LOCUS       NM_031549               1130 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus transgelin (Tagln), mRNA.
ACCESSION   NM_031549 XM_346822
VERSION     NM_031549.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Dong,K., Shen,J., He,X., Hu,G., Wang,L., Osman,I., Bunting,K.M.,
            Dixon-Melvin,R., Zheng,Z., Xin,H., Xiang,M., Vazdarjanova,A.,
            Fulton,D.J.R. and Zhou,J.
  TITLE     CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific
            LncRNA That Maintains Contractile Phenotype by Binding Myocardin
  JOURNAL   Circulation 144 (23), 1856-1875 (2021)
   PUBMED   34694145
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Ren,M., Wang,T., Wei,X., Wang,Y., Ouyang,C., Xie,Y., Ye,X. and
            Han,Z.
  TITLE     LncRNA H19 regulates smooth muscle cell functions and participates
            in the development of aortic dissection through sponging
            miR-193b-3p
  JOURNAL   Biosci Rep 41 (1) (2021)
   PUBMED   33403385
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Schellekens,D.H.S.M., Reisinger,K.W., Lenaerts,K., Hadfoune,M.,
            Olde Damink,S.W., Buurman,W.A., Dejong,C.H.C. and Derikx,J.P.M.
  TITLE     SM22 a Plasma Biomarker for Human Transmural Intestinal Ischemia
  JOURNAL   Ann Surg 268 (1), 120-126 (2018)
   PUBMED   28525410
  REMARK    GeneRIF: SM22 concentrations were significantly elevated in rats
            from 4 hours of mesenteric ischemia onwards. Furthermore, SM22
            plasma concentrations closely paralleled the histological
            increasing degree of intestinal smooth muscle damage.
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Shu,Y.N., Dong,L.H., Li,H., Pei,Q.Q., Miao,S.B., Zhang,F.,
            Zhang,D.D., Chen,R., Yin,Y.J., Lin,Y.L., Xue,Z.Y., Lv,P., Xie,X.L.,
            Zhao,L.L., Nie,X., Chen,P. and Han,M.
  TITLE     CKII-SIRT1-SM22alpha loop evokes a self-limited inflammatory
            response in vascular smooth muscle cells
  JOURNAL   Cardiovasc Res 113 (10), 1198-1207 (2017)
   PUBMED   28419207
  REMARK    GeneRIF: CKII-SIRT1-SM22alpha acts in a loop to reinforce the
            expression of SM22alpha, which limits the inflammatory response in
            vascular smooth muscle cells.
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Fujii,Y., Funakoshi,T., Unuma,K., Noritake,K., Aki,T. and Uemura,K.
  TITLE     Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2
            cells that is associated with cellular shrinkage, transgelin
            expression and myosin phosphorylation
  JOURNAL   J Toxicol Sci 41 (5), 645-654 (2016)
   PUBMED   27665774
  REMARK    GeneRIF: Enhancements in smooth muscle cell properties such as
            transgelin expression and actomyosin-mediated
            contractility/motility might be involved in cell survival after
            NaHS exposure.
REFERENCE   6  (bases 1 to 1130)
  AUTHORS   Koike,G., Miano,J.M., Vanvooren,P., Shiozawa,M., Szpirer,C. and
            Jacob,H.J.
  TITLE     Mapping of the rat SM22 gene to chromosome 8q24: a candidate for
            high blood pressure and cardiac hypertrophy
  JOURNAL   Mamm Genome 9 (1), 76-77 (1998)
   PUBMED   9434951
REFERENCE   7  (bases 1 to 1130)
  AUTHORS   Prinjha,R.K., Shapland,C.E., Hsuan,J.J., Totty,N.F., Mason,I.J. and
            Lawson,D.
  TITLE     Cloning and sequencing of cDNAs encoding the actin cross-linking
            protein transgelin defines a new family of actin-associated
            proteins
  JOURNAL   Cell Motil Cytoskeleton 28 (3), 243-255 (1994)
   PUBMED   7954852
  REMARK    Erratum:[Cell Motil Cytoskeleton 1994;29(4):383]
REFERENCE   8  (bases 1 to 1130)
  AUTHORS   Nishida,W., Kitami,Y. and Hiwada,K.
  TITLE     cDNA cloning and mRNA expression of calponin and SM22 in rat aorta
            smooth muscle cells
  JOURNAL   Gene 130 (2), 297-302 (1993)
   PUBMED   8359698
REFERENCE   9  (bases 1 to 1130)
  AUTHORS   Shanahan,C.M., Weissberg,P.L. and Metcalfe,J.C.
  TITLE     Isolation of gene markers of differentiated and proliferating
            vascular smooth muscle cells
  JOURNAL   Circ Res 73 (1), 193-204 (1993)
   PUBMED   8508530
REFERENCE   10 (bases 1 to 1130)
  AUTHORS   Nishida,W., Kitami,Y., Abe,M. and Hiwada,K.
  TITLE     Gene cloning and nucleotide sequence of SM22 alpha from the chicken
            gizzard smooth muscle
  JOURNAL   Biochem Int 23 (4), 663-668 (1991)
   PUBMED   1872880
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061770.1.
            
            On Mar 2, 2007 this sequence version replaced NM_031549.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061770.1, FQ220668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1130
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /note="transgelin"
                     /db_xref="GeneID:25123"
                     /db_xref="RGD:3723"
     exon            1..40
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /inference="alignment:Splign:2.1.0"
     exon            41..232
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..658
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /note="smooth muscle 22 protein; SM22-alpha; smooth muscle
                     protein 22-alpha"
                     /codon_start=1
                     /product="transgelin"
                     /protein_id="NP_113737.1"
                     /db_xref="GeneID:25123"
                     /db_xref="RGD:3723"
                     /translation="MANKGPSYGMSREVQSKIEKKYDEELEERLVEWIVMQCGPDVGR
                     PDRGRLGFQVWLKNGVILSKLVNSLYPEGSKPVKVPENPPSMVFKQMEQVAQFLKAAE
                     DYGVTKTDMFQTVDLFEGKDMAAVQRTVMALGSLAVTKNDGHYRGDPNWFMKKAQEHK
                     REFTDSQLQEGKHVIGLQMGSNRGASQAGMTGYGRPRQIIS"
     exon            233..410
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /inference="alignment:Splign:2.1.0"
     exon            411..513
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1051
                     /gene="Tagln"
                     /gene_synonym="Sm22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacgctact ctccttccag cccacaaacg accaagcctt ttctgcctca acatggccaa
       61 caagggtcca tcctatggca tgagccgtga agtgcagtcc aagattgaga agaagtatga
      121 tgaggagctg gaggagcggc tagtggagtg gattgtaatg cagtgtggcc ctgatgtggg
      181 ccgtccagat cgtgggcgcc tgggcttcca ggtgtggctg aagaatggcg tgattctgag
      241 caagttggtg aacagcctgt accccgaggg atccaagcca gtgaaggtgc ctgagaaccc
      301 gccctccatg gtcttcaagc agatggaaca ggtggctcaa ttcttgaagg cagctgagga
      361 ttatggagtc acgaagactg acatgttcca gactgttgac ctctttgaag gaaaagatat
      421 ggcagcagtg cagaggactg taatggcttt gggcagtttg gccgtgacca agaacgatgg
      481 acactaccgt ggagatccca actggtttat gaagaaagcc caggagcata agagggagtt
      541 cacagacagt caactgcagg aggggaagca cgtcattggc cttcaaatgg gcagcaacag
      601 aggggcctca caggctggca tgacaggcta tgggcgaccc cggcagatca tcagttagaa
      661 agggaaggcc agctctgagc tgcagcatcc tgcttagcct gcctcaccca cgcctatata
      721 ggttcttagc ccggacagct ttgaggtatc actgggcaaa gatgactgca catgggcagc
      781 tcccacctat cctcagcctc agccccgctt cttaccccag agccaccact gtcctggccc
      841 ctgttcccag ctgtcccccc acctctaccg tttcccccat cctggagtaa gcagggagaa
      901 gtgggctgag gtagcctgac tgtaggccag cccactgtcc ttggaagcca atgtcctttg
      961 aaagagaccc tgcctctaca tctttttctg gaatattttt tgggttgaaa ttcaaaaagg
     1021 aaaaaaatat atacatatac atatatctcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
