LOCUS       NM_001191723            7260 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus TATA-box binding protein associated factor 1
            (Taf1), mRNA.
ACCESSION   NM_001191723 XM_228551
VERSION     NM_001191723.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7260)
  AUTHORS   Cirnaru,M.D., Creus-Muncunill,J., Nelson,S., Lewis,T.B., Watson,J.,
            Ellerby,L.M., Gonzalez-Alegre,P. and Ehrlich,M.E.
  TITLE     Striatal Cholinergic Dysregulation after Neonatal Decrease in
            X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms
  JOURNAL   Mov Disord 36 (12), 2780-2794 (2021)
   PUBMED   34403156
  REMARK    GeneRIF: Striatal Cholinergic Dysregulation after Neonatal Decrease
            in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
REFERENCE   2  (bases 1 to 7260)
  AUTHORS   Janakiraman,U., Yu,J., Moutal,A., Chinnasamy,D., Boinon,L.,
            Batchelor,S.N., Anandhan,A., Khanna,R. and Nelson,M.A.
  TITLE     TAF1-gene editing alters the morphology and function of the
            cerebellum and cerebral cortex
  JOURNAL   Neurobiol Dis 132, 104539 (2019)
   PUBMED   31344492
  REMARK    GeneRIF: Deletion of the TAF1 gene in embryonic animals using
            CRISPR-Cas9 alters the morphology and function of the cerebellum
            and cerebral cortex.
REFERENCE   3  (bases 1 to 7260)
  AUTHORS   Louder,R.K., He,Y., Lopez-Blanco,J.R., Fang,J., Chacon,P. and
            Nogales,E.
  TITLE     Structure of promoter-bound TFIID and model of human pre-initiation
            complex assembly
  JOURNAL   Nature 531 (7596), 604-609 (2016)
   PUBMED   27007846
  REMARK    Erratum:[Nature. 2016 Aug 4;536(7614):112. PMID: 27096372]
REFERENCE   4  (bases 1 to 7260)
  AUTHORS   O'Rawe,J.A., Wu,Y., Dorfel,M.J., Rope,A.F., Au,P.Y.,
            Parboosingh,J.S., Moon,S., Kousi,M., Kosma,K., Smith,C.S.,
            Tzetis,M., Schuette,J.L., Hufnagel,R.B., Prada,C.E., Martinez,F.,
            Orellana,C., Crain,J., Caro-Llopis,A., Oltra,S., Monfort,S.,
            Jimenez-Barron,L.T., Swensen,J., Ellingwood,S., Smith,R., Fang,H.,
            Ospina,S., Stegmann,S., Den Hollander,N., Mittelman,D., Highnam,G.,
            Robison,R., Yang,E., Faivre,L., Roubertie,A., Riviere,J.B.,
            Monaghan,K.G., Wang,K., Davis,E.E., Katsanis,N., Kalscheuer,V.M.,
            Wang,E.H., Metcalfe,K., Kleefstra,T., Innes,A.M., Kitsiou-Tzeli,S.,
            Rosello,M., Keegan,C.E. and Lyon,G.J.
  TITLE     TAF1 Variants Are Associated with Dysmorphic Features, Intellectual
            Disability, and Neurological Manifestations
  JOURNAL   Am J Hum Genet 97 (6), 922-932 (2015)
   PUBMED   26637982
REFERENCE   5  (bases 1 to 7260)
  AUTHORS   Wang,H., Curran,E.C., Hinds,T.R., Wang,E.H. and Zheng,N.
  TITLE     Crystal structure of a TAF1-TAF7 complex in human transcription
            factor IID reveals a promoter binding module
  JOURNAL   Cell Res 24 (12), 1433-1444 (2014)
   PUBMED   25412659
REFERENCE   6  (bases 1 to 7260)
  AUTHORS   Gegonne,A., Weissman,J.D. and Singer,D.S.
  TITLE     TAFII55 binding to TAFII250 inhibits its acetyltransferase activity
  JOURNAL   Proc Natl Acad Sci U S A 98 (22), 12432-12437 (2001)
   PUBMED   11592977
REFERENCE   7  (bases 1 to 7260)
  AUTHORS   Saadane,N., Alpert,L. and Chalifour,L.E.
  TITLE     TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal
            rat cardiomyocytes treated with doxorubicin
  JOURNAL   Am J Physiol 276 (3), H803-H814 (1999)
   PUBMED   10070062
REFERENCE   8  (bases 1 to 7260)
  AUTHORS   O'Brien,T. and Tjian,R.
  TITLE     Functional analysis of the human TAFII250 N-terminal kinase domain
  JOURNAL   Mol Cell 1 (6), 905-911 (1998)
   PUBMED   9660973
REFERENCE   9  (bases 1 to 7260)
  AUTHORS   Mizzen,C.A., Yang,X.J., Kokubo,T., Brownell,J.E., Bannister,A.J.,
            Owen-Hughes,T., Workman,J., Wang,L., Berger,S.L., Kouzarides,T.,
            Nakatani,Y. and Allis,C.D.
  TITLE     The TAF(II)250 subunit of TFIID has histone acetyltransferase
            activity
  JOURNAL   Cell 87 (7), 1261-1270 (1996)
   PUBMED   8980232
REFERENCE   10 (bases 1 to 7260)
  AUTHORS   Dikstein,R., Ruppert,S. and Tjian,R.
  TITLE     TAFII250 is a bipartite protein kinase that phosphorylates the base
            transcription factor RAP74
  JOURNAL   Cell 84 (5), 781-790 (1996)
   PUBMED   8625415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_228551.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760393, SAMEA5760433
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000021.1  70680977-70681168
            193-307             JAXUCZ010000021.1  70681758-70681872
            308-424             JAXUCZ010000021.1  70682132-70682248
            425-544             JAXUCZ010000021.1  70686769-70686888
            545-786             JAXUCZ010000021.1  70688933-70689174
            787-1005            JAXUCZ010000021.1  70690636-70690854
            1006-1224           JAXUCZ010000021.1  70691224-70691442
            1225-1432           JAXUCZ010000021.1  70691954-70692161
            1433-1609           JAXUCZ010000021.1  70696974-70697150
            1610-1737           JAXUCZ010000021.1  70698108-70698235
            1738-1845           JAXUCZ010000021.1  70698329-70698436
            1846-2019           JAXUCZ010000021.1  70698528-70698701
            2020-2193           JAXUCZ010000021.1  70699214-70699387
            2194-2298           JAXUCZ010000021.1  70699833-70699937
            2299-2499           JAXUCZ010000021.1  70709611-70709811
            2500-2641           JAXUCZ010000021.1  70709943-70710084
            2642-2772           JAXUCZ010000021.1  70710726-70710856
            2773-2853           JAXUCZ010000021.1  70712295-70712375
            2854-3003           JAXUCZ010000021.1  70714594-70714743
            3004-3123           JAXUCZ010000021.1  70714892-70715011
            3124-3299           JAXUCZ010000021.1  70715260-70715435
            3300-3478           JAXUCZ010000021.1  70717345-70717523
            3479-3692           JAXUCZ010000021.1  70719353-70719566
            3693-3858           JAXUCZ010000021.1  70720061-70720226
            3859-4070           JAXUCZ010000021.1  70720519-70720730
            4071-4179           JAXUCZ010000021.1  70722797-70722905
            4180-4278           JAXUCZ010000021.1  70724225-70724323
            4279-4456           JAXUCZ010000021.1  70725585-70725762
            4457-4524           JAXUCZ010000021.1  70730709-70730776
            4525-4647           JAXUCZ010000021.1  70732837-70732959
            4648-4740           JAXUCZ010000021.1  70734094-70734186
            4741-4825           JAXUCZ010000021.1  70734272-70734356
            4826-4893           JAXUCZ010000021.1  70744242-70744309
            4894-5010           JAXUCZ010000021.1  70744792-70744908
            5011-5016           JAXUCZ010000021.1  70745054-70745059
            5017-5142           JAXUCZ010000021.1  70748347-70748472
            5143-5299           JAXUCZ010000021.1  70749490-70749646
            5300-5477           JAXUCZ010000021.1  70750307-70750484
            5478-7260           JAXUCZ010000021.1  70754753-70756535
FEATURES             Location/Qualifiers
     source          1..7260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..7260
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /note="TATA-box binding protein associated factor 1"
                     /db_xref="GeneID:317256"
                     /db_xref="RGD:1562050"
     exon            1..192
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..5694
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /EC_number="2.7.11.1"
                     /note="TAF1 RNA polymerase II, TATA box binding protein
                     (TBP)-associated factor; transcription initiation factor
                     TFIID subunit 1-like"
                     /codon_start=1
                     /product="transcription initiation factor TFIID subunit 1"
                     /protein_id="NP_001178652.1"
                     /db_xref="GeneID:317256"
                     /db_xref="RGD:1562050"
                     /translation="MGPGWAGLLPEDGSGSPSAVMSDTDSDEDSAGGGPFSLTGFLFG
                     NINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELSGTDGTLVNDEGWIR
                     SREDAVDYSDINEVAEDESRRYQQTMGSLQPLCHTDYDEDDYDADCEDIDCKLMPPPP
                     PPPGPVKKERDQDGITGVSEDGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEA
                     TQSESKDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVW
                     RSARRKRKKKHRELIQEEQIQEEECSVELEVNQKSLWNYDYAPPPLPEQCLSDDEITM
                     MAPVESKFSQSTGDTDKVMDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKMKKT
                     EHDSTMKYNIMKKLRKLEENNGVDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQ
                     RASLAGWLPSSMTRNAMAYNVQQGFTATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWD
                     AQNMPRILEPPVLTLDPNDENLILEIPDEKEEATSNSPSKENKKESSLKKSRILLGKT
                     GVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFF
                     PTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGE
                     MFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY
                     GETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPESDFLIIRTRQGYYIRELV
                     DIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFP
                     SHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIA
                     AEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVT
                     GVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRK
                     FGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQ
                     RIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQE
                     RKELQRMLLAAGSAAGGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCE
                     TVRKAAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKE
                     KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
                     EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRR
                     VGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVK
                     DYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSM
                     LDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHP
                     VNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQY
                     TKTAQEIVNVCHQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAK
                     PPDLYDNSTSLSVSRDASVYQDESNLSVLDIPSATSEKQLTQEGGDGDGDLADEEEGT
                     VQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVESGSIRPKQ
                     PRMLQENTRMGMENEESMMSYEGDGGEASRGLEDSNISYGSYEEPDPKSNTQDTSFSS
                     IGGYEVSEEEEDEEEQRSGPSVLSQVQLSEDEEDSEDLHSIAGDSDLDSDE"
     exon            193..307
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            308..424
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            425..544
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            545..786
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1005
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1224
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1432
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1609
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1737
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1845
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2019
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2193
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2298
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2499
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2641
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2772
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2853
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..3003
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3123
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3299
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3478
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3692
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3858
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            3859..4070
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4179
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4278
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4456
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4524
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4647
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4740
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4741..4825
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4826..4893
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            4894..5010
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            5011..5016
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5142
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            5143..5299
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5477
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..7260
                     /gene="Taf1"
                     /gene_synonym="RGD1562050"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtttccggc ccatggggcc agggtgggct ggactgctgc ccgaagacgg ttctggtagc
       61 ccttccgccg tcatgtcaga cacagacagc gatgaagatt ctgctggtgg aggcccgttt
      121 tctttgactg ggttcctgtt cggcaacata aatggagcag ggcagctgga gggtgaaagc
      181 gtcttggacg atgagtgcaa gaagcatctt gcaggcttgg gggcattggg ccttggtagc
      241 ctgatcactg aactcacagc aaatgaagaa ttgtctggga ctgatggtac cctggtaaat
      301 gatgaaggat ggattaggag tagagaagat gctgtggact actcagacat caacgaggtg
      361 gcagaagatg aaagtcgaag atatcagcag acaatgggga gcttgcaacc cctttgccac
      421 acagattatg atgaagatga ctatgatgct gattgtgaag atattgattg caaattgatg
      481 cctcccccac ctccaccccc aggaccagtg aagaaagaga gggaccaaga tggtattact
      541 ggtgtgtctg aagatggaga aggcatcatc ttgccctcca tcattgcccc ttcctctttg
      601 gcctcagaga aagtggactt cagtagttcc tctgactcag aatctgagat gggacctcag
      661 gaagcaacac agtcagaatc taaggatgga aagctgaccc taccattggc tgggattatg
      721 cagcatgatg ccaccaagct gttgccaagt gtcacagaac tttttccaga atttagacct
      781 ggaaaggtgt tacgcttttt acggcttttt ggaccaggga agaatgtccc atctgtttgg
      841 aggagtgctc ggagaaagag gaaaaagaag caccgtgaac ttatacagga agagcagatc
      901 caggaagagg agtgttcagt agaattagaa gtcaaccaga aatctctgtg gaactatgac
      961 tatgctccac caccacttcc agagcagtgt ctctctgatg atgaaatcac aatgatggct
     1021 cctgtggagt ccaagttttc ccagtcaact ggagatacag ataaagtaat ggataccaaa
     1081 ccaagagtgg cagaatggcg ttatggacct gcccggctat ggtatgatat gctaggtgtt
     1141 cctgaagatg gcagtggctt tgactatggc ttcaaaatga agaagactga acatgactct
     1201 acaatgaaat ataacataat gaagaaacta agaaaacttg aggaaaacaa tggcgttgat
     1261 cttctggcag atgaaaactt cctaatggtg acacaactgc attgggaaga tgatatcatc
     1321 tgggatgggg aggatgtcaa acacaaagga acaaaacctc agcgtgcaag tttggcaggt
     1381 tggcttccct ccagtatgac taggaatgcc atggcctaca atgttcagca aggttttaca
     1441 gctacattgg atgatgataa accatggtac tccattttcc ccattgataa tgaagatctg
     1501 gtatatggac gttgggagga caatatcatt tgggatgctc agaacatgcc taggattttg
     1561 gagcctcctg ttttgacact tgatcccaat gatgagaact tgattttgga gatccccgat
     1621 gagaaggaag aagctacttc taattcccct tctaaggaga ataagaaaga atcatctctg
     1681 aagaagagtc gaattctctt gggaaaaaca ggagttatca aggaagagcc acagcagaac
     1741 atgtctcagc cagaagtgaa agatccatgg aatctctcca atgatgagta ttactatccc
     1801 aagcaacagg gtcttcgagg tactttcgga gggaatatta tccagcactc aattccagct
     1861 gtagaattac ggcagccctt ctttcccacc cacatgggac ccatcaaact ccggcagttc
     1921 catcgcccac ctctaaaaaa gtactccttt ggggcactat ctcagccagg cccacactca
     1981 gtccagcctt tgttgaagca tatcaaaaag aaggccaaga tgagagaaca agagagacaa
     2041 gcctcgggtg gtggagagat gttttttatg cgtacacctc aggaccttac aggcaaagat
     2101 ggagacctta ttcttgctga atacagtgaa gaaaatggac cattaatgat gcaagttggc
     2161 atggcaacta agataaaaaa ctactataaa cggaaacctg gaaaagatcc tggagcccca
     2221 gattgcaaat atggagaaac tgtttattgt catacatcac ctttcctggg ttctcttcat
     2281 cctggccagt tactgcaggc atttgaaaac aacctttttc gtgctccaat ttatcttcat
     2341 aagatgccag agtctgactt cctgatcatt cgcacaaggc agggttacta tattcgagaa
     2401 ttggtggata tttttgttgt gggccagcag tgtcccttgt ttgaagttcc tggtcctaat
     2461 tccaaaaggg ccaatacaca catcagagac tttctgcagg tttttattta ccggctcttt
     2521 tggaagagta aagataggcc acggaggata cggatggaag atataaagaa agcctttcct
     2581 tcacattcag aaagcagcat ccggaagagg ctaaagctct gtgctgactt caaacgtaca
     2641 gggatggatt caaactggtg ggtgctgaag tctgattttc gtttaccaac ggaagaggag
     2701 atcagagcta tggtctctcc agaacagtgc tgtgcttatt atagcatgat agctgcagaa
     2761 cagagactaa aggatgctgg ctatggagag aagtcctttt ttgctcctga ggaagaaaat
     2821 gaagaagatt tccagatgaa gattgatgat gaagttcgta ctgctccttg gaatactaca
     2881 agggctttca ttgctgccat gaagggcaaa tgtctcctgg aggtgactgg agtagcagat
     2941 cctacaggtt gtggtgaagg gttctcctat gtgaagattc caaacaaacc aacacagcag
     3001 aaggatgata aggagcctca gccagtgaag aaaacagtca caggaacaga tgcagacctt
     3061 cgtcgcctat ctttgaaaaa tgccaagcaa cttcttcgta aatttggtgt gcctgaggaa
     3121 gagattaaaa agttgtcccg ctgggaagtt attgatgtgg tacgcacaat gtcaacagaa
     3181 caggctcgtt ccggagaggg gcccatgagt aaatttgctc gtggatcaag gttttctgtg
     3241 gctgagcatc aagaacgtta caaagaggaa tgtcagcgca tctttgacct acagaacaag
     3301 gttttgtctt caacagaggt cttatcaact gacacagaca gcagctcagc tgaagacagt
     3361 gactttgaag aaatgggaaa aaacattgag aatatgctgc agaacaagaa aacaagctct
     3421 cagctgtcca gggaacggga ggagcaggaa cgaaaggaac tccagcggat gctactggca
     3481 gcaggctcgg cagcaggagg aaacaaccac agagatgatg acacagcctc ggtgactagc
     3541 cttaactctt ctgccactgg ccgctgtctc aagatttatc gaacatttcg agatgaggag
     3601 gggaaggaat atgttcgttg tgagacagtc cgaaaagcag ctgttattga tgcttatgta
     3661 cgcatacgga ccacaaaaga tgaagaattc attcgaaaat ttgccctttt tgatgagcaa
     3721 caccgagaag agatgagaaa agaacggcgg aggattcagg agcaactgag gagacttaaa
     3781 cgaaaccagg aaaaggagaa actgaagggt cctcctgaga aaaagcccaa aaagatgaag
     3841 gaacgtcctg acttaaaact aaaatgtgga gcatgtggtg caattggaca catgaggaca
     3901 aataaattct gccctcttta ttatcaaaca aatgcaccac cttctaatcc tgttgcaatg
     3961 acagaggaac aggaagaaga gctggaaaag acagtcattc acaatgataa tgaagaactt
     4021 atcaaggtcg aagggaccaa gatcgttttg ggaaaacagc taattgagag tgcggatgaa
     4081 gtacgcagaa aatctctggt tctgaagttc cctaaacaac aacttcctcc caagaaaaag
     4141 cgtcgggttg gaaccactgt tcactgtgac tatttgaata gacctcataa atccatccac
     4201 cgacgccgga cagaccctat ggtgacactg tcttctatct tggaatctat tatcaatgac
     4261 atgagagatc ttccaaatac ataccctttc catactccag ttaatgcaaa agttgtaaag
     4321 gattactaca aaatcatcac tcggccaatg gatctacaaa cactccgtga aaatgtgcgc
     4381 aaacgtcttt atccatctcg agaagaattc agagaacatt tggaattaat tgtgaaaaat
     4441 agtgcaactt ataatgggcc aaaacattca ctgactcaga tttctcaatc catgctggat
     4501 ctctgtgatg aaaaactcaa agagaaagag gataagttgg cacgtttaga gaaagctatc
     4561 aaccccttgc ttgatgatga tgatcaagta gcattttctt ttattctgga taacattgtc
     4621 actcagaaaa tgatggcagt tccagattct tggccatttc atcacccagt taataagaag
     4681 tttgttccag attattacaa agtgattgtc aatccaatgg atttggagac tatacgtaag
     4741 aatatctcca agcacaaata ccagagtcga gagagctttt tagatgatgt aaacctgatt
     4801 ctggccaaca gtgttaagta caatgggcct gagagtcagt atactaagac tgctcaggag
     4861 attgtgaacg tttgtcacca gacattaact gagtatgatg aacatttgac tcaacttgag
     4921 aaagatattt gtacagctaa agaagcagct ctggaggaag cagaattaga aagtctagac
     4981 ccaatgactc caggacctta tacccctcag gctaagcctc ctgatttata tgataacagc
     5041 acatccctca gtgtttctcg agatgcttcg gtgtatcaag atgagagcaa tctgtctgtc
     5101 ttggatattc ccagtgctac ttcagaaaag cagctaacac aggaaggtgg agacggagat
     5161 ggtgatcttg cagatgaaga ggaaggaact gtacaacagc cccaagccag tgtcctgtat
     5221 gaggatttgc ttatgtctga aggtgaagat gatgaagaag atgctgggag tgatgaagaa
     5281 ggagataacc ctttctctgc tattcagcta agtgaaagtg gaagtgactc tgatgtggaa
     5341 tctggcagca taagacccaa acagccccgc atgcttcaag agaatacaag gatgggcatg
     5401 gaaaatgaag aaagcatgat gtcctatgag ggagatggtg gggaggcttc ccgtggtttg
     5461 gaggatagca acatcagtta tgggagctat gaggagcctg atcccaagtc gaacacccag
     5521 gatacaagct tcagcagcat cggtgggtat gaggtatcag aggaggaaga agatgaggaa
     5581 gagcagcgct ctgggcccag cgttctaagc caggtccaac tctcagagga cgaggaggac
     5641 agtgaggatc tccactccat tgctggagac agtgacttgg actctgatga atgaggcttc
     5701 ctttaagcct cttcaatcag cctaggcctg ttacctttcc cccagcttgt ttatgtgtat
     5761 atagtagcta ataatgatat cactagatta acacctcagt tttagtaata agtaaaatag
     5821 taattatttc tctagatcat agagtagcaa gttcttttcc ctaagagaga gcagactccc
     5881 tcttcctcat tatactcctt taatggcatt tattgttttt ggtgtataaa catgccacca
     5941 ttttattttc taattggtag actagaatag acgaaaaccc ttctgctggt ttagagaatt
     6001 aggtcctgat gggctggctc tgtgtcacac ttaaaatgta atcctctcga acaaactgat
     6061 tgttcatgta ttacttactt ggatggacaa tgccttgttg ctaaatagat tacagggatg
     6121 tagctataaa tctgtgaaac agcctatgta tccatgtaaa cgtgctctct cccatcctag
     6181 aaaaaattat aggaaaacgg ttccttaggg caatgactgt cttttgtttc ttttttatgc
     6241 ttaggatatg gttttatgca aagtagctac tcagtagatg gtcttaaaaa tcacaaaatc
     6301 ccaacaaata tgttactgtg tacctgactc atgctaagca ctctatcata tccttggagt
     6361 gcaaaggtta aataagagct tgccatcaag ttggggcagt gagactggaa ttcaagccat
     6421 gttaataaat catagaatgt aagtacaatt aagaaactag gtgtaaagta caaagaaaag
     6481 aattagaaga ggtcatgttt ggaaagcaga gaagtcttcc agaggccgcc tgaaagctga
     6541 ctgttgagaa gtcgtagata agtactatct caaaaagttc aggcagggtg ttaacagttc
     6601 acagtctaga tatgacagaa cgtgttcctt gtttgtacct gccttgtttc agaaaggatg
     6661 ctgaagtgac tagacatgac actgaaagac ggacaggaag catatcttca agagctttgc
     6721 atttgagcta ggcgtggtgg cgcacacctt taatcccagc actcgggagg cagaggcaga
     6781 ggcaggtgaa tctcttgagt tcgaggccag cctggtctgc agagtgagtt ccaggacagc
     6841 cagggctgta aaaaagaaac cctgtctcag aaaatcaaaa gagagagata gataacagtg
     6901 agtaaatgtt atatttaaga atataaagtc tcgaggatta gatttgttta agaagttttc
     6961 agaatgttga atgaagacag aaattgagtc aaataataga catgtatgat tcagtttatg
     7021 taagactcaa aaactggatg tatatgatat gtttatatat acttgtatgt gcaaagtttt
     7081 caaaaagata tgaaagaata tacattaaag tattagcaat gataacctct gaaggatggg
     7141 aatagagagg aggtggttta tttagtttat atacagtagg taagtgttac gcttttattt
     7201 ctgtatctca attttataat gtgtattttt ttttaaataa aactttaatt taacagagat
//
