LOCUS       NM_001009540            1724 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus tumor-associated calcium signal transducer 2
            (Tacstd2), mRNA.
ACCESSION   NM_001009540
VERSION     NM_001009540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Stoyanova,T., Goldstein,A.S., Cai,H., Drake,J.M., Huang,J. and
            Witte,O.N.
  TITLE     Regulated proteolysis of Trop2 drives epithelial hyperplasia and
            stem cell self-renewal via beta-catenin signaling
  JOURNAL   Genes Dev 26 (20), 2271-2285 (2012)
   PUBMED   23070813
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   McDougall,A.R., Hooper,S.B., Zahra,V.A., Sozo,F., Lo,C.Y.,
            Cole,T.J., Doran,T. and Wallace,M.J.
  TITLE     The oncogene Trop2 regulates fetal lung cell proliferation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 301 (4), L478-L489 (2011)
   PUBMED   21743029
  REMARK    GeneRIF: The oncogene Trop2 regulates fetal lung cell
            proliferation.
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Tsukahara,Y., Tanaka,M. and Miyajima,A.
  TITLE     TROP2 expressed in the trunk of the ureteric duct regulates
            branching morphogenesis during kidney development
  JOURNAL   PLoS One 6 (12), e28607 (2011)
   PUBMED   22194864
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Tsujikawa,M., Kurahashi,H., Tanaka,T., Nishida,K., Shimomura,Y.,
            Tano,Y. and Nakamura,Y.
  TITLE     Identification of the gene responsible for gelatinous drop-like
            corneal dystrophy
  JOURNAL   Nat Genet 21 (4), 420-423 (1999)
   PUBMED   10192395
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   El Sewedy,T., Fornaro,M. and Alberti,S.
  TITLE     Cloning of the murine TROP2 gene: conservation of a PIP2-binding
            sequence in the cytoplasmic domain of TROP-2
  JOURNAL   Int J Cancer 75 (2), 324-330 (1998)
   PUBMED   9462726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY185508.1.
            
            On Nov 23, 2005 this sequence version replaced NM_001009540.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY185508.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1724              AY185508.1         1-1724
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..1724
                     /gene="Tacstd2"
                     /gene_synonym="Prp1; Trop2"
                     /note="tumor-associated calcium signal transducer 2"
                     /db_xref="GeneID:494343"
                     /db_xref="RGD:1359498"
     exon            1..1701
                     /gene="Tacstd2"
                     /gene_synonym="Prp1; Trop2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1041
                     /gene="Tacstd2"
                     /gene_synonym="Prp1; Trop2"
                     /note="parturition-related protein 1"
                     /codon_start=1
                     /product="tumor-associated calcium signal transducer 2
                     precursor"
                     /protein_id="NP_001009540.2"
                     /db_xref="GeneID:494343"
                     /db_xref="RGD:1359498"
                     /translation="MARGLDLAPLLLLLLAMVAGFCTAQINCTCPTNKMTVCNSNGPG
                     GVCQCRAIGSQVLVDCSTLTSKCLLLKARMSARKSSRRLVNPSEHAILDNDGLYDPEC
                     DDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRA
                     FNHSDLDSELRRLFKERYKLHPSFLAAVHYEEPTIQIELQQNASQKGLRDVDIADAAY
                     YFERDIKGESLFVGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTTGLIAVIA
                     VVAVALVAGVVVLVVTNRRKSGKYKKVELKELGEMRSEPSL"
ORIGIN      
        1 agtcgcctgc agtatcctac ccaacctgat ccttcagaat ccctgccctt ggtctgtagt
       61 tgtaggtccg ttctattcta taccaccatg gcgaggggct tggatctagc accgctgcta
      121 ctgctactgc tggcgatggt ggccggcttt tgcacggccc agatcaactg cacatgccct
      181 accaacaaga tgaccgtctg caactctaat ggcccaggtg gggtctgcca atgtcgggca
      241 atcggctcgc aggtgttggt cgactgctcc acgctaactt ccaagtgcct gctactcaag
      301 gcgcgcatga gcgcccgaaa gagcagccgc agactggtga atccgagcga gcacgcgatc
      361 ttggacaacg atggcctcta cgacccggag tgtgacgaca agggccgctt caaggcgcgc
      421 cagtgcaacc agacctcggt gtgctggtgc gtaaactcgg tgggcgtgcg ccgaacggac
      481 aagggagacc agagcctgcg ctgcgacgaa gtggtgcgaa cccaccacat cctcattgag
      541 ttgcgccacc gcccgacaga ccgagccttc aaccactctg acctagactc cgagctgcgg
      601 cggctcttca aggaacgcta caagctgcac cccagcttcc tggccgcggt gcactacgaa
      661 gagcccacca tccagatcga gctgcagcag aacgcgtcac agaagggcct gagagacgtg
      721 gacatcgctg acgccgccta ctacttcgaa agggacatca aaggcgagtc actgttcgtg
      781 ggccgtcgcg gcctggacgt gcaggtgcgt ggggagcccc tgcatgtgga gcggactctc
      841 atctactacc tggacgagaa gcccccccag ttctccatga agcgcctcac caccggcctc
      901 attgccgtca tcgctgtcgt cgcggtggca ctagtggccg gtgtggtggt cttggtggtc
      961 accaaccgga ggaaatcagg aaaatacaaa aaggtggagc ttaaggagct aggggagatg
     1021 agaagcgaac ctagcttgta gatttccccg ggcttccttg gcacctcaga ccaaatgtgt
     1081 tggcctgttg attcttagcc aggaggtaat tttcctccca gctgtgacct cttccttctc
     1141 tctccacaaa caagttccct agatgctgag ctcaggtcac ctcctcgccc ttgattttga
     1201 aggacgcatt tctgaaattc cttatccagt ctctcaaaac ctgacccgga gggttaagca
     1261 aagactggct tgtgccaggc agcccagtcg tttcccagag acgtgaatct acccaaagac
     1321 ttaaaaaacg gtttgaaatg ggaacgcagc tcttttgctg tcctgggttg ttggcgaacc
     1381 attcactccc tgcctcacaa ccttcaggaa aggaagaact aactgatcct gtgcagtgtt
     1441 cctctgccat cgttcatatg gaataaaagg cgtgtccgac gtctgcagtc attttaaatg
     1501 gctttgttgg actgcatcta tttttctgcc tgcccctgat gtagctgata ctagaaagtt
     1561 ttcttttgta aagtgtttgt acagatgcgt ctttgataat gctgctggtt tttttaaagc
     1621 aacaactcaa gtttaataaa atatgggaaa ggcacaccta aaaagatagg ctgtgtaaat
     1681 attccctcca gatttatatc aaaaaaaaaa aaaaaaaaaa aaaa
//
