LOCUS       NM_080768               2979 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tachykinin receptor 2 (Tacr2), mRNA.
ACCESSION   NM_080768
VERSION     NM_080768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2979)
  AUTHORS   Xiang,D., Xiao,J., Fu,L., Yao,L., Wan,Q., Xiao,L., Zhu,F., Wang,G.
            and Liu,Z.
  TITLE     DNA methylation of the Tacr2 gene in a CUMS model of depression
  JOURNAL   Behav Brain Res 365, 103-109 (2019)
   PUBMED   30711443
  REMARK    GeneRIF: Stress-induced increase in Tacr2 expression in the
            hypothalamus correlated with a specific decrease in DNA methylation
            of the Tacr2 gene.
REFERENCE   2  (bases 1 to 2979)
  AUTHORS   Schable,S., Huston,J.P. and Silva,M.A.
  TITLE     Neurokinin2-R in medial septum regulate hippocampal and amygdalar
            ACh release induced by intraseptal application of neurokinins A and
            B
  JOURNAL   Hippocampus 22 (5), 1058-1067 (2012)
   PUBMED   20882546
  REMARK    GeneRIF: These results indicate that medial septal NK(2)-R have an
            important role in mediating acetylcholine release, for one, via the
            septal-hippocampal cholinergic projection and, secondly, via direct
            or indirect route to the amygdala, but not frontal cortex.
REFERENCE   3  (bases 1 to 2979)
  AUTHORS   Schable,S., Huston,J.P., Brandao,M.L., Dere,E. and de Souza
            Silva,M.A.
  TITLE     Neurokinin-2 receptor antagonism in medial septum influences
            temporal-order memory for objects and forebrain cholinergic
            activity
  JOURNAL   Peptides 31 (1), 108-115 (2010)
   PUBMED   19854231
  REMARK    GeneRIF: Data show that injection of vehicle alone into the medial
            septum impaired memory for temporal order and spatial location,
            while the NK(2) receptor antagonist partially reversed this deficit
            by reinstating memory for temporal order.
REFERENCE   4  (bases 1 to 2979)
  AUTHORS   Ye,Y.M., Lee,H.Y., Kim,S.H., Jee,Y.K., Lee,S.K., Lee,S.H. and
            Park,H.S.
  TITLE     Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21
            H33Q C>G polymorphisms on asthma control with inhaled
            corticosteroid treatment
  JOURNAL   J Clin Pharm Ther 34 (6), 693-701 (2009)
   PUBMED   20175803
REFERENCE   5  (bases 1 to 2979)
  AUTHORS   Schelfhout,V., Van De Velde,V., Maggi,C., Pauwels,R. and Joos,G.
  TITLE     The effect of the tachykinin NK(2) receptor antagonist MEN11420
            (nepadutant) on neurokinin A-induced bronchoconstriction in
            asthmatics
  JOURNAL   Ther Adv Respir Dis 3 (5), 219-226 (2009)
   PUBMED   19880429
REFERENCE   6  (bases 1 to 2979)
  AUTHORS   Patacchini,R., Cox,H.M., Stahl,S., Tough,I.R. and Maggi,C.A.
  TITLE     Tachykinin NK(2) receptor mediates contraction and ion transport in
            rat colon by different mechanisms
  JOURNAL   Eur J Pharmacol 415 (2-3), 277-283 (2001)
   PUBMED   11275010
REFERENCE   7  (bases 1 to 2979)
  AUTHORS   Hallgren,A., Flemstrom,G., Hellstrom,P.M., Lordal,M., Hellgren,S.
            and Nylander,O.
  TITLE     Neurokinin A increases duodenal mucosal permeability, bicarbonate
            secretion, and fluid output in the rat
  JOURNAL   Am J Physiol 273 (5), G1077-G1086 (1997)
   PUBMED   9374705
REFERENCE   8  (bases 1 to 2979)
  AUTHORS   Debeljuk,L., Bandera,R. and Bartke,A.
  TITLE     Effect of a non-peptide NK-2 tachykinin receptor antagonist on LH,
            FSH, and prolactin release by rat hemipituitaries in vitro
  JOURNAL   J Physiol Pharmacol 48 (3), 461-478 (1997)
   PUBMED   9376629
REFERENCE   9  (bases 1 to 2979)
  AUTHORS   Ingi,T., Kitajima,Y., Minamitake,Y. and Nakanishi,S.
  TITLE     Characterization of ligand-binding properties and selectivities of
            three rat tachykinin receptors by transfection and functional
            expression of their cloned cDNAs in mammalian cells
  JOURNAL   J Pharmacol Exp Ther 259 (3), 968-975 (1991)
   PUBMED   1662278
REFERENCE   10 (bases 1 to 2979)
  AUTHORS   Sasai,Y. and Nakanishi,S.
  TITLE     Molecular characterization of rat substance K receptor and its
            mRNAs
  JOURNAL   Biochem Biophys Res Commun 165 (2), 695-702 (1989)
   PUBMED   2480781
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M31838.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2979
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2979
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /note="tachykinin receptor 2"
                     /db_xref="GeneID:25007"
                     /db_xref="RGD:3812"
     exon            1..840
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..1621
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /note="SKR; NK-2R; NK-2 receptor; neurokinin A receptor;
                     Tachykinin 2 (substance K) receptor"
                     /codon_start=1
                     /product="substance-K receptor"
                     /protein_id="NP_542946.1"
                     /db_xref="GeneID:25007"
                     /db_xref="RGD:3812"
                     /translation="MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALV
                     LVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFG
                     RAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVAL
                     ALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYS
                     VIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQ
                     EDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEED
                     RLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA"
     exon            841..1035
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1189
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1386
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..2979
                     /gene="Tacr2"
                     /gene_synonym="Tac2r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccacaga cttggcacac tgtgcacctc cgtcatctgg gatgtaccct gaatagcatt
       61 aagagagatc tgaattcaaa ttcgggtttg tcaccaactt ccggaatgcc tgttgctgga
      121 cgcgtctttt ctctgactct cagcgttctg actctggtgt gaaagagagg agccgatcca
      181 acgcgctatc aggatgcctc ctgctctgag actggagttt gagttctcca tctccaagag
      241 atgcttgaac agtctgattg ggaccttgct tcctgctcag cctgactcat ttctgcccga
      301 gctgtaggcg tggccctctg gctacacgtg tctgcttttg aatcgtcctt ccccccttaa
      361 atctacacac cgaagaggat ttctcttctg tggcaattcg agacggaact gcagggccag
      421 accctgtgtt ccaggcccag aatcagtcat ggggacccgt gccattgttt ctgacgccaa
      481 catcttgtct ggcctcgaga gcaatgccac gggtgttaca gccttctcca tgcctggctg
      541 gcagctggcg ttatgggcca cagcctacct ggccctggtg ctggtggctg tgacaggcaa
      601 tgccacagtc atctggatca ttctggccca cgagaggatg cgcacagtca ccaactattt
      661 catcatcaac ctggccttgg cggacctctg catggcagcc ttcaacgcga ccttcaactt
      721 catctacgcc agtcacaaca tctggtactt cggccgtgcc ttctgctatt tccagaacct
      781 ctttcccatc acagccatgt tcgtcagcat ctactccatg accgccattg ctgctgacag
      841 gtacatggcc atcgttcacc ccttccagcc acggctctcg gcccccagca ccaaggcgat
      901 tatcgctggc atctggctgg tagccctggc tctcgcctcc ccgcaatgct tctactccac
      961 catcactgtg gacgaggggg ccaccaagtg tgtggtggcc tggcccaatg acaacggagg
     1021 caagatgctc ctactgtatc atctggtcgt gtttgtcctc atctacttcc tgcctctcct
     1081 ggtgatgttc ggggcttaca gtgtcatcgg cctcacactg tggaagcgcg cggtacccag
     1141 acaccaggct cacggagcca acttacgcca tctacaggcc aagaagaagt ttgtgaaggc
     1201 catggtactg gtggtgctga catttgccat ctgctggctg ccctaccacc tctacttcat
     1261 cctggggacc ttccaagagg acatctacta ccacaagttt atccagcagg tctacctggc
     1321 gctcttctgg ctggccatga gctccacaat gtacaaccct atcatttatt gctgccttaa
     1381 ccacaggttt cgctctggat tccggcttgc tttccggtgc tgcccctggg tgacaccaac
     1441 tgaggaagac aggctggagc tgactcacac gccatccctc tccaggagag tcaaccggtg
     1501 tcataccaag gagactttgt tcatgacggg ggacatgacc cactctgagg ctaccaatgg
     1561 acaggttggg agtccccagg atggggagcc tgctggaccc atctgcaagg cccaggctta
     1621 gcccctttga gaagcagctg acggaaaagc ccctacataa tagcttgtcc cacaccccat
     1681 tcttcaacac accaacagaa aaaacagaat ggtgctcgga atgccacagg caatacaggt
     1741 gtcaacaaag aactctgagc acagacacct gtcacaggca atccagtgat ggaggaaggc
     1801 gctgggagga ctgggaagcc acacttggcc aacctagaag ctgcaaagtg agatgtctcc
     1861 caggagtata gagagagaag gaaaactgga tcccagcgaa gaaaactgca gttgtaatga
     1921 gaagggcagc tgaaggacag agagatggct tggcgaggtg gaaaagcctc tgctaagtaa
     1981 gcagtggaaa agcctctgct aagccttgtg acctaagtgc agtacctgca acccacaggg
     2041 aaggtaagaa ccaaagccta caagttgtcc tctgacttcc tccaatgtat gcatgcatca
     2101 tgtatgcatc tgtgtgtgca catacatctg cacatgcacg cacatacaaa atatgcgcat
     2161 gcacgtgcac acttacaatg ttaaagagga agaaggcgac agctcccaca ggactgtaac
     2221 agattgcaga ggacaagcgc ccaaagggaa acccagctgc ttcgctcgct ctggaacaca
     2281 attgccaggt tttccgaata aagaaagcct aagatccaaa tatatatgta tgggagctcc
     2341 gggcttctaa atttggttca tgaaaacgct tagagacact ggctaaccca gagcggtgca
     2401 catccacacc accacctcct cgccaaagac aagccacaaa ggaagtcacc tatttggctg
     2461 cgaatggatc catggttttt ctaccttagg atctaaaagc tcccatccag cccagagggg
     2521 agggcagtta acagtccaga ggagcttcag ctgagatgta agatactctg accccctgct
     2581 tgatggcagg attgccgtga ggcttgttgg aaacgatgcc ttcaaaccag caggccacat
     2641 ccagcgaaat gctcaataaa tagtaaccac gattcttcgc acggcgtcag cttttaagac
     2701 acaaaagcca cctacaagtt aggagaatgg ctccccctct cacttctgca gtgaggagct
     2761 ggcaggcaga gcacaccgat ggtcccagtt ctaagaacgc ctggcctagg ccgctccagg
     2821 ccagtccgtc tccctgcttg gtggtcactc atttgctgtc taccccgtgc cctctgaaag
     2881 ccaaagacgc tgtaaacacg tgttcaaagt ttaatgtcac ctgagctttc ccagagttca
     2941 ctgcgccagt acccccaata aagggttctg atgtcactt
//
