccagagg
      121 ccgtctgtgc cttgctgttg cggggtcccc tgatgtgtgc gtgggggctt cttctaatct
      181 ggaagatgaa ccgcgctcgc tgaggccagc gtcttcccgc ccgcagcgcc gggcctggat
      241 tcgcgctgcg atcaggtttc gcctatttct gaccgcgtag gacctcacgg caagctaagt
      301 aactgctggt ctctcagcga gagcctggaa aacacagctc cggggtccta cctcgacccc
      361 tctccagcgg aggagtggag gtcctaacca gccgggtcgg tctctctaaa tatgccccag
      421 gatgacggag cggccgccga gcgaggcggc acgcagtgac cctcaactag aggggcagga
      481 ggcggccgag gcccgcatgg cccccccgca cctagtcctg ctcaacggcg tcaccaagga
      541 aacgaaccgc gcagccccgg ctgagacccc agtcatcgag ctaggcgcgc gcagcagcgc
      601 ggggggcggc cccgccggtg ggggcggtgc cgcgagggac ttaaagggcc gcgacgctgt
      661 agcaactgaa gctcgccatc gggtgcccac caccgagctg tgcagacctc ccggacccgc
      721 cccagcgccc gcgcccgcct cggctcctgc agagctgccc ggagacggcc gcatggtgca
      781 gctgagcccg cccgcgctgg cagcccccgc cggccccggc cgagcgctgc tctatagcct
      841 tagccagccg ctcgcctcac taggcagtgg gttcttcggg gaaccggatg ccttccccat
      901 gttcaccaac aacaaccggg tgaagaggag gccctcccca tatgagatgg agataacgga
      961 tggtccccac accaaggtag tgcggcgaat cttcaccaac agccgggagc gatggaggca
     1021 gcagaatgtg aatggggcat ttgctgaact ccgaaagctg atccccaccc atccaccaga
     1081 caagaagcta agcaagaatg agatcctccg cctcgccatg aagtacatca atttcctggc
     1141 caagttgctc aacgaccagg aggaggaagg cacccagcgt gccaagcctg gcaaggaccc
     1201 catggtggga gctggtgggg gtggggcagg gggtggcata ccccctgaag accttctaca
     1261 ggatgtgctt tcccccaact ccagctgtgg cagctccctg gatggggcag ccagcccgga
     1321 cagttataca gaggagccaa cacccaagca cactccccgc agcctccatc ctgccctact
     1381 gcctgctgct gatggggctg gccctcggtg atgtgtctag ggctgcccag ggccagcagg
     1441 cagaggggcc tttaggcccc ttggttgctg ggcttcaggg caggtgggtg agaagcaggg
     1501 cgatggactt aatgaacttc ccttatggtc tgaactttgg gaagtcccaa ctgaccctgg
     1561 gctggcattt ctgtttcctg cctggaaaca gaagaagaaa acagagtgaa gtagtaggta
     1621 ctttttctga agatggcacg gtcttctccc tttcccaagc cccaagattt ccccaatgat
     1681 gaggctcaag ggtcactatt ttttggtctc aagtttgtga gccatttttt ggacaagatc
     1741 tggggttgtc acctgttacc caaggcatcc acttggcttc tgccttgcct ttatcccatc
     1801 ccgagctggc tggggtggct tttgtggcag cttctgttca aatacatagg tacccaagag
     1861 ctgaccattt cttgagcctc atcttcaccc agttctcagt tggtccaacc agcttgccag
     1921 ctgctgtgga tagtcaaggt gccttcttca gggcctggtt ggaaatgatg gccagtaacc
     1981 agacaagctg ctctcgacta gctggggcag aaaacccaat caccctttat gctcgggaat
     2041 cagagctctg attttctacc cagtgagact tgccttcctc tacggtgact gtgaggacca
     2101 agtcagcagc cttgagcatg ctctgttggg ctgtgtgctg gcactgaaag ggaaagtgac
     2161 attagggtga gccaagcaag agtgtttggg ccactgggtt tcaactcctg cacatcactg
     2221 ggcaggagag caaatgatcg tgtgctggtg tgttgcatgt tggtgctggg gctatgcagc
     2281 ccatccactt ccccaggaag cttaaaggga gcttcccgtt gcaagatgtc tgttggctga
     2341 cggtctggac ttccaaatgg agtacaaact gtcctgtaaa tactctattt gggattctgc
     2401 ctgaccagtt gttggtggca actcttggcc atgatacaac ccgagatgca gcctgatgct
     2461 aaggcaaggc gttcagtcag agcaaggaag gccctggctg agacctgagc atgcatattt
     2521 gctcagctta aactttaagt actctcccct cacacaactg cagtccccac gtgtgtgcat
     2581 agtaagttgg tttaacacga agtgagtgtc ccctctaaaa actgtacatg aaatttttgt
     2641 aaagcaaatc cttcttctcc atcttttaaa gacataactc ctgcaggtca ttttgtaaag
     2701 tggagaatcc ttttgtagta tggacaacta ccccactgtt tgtcccctgt gtcaattcag
     2761 gtggtgggac caatttttcc tgaagctaga cctctaatga agttcaagct catggaacaa
     2821 agtgcacaga agccctgtgt atctgtcgtc gtattggtgt cactcagctc tcactgcagg
     2881 ctttgccttc gagctagaga gaaaatatcc aaaggcccca ttgtgtaatg tatgagccca
     2941 tctcttctct gttggagttt cagcgccatg gcttgttggc cccatggtaa ggcctgagca
     3001 tagacttagg tggacagaga tggatccttc taccttctcc ttcctattaa gcactgagga
     3061 ccctcaggag tagggacaat ttggtcagct actaaggctc tgtgattctt tgtctcatat
     3121 cgcattctgc caacacccat actgccatga acattaaggt tggttccttc ccatcgcttg
     3181 ggagttagtt caaggagtcc gagccatgga actgctgtcc tggcctctaa ggctatttgc
     3241 gtcttagtgg aatgatgact tgggaatgaa aaatgtggat ctgtaggtgg atatggttct
     3301 gtgttctata cccagtacag acacaaaaga agctttgtta cccttagtac tgaccatgct
     3361 gtgaagttcc agccagagtt caggacctgg gcagttgatg tttgtatcat ttatattata
     3421 aaatattttc cattgagtta tctagatgcc catttctcaa gattaatatc aatttcttcc
     3481 tgattccaag gcaagagacg ggagtaagaa agggagagag attgctacag tctctaatgg
     3541 ggctgggcag gtaagatcta aggaagaccc cgaattccgt tctcatactc cacatcccat
     3601 cttttttcct ttacttcctc cctgcccttg agaaatagca gcatcccaag aacaatatct
     3661 gtacaaaggg gggaaaatgt aagcatgaga aaacattgac aaacaaaacc agtgaggaat
     3721 ataagtacag agagattccc gtccttcaag aataatccat gtttatttgt ggtggcaagt
     3781 gacaagatgg tacaaccttt atccttttcc agaaacaaaa ataaagagca cagcaactgt
     3841 agtgagccaa cagctatttt ggccttttgg gtgggtctag cagtacttgg gatcccagtg
     3901 gtacatgacc ctctgcctaa ggcttgcctc agcctgtgta cgtagcacgc cgtgtctgtg
     3961 ggcaagccca gcactttccg tcagtgtcgt actgtatgtg atgaactgtg ttggtctctg
     4021 tgtgtttctg cagaagagga gtaactactc cgggtacctt gatatttgta cagcctagag
     4081 accaacactg cgggcgtgtg actctttatt gggaaaaaaa aagacaaaaa caaaacaaaa
     4141 aaaaatacca gtgtggtgac aatagtgtgt gtatatatat ataaggttat atgggaagat
     4201 ttctaaataa aagttttaca aaggg
//
