LOCUS       NM_012667               3418 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus tachykinin receptor 1 (Tacr1), mRNA.
ACCESSION   NM_012667 XM_346709
VERSION     NM_012667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3418)
  AUTHORS   Liu,Y., Qu,H.Q., Chang,X., Qu,J., Mentch,F.D., Nguyen,K., Tian,L.,
            Glessner,J., Sleiman,P.M.A. and Hakonarson,H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   2  (bases 1 to 3418)
  AUTHORS   Chen,W. and Marvizon,J.C.
  TITLE     Neurokinin 1 receptor activation in the rat spinal cord maintains
            latent sensitization, a model of inflammatory and neuropathic
            chronic pain
  JOURNAL   Neuropharmacology 177, 108253 (2020)
   PUBMED   32736088
  REMARK    GeneRIF: Neurokinin 1 receptor activation in the rat spinal cord
            maintains latent sensitization, a model of inflammatory and
            neuropathic chronic pain.
REFERENCE   3  (bases 1 to 3418)
  AUTHORS   Jiang,W., Wang,X., Wang,W., Hua,F., Zhang,Z., Zhang,Z., Xiang,J.
            and Yang,X.
  TITLE     Inhibition of NK1R attenuates LPS-induced microglial inflammation
            and consequent death of PC12 cells
  JOURNAL   Brain Res Bull 162, 115-124 (2020)
   PUBMED   32540418
  REMARK    GeneRIF: Inhibition of NK1R attenuates LPS-induced microglial
            inflammation and consequent death of PC12 cells.
REFERENCE   4  (bases 1 to 3418)
  AUTHORS   Yan,K., Lin,Q., Tang,K., Liu,S., Du,Y., Yu,X. and Li,S.
  TITLE     Substance P participates in periodontitis by upregulating
            HIF-1alpha and RANKL/OPG ratio
  JOURNAL   BMC Oral Health 20 (1), 27 (2020)
   PUBMED   32000757
  REMARK    GeneRIF: Substance P participates in periodontitis by upregulating
            HIF-1alpha and RANKL/OPG ratio.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3418)
  AUTHORS   Widiapradja,A., Manteufel,E.J., Dehlin,H.M., Pena,J.,
            Goldspink,P.H., Sharma,A., Kolb,L.L., Imig,J.D., Janicki,J.S.,
            Lu,B. and Levick,S.P.
  TITLE     Regulation of Cardiac Mast Cell Maturation and Function by the
            Neurokinin-1 Receptor in the Fibrotic Heart
  JOURNAL   Sci Rep 9 (1), 11004 (2019)
   PUBMED   31358823
  REMARK    GeneRIF: Regulation of Cardiac Mast Cell Maturation and Function by
            the Neurokinin-1 Receptor in the Fibrotic Heart.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3418)
  AUTHORS   Liu,H., Brown,J.L., Jasmin,L., Maggio,J.E., Vigna,S.R., Mantyh,P.W.
            and Basbaum,A.I.
  TITLE     Synaptic relationship between substance P and the substance P
            receptor: light and electron microscopic characterization of the
            mismatch between neuropeptides and their receptors
  JOURNAL   Proc Natl Acad Sci U S A 91 (3), 1009-1013 (1994)
   PUBMED   7508118
REFERENCE   7  (bases 1 to 3418)
  AUTHORS   Kwatra,M.M., Schwinn,D.A., Schreurs,J., Blank,J.L., Kim,C.M.,
            Benovic,J.L., Krause,J.E., Caron,M.G. and Lefkowitz,R.J.
  TITLE     The substance P receptor, which couples to Gq/11, is a substrate of
            beta-adrenergic receptor kinase 1 and 2
  JOURNAL   J Biol Chem 268 (13), 9161-9164 (1993)
   PUBMED   7683643
REFERENCE   8  (bases 1 to 3418)
  AUTHORS   Hershey,A.D., Dykema,P.E. and Krause,J.E.
  TITLE     Organization, structure, and expression of the gene encoding the
            rat substance P receptor
  JOURNAL   J Biol Chem 266 (7), 4366-4374 (1991)
   PUBMED   1705552
REFERENCE   9  (bases 1 to 3418)
  AUTHORS   Hershey,A.D. and Krause,J.E.
  TITLE     Molecular characterization of a functional cDNA encoding the rat
            substance P receptor
  JOURNAL   Science 247 (4945), 958-962 (1990)
   PUBMED   2154852
REFERENCE   10 (bases 1 to 3418)
  AUTHORS   Yokota,Y., Sasai,Y., Tanaka,K., Fujiwara,T., Tsuchida,K.,
            Shigemoto,R., Kakizuka,A., Ohkubo,H. and Nakanishi,S.
  TITLE     Molecular characterization of a functional cDNA for rat substance P
            receptor
  JOURNAL   J Biol Chem 264 (30), 17649-17652 (1989)
   PUBMED   2478537
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05097.1, SRR26643299.19824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               JAXUCZ010000004.1  116478617-116479564
            949-1143            JAXUCZ010000004.1  116571654-116571848
            1144-1294           JAXUCZ010000004.1  116641736-116641886
            1295-1491           JAXUCZ010000004.1  116643657-116643853
            1492-3418           JAXUCZ010000004.1  116645566-116647492
FEATURES             Location/Qualifiers
     source          1..3418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3418
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /note="tachykinin receptor 1"
                     /db_xref="GeneID:24807"
                     /db_xref="RGD:3811"
     exon            1..948
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..1783
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /note="SPR; NK-1R; NK-1 receptor; substance p receptor;
                     neurokinin 1 receptor"
                     /codon_start=1
                     /product="substance-P receptor"
                     /protein_id="NP_036799.1"
                     /db_xref="GeneID:24807"
                     /db_xref="RGD:3811"
                     /translation="MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVV
                     TSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGL
                     FYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALL
                     LAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTV
                     VGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPD
                     LYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGL
                     EMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNS
                     KTMTESSSFYSNMLA"
     exon            949..1143
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1294
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1491
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..3418
                     /gene="Tacr1"
                     /gene_synonym="Tac1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggacca agacggacaa gctgcgggtg acagtagaag cttcaagcga agcaaagaaa
       61 aagggagctc accagctgga tgcggacctc agaacccggc cagaggacca gaacttttgc
      121 aagcaacact gcactgcgag cagcccttct tatcccttga gcacccaccc agcacccagc
      181 tttgcctttc ccgccgcacg tatgttagtg ggagttgcta gcagcagcag gtgcagaaag
      241 gcgggctgtc ttgccttctg gaactgtgtg gcgtgcagct gctttaacgc aaacaagagc
      301 ctagcttgaa agtggaggaa tgtagagcga ccaggcaaag agcctacaca ggagaagcat
      361 tgctcttgtg agcaagtctc ctgctaacca ggactgagtt ctgcccagga aacttcccac
      421 ttcctgtgtg gcagaacctc aagcctcagg catctgcaac aaggtcctgc ggcaaggagg
      481 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta cctctgtgtg
      541 tgtttgtgat tgccccaaaa tggataacgt ccttcctatg gactctgatc tcttccccaa
      601 catctccacc aacacctctg agtctaacca gttcgtgcag cctacctggc aaatcgttct
      661 ttgggcggct gcctacacgg tcatcgtggt gacttccgtg gtgggcaacg tagtggtgat
      721 atggatcatt ttggcccaca agagaatgag gacagtgacc aattatttcc tggtgaacct
      781 ggccttcgct gaggcctgca tggctgcatt caatacggtg gtgaacttca cctacgcagt
      841 ccacaatgtg tggtactacg gcctcttcta ttgcaagttt cacaacttct tccccatcgc
      901 tgctctcttc gccagtatct actccatgac agccgtggcc ttcgacagat acatggccat
      961 catccaccct ctccagcccc ggctctcagc cacggctacc aaagtggtca tctttgtcat
     1021 ctgggtcctg gctctcctgc tggcctttcc acaaggctac tactccacca cagagaccat
     1081 gcccagcaga gtcgtgtgca tgatcgagtg gccggagcat cccaacagga cttatgagaa
     1141 agcgtaccac atctgcgtga ctgtactgat ctacttcctg cctctactgg tgatcggcta
     1201 cgcgtacact gtggtgggga ttacactgtg ggccagtgag atccccggcg actcctctga
     1261 ccgctaccat gagcaagtct ctgccaaacg caaggtggtc aaaatgatga tcgtggttgt
     1321 gtgtaccttc gccatctgct ggctgccctt ccacgtcttc ttcctcctgc cctacatcaa
     1381 cccagatctc tacctgaaga agttcatcca gcaggtctac ctggccagca tgtggctggc
     1441 catgagttct accatgtaca accccatcat ctactgttgc ctcaacgaca ggttccgtct
     1501 gggcttcaag cacgccttcc gctgctgccc cttcatcagt gcaggtgatt atgaggggct
     1561 ggaaatgaaa tccacccgat acctccagac acagagcagc gtgtacaagg tcagccgcct
     1621 ggagaccacc atctccactg tggtgggagc ccatgaagag gagcccgagg aaggccccaa
     1681 ggccacaccc tcatccttgg atctcacctc caacggctcc tctcgcagca actccaagac
     1741 catgacagaa agctccagct tctactctaa catgctggcc taggcatatt caaggcatgg
     1801 cctctagccc atcttgtgtt gcttattcat ggaagcctct gatttggact ttgttggaaa
     1861 taccctagca ctggggcctt tggagaaggg tcacaatggt ttaaggaaaa cgtttcatgc
     1921 tgtatgcaat ctggattcct tcctgtcttt gtcaaccatc ctccatgctg gtgacccaag
     1981 gcagactagt aaacttctat aaagtgagaa ggctatcctt gctttcccct gcagccatcc
     2041 cacgattcct gaaatgactt catctgcatg caaggtgctt atctggggag gaattctgca
     2101 aggcacctga cctatttgtc tggagcgtct gtctttcttc agcgaagtca gtctcagcca
     2161 tgcgtggact agctcacacc actccagcct tccacaggac agtgtgagcg aaagaaggtg
     2221 ccacctaaac tgtaatgaaa gctgtacccc aacctaagca cacatgaaga gaggacacct
     2281 gccattgtga cacgccgatg tttcagtcca ttcaaacatc acgggcttga caatactgga
     2341 ttcttctgca ttgtgtccgc agtgcaacca acacggactg aatacgtcta cacaggccag
     2401 ctgatgttct aaccaagagt caggagatcc ctgccaggct atctgagctt cttttccttc
     2461 tttgcaaaac atcagaactg aaccaaatac tcttaagtgt tcctttgaat ctcagtgttc
     2521 cctggtttaa tggtgtatat agttcatttt ccgtctccct ctccctctcc ctctccctct
     2581 ccctctccct ctccctctcc ctctccctct ccctctccct ctctctctct ctctctctct
     2641 ctctctctct ctctctctct ctctctctct cacacacaca cacacacaca cacacttaaa
     2701 aaaaagcaat ggcagcctca aaaataccag gggtgtcaat acttagagat gggtgtgtat
     2761 aaatatcccc ccattgatcc aaaatccctg cttcaaaaat tccttctcca ggaagtttct
     2821 cctctttgac agagcagaga acttcacagg aaaacttgat gtctccagca ggctgcatcc
     2881 cggctctgag agcagcactg aggaggacaa gtgtgtggac ttcctgctct ggctgttcgc
     2941 gtctttgtgc atgttcttca ctttttgcta cacacagtgg agagtaggga ggctgtcctc
     3001 ctggaaagag gagccttgtg tcttctcttc agactctgaa ccttgccctc ctgctccgct
     3061 ttgccgatct ccgtctataa gaagttaaag gatccaccaa tccgaaagga catttagtct
     3121 aacaagagcc aagaactgaa actttgcatc ctgagatggc ttcaggaccc ctggcaggtg
     3181 agaatgctgt tcctttccgt ctcagatgtg actggaagcg aaagcttcat gtgacatccg
     3241 tgaacatcct catggttcag ataattggat gcacaaaagc tctattcatc gtgtcagaaa
     3301 aaacaaggcc acccaccacc aggatttata acttctgcca gccttgttga atcaaacatt
     3361 ttgaggacat cggcatacct ggagaaggca agatttatac agaagtaata taaaccag
//
