LOCUS       NM_001109976            2971 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus TGF-beta activated kinase 1/MAP3K7 binding
            protein 1 (Tab1), mRNA.
ACCESSION   NM_001109976
VERSION     NM_001109976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2971)
  AUTHORS   Yuan L, Bu S, Du M, Wang Y, Ju C, Huang D, Xu W, Tan X, Liang M,
            Deng S, Yang L and Huang K.
  TITLE     RNF207 exacerbates pathological cardiac hypertrophy via
            post-translational modification of TAB1
  JOURNAL   Cardiovasc Res 119 (1), 183-194 (2023)
   PUBMED   35352799
REFERENCE   2  (bases 1 to 2971)
  AUTHORS   Li Y, Klena NT, Gabriel GC, Liu X, Kim AJ, Lemke K, Chen Y,
            Chatterjee B, Devine W, Damerla RR, Chang C, Yagi H, San Agustin
            JT, Thahir M, Anderton S, Lawhead C, Vescovi A, Pratt H, Morgan J,
            Haynes L, Smith CL, Eppig JT, Reinholdt L, Francis R, Leatherbury
            L, Ganapathiraju MK, Tobita K, Pazour GJ and Lo CW.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   3  (bases 1 to 2971)
  AUTHORS   Brown J, Wang H, Hajishengallis GN and Martin M.
  TITLE     TLR-signaling networks: an integration of adaptor molecules,
            kinases, and cross-talk
  JOURNAL   J Dent Res 90 (4), 417-427 (2011)
   PUBMED   20940366
  REMARK    Review article
REFERENCE   4  (bases 1 to 2971)
  AUTHORS   Liu S and Chen ZJ.
  TITLE     Expanding role of ubiquitination in NF-kappaB signaling
  JOURNAL   Cell Res 21 (1), 6-21 (2011)
   PUBMED   21135871
  REMARK    Review article
REFERENCE   5  (bases 1 to 2971)
  AUTHORS   Du CS, Yang RF, Song SW, Wang YP, Kang JH, Zhang R, Su DF and Xie
            X.
  TITLE     Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic
            Injury Via Inhibition of TAB1-p38 Apoptosis Signaling
  JOURNAL   Front Pharmacol 1, 111 (2010)
   PUBMED   21607062
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2971)
  AUTHORS   Weber A, Wasiliew P and Kracht M.
  TITLE     Interleukin-1 (IL-1) pathway
  JOURNAL   Sci Signal 3 (105), cm1 (2010)
   PUBMED   20086235
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2971)
  AUTHORS   Verstrepen L, Bekaert T, Chau TL, Tavernier J, Chariot A and
            Beyaert R.
  TITLE     TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a
            common theme
  JOURNAL   Cell Mol Life Sci 65 (19), 2964-2978 (2008)
   PUBMED   18535784
  REMARK    Review article
REFERENCE   8  (bases 1 to 2971)
  AUTHORS   Xia W, Mruk DD, Lee WM and Cheng CY.
  TITLE     Differential interactions between transforming growth
            factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier
            and Sertoli-germ cell adhesion
  JOURNAL   J Biol Chem 281 (24), 16799-16813 (2006)
   PUBMED   16617054
  REMARK    GeneRIF: TGF-beta3 selectively disrupts Sertoli-germ cell adhesion
            in the seminiferous epithelium to facilitate germ cell migration
            without compromising BTB when TbetaRI interacts only with adaptor
            CD2AP.
REFERENCE   9  (bases 1 to 2971)
  AUTHORS   Lu G, Kang YJ, Han J, Herschman HR, Stefani E and Wang Y.
  TITLE     TAB-1 modulates intracellular localization of p38 MAP kinase and
            downstream signaling
  JOURNAL   J Biol Chem 281 (9), 6087-6095 (2006)
   PUBMED   16407200
  REMARK    GeneRIF: Data suggest that TAB-1 can mediate MKK-independent p38
            kinase activation while negatively modulating MKK-dependent p38
            function.
REFERENCE   10 (bases 1 to 2971)
  AUTHORS   Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado
            K, Sekimoto T, Ueno N, Matsumoto K and Yamada G.
  TITLE     Targeted disruption of the Tab1 gene causes embryonic lethality and
            defects in cardiovascular and lung morphogenesis
  JOURNAL   Mech Dev 119 (2), 239-249 (2002)
   PUBMED   12464436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB802111.1, CB605878.1, EV771639.1, DY311072.1, DN948807.1,
            CO567997.1, BP466072.1, CB706441.1 and BP483385.1.
            
            On Nov 25, 2008 this sequence version replaced NM_001109976.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                CB802111.1         59-120
            63-558              CB605878.1         1-496
            559-754             EV771639.1         330-525
            755-1268            DY311072.1         99-612
            1269-1504           DN948807.1         196-431
            1505-1921           CO567997.1         309-725
            1922-2323           BP466072.1         98-499
            2324-2603           CB706441.1         85-364
            2604-2971           BP483385.1         2-369               c
FEATURES             Location/Qualifiers
     source          1..2971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2971
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /note="TGF-beta activated kinase 1/MAP3K7 binding protein
                     1"
                     /db_xref="GeneID:315139"
                     /db_xref="RGD:1306216"
     exon            1..47
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1523
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /note="Tak1-binding protein 1; mitogen-activated protein
                     kinase kinase kinase 7 interacting protein 1"
                     /codon_start=1
                     /product="TGF-beta-activated kinase 1 and MAP3K7-binding
                     protein 1"
                     /protein_id="NP_001103446.1"
                     /db_xref="GeneID:315139"
                     /db_xref="RGD:1306216"
                     /translation="MAAQRRSLLQSEQQPSWTDDLPLCHFSGVGSASNRSYSADGKGT
                     ESHPPEDNWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTDADV
                     RRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLLPQYQKILERLKALEK
                     EISGGAMAVVAVLLNNKLYVANVGTNRALLCRSTVDGLQVTQLNVDHTAENEDELFRL
                     SQLGLDAGKIKQVGVICGQESTRRIGDYKVKYGYTDIDLLSTAKSKPIIAEPEIHGAQ
                     PLDGVTGFLVLMSEGLYKALEAAHGPGQANQEVAAMIDTEFAKQTSLDAVAQAVVDRV
                     KRIHSDTFASGGERAKFCPRHEDMTLLVRNFGYPLGEMSQPTPTPAPGGRVYPVSVPY
                     SSAQSTSKTSVTLSLVMPSQGQMVNGSHSASTLDEATPTLTNQSPTLTLQSTNTHTQS
                     SSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVMTAP"
     exon            48..184
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..338
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..425
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..564
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..678
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..790
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..935
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1158
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1315
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..2971
                     /gene="Tab1"
                     /gene_synonym="Map3k7ip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggtcctc caagatggcg gcgcagagga ggagcctgct ccagagtgag cagcagccaa
       61 gctggacaga tgacctgcca ctctgtcact tctccggcgt tggttcagct tccaaccgta
      121 gctactctgc tgatggcaag ggcactgaga gtcaccctcc ggaggacaac tggctcaagt
      181 tcagaagtga aaacaactgc ttcctgtatg gggtcttcaa tggctatgat ggcaaccgcg
      241 tgaccaactt tgtggcgcag agactctctg cagagctcct gctgggccag ctcaacaccg
      301 aacacacaga tgctgatgtg cgacgggtcc tgctgcaggc cttcgatgtg gtggagagga
      361 gcttcctgga gtctatcgat gatgccttgg ctgagaaagc aagcctccag tcccagctgc
      421 cggagggtgt gccccaacac cagctgctac ctcagtatca gaagatcctg gagagactca
      481 aggcactgga gaaggagatc tcgggagggg ccatggctgt tgtggcggtc cttctcaaca
      541 acaagctcta cgttgccaat gttggtacga acagggccct tctgtgcaga tccaccgtgg
      601 acgggctaca ggtcacacag ctgaacgtgg accacaccgc cgagaatgag gacgagctct
      661 tccgtctctc acaactgggt ttagacgcag ggaagatcaa gcaggtgggc gtcatctgtg
      721 gacaggagag caccaggcga attggggatt acaaggtcaa atatggctac actgacattg
      781 acctgctcag cactgccaaa tccaaaccca tcatcgcaga gcccgaaatc cacggcgcac
      841 agcctctgga tggcgtgacg ggcttcctgg tactgatgtc ggaggggctg tacaaggccc
      901 tggaggcagc ccatgggcct gggcaggcca accaggaggt tgccgcaatg attgacaccg
      961 aatttgccaa gcagacctcc ctcgatgcag ttgcccaggc tgtggtagac cgtgtaaagc
     1021 gtatccacag tgacaccttt gccagcggtg gggagcgggc caagttctgc ccacggcatg
     1081 aagacatgac cctgctggtg aggaactttg gctatccatt aggtgaaatg agccagccga
     1141 cacccacccc ggccccaggg ggccgtgtgt accctgtttc tgtgccctac tcaagtgccc
     1201 agagcaccag caagaccagt gtgactctgt ccctcgtcat gccttctcag ggccagatgg
     1261 tcaacggctc tcacagtgcc tccaccttgg atgaagccac tcctactctc actaaccaga
     1321 gccccactct gaccctgcag tctaccaaca cccacaccca gagcagcagc tccagctcgg
     1381 acgggggcct cttccgctcc agaccggctc actcacttcc acctggagag gatggcaggg
     1441 tcgagcccta tgtggacttt gctgagtttt accgactctg gagcgtggac catggcgagc
     1501 agagtgtgat gacggcacct tagtctagcc tcagagggcg agtgacaaga caagacaaga
     1561 caagacaaga caagcttctt aacctttgca ggtgccgtgg aaccagtggg cagtgtgtca
     1621 ctgatgtact gcagcctgag tactgactgc actgctgctc cacacaggaa gctagagtcc
     1681 agactacagg caaccttagg cagggccaac gggaaagccg caggtggctt acaaaccatc
     1741 aagagtgcct cttgacaagt tcaaagaagg aagccatcct gtggacccca tctactacag
     1801 gccagacaga cactgctccc tcgaggctgc tctacctgcc tcaagttccc ctggaatagc
     1861 ctgtggcctc tgctttagct gagttcctct ggaatagcta gtgccctttg cttctgggtg
     1921 gttatccctt tcccatcttt cagcctaaac tcctagatcc agagtacaga gtaatgggag
     1981 taggtgcctg tcattggatg tcactggaaa agtctaggga agcagagggg cctgcaacag
     2041 tcacagggga gcaggacaag gaaggactgg accagagaga gctggccaag gaatgtcagt
     2101 cctgggctgc aggtcagcca gctggcagct gagctaaccc agagagctgg cttcccagtg
     2161 gggtacagat ggcaggacag gcccaagtgc tgtagtgtct gcttctgtta gatcctgccc
     2221 tggggtgggg caggccaagt cagaagccag tgcctttctc ccagctggta ctgggaagcc
     2281 ggtgataggg gtgctgagtc aacagctttc actctgatga ggaagctgat tggctctggg
     2341 ttctgctgaa agaggagtag aagatggctg tgagacggaa gagattgagt cgcccaccca
     2401 gaaagaccaa gggcatcaga tgtgatggtg tggacatgct ggggaaagat tgtgcctgtc
     2461 aggctctgac ttggacctgt tgacatgttt cctaccatca gacaggaggt cactacagct
     2521 gcctgcagtg tggctgcccc tatgctcaga ggaggaagca ggctgggtgc tcccccttac
     2581 ctgagccctc ccatcaggat tggagtccaa gctcaaatct gtagccttgt aactggtatt
     2641 ctgcaaccct ttctacggtg cagctagtgg gcgggtgagt ccagtgtctc ctgttggcaa
     2701 aggccagttt agagcatgtc tcactcagac tccatttccg taaggaggct gtttgctcag
     2761 tgctgaggag aaaccgtggg atggtgggga gaagaggaag aagccttctt gctccccact
     2821 aggaagtcac cttgcccttc aggtgagcag ctttcagccg atgcacaaag acctgggaca
     2881 atggagagcc tcccctgggg atgtggtgct gtttggtctc tagaaataga accatgttct
     2941 taatgcagta cagtaaagat gtcatgtgtc a
//
