LOCUS       NM_001393814            4457 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus TGF-beta activated kinase 1/MAP3K7 binding
            protein 2 (Tab2), mRNA.
ACCESSION   NM_001393814 XM_039110922
VERSION     NM_001393814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4457)
  AUTHORS   Li,Q., Li,S., Xu,C., Zhao,J., Hou,L., Jiang,F., Zhu,Z., Wang,Y. and
            Tian,L.
  TITLE     microRNA-149-5p mediates the PM2.5-induced inflammatory response by
            targeting TAB2 via MAPK and NF-kappaB signaling pathways in vivo
            and in vitro
  JOURNAL   Cell Biol Toxicol 39 (3), 703-717 (2023)
   PUBMED   34331613
REFERENCE   2  (bases 1 to 4457)
  AUTHORS   Xu,W., Graves,A., Weisz-Hubshman,M., Hegazy,L., Magyar,C., Liu,Z.,
            Nasiotis,E., Samee,M.A.H., Burris,T., Lalani,S. and Zhang,L.
  TITLE     Assigning pathogenicity for TAB2 variants using a novel scalable
            functional assay and expanding TAB2 disease spectrum
  JOURNAL   Hum Mol Genet 32 (6), 959-970 (2023)
   PUBMED   36229919
REFERENCE   3  (bases 1 to 4457)
  AUTHORS   Ni,X., Yan,J., Hu,S. and Wang,X.
  TITLE     MiR-199a target regulates TAB2 to promote the migration of
            endodermal progenitor cells and inhibit deep vein thrombosis in
            rats
  JOURNAL   Minerva Pediatr (Torino) 75 (1), 150-152 (2023)
   PUBMED   36322021
  REMARK    GeneRIF: MiR-199a target regulates TAB2 to promote the migration of
            endodermal progenitor cells and inhibit deep vein thrombosis in
            rats.
REFERENCE   4  (bases 1 to 4457)
  AUTHORS   Yin,H., Guo,X., Chen,Y., Zeng,Y., Mo,X., Hong,S., He,H., Li,J.,
            Steinmetz,R. and Liu,Q.
  TITLE     TAB2 deficiency induces dilated cardiomyopathy by promoting
            RIPK1-dependent apoptosis and necroptosis
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34990405
REFERENCE   5  (bases 1 to 4457)
  AUTHORS   Guan,S., Li,L., Chen,W.S., Jiang,W.Y., Ding,Y., Zhao,L.L.,
            Shi,Y.F., Wang,J., Gui,Q., Xu,C.C., Cheng,Y. and Zhang,W.
  TITLE     Circular RNA WHSC1 exerts oncogenic properties by regulating
            miR-7/TAB2 in lung cancer
  JOURNAL   J Cell Mol Med 25 (20), 9784-9795 (2021)
   PUBMED   34551195
REFERENCE   6  (bases 1 to 4457)
  AUTHORS   Ceppi,M., Pereira,P.M., Dunand-Sauthier,I., Barras,E., Reith,W.,
            Santos,M.A. and Pierre,P.
  TITLE     MicroRNA-155 modulates the interleukin-1 signaling pathway in
            activated human monocyte-derived dendritic cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (8), 2735-2740 (2009)
   PUBMED   19193853
REFERENCE   7  (bases 1 to 4457)
  AUTHORS   Verstrepen,L., Bekaert,T., Chau,T.L., Tavernier,J., Chariot,A. and
            Beyaert,R.
  TITLE     TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a
            common theme
  JOURNAL   Cell Mol Life Sci 65 (19), 2964-2978 (2008)
   PUBMED   18535784
  REMARK    Review article
REFERENCE   8  (bases 1 to 4457)
  AUTHORS   Ma,Q., Zhou,L., Shi,H. and Huo,K.
  TITLE     NUMBL interacts with TAB2 and inhibits TNFalpha and
            IL-1beta-induced NF-kappaB activation
  JOURNAL   Cell Signal 20 (6), 1044-1051 (2008)
   PUBMED   18299187
REFERENCE   9  (bases 1 to 4457)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   10 (bases 1 to 4457)
  AUTHORS   Wang,C., Deng,L., Hong,M., Akkaraju,G.R., Inoue,J. and Chen,Z.J.
  TITLE     TAK1 is a ubiquitin-dependent kinase of MKK and IKK
  JOURNAL   Nature 412 (6844), 346-351 (2001)
   PUBMED   11460167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 16, 2021 this sequence version replaced XM_039110922.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3227549.1,
                                           SRR26643288.43.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               JAXUCZ010000001.1  4244998-4245485     c
            489-676             JAXUCZ010000001.1  4213665-4213852     c
            677-2177            JAXUCZ010000001.1  4208922-4210422     c
            2178-2338           JAXUCZ010000001.1  4201879-4202039     c
            2339-2432           JAXUCZ010000001.1  4201582-4201675     c
            2433-2513           JAXUCZ010000001.1  4200511-4200591     c
            2514-4457           JAXUCZ010000001.1  4195400-4197343     c
FEATURES             Location/Qualifiers
     source          1..4457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..4457
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /note="TGF-beta activated kinase 1/MAP3K7 binding protein
                     2"
                     /db_xref="GeneID:308267"
                     /db_xref="RGD:1309527"
     exon            1..488
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..676
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..2656
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /note="mitogen-activated protein kinase kinase kinase
                     7-interacting protein 2; TGF-beta-activated kinase
                     1-binding protein 2"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 2"
                     /protein_id="NP_001380743.1"
                     /db_xref="GeneID:308267"
                     /db_xref="RGD:1309527"
                     /translation="MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCA
                     VLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRT
                     LTHSVSDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLG
                     SKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPY
                     ITTPSGAARQTQQHSGWVSQFNPVNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQ
                     GHQTSHVYMPISSPTTPQPPTVHSSASSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQ
                     RNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPSTDEMISRSQPKVYISAN
                     ASTGDEQGMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSAAS
                     PRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETETIQHLTD
                     PTLAHVDRVSEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVN
                     EMENSLTRRRLKRSNSMSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFN
                     PSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDTEDEEGAQWNCTACTFLNHPALI
                     RCEQCEMPRHF"
     exon            677..2177
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2338
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2432
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2513
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..4457
                     /gene="Tab2"
                     /gene_synonym="Map3k7ip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatattgt gcagccgtat tttgatgcgg actgggctgg cggagccgcg gcgcgagcta
       61 gcgagaactg ggggggtggg gggagggcag gcgagcggcc ggggggtggg ggcggaggga
      121 ggcagggcgg ccgtgcgagc cggagccgag cagcgggccg cggcaacgcc gccccggcca
      181 tcgctttgat tcgcggcagg cgccggcggc ggggcgcccc aggccgaccc cctcccctcc
      241 ccctcagccg tgagcggcgg cagcggcggc ggcccgaggg agttggcggc ggcggccggg
      301 cggagggggc tgagcgggga gggagggagg gctgaggtgt cccccctgcc gggtggaatc
      361 ggcgctggcg gcggccgagg tgacggaggc ggcagcagcg gcggcgacga cgggggagac
      421 ggctgcccaa gtgggagagg cggcggcggc ggacgaggag gagggggaag ccgcggcggc
      481 ggcgaaggaa aatgcttggc cagaagagat gagtactact tccacccagg cctagaattg
      541 cctattgaga tagtcctgag caggcgacat acgaatggcc caaggaagcc accaaattga
      601 ttttcaggtt ttacatgacc tgcgacaaaa gttccctgaa gtgcctgaag ttgttgtatc
      661 caggtgcatg ttacagaaca ataataacct ggatgcctgc tgtgctgttc tctctcagga
      721 gagtacaagg tatctttacg gtgaaggaga cctgaatttt tcagatgagt ctggaatttc
      781 tggtctacgc aatcacatga cttctctcaa cttggacttg cagtcacaga atgtttacca
      841 ccatggaaga gaaggaagtc gagtgaacgg aagtaggact ttaacacaca gtgttagcga
      901 tggacagctt caaggtgggc agtccaataa cgaactgttt cagcaggagc cacaaacagc
      961 accagctcaa gttcctcaag gctttaatgt ttttggaatg cccagtacat ctggtgcttc
     1021 taattcaaca ccacatcttg gatttcacct aggcagcaaa gggacatcaa acctctctca
     1081 acaaactccc aggtttaatc ctattatggt aactttagcc ccaaacatac agactggccg
     1141 aagcacccct acgtctttgc acatacatgg tgtgcctcca cctgtactca acagcccaca
     1201 ggggaattct atctacatta ggccttacat cacaactcct agtggtgcag ctcgacagac
     1261 acagcagcat tctggctggg tatctcagtt taatcccgtg aaccctcagc aagcctatca
     1321 gccttcacag cctggacctt ggactactta tcctgcatcc aatcctttgc cacatacctc
     1381 aacccagcag ccgaatcagc agggccatca gacctctcat gtctacatgc ctatcagttc
     1441 gccaactact ccacaaccgc caacagttca ctcgtctgct agctctcagt cttctgccca
     1501 tagccaatat aacattcaga atatttcaac aggacctcga aaaaaccaga tagaaatcaa
     1561 acttgaaccc ccacaaagaa acagttcttc aaaattacgt tcttctggac ctcgaactgc
     1621 cagcacttcc tcattggtca acagccagac cttaaataga aatcagccca ctgtttacat
     1681 agctgccagt cctccaagca ctgatgagat gatctcccgt agtcaaccca aggtctacat
     1741 ctcagccaat gccagcacag gagatgagca gggcatgcgg aatcagccta cactcttcat
     1801 atccacgaac tctggggcct ctgcagcctc caggaacatg tctgggcaag tgagcatggg
     1861 tcctgccttt atccaccacc accctcccaa aagccgggtg ttaggtggca actccgcagc
     1921 ctcccctcga gtggtggtga cgcagcccaa cacaaagtac accttcaaaa tcacagtttc
     1981 tcccaataag ccccctgccg tctccccggg ggttgtctcc cccacctttg aacttacaaa
     2041 tcttctgaat caccctgacc attatgtaga aacagagact attcagcacc tcacagaccc
     2101 tactctagca cacgtggata gagtaagcga agcacggaaa ctgagtatgg gatctgatga
     2161 tgctgcctac acacaagctc tgctggtgca ccagaaggcc aggatggaac ggcttcaaag
     2221 agagctcgag atgcagaaga aaaagctgga caaactcaaa tctgaggtca atgagatgga
     2281 aaacagtcta acgcgaaggc gcctgaagag gtccaactcc atgtcccaga taccttcact
     2341 cgaagaaatg cagcagttga gaagttgtaa tagacaactc cagattgaca ttgactgctt
     2401 aaccaaagaa attgatcttt ttcaagcccg aggaccgcat tttaacccca gcgctatcca
     2461 taacttttat gacaatattg gatttgtagg ccctgtgccg cccaaaccta aagatcaaag
     2521 gtccaccatc aaagcaccaa agactcaaga cacagaggat gaggaggggg ctcagtggaa
     2581 ttgcactgcc tgtacatttc tgaaccaccc ggccttgatc cgctgtgagc agtgtgagat
     2641 gccgcggcat ttctgagcca aaggccccgt cttcctctga agccacgtct aaacttcaag
     2701 accgtcgcct gtcatgggga agtgtgtcac ccacgtagga gttagtccag ttgaaggtgt
     2761 ggggagacag cggtgtgctg tgtcgagtgt cagcccacag agctaacgat acctcagtct
     2821 aagtcacggg cagtgggatt cgtcacctga aaggtgacct gagagaccgg gctgcctgct
     2881 gcctgaccat gtgcagtgtc accgtgtcaa tgcctaggcg ttcccaggac ttctcccctc
     2941 ttgtcactac tgatctcgat gggaggaagg aacaggatga tcgctttttg tgtttttaaa
     3001 gcttttggtg aaacactaca tacacaaaga gaaggaacaa ggtttgacta ttaaaaactc
     3061 tgctgccaca tagtgccagt agatgtggga atcgtcacaa atctgtggta cttttggcct
     3121 tgtcctctgt cttccctgag gacgtctctg tgaagccagc atctaggtgt gagatcaaag
     3181 gaaagcagtg tgtctgtctg tacaatccgc agtgcgctcc ccaagccttt cctactgtac
     3241 agacctctca cgtctgcttt gatttcttca ttatcttctt atatttctat atgtatagtg
     3301 taatagactt ttgttaactc atgttctttt tcccttttag taagcacgat catgttctta
     3361 ccttacctta ccttacctga gaaaagcaat gccatacgat agaaagagca ttaatgaagt
     3421 gaagaaactg tgcacaacac accttcccct ccttcccccc acctcccacc cgcctgcccg
     3481 tccgtcgtcc ccttggtgcc agtgcaggtg ctgcatggga gttgcaggaa acacggcagc
     3541 catgtaggat ggtcatgctg tacactgact taagcagtgg gtggccaaac atgtcgtttt
     3601 gtcttctcca gcagcttaaa gcaaaaagta tttaaaccca ccgccatctc gccccgtctg
     3661 tgtggtgtcc cgtagaactc cacgggaggt tcttgttggg aaagtgcagt ttgagaagca
     3721 gccacagcag ccgctcccac agcctcttct ctccgggaag aaggggagct gccctgcagg
     3781 tggtacagcc cacgtctgac ctagcgtggg gagagtcatg ggtatttaca acatagtcat
     3841 cactaggaca actgaagaaa agctggaaaa agaaagaaaa caagcagact tgaacactga
     3901 agcaacctca gacatctctt tattttgatg atatattttt gtaaggaaaa taaatattca
     3961 tatgatcagg aatgtatata actaaataaa atcaagaaaa aataagtttg cattttaaga
     4021 aaattatgaa attatcagtg cttggaatgg ggctgaggga agtgctgaaa tagaataaaa
     4081 ataggaaatc agactgtccc actgtaaatg ttcacacgtg gctatgcttc acataaacag
     4141 gattattaca gaggagtgta caaaggtcag agcctcgcct ccggctctgc accgtggcta
     4201 tgggaagaga tccggcaagc atggtcacta gtcagcagac cccaaactcg tgtgtttgac
     4261 gcgttgtgct ttaaagtagg ccttgttttt cagctttctc tgcagttcta tgtgaagatt
     4321 ggtaagtcag tttttactgg ttttattaat aaaacgtaat ttggatatct tgagttgatg
     4381 gttttgtgat ttagctgggt aaactatctt tgtaacagat aagttattta taaaaattaa
     4441 aaaaacttat attctaa
//
