LOCUS       NM_001124768            1004 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tachykinin, precursor 1 (Tac1), transcript
            variant 2, mRNA.
ACCESSION   NM_001124768
VERSION     NM_001124768.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1004)
  AUTHORS   Carboni,L., El Khoury,A., Beiderbeck,D.I., Neumann,I.D. and
            Mathe,A.A.
  TITLE     Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A
            in brain regions of HAB rats correlate with anxiety-like behaviours
  JOURNAL   Eur Neuropsychopharmacol 57, 1-14 (2022)
   PUBMED   35008014
  REMARK    GeneRIF: Neuropeptide Y, calcitonin gene-related peptide, and
            neurokinin A in brain regions of HAB rats correlate with
            anxiety-like behaviours.
REFERENCE   2  (bases 1 to 1004)
  AUTHORS   Etemadi,L., Pettersson,L.M.E. and Danielsen,N.
  TITLE     UVB irradiation induces contralateral changes in galanin, substance
            P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal
            horn and lateral spinal nucleus
  JOURNAL   Peptides 136, 170447 (2021)
   PUBMED   33212101
  REMARK    GeneRIF: UVB irradiation induces contralateral changes in galanin,
            substance P and c-fos immunoreactivity in rat dorsal root ganglia,
            dorsal horn and lateral spinal nucleus.
REFERENCE   3  (bases 1 to 1004)
  AUTHORS   He,M., Pang,J., Sun,H., Zheng,G., Lin,Y. and Ge,W.
  TITLE     Overexpression of TIMP3 inhibits discogenic pain by suppressing
            angiogenesis and the expression of substance P in nucleus pulposus
  JOURNAL   Mol Med Rep 21 (3), 1163-1171 (2020)
   PUBMED   31922222
  REMARK    GeneRIF: Overexpression of TIMP3 inhibits discogenic pain by
            suppressing angiogenesis and the expression of substance P in
            nucleus pulposus.
REFERENCE   4  (bases 1 to 1004)
  AUTHORS   Richter,F., Eitner,A., Leuchtweis,J., Bauer,R., Ebersberger,A.,
            Lehmenkuhler,A. and Schaible,H.G.
  TITLE     The potential of substance P to initiate and perpetuate cortical
            spreading depression (CSD) in rat in vivo
  JOURNAL   Sci Rep 8 (1), 17656 (2018)
   PUBMED   30518958
  REMARK    GeneRIF: The tachykinin substance P increases neuronal
            excitability, participates in homeostatic control, but induces
            brain oedema after stroke or trauma. Blocking the NK-1 receptor
            prevents the occurrence of cortical spreading depression waves
            induced by substance P dissolved in aqua and prevents the ignition
            of cortical spreading depression waves by aqua alone.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1004)
  AUTHORS   Zhang,M., Ahn,W., Kim,S., Hong,H.S., Quan,C. and Son,Y.
  TITLE     Endothelial precursor cells stimulate pericyte-like coverage of
            bone marrow-derived mesenchymal stem cells through platelet-derived
            growth factor-BB induction, which is enhanced by substance P
  JOURNAL   Microcirculation 24 (8) (2017)
   PUBMED   28791754
  REMARK    GeneRIF: BM-EPCs along with SP promote the pericyte-like coverage
            of BM-MSCs on endothelial tubules possibly through the induction of
            PDGF-BB.
REFERENCE   6  (bases 1 to 1004)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   7  (bases 1 to 1004)
  AUTHORS   Harmar,A.J., Hyde,V. and Chapman,K.
  TITLE     Identification and cDNA sequence of delta-preprotachykinin, a
            fourth splicing variant of the rat substance P precursor
  JOURNAL   FEBS Lett 275 (1-2), 22-24 (1990)
   PUBMED   1702066
REFERENCE   8  (bases 1 to 1004)
  AUTHORS   Yankner,B.A., Duffy,L.K. and Kirschner,D.A.
  TITLE     Neurotrophic and neurotoxic effects of amyloid beta protein:
            reversal by tachykinin neuropeptides
  JOURNAL   Science 250 (4978), 279-282 (1990)
   PUBMED   2218531
REFERENCE   9  (bases 1 to 1004)
  AUTHORS   Carter,M.S. and Krause,J.E.
  TITLE     Structure, expression, and some regulatory mechanisms of the rat
            preprotachykinin gene encoding substance P, neurokinin A,
            neuropeptide K, and neuropeptide gamma
  JOURNAL   J Neurosci 10 (7), 2203-2214 (1990)
   PUBMED   1695945
REFERENCE   10 (bases 1 to 1004)
  AUTHORS   Kawaguchi,Y., Hoshimaru,M., Nawa,H. and Nakanishi,S.
  TITLE     Sequence analysis of cloned cDNA for rat substance P precursor:
            existence of a third substance P precursor
  JOURNAL   Biochem Biophys Res Commun 139 (3), 1040-1046 (1986)
   PUBMED   2429656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M34184.1, M14312.1 and AA818532.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34183.1, CB315982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                M34184.1           3-90
            89-984              M14312.1           1-896
            985-1004            AA818532.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1004
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1004
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /note="tachykinin, precursor 1"
                     /db_xref="GeneID:24806"
                     /db_xref="RGD:3807"
     exon            1..88
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
     exon            89..220
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..445
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; protachykinin-1; PPT; tachykinin 1; Tachykinin
                     (substance P, neurokinin A, neuropeptide K, neuropeptide
                     gamma)"
                     /codon_start=1
                     /product="protachykinin-1 isoform b precursor"
                     /protein_id="NP_001118240.1"
                     /db_xref="GeneID:24806"
                     /db_xref="RGD:3807"
                     /translation="MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAM
                     PEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSVAY
                     ERSAMQNYERRRK"
     exon            221..317
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
     exon            318..341
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
     exon            342..395
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
     exon            396..989
                     /gene="Tac1"
                     /gene_synonym="Ppt5fl; PPTA3; RATPPTA3; TAC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccagctcc actccagcac cgcggcggag gagagcgagg agcgcccagc aagtgcgcac
       61 ctgcggagca tcaccgggtc cgaccgcaaa atccaacatg aaaatcctcg tggcggtggc
      121 ggtctttttt ctcgtttcca ctcaactgtt tgcagaggaa atcggtgcca acgatgatct
      181 aaattattgg tccgactggt ccgacagtga ccaaatcaag gaggcaatgc cggagccctt
      241 tgagcatctt cttcagagaa tcgcccgaag acccaagcct cagcagttct ttggattaat
      301 gggcaaacgg gatgctgggc atggtcagat ctctcacaaa aggcataaaa cagattcctt
      361 tgttggacta atgggcaaaa gagctttaaa ttctgtggct tatgaaagaa gcgcaatgca
      421 gaactacgaa agaaggcgta aataaaccct gtaacgcact atctattcat ctccatctgt
      481 gtccgcgagc agtgagcggt aaaataaaaa tgtgcgctat gaggaatgat tatttattta
      541 atatcaaatg ttgttatgag tgaaaaactc aaaaaagtgt ttattttttc atattgtgcc
      601 aataagcatt gtaattctaa tgtggtgacc tcctcagaca gaagtagaaa ttagttgtaa
      661 cttcagcaaa gcacagtgtt gatggagttg tacaagtttg ccagcgatgc agtctccaaa
      721 gacagaaagg ctgctgtgag gcagtgcagg cggctgctgc tggaggcaga gaaactcctg
      781 tgtgtcttgc gcttcccttg gttgctttta tcctaatgat gtactgagag tttggtatct
      841 gactctattt gtatcctagc agcatgtttc ctgtgttgtg actatataga gatgttttta
      901 aaagtttcaa tgtacttctc tggtcttcag tcattgtatg atgtgttgtg atagctacca
      961 ttttaaataa aagaatgtat cttcaggaaa aaaaaaaaaa aaaa
//
