LOCUS       NM_001004424            2049 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transforming, acidic coiled-coil containing
            protein 3 (Tacc3), mRNA.
ACCESSION   NM_001004424 XM_006251331 XM_341242
VERSION     NM_001004424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Cheeseman,L.P., Harry,E.F., McAinsh,A.D., Prior,I.A. and Royle,S.J.
  TITLE     Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates
            kinetochore fiber tension
  JOURNAL   J Cell Sci 126 (Pt 9), 2102-2113 (2013)
   PUBMED   23532825
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Booth,D.G., Hood,F.E., Prior,I.A. and Royle,S.J.
  TITLE     A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by
            inter-microtubule bridging
  JOURNAL   EMBO J 30 (5), 906-919 (2011)
   PUBMED   21297582
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Still,I.H., Vettaikkorumakankauv,A.K., DiMatteo,A. and Liang,P.
  TITLE     Structure-function evolution of the transforming acidic coiled coil
            genes revealed by analysis of phylogenetically diverse organisms
  JOURNAL   BMC Evol Biol 4, 16 (2004)
   PUBMED   15207008
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Hao,Z., Stoler,M.H., Sen,B., Shore,A., Westbrook,A.,
            Flickinger,C.J., Herr,J.C. and Coonrod,S.A.
  TITLE     TACC3 expression and localization in the murine egg and ovary
  JOURNAL   Mol Reprod Dev 63 (3), 291-299 (2002)
   PUBMED   12237944
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Piekorz,R.P., Hoffmeyer,A., Duntsch,C.D., McKay,C., Nakajima,H.,
            Sexl,V., Snyder,L., Rehg,J. and Ihle,J.N.
  TITLE     The centrosomal protein TACC3 is essential for hematopoietic stem
            cell function and genetically interfaces with p53-regulated
            apoptosis
  JOURNAL   EMBO J 21 (4), 653-664 (2002)
   PUBMED   11847113
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Sadek,C.M., Jalaguier,S., Feeney,E.P., Aitola,M.,
            Damdimopoulos,A.E., Pelto-Huikko,M. and Gustafsson,J.A.
  TITLE     Isolation and characterization of AINT: a novel ARNT interacting
            protein expressed during murine embryonic development
  JOURNAL   Mech Dev 97 (1-2), 13-26 (2000)
   PUBMED   11025203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Ivan Still. The reference sequence was derived
            from JAXUCZ010000014.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001004424.2.
            
            Summary: This gene encodes a member of the transforming, acidic
            coiled-coil (TACC) family of proteins. Members of this family are
            centrosomal proteins that interact with microtubules and tubulin.
            TACC proteins are thought to be involved in centrosome/mitotic
            spindle dynamics and gene regulation. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2076770.1,
                                           SRR26360190.2446045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000014.1  81289564-81289698   c
            136-298             JAXUCZ010000014.1  81286989-81287151   c
            299-441             JAXUCZ010000014.1  81286716-81286858   c
            442-523             JAXUCZ010000014.1  81283122-81283203   c
            524-968             JAXUCZ010000014.1  81282318-81282762   c
            969-1021            JAXUCZ010000014.1  81280785-81280837   c
            1022-1131           JAXUCZ010000014.1  81280365-81280474   c
            1132-1219           JAXUCZ010000014.1  81279386-81279473   c
            1220-1321           JAXUCZ010000014.1  81279204-81279305   c
            1322-1398           JAXUCZ010000014.1  81278768-81278844   c
            1399-1442           JAXUCZ010000014.1  81278646-81278689   c
            1443-1603           JAXUCZ010000014.1  81277987-81278147   c
            1604-1710           JAXUCZ010000014.1  81276361-81276467   c
            1711-1831           JAXUCZ010000014.1  81276159-81276279   c
            1832-2049           JAXUCZ010000014.1  81275755-81275972   c
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2049
                     /gene="Tacc3"
                     /note="transforming, acidic coiled-coil containing protein
                     3"
                     /db_xref="GeneID:360962"
                     /db_xref="RGD:1302948"
     exon            1..135
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            136..298
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1900
                     /gene="Tacc3"
                     /note="transforming acidic coiled coil 3"
                     /codon_start=1
                     /product="transforming acidic coiled-coil-containing
                     protein 3"
                     /protein_id="NP_001004424.3"
                     /db_xref="GeneID:360962"
                     /db_xref="RGD:1302948"
                     /translation="MNLHILTDENVPNEKSSESRDFLFSAPELTGRSSVLRLSQKENV
                     PPKNQAKAAKVTFQTPLRDPQTHRILSPNMTSKLEAPFALDDSVGLQNDHCVFLQKEN
                     QLPVAPVDDVPVVQMAAEILKAEDELQEGILNSLSPSAFTSFPDGELVTPPIEPMPEP
                     SPQGPEPLLDSEPVTPPVKPVLEPTPQGPEPLLDSEPVTPPVKPVLEPTPQGSEPLLD
                     SEPVTLPVEPVPESSHQGPEPLLDSEPVTLPVEPVPESSHQGPEPLLDPKEESFRDPA
                     EVLGAGAEVDYLEQFGTSSFKESAWRKQSLYLKFDPLLKESPLRSMPVPVAPVTNSTQ
                     DTEESGSGNPTEAKLVDLDFLGGLDVPVSAPPLCVLEPRGLLPAEPIVDVLKYSQKDL
                     DAVVNVMQQENLELRNKYEDLNTKYLEMGKIVDGFEKIVYKSMEEAEKQKELAEDKIQ
                     KILRERDQLTADLNSMEKSFSDLFKRFEKQKEVIEGYQKNEDSLKKCVEDYIVKIGKE
                     GQRYQALKAHAEEKLKMANEEIAQVRSKAQAEALALQASLRKAQLQIQSLEKTVEQKT
                     KENDELNRICDELIAKMEKKI"
     exon            299..441
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..523
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..968
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1021
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1131
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1219
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1321
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1398
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1442
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1603
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1710
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1831
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2049
                     /gene="Tacc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagagcaga gcttgttcgg attcctttgg ctcggtttct ctagctcgtt tttctgttgc
       61 ggagcaaata cggctctcct cccttgcggt tggcgtccgc gcgggcccag ggctccgcag
      121 ccgtaggcag gaaaggatga atctgcatat cttaactgac gaaaatgtcc ccaacgagaa
      181 gagttcagaa agccgtgact tcctgttttc agcaccagaa cttaccggaa gatcctctgt
      241 tcttcgcctg tcacagaaag aaaatgtacc tcccaagaac caggctaaag ccgcaaaggt
      301 gacttttcag acacctcttc gggatccaca gacacacagg atcttaagtc ctaatatgac
      361 cagcaaactt gaggctcctt ttgctctgga tgacagtgtt ggattacaaa atgaccactg
      421 tgtcttctta cagaaagaga accagctgcc ggtagcccca gtggacgatg tacctgtggt
      481 tcagatggca gccgagatcc tgaaagcaga ggacgagtta caggagggaa ttttgaattc
      541 cttgagccct tcagctttca caagttttcc agacggtgag ctggtaaccc ctccaatcga
      601 gccgatgccg gagccttccc ctcaggggcc agagcctctc ttggacagcg agccagtgac
      661 ccctccagtc aagccagtgc tggaacctac tcctcagggg ccagagcctc tcttggacag
      721 tgagccggtg acccctccag tcaagccagt actggaacct acccctcagg gatcagagcc
      781 tctcttggac agtgagccag tgacccttcc tgttgaacca gtgccagagt cttcccatca
      841 gggaccagaa cctctcttgg acagtgagcc agtgaccctt cctgttgaac cagtgccaga
      901 gtcttcccat cagggaccag aacctctctt ggacccaaag gaagagagct ttagagaccc
      961 agcagaagtt ctaggtgctg gtgctgaagt ggattatctg gagcaatttg gaacttcctc
     1021 gttcaaggag tcagcctgga ggaagcagtc tttgtacttg aaatttgacc cccttctgaa
     1081 agagagccct ttgcggtcaa tgccagtgcc agtggcccca gtgacaaata gtacacagga
     1141 tacagaggag tctggctccg gaaatccaac agaagccaag ctcgtcgact tagatttctt
     1201 gggaggtctg gatgttcctg tgtcggcccc acccctgtgt gtccttgagc ctcgaggtct
     1261 ccttcctgcc gagcctattg tggacgtgct gaaatacagt cagaaagacc tggatgcagt
     1321 ggtgaacgtg atgcagcagg agaacttgga gctgagaaac aaatatgagg acctcaacac
     1381 gaagtatctg gagatgggga agatcgttga tggatttgag aagatcgtgt ataaatcaat
     1441 ggaggaggct gagaaacaga aggaactagc tgaagacaaa attcaaaaga ttttaagaga
     1501 gagagaccaa cttactgcgg atctgaactc tatggagaag tccttctctg acctcttcaa
     1561 gcggtttgag aagcagaagg aagtgattga aggctaccag aagaatgaag attcactgaa
     1621 gaagtgtgtt gaggattaca tagtgaagat tggaaaagaa ggccagaggt accaggcgct
     1681 gaaggcccac gcagaagaaa aactcaagat ggcaaatgaa gagatcgccc aagtgcgaag
     1741 caaggcccaa gcagaggcac tggctctcca ggcaagcctg aggaaggcac agttgcagat
     1801 ccagtcactg gagaagactg tggagcagaa gactaaagag aacgatgaac tgaacaggat
     1861 ctgcgatgaa ctcattgcta agatggagaa gaagatctga ccacagctga ctgtcgccag
     1921 ccctcttctg tctgtctgtc tgtctgccca tttccttgtc tgtctgactt ctgtgtggtt
     1981 tatttaaacc tctattcatt tctaagttac attactttga aaagagtaaa gtttaatttc
     2041 aaactcaaa
//
