LOCUS       NM_001025748            1813 bp    mRNA    linear   ROD 04-MAY-2024
DEFINITION  Rattus norvegicus tafazzin, phospholipid-lysophospholipid
            transacylase (Tafazzin), mRNA.
ACCESSION   NM_001025748 XM_343845
VERSION     NM_001025748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1813)
  AUTHORS   Aravamudhan,A., Dieffenbach,P.B., Choi,K.M., Link,P.A.,
            Meridew,J.A., Haak,A.J., Fredenburgh,L.E. and Tschumperlin,D.J.
  TITLE     Non-canonical IKB kinases regulate YAP/TAZ and pathological
            vascular remodeling behaviors in pulmonary artery smooth muscle
            cells
  JOURNAL   Physiol Rep 12 (7), e15999 (2024)
   PUBMED   38610069
REFERENCE   2  (bases 1 to 1813)
  AUTHORS   Fernandez-Mendez,C. and Santisteban,P.
  TITLE     A Critical Balance Between PAX8 and the Hippo Mediator TAZ
            Determines Sodium/Iodide Symporter Expression and Function
  JOURNAL   Thyroid 32 (3), 315-325 (2022)
   PUBMED   34726504
REFERENCE   3  (bases 1 to 1813)
  AUTHORS   Gurtler,S., Wolke,C., Otto,O., Heise,N., Scholz,F., Laporte,A.,
            Elsner,M., Jorns,A., Weinert,S., Doring,M., Jansing,S.,
            Gardemann,A., Lendeckel,U. and Schild,L.
  TITLE     Tafazzin-dependent cardiolipin composition in C6 glioma cells
            correlates with changes in mitochondrial and cellular functions,
            and cellular proliferation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (4), 452-465 (2019)
   PUBMED   30639735
  REMARK    GeneRIF: Results find that knock-out of tafazzin (Taz) changed
            substantially the profile of fatty acids incorporated in
            cardiolipin (CL) and the distribution of CL species. It was further
            associated with decreased capacity of oxidative phosphorylation and
            switch to glycolysis, altered morphology and arrangement, and
            reduction in glioma cell proliferation.
REFERENCE   4  (bases 1 to 1813)
  AUTHORS   Ohlig,T., Le,D.V., Gardemann,A., Wolke,C., Gurtler,S., Peter,D.,
            Schild,L. and Lendeckel,U.
  TITLE     Effects of siRNA-dependent knock-down of cardiolipin synthase and
            tafazzin on mitochondria and proliferation of glioma cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (4), 379-387 (2018)
   PUBMED   29325722
  REMARK    GeneRIF: Knock-down of tafazzin had no consequence with respect to
            the pattern of cellular fatty acids but caused a decrease in cell
            proliferation.
REFERENCE   5  (bases 1 to 1813)
  AUTHORS   Ren,M., Phoon,C.K. and Schlame,M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   6  (bases 1 to 1813)
  AUTHORS   McKenzie,M., Lazarou,M., Thorburn,D.R. and Ryan,M.T.
  TITLE     Mitochondrial respiratory chain supercomplexes are destabilized in
            Barth Syndrome patients
  JOURNAL   J Mol Biol 361 (3), 462-469 (2006)
   PUBMED   16857210
REFERENCE   7  (bases 1 to 1813)
  AUTHORS   Ma,L., Vaz,F.M., Gu,Z., Wanders,R.J. and Greenberg,M.L.
  TITLE     The human TAZ gene complements mitochondrial dysfunction in the
            yeast taz1Delta mutant. Implications for Barth syndrome
  JOURNAL   J Biol Chem 279 (43), 44394-44399 (2004)
   PUBMED   15304507
REFERENCE   8  (bases 1 to 1813)
  AUTHORS   Vaz,F.M., Houtkooper,R.H., Valianpour,F., Barth,P.G. and
            Wanders,R.J.
  TITLE     Only one splice variant of the human TAZ gene encodes a functional
            protein with a role in cardiolipin metabolism
  JOURNAL   J Biol Chem 278 (44), 43089-43094 (2003)
   PUBMED   12930833
  REMARK    Erratum:[J Biol Chem. 2004 Jun 18;279(25):26802]
REFERENCE   9  (bases 1 to 1813)
  AUTHORS   Bissler,J.J., Tsoras,M., Goring,H.H., Hug,P., Chuck,G.,
            Tombragel,E., McGraw,C., Schlotman,J., Ralston,M.A. and Hug,G.
  TITLE     Infantile dilated X-linked cardiomyopathy, G4.5 mutations, altered
            lipids, and ultrastructural malformations of mitochondria in heart,
            liver, and skeletal muscle
  JOURNAL   Lab Invest 82 (3), 335-344 (2002)
   PUBMED   11896212
REFERENCE   10 (bases 1 to 1813)
  AUTHORS   Vreken,P., Valianpour,F., Nijtmans,L.G., Grivell,L.A., Plecko,B.,
            Wanders,R.J. and Barth,P.G.
  TITLE     Defective remodeling of cardiolipin and phosphatidylglycerol in
            Barth syndrome
  JOURNAL   Biochem Biophys Res Commun 279 (2), 378-382 (2000)
   PUBMED   11118295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099221.1.
            
            On Jul 22, 2005 this sequence version replaced XM_343845.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1813
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1813
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /note="tafazzin, phospholipid-lysophospholipid
                     transacylase"
                     /db_xref="GeneID:363521"
                     /db_xref="RGD:1588532"
     exon            1..356
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1036
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /note="tafazzin (cardiomyopathy, dilated 3A (X-linked);
                     endocardial fibroelastosis 2; Barth syndrome)"
                     /codon_start=1
                     /product="tafazzin"
                     /protein_id="NP_001020919.1"
                     /db_xref="GeneID:363521"
                     /db_xref="RGD:1588532"
                     /translation="MPLHVKWPFPAVPRLTWTLASSVVMGLVGTYSCFWTKYMNHLTV
                     YNKEVLYELIENRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRWTPAAADI
                     CFTKELHSHFFSLGKCVPVCRGDGVYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFL
                     RFKWGIGRLIAECHLNPIILPLWHVGMNDVLPNSPPYFPRFGQKITVLIGKPFSTLPV
                     LERLRAENKSAVEMRKALTDFIQEEFQRLKMQAEQLHNHFQPGR"
     exon            357..485
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            486..531
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            532..617
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            618..698
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            699..740
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            741..803
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            804..856
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            857..934
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1786
                     /gene="Tafazzin"
                     /gene_synonym="Taz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacctgagg ccaccaagac ttgcttttta gtgcgcgtgg ctttgcaacc ctgtctcgtc
       61 ccctgagcgg cgcctcttct ctatccggag agcagtgcta gggaggctct gagctgtccc
      121 accaggcgat cttagtctag gtctctgcca gtctgttgga gagccctctc ctgagtagtg
      181 gaggacaccg gctggcctgg ggccagagga gctccgggct ccgggggcgg ggccggagcc
      241 gaaggagatg cccctccacg tgaagtggcc attccccgcg gtgccccgac tcacctggac
      301 cctagccagc agtgtcgtca tgggtctagt tggcacctac agctgcttct ggaccaagta
      361 tatgaaccac cttaccgtgt acaacaagga agtgctgtat gagctcattg agaaccgagg
      421 tcctgcgacc cctcttatca ccgtctctaa ccaccagtct tgcatggatg accctcatct
      481 ctgggggatc ctgaaactcc gccacatctg gaacctgaag ttgatgcgtt ggaccccagc
      541 agctgcagac atctgcttca ccaaggagct gcattcccat ttcttcagct tgggcaaatg
      601 tgtgcctgta tgtcgaggag atggtgtcta tcagaaaggg atggacttca ttttggagaa
      661 gcttaaccat ggggactggg tacacatctt tccagaagga aaagtaaaca tgagttctga
      721 gttcctgcgc ttcaaatggg gaattggacg gctgattgct gagtgtcatc taaaccccat
      781 catcctgcca ctatggcatg ttggaatgaa tgatgtcctc cctaacagtc caccctactt
      841 cccccgcttt ggacagaaaa tcaccgtgct gattgggaag cccttcagta cactccctgt
      901 gcttgagcgg ctccgggcag aaaacaagtc agctgtggag atgcggaaag ccctcacaga
      961 cttcattcaa gaggaattcc agcggctgaa gatgcaggca gaacagctcc acaatcattt
     1021 ccagcctgga agataggctt tgcctgctca gtctgtgccc tgcagttctt agccaaggga
     1081 acactgggcc cttcagggtt tgggaagcgg tggtacagga ggaccctgac caagcctgct
     1141 tggatcttta ctgcttttga gattcttccc tatacaaaac tgaggctggg aaatggactg
     1201 atgcttttaa ttcagataga ttgactccta attcctgctg gatacccttt tttattcttg
     1261 aacatctgac tcctctgggt cttgaactaa aagaagagct ttggctgtcc cttacacttt
     1321 gtggagaagg aagggacact cttaggcagg gccctccttc tcacctctct cagggagaga
     1381 acaaagcagg tagttaatca actagttcag taggagaata ggtgtcttgg ttataggtgc
     1441 agaaagagga ctcaaatggt cccttgatag gctaccactt gcccactgct cacaaacctc
     1501 ctcagggatg gctgtcagcc aagtcattct acctgagctc ctggtacaag gtttgtcctt
     1561 gggtggcctg tagatgagaa gtgaagtatt ggtcaggatt caagcacagc taaacttagc
     1621 tagatgtttc ttgtagatgg cagaaaaagg accccaagac ctgaccatga acccccaata
     1681 tcagggccta cctacttctc tcatcatttt gccttgacct cctctattac ctgggatctg
     1741 ggttttaatg tttttagagt aataaaacat ttgtgttgtg ccaccaaaaa aaaaaaaaaa
     1801 aaaaaaaaaa aaa
//
