LOCUS       NM_017053               2159 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Rattus norvegicus tachykinin receptor 3 (Tacr3), mRNA.
ACCESSION   NM_017053
VERSION     NM_017053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Zoubkova,H., Tomaskova,A., Nohejlova,K., Cerna,M. and Slamberova,R.
  TITLE     Prenatal Exposure to Methamphetamine: Up-Regulation of Brain
            Receptor Genes
  JOURNAL   Front Neurosci 13, 771 (2019)
   PUBMED   31417344
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   Khajehnasiri,N., Khazali,H. and Sheikhzadeh,F.
  TITLE     Various responses of male pituitary-gonadal axis to different
            intensities of long-term exercise: Role of expression of
            KNDYrelated genes
  JOURNAL   J Biosci 43 (4), 569-574 (2018)
   PUBMED   30207304
  REMARK    GeneRIF: The different impacts of diverse long-term exercise
            intensities on the male pituitary-gonadal axis maybe relay by the
            various changes in hypothalamic Nkb and Pdyn gene expressions.
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   Duarte,F.S., Duzzioni,M., Leme,L.R., Smith Sde,P. and De Lima,T.C.
  TITLE     Evidence for involvement of NK receptors in the anxiogenic-like
            effect of SP6-11(C-terminal), a metabolite of substance P, in rats
            evaluated in the elevated plus-maze
  JOURNAL   Behav Brain Res 303, 168-175 (2016)
   PUBMED   26851555
  REMARK    GeneRIF: Results give support to the involvement of NK3 receptors
            in the anxiogenic-like actions of SP6-11(C-terminal), where this
            metabolite seems to behave as an antagonist, in a way similar to
            SR142801.
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Mittelman-Smith,M.A., Krajewski-Hall,S.J., McMullen,N.T. and
            Rance,N.E.
  TITLE     Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic
            Nucleus Modulate Heat-Dissipation Effectors in the Female Rat
  JOURNAL   Endocrinology 156 (7), 2552-2562 (2015)
   PUBMED   25825817
  REMARK    GeneRIF: Median preoptic nucleus NK3R neurons facilitate cutaneous
            vasodilation, an important heat-dissipation effector.
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   Li,S.Y., Li,X.F., Hu,M.H., Shao,B., Poston,L., Lightman,S.L. and
            O'Byrne,K.T.
  TITLE     Neurokinin B receptor antagonism decreases luteinising hormone
            pulse frequency and amplitude and delays puberty onset in the
            female rat
  JOURNAL   J Neuroendocrinol 26 (8), 521-527 (2014)
   PUBMED   24863620
  REMARK    GeneRIF: data suggest that endogenous NeuroKinin B-Neurokinin 3
            Receptor signalling plays a role in controlling the timing of
            puberty.
REFERENCE   6  (bases 1 to 2159)
  AUTHORS   Ingi,T., Kitajima,Y., Minamitake,Y. and Nakanishi,S.
  TITLE     Characterization of ligand-binding properties and selectivities of
            three rat tachykinin receptors by transfection and functional
            expression of their cloned cDNAs in mammalian cells
  JOURNAL   J Pharmacol Exp Ther 259 (3), 968-975 (1991)
   PUBMED   1662278
REFERENCE   7  (bases 1 to 2159)
  AUTHORS   Shigemoto,R., Yokota,Y., Tsuchida,K. and Nakanishi,S.
  TITLE     Cloning and expression of a rat neuromedin K receptor cDNA
  JOURNAL   J Biol Chem 265 (2), 623-628 (1990)
   PUBMED   2153106
REFERENCE   8  (bases 1 to 2159)
  AUTHORS   Nagashima,A., Takano,Y., Tateishi,K., Matsuoka,Y., Hamaoka,T. and
            Kamiya,H.
  TITLE     Central pressor actions of neurokinin B: increases in neurokinin B
            contents in discrete nuclei in spontaneously hypertensive rats
  JOURNAL   Brain Res 499 (1), 198-203 (1989)
   PUBMED   2478257
REFERENCE   9  (bases 1 to 2159)
  AUTHORS   Nagashima,A., Takano,Y., Tateishi,K., Matsuoka,Y., Hamaoka,T. and
            Kamiya,H.
  TITLE     Cardiovascular roles of tachykinin peptides in the nucleus tractus
            solitarii of rats
  JOURNAL   Brain Res 487 (2), 392-396 (1989)
   PUBMED   2471579
REFERENCE   10 (bases 1 to 2159)
  AUTHORS   Massi,M., Polidori,C., Gentili,L., Perfumi,M., de Caro,G. and
            Maggi,C.A.
  TITLE     The tachykinin NH2-senktide, a selective neurokinin B receptor
            agonist, is a very potent inhibitor of salt appetite in the rat
  JOURNAL   Neurosci Lett 92 (3), 341-346 (1988)
   PUBMED   2462199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05189.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..2159
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /note="tachykinin receptor 3"
                     /db_xref="GeneID:24808"
                     /db_xref="RGD:3810"
     exon            1..735
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1585
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /EC_number="2.7.11.14"
                     /note="NK-3R; NK-3 receptor; Neuromedin K receptor
                     (Neurokinin B/Tachikin 3); tachikin receptor 3; neurokinin
                     B receptor"
                     /codon_start=1
                     /product="neuromedin-K receptor"
                     /protein_id="NP_058749.1"
                     /db_xref="GeneID:24808"
                     /db_xref="RGD:3810"
                     /translation="MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSA
                     LGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKR
                     MRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASI
                     YSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRT
                     LCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHE
                     QLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMS
                     STMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSR
                     MESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDE
                     YS"
     exon            736..924
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1075
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1272
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..2159
                     /gene="Tacr3"
                     /gene_synonym="Nkr; Nmkr; Tac3r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctctggtt ctctcctgcc cagaagagca gcaaactacc aggagtaagt gaggctccag
       61 ctccgtcgcc tttgccccaa tcacagcatc ccagggggcg gtaccatcac tgccggctac
      121 caggtagtac cccaaaacaa cgtgcctaag gggtgaagaa cttcaaggga gctggctcct
      181 gctagccgcc cggagtgtgg caggtcccag gctgcagacg ctggccatgg cctcagtccc
      241 caggggcgaa aactggaccg acgggacggt ggaagtgggg acccatacag ggaatctgag
      301 ctccgcgctg ggggtcactg agtggcttgc gctccaagct ggcaacttct cttcagcgct
      361 ggggttgccg gcgacaaccc aggcaccttc ccaggtccgg gctaacctga ccaaccagtt
      421 cgtgcagccg tcctggcgga tcgcgctctg gtccctggcc tatggcttgg tggtggccgt
      481 ggcagtcttc ggaaacctca tcgttatctg gatcatccta gcccacaagc gcatgagaac
      541 tgtcaccaac tatttcctgg taaacctggc tttctccgac gcctccgtgg ctgccttcaa
      601 caccttgatc aatttcatct atggtcttca cagcgagtgg tactttggcg ccaactactg
      661 ccgcttccag aacttctttc ccatcacagc ggtgtttgcc agcatctact ctatgacagc
      721 cattgcagtg gacaggtata tggctattat tgatccgttg aaacccagac tttctgccac
      781 agccactaag attgtcattg gaagtatttg gattttggca tttctacttg ccttccctca
      841 atgcctttat tccaaaataa aagtcatgcc gggccgtact ctttgctacg tgcagtggcc
      901 agaaggtccc aagcaacatt tcacgtacca catcattgtg atcatcctgg tgtactgttt
      961 cccactgctc atcatgggtg tcacctacac catcgttgga attactctct ggggaggaga
     1021 gatcccagga gacacctgtg acaagtacca tgagcagctg aaggctaaac gaaaggtggt
     1081 aaagatgatg atcattgtgg tggtgacgtt tgccatctgc tggctgccct atcacgtgta
     1141 tttcattctc actgcgatct accaacagtt aaacagatgg aaatacattc aacaggtcta
     1201 cctggctagc ttctggctgg caatgagctc gaccatgtac aaccccatca tctactgctg
     1261 tttgaacaaa agattccgcg caggcttcaa gagagcattt cgctggtgtc ctttcatcca
     1321 agtctccagc tacgatgagc tggagctcaa gaccaccagg tttcatccca cacgacagag
     1381 cagcctgtac accgtgagca ggatggagtc ggtgaccgtg ctgtttgacc ccaatgatgg
     1441 agacccaacc aaatccagcc gcaagaagag ggcggtgccc agagacccca gtgccaatgg
     1501 ctgttcccac agaggttcca aatctgcctc caccacatca agtttcataa gctcacccta
     1561 tacctctgtg gatgaatatt cctaagtcca tgtcccaagg tgatagctat catgaggcca
     1621 ccgtgaggcc agcctaggtc cctcattctc ctaaccatgc cagatcctgt tctaggtact
     1681 ttggggaagc agaagggcag ttcttaggtg ggcatactta atctgagaaa agtggaatac
     1741 caatgtaacg aaaactacca acatgtcagc cagcacagag aaaactgagt ctttaattta
     1801 ttctttaaga ttcttaaggg tcatatgcag caggtacaaa gtgtgagtct gaaaaatgac
     1861 ctaagtgtcc actgtccgcc atttaacaac ggcagtgcac ctttgtgacc gcagaagagc
     1921 agaggggttt tccaagagat taaggaagct ctaaattgca aatctgacca agggaaacat
     1981 gacctacata aaacagaaat tctctgtggc tatgaagtag aaagggcaaa tgactgactt
     2041 cccacacaca agtaataaaa aaataacctc aaagagtagg aaaatatgaa agccttttct
     2101 cattcaaaat tcattttgta gaatgaaaat tttcagaaat tccctctaat acattttgc
//
