LOCUS       NM_001309449            2868 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus T-cell activation RhoGTPase activating protein
            (Tagap), mRNA.
ACCESSION   NM_001309449
VERSION     NM_001309449.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Sun,H.G., Jiang,Q., Fan,W.J., Shen,X.Y., Wang,Z.W. and Wang,X.
  TITLE     TAGAP activates Th17 cell differentiation by promoting RhoA and
            NLRP3 to accelerate rheumatoid arthritis development
  JOURNAL   Clin Exp Immunol 214 (1), 26-35 (2023)
   PUBMED   37458218
  REMARK    GeneRIF: TAGAP activates Th17 cell differentiation by promoting
            RhoA and NLRP3 to accelerate rheumatoid arthritis development.
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Liao,J., Jijon,H.B., Kim,I.R., Goel,G., Doan,A., Sokol,H.,
            Bauer,H., Herrmann,B.G., Lassen,K.G. and Xavier,R.J.
  TITLE     An image-based genetic assay identifies genes in T1D susceptibility
            loci controlling cellular antiviral immunity in mouse
  JOURNAL   PLoS One 9 (9), e108777 (2014)
   PUBMED   25268627
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LT158649.1, LT158648.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000001.1  49583754-49583780   c
            28-81               JAXUCZ010000001.1  49583613-49583666   c
            82-148              JAXUCZ010000001.1  49583273-49583339   c
            149-315             JAXUCZ010000001.1  49581937-49582103   c
            316-477             JAXUCZ010000001.1  49581249-49581410   c
            478-587             JAXUCZ010000001.1  49580731-49580840   c
            588-783             JAXUCZ010000001.1  49579213-49579408   c
            784-898             JAXUCZ010000001.1  49578392-49578506   c
            899-2868            JAXUCZ010000001.1  49575750-49577719   c
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2868
                     /gene="Tagap"
                     /note="T-cell activation RhoGTPase activating protein"
                     /db_xref="GeneID:308097"
                     /db_xref="RGD:1308618"
     CDS             1..2145
                     /gene="Tagap"
                     /note="T-cell activation GTPase activating protein"
                     /codon_start=1
                     /product="T-cell activation Rho GTPase-activating protein"
                     /protein_id="NP_001296378.1"
                     /db_xref="GeneID:308097"
                     /db_xref="RGD:1308618"
                     /translation="MKLISSLDGAKTLNANNMDTLIECQSEGDIKVLPLLTSCESEDS
                     ICQLIEVKKRKKVLSWPSLMRKLSPSPDFSGSLEPELKVSLFDQPLSIICKENDTLPR
                     PIQDILTILCLKGPSTEGIFRKAASEKARKELKEELNCGGSVNLNQLPVHLLAVVFKD
                     FLRGIPLKLLSCDLFEDWMGALEKPSEEDRIEALKQVADRLPRPNLLLLRTLVYVLHL
                     ISKNAEVNKMDSSNLAICIGPNMLTLKNDQSLSFQAQRDLNNKVKILVEFLIDNCLEI
                     FGENIPTHPRITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVEPANGVASPCRQLEGPS
                     TTVAGMDTRGPRNTCESSSESSVSMVARLKSSIGQQDRRFSEPNMPPSRECFVGPITK
                     QKLTRSEDSFVLPQEASCSEGNEAEDPFTEEVFPAVEGKPMRPVDLKIKNLTQGLASP
                     QGPANKAFSSFSAGESLDSSPVPSPSCPKRNFFTRHQSFTTKTDKTKPQREIRKHSMS
                     FSFASHKKVLPRTSSIGSEKSKDFSRDQLQKDLRKESQLAGRIIRENESEIQSQTNLG
                     SSLSGTWALSVDNTFQFIDVRKPGSPPSYEEAIYYHTSGLTAYSGQTVGSMRARMLKQ
                     SMAVPPVPSHHEGELSEGIPGGHRSSSVTEHWTQSQTVHVSVETRGRSELHRLRTVSE
                     SVQRAKLDYLGQQRSHLVFEVDQLRCAKESYI"
     exon            1..27
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            28..81
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            82..148
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            149..315
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            316..477
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            478..587
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            588..783
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            784..898
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
     exon            899..2868
                     /gene="Tagap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagttga taagcagtct cgatggtgca aaaacgctta atgccaacaa catggacaca
       61 ttaattgaat gtcagtcaga gggcgatatc aaggtgcttc cattgctgac gtcatgtgag
      121 agtgaagaca gcatttgcca gctaattgaa gttaagaaga gaaagaaagt gctgtcctgg
      181 ccatctctca tgagaaagct ctctccttca ccagacttct ctgggtcatt ggaaccagag
      241 ctgaaagtgt cgctgtttga tcaacccttg tcaatcatct gtaaggagaa tgacacactc
      301 cctagaccca tccaggacat cctcaccatc ctctgcctta aaggtccttc aactgaagga
      361 atattcagga aagcagccag cgagaaagcc cgcaaggagc tgaaggagga gcttaactgt
      421 gggggctctg tgaatctgaa ccagctccct gtgcacctcc tggctgtggt cttcaaggac
      481 ttcctccgag gaatccccct gaagctgctc tcctgtgacc tctttgagga ctggatggga
      541 gccctggaga agcccagtga ggaggacagg atcgaggccc tgaagcaggt tgctgatcgg
      601 ctcccccggc ccaacctcct tctgctcagg accttagtct acgtgctaca ccttatcagc
      661 aagaacgccg aggtcaacaa gatggactcc agcaacctgg ccatctgcat cggacccaac
      721 atgctcacac tgaagaatga ccagagcctg tccttccagg cccagaggga cctgaacaat
      781 aaggttaaga tcttggtgga attcctcatt gacaactgcc ttgaaatatt tggggagaac
      841 attccgacac atccccgcat cacttctgat gactctctgg aacacactga cagctcagac
      901 gtgtcgactc tgcagaacga ctcagcctat gacagcaatg acccggatgt agagcccgcg
      961 aatggagttg cctctccctg caggcagttg gagggtccct ctaccacagt ggctggcatg
     1021 gatacccggg ggccccggaa cacctgtgag tcgagctcag aatccagtgt cagcatggta
     1081 gccaggctga aaagctccat tggccagcaa gacaggcgtt tctctgaacc caacatgcca
     1141 ccctcacgag agtgcttcgt gggcccgata accaagcaaa agctaacgag gagcgaggac
     1201 agcttcgttc tgccccagga agcctcctgt tctgaaggca atgaagccga agatcccttt
     1261 acagaggaag tcttcccagc agttgaaggc aaacccatga gaccagtgga tttgaagata
     1321 aagaacttga cccaaggttt agcatctcca cagggacctg caaacaaagc tttctccagc
     1381 ttctccgcgg gggaatcttt ggacagctca cctgtgcctt ctccatcctg tcccaagaga
     1441 aacttcttca ccagacacca gagtttcacc acaaagacgg acaagaccaa gccccagaga
     1501 gaaattagaa agcactccat gtcattttcc tttgcgtctc acaagaaagt gctgccccgg
     1561 acctccagca ttgggtctga gaaatccaaa gacttctcta gagaccagct ccagaaggac
     1621 ttgaggaaag agagccagct tgccggcaga atcatccggg aaaatgagtc cgaaatccaa
     1681 agccaaacaa atctgggctc cagcttgtct ggaacctggg ccctctcagt tgataacacg
     1741 ttccagttca ttgatgtgag gaagccagga agcccaccat cttatgaaga ggccatttat
     1801 taccacacat caggactcac agcctacagt ggccagacag ttgggagtat gagagcaaga
     1861 atgttgaagc agagcatggc ggtgccccct gtgccttctc accatgaagg tgagctcagt
     1921 gaagggatac ctggtggaca cagatcgtct tccgtgactg agcactggac acagagtcag
     1981 actgtccatg tctctgtaga aactcggggg agatctgagc tacatcgatt gaggacagtg
     2041 tctgagtccg tgcagagggc taagctggac taccttgggc agcaacgcag ccacttggtc
     2101 tttgaggttg accaactccg atgtgctaaa gaatcctaca tttaggaagg agaccgtgta
     2161 ccatggctaa cttgtatgtg aggatactgc tgcagagaac tgcctgtcga gtctgtttcc
     2221 caaaaagtca tagataagct cattcagaat gtcatgtgga gctctcctct gtgaggatgg
     2281 ctctcacagt gacaccagat cgtgtccgtg tgtaacaggg tttgtgcaat atgtagtaaa
     2341 tgtataaaat gtattatata caaggtattt gatacaaagg gtgttatgtg catgcacttc
     2401 tgtacttttc atatgctgct ttcttgtcct caggcacttg tttctataga caaagaatct
     2461 ttacttttaa cattacagca aatgtcatgc ccatgttcac attttctgtg agccacatgt
     2521 aggcagaaat gtctgcgcct ctgatgcgtc ttcccctaag caggcttata acaactaatc
     2581 agcatcatag aagagaacag actgaaagac tgtactcggt gtgtgagctg tcagccgcgc
     2641 tgggcgaagg tttttcaatc atgtaacgga atgtgagtgg cgcggtggaa atgcgttctg
     2701 tcagtattaa ctcacgcaga gcactttgag cctctgcagc tcagtgatgc cttgtgaggc
     2761 tgtgtggagg tatgtgatgt cgtatgcact ggggagtctt gtataagtct tcagtgcagt
     2821 tcatttatta ttcacaataa actgtcccct tctttagaca gttcatta
//
