LOCUS       NM_019162                723 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tachykinin precursor 3 (Tac3), mRNA.
ACCESSION   NM_019162
VERSION     NM_019162.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 723)
  AUTHORS   Kim,E., Chung,M.J., Chung,Y. and Jun,Y.
  TITLE     The effect of diet control on puberty onset and immunoreactivity of
            kisspeptin and neurokinin B in female rats
  JOURNAL   Endocr J 65 (12), 1177-1185 (2018)
   PUBMED   30224608
  REMARK    GeneRIF: At the onset of puberty, the densities of kisspeptin and
            neurokinin B IR cells were significantly higher in the high-fat
            diet group than in the control group
REFERENCE   2  (bases 1 to 723)
  AUTHORS   Nakao,K., Iwata,K., Takeshita,T. and Ozawa,H.
  TITLE     Expression of hypothalamic kisspeptin, neurokinin B, and dynorphin
            A neurons attenuates in female Zucker fatty rats
  JOURNAL   Neurosci Lett 665, 135-139 (2018)
   PUBMED   29203206
  REMARK    GeneRIF: The expressions of each mRNA (Kiss1, Tac3, and Pdyn) and
            each peptide (kisspeptin, NKB, and DynA) in the ARC significantly
            decreased in Zucker fatty rats compared with Zucker lean rats
REFERENCE   3  (bases 1 to 723)
  AUTHORS   Ruiz-Pino,F., Garcia-Galiano,D., Manfredi-Lozano,M., Leon,S.,
            Sanchez-Garrido,M.A., Roa,J., Pinilla,L., Navarro,V.M. and
            Tena-Sempere,M.
  TITLE     Effects and interactions of tachykinins and dynorphin on FSH and LH
            secretion in developing and adult rats
  JOURNAL   Endocrinology 156 (2), 576-588 (2015)
   PUBMED   25490143
  REMARK    GeneRIF: NKB agonist stimulates FSH secretion in a strikingly
            developmental-dependent manner
REFERENCE   4  (bases 1 to 723)
  AUTHORS   Overgaard,A., Ruiz-Pino,F., Castellano,J.M., Tena-Sempere,M. and
            Mikkelsen,J.D.
  TITLE     Disparate changes in kisspeptin and neurokinin B expression in the
            arcuate nucleus after sex steroid manipulation reveal differential
            regulation of the two KNDy peptides in rats
  JOURNAL   Endocrinology 155 (10), 3945-3955 (2014)
   PUBMED   25051440
  REMARK    GeneRIF: The divergent regulation of kisspeptin and NKB peptide
            contents in the arcuate nucleus as a function of sex and steroid
            milieu enlarge our understanding on how these neuropeptides are
            posttranscriptionally regulated in KNDy neurons.
REFERENCE   5  (bases 1 to 723)
  AUTHORS   Li,S.Y., Li,X.F., Hu,M.H., Shao,B., Poston,L., Lightman,S.L. and
            O'Byrne,K.T.
  TITLE     Neurokinin B receptor antagonism decreases luteinising hormone
            pulse frequency and amplitude and delays puberty onset in the
            female rat
  JOURNAL   J Neuroendocrinol 26 (8), 521-527 (2014)
   PUBMED   24863620
  REMARK    GeneRIF: data suggest that endogenous NeuroKinin B-Neurokinin 3
            Receptor signalling plays a role in controlling the timing of
            puberty.
REFERENCE   6  (bases 1 to 723)
  AUTHORS   Duarte,C.R., Schutz,B. and Zimmer,A.
  TITLE     Incongruent pattern of neurokinin B expression in rat and mouse
            brains
  JOURNAL   Cell Tissue Res 323 (1), 43-51 (2006)
   PUBMED   16160861
  REMARK    GeneRIF: although the expression patterns of Tac2 and NKB are
            similar in rats and mice, noteworthy differences exist. Our results
            have important implications for the interpretation of behavioral
            results concerning the NKB/NK3 system in these species.
REFERENCE   7  (bases 1 to 723)
  AUTHORS   Page,N.M., Bell,N.J., Gardiner,S.M., Manyonda,I.T., Brayley,K.J.,
            Strange,P.G. and Lowry,P.J.
  TITLE     Characterization of the endokinins: human tachykinins with
            cardiovascular activity
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 6245-6250 (2003)
   PUBMED   12716968
REFERENCE   8  (bases 1 to 723)
  AUTHORS   McCarson,K.E. and Krause,J.E.
  TITLE     The formalin-induced expression of tachykinin peptide and
            neurokinin receptor messenger RNAs in rat sensory ganglia and
            spinal cord is modulated by opiate preadministration
  JOURNAL   Neuroscience 64 (3), 729-739 (1995)
   PUBMED   7536308
REFERENCE   9  (bases 1 to 723)
  AUTHORS   Nagashima,A., Takano,Y., Tateishi,K., Matsuoka,Y., Hamaoka,T. and
            Kamiya,H.
  TITLE     Central pressor actions of neurokinin B: increases in neurokinin B
            contents in discrete nuclei in spontaneously hypertensive rats
  JOURNAL   Brain Res 499 (1), 198-203 (1989)
   PUBMED   2478257
REFERENCE   10 (bases 1 to 723)
  AUTHORS   Bonner,T.I., Affolter,H.U., Young,A.C. and Young,W.S. 3rd.
  TITLE     A cDNA encoding the precursor of the rat neuropeptide, neurokinin B
  JOURNAL   Brain Res 388 (3), 243-249 (1987)
   PUBMED   3479225
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M16410.1.
            
            On Feb 21, 2013 this sequence version replaced NM_019162.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M16410.1, DV713681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               M16410.1           1-723
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..723
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /note="tachykinin precursor 3"
                     /db_xref="GeneID:29191"
                     /db_xref="RGD:3809"
     exon            1..109
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     exon            110..219
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..465
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /note="neurokinin B; tachykinin 2; tachykinin 3"
                     /codon_start=1
                     /product="tachykinin-3 precursor"
                     /protein_id="NP_062035.1"
                     /db_xref="GeneID:29191"
                     /db_xref="RGD:3809"
                     /translation="MRSAMLFAAVLALSLAWTFGAACEEPQEQGGRLSKDSDLSLLPP
                     PLLRRLYDSRSISLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPA
                     DVVEENTPSFGVLK"
     exon            220..325
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..355
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..409
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..483
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..723
                     /gene="Tac3"
                     /gene_synonym="Tac2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgggact ggttcctgcc acctccccga gcccctgcac tcttgtctct ctctgtctcc
       61 acagcagcgt caccggctcc cggatcctgc cagccgtcca gctctacagg caccatgagg
      121 agcgccatgc tgttcgcggc tgtcctcgcc ctcagcttgg catggacctt cggggctgcg
      181 tgtgaggaac ctcaggagca gggtgggagg ctcagtaagg actctgatct ctctctgcta
      241 cctccacccc tgcttcggag actctacgac agccgctcca tctctctgga aggattgctg
      301 aaagtgctga gcaaggctag cgtgggaccg aaggagacat cacttccaca gaaacgtgac
      361 atgcacgact tctttgtggg acttatgggc aagaggaaca gccaaccaga cactcccgct
      421 gatgtggttg aagagaacac ccccagcttt ggcgtcctca aataggccag cagtgcagaa
      481 aagcactcca ctctcagacc ctggactgca tcataaagac agggttcctg tggcggtccc
      541 agtgcctgcg ctcctgcttc cctgcctgca aggtcctcct gttggctccc ttccctactc
      601 tgcacagatg ctgcatatga acagcctcta cccccatatc aattatggtt tctgtagtgt
      661 cctgcattaa aaataccatg tctcctcctc aacaataaag ggtttttaca atggagtgac
      721 tga
//
