LOCUS       NM_172328               1083 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tachykinin precursor 4 (Tac4), mRNA.
ACCESSION   NM_172328
VERSION     NM_172328.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Song,H., Yin,W., Zeng,Q., Jia,H., Lin,L., Liu,X., Mu,L. and Wang,R.
  TITLE     Hemokinins modulate endothelium function and promote angiogenesis
            through neurokinin-1 receptor
  JOURNAL   Int J Biochem Cell Biol 44 (9), 1410-1421 (2012)
   PUBMED   22554585
  REMARK    GeneRIF: HKs emerge as pivotal endogenous regulators of
            angiogenesis through neurokinin-1 receptor
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Sakai,A., Takasu,K., Sawada,M. and Suzuki,H.
  TITLE     Hemokinin-1 gene expression is upregulated in microglia activated
            by lipopolysaccharide through NF-kappaB and p38 MAPK signaling
            pathways
  JOURNAL   PLoS One 7 (2), e32268 (2012)
   PUBMED   22384199
  REMARK    GeneRIF: Hemokinin-1 gene expression is upregulated in microglia
            activated by lipopolysaccharide through NF-kappaB and p38 MAPK
            signaling pathways
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Sunakawa,N., Naono,R., Ikeda,T., Matsushima,O., Sakoda,S. and
            Nishimori,T.
  TITLE     The amino-terminal region of hemokinin-1 regulates the induction of
            thermal hyperalgesia in rats
  JOURNAL   Neuropeptides 44 (3), 273-278 (2010)
   PUBMED   20176398
  REMARK    GeneRIF: These findings indicate that three amino acids, Ser, Thr
            and Arg at the 2nd, 4th and 5th positions of HK-1, respectively,
            regulate the induction of thermal hyperalgesia by HK-1.
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Naono,R., Nakayama,T., Ikeda,T., Matsushima,O. and Nishimori,T.
  TITLE     Leucine at the carboxyl-terminal of endokinins C and D contributes
            to elicitation of the antagonistic effect on substance P in rat
            pain processing
  JOURNAL   Brain Res 1165, 71-80 (2007)
   PUBMED   17655832
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Ravina,C.G., Seda,M., Pinto,F.M., Orea,A., Fernandez-Sanchez,M.,
            Pintado,C.O. and Candenas,M.L.
  TITLE     A role for tachykinins in the regulation of human sperm motility
  JOURNAL   Hum Reprod 22 (6), 1617-1625 (2007)
   PUBMED   17437961
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Yoshioka,D., Takebuchi,F., Nishimori,T., Naono,R., Ikeda,T. and
            Nakayama,T.
  TITLE     Intrathecal administration of the common carboxyl-terminal
            decapeptide in endokinin A and endokinin B evokes scratching
            behavior and thermal hyperalgesia in the rat
  JOURNAL   Neurosci Lett 410 (3), 193-197 (2006)
   PUBMED   17101218
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Page,N.M.
  TITLE     Hemokinins and endokinins
  JOURNAL   Cell Mol Life Sci 61 (13), 1652-1663 (2004)
   PUBMED   15224188
  REMARK    Review article
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Page,N.M., Bell,N.J., Gardiner,S.M., Manyonda,I.T., Brayley,K.J.,
            Strange,P.G. and Lowry,P.J.
  TITLE     Characterization of the endokinins: human tachykinins with
            cardiovascular activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6245-6250 (2003)
   PUBMED   12716968
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Kurtz,M.M., Wang,R., Clements,M.K., Cascieri,M.A., Austin,C.P.,
            Cunningham,B.R., Chicchi,G.G. and Liu,Q.
  TITLE     Identification, localization and receptor characterization of novel
            mammalian substance P-like peptides
  JOURNAL   Gene 296 (1-2), 205-212 (2002)
   PUBMED   12383518
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Zhang,Y., Lu,L., Furlonger,C., Wu,G.E. and Paige,C.J.
  TITLE     Hemokinin is a hematopoietic-specific tachykinin that regulates B
            lymphopoiesis
  JOURNAL   Nat Immunol 1 (5), 392-397 (2000)
   PUBMED   11062498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY471575.1.
            
            On Oct 17, 2004 this sequence version replaced NM_172328.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY471575.1, AF521561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="NEDH"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..1083
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /note="tachykinin precursor 4"
                     /db_xref="GeneID:282829"
                     /db_xref="RGD:628842"
     CDS             1..513
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /note="preprotachykinin-C; tachykinin 4 (hemokinin);
                     tachykinin-4"
                     /codon_start=1
                     /product="tachykinin-4 preproprotein"
                     /protein_id="NP_758831.1"
                     /db_xref="GeneID:282829"
                     /db_xref="RGD:628842"
                     /translation="MLPLLALFLLIGPAVSTTTRDREDLTFGAEAESWVTVNLKGIPV
                     PSIELKLQELKRSRTRQFYGLMGKRVEGVHPIQSAERTGYQLGRIVQDLLGTRGLSIE
                     GSCRQETNHQSAGPGAVARESLQSQRGRSEPPNHQQHVALSLGTEEDDQSSERAPRDA
                     SQMMPRPSRP"
     exon            1..120
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /inference="alignment:Splign:2.1.0"
     exon            121..214
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /inference="alignment:Splign:2.1.0"
     exon            215..247
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /inference="alignment:Splign:2.1.0"
     exon            248..307
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /inference="alignment:Splign:2.1.0"
     exon            308..1083
                     /gene="Tac4"
                     /gene_synonym="Ppt-c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcctc tccttgccct gtttctcctg atcgggccgg cagtgtccac tacaacacga
       61 gacagagagg acctgacttt cggtgcagaa gcagagtctt gggtgaccgt gaacctgaag
      121 ggaatccctg tccccagcat cgaacttaag cttcaggaat tgaagagaag caggactcgc
      181 cagttctacg gtctgatggg gaagcgggtg gagggagtac atcccatcca gtcagcggag
      241 agaacggggt atcagctggg acgtatagtg caggacctcc ttggcaccag agggttgtcc
      301 atcgaaggaa gctgcagaca ggagacaaat caccagagtg cagggcctgg agcggtggcc
      361 agagaaagcc tccagagtca aagaggaaga tcagagcccc ctaaccacca gcaacatgta
      421 gcactgtcct tgggcacaga agaggatgac cagagctcag agagagcccc aagggatgcc
      481 tcccaaatga tgccacgccc atctcgcccc tgaacatcac agcagatgaa cttcagccaa
      541 gtcctgtgcc ttctgtcctc aacccgggta gctcctgcca gacccgcacc acccaaattc
      601 tgcatttctc ccgggactct tggcctctgg tagcaatgac acacaaagca cttttgcctc
      661 ctcacaagct agactgaccc agctttccct tgtacctaag gtaaaacttc ccactctgta
      721 ttccatgccc cacacacagc agggctcgat aaaggagtta gcaataggca gcttcctcag
      781 ccatgctggg tagagggctg aatgccagaa taacagagca gcatttccca gcccaggccc
      841 aattccttat cagcctggct aaaatggcaa tagaaacaag aaaaagatcc tggtggagaa
      901 ggtgcatgtt ttgggggtgg ggacaggcac cttcttccct ttaggttcct gatatggctc
      961 cgtgggctaa ggcagttgtt tcaattcaat ccccaggatc cacaagatgg aaggaaaaag
     1021 aggttgtcct tttacctctc tgcatgtatc atggcatgtg ttatacaaaa taaagttaaa
     1081 aga
//
