LOCUS       NM_134328                999 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus trace-amine-associated receptor 1 (Taar1), mRNA.
ACCESSION   NM_134328
VERSION     NM_134328.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Raony,I., Domith,I., Lourenco,M.V., Paes-de-Carvalho,R. and
            Pandolfo,P.
  TITLE     Trace amine-associated receptor 1 modulates motor hyperactivity,
            cognition, and anxiety-like behavior in an animal model of ADHD
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 117, 110555 (2022)
   PUBMED   35346791
  REMARK    GeneRIF: Trace amine-associated receptor 1 modulates motor
            hyperactivity, cognition, and anxiety-like behavior in an animal
            model of ADHD.
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Liu,J.F., Siemian,J.N., Seaman,R. Jr., Zhang,Y. and Li,J.X.
  TITLE     Role of TAAR1 within the Subregions of the Mesocorticolimbic
            Dopaminergic System in Cocaine-Seeking Behavior
  JOURNAL   J Neurosci 37 (4), 882-892 (2017)
   PUBMED   28123023
  REMARK    GeneRIF: TAAR1 in different subregions of the mesocorticolimbic
            system contributes to reinstatement of cocaine-seeking behavior.
REFERENCE   3  (bases 1 to 999)
  AUTHORS   De Gregorio,D., Posa,L., Ochoa-Sanchez,R., McLaughlin,R.,
            Maione,S., Comai,S. and Gobbi,G.
  TITLE     The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine
            firing activity through 5-HT1A, D2 and TAAR1 receptors
  JOURNAL   Pharmacol Res 113 (Pt A), 81-91 (2016)
   PUBMED   27544651
  REMARK    GeneRIF: Pretreatment with the trace amine-associate receptor 1
            (TAAR1) antagonist EPPTB (5mg/kg, i.v.) blocked the inhibitory
            effect of LSD on VTA DA neurons.
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Harmeier,A., Obermueller,S., Meyer,C.A., Revel,F.G., Buchy,D.,
            Chaboz,S., Dernick,G., Wettstein,J.G., Iglesias,A., Rolink,A.,
            Bettler,B. and Hoener,M.C.
  TITLE     Trace amine-associated receptor 1 activation silences GSK3beta
            signaling of TAAR1 and D2R heteromers
  JOURNAL   Eur Neuropsychopharmacol 25 (11), 2049-2061 (2015)
   PUBMED   26372541
  REMARK    GeneRIF: Results demonstrate that betaArr2 signaling may be an
            important pathway for TAAR1 function and that the activation of the
            TAAR1-D2R complex negatively modulates GSK3b signaling
REFERENCE   5  (bases 1 to 999)
  AUTHORS   Staubert,C., Bohnekamp,J. and Schoneberg,T.
  TITLE     Determinants involved in subtype-specific functions of rat trace
            amine-associated receptors 1 and 4
  JOURNAL   Br J Pharmacol 168 (5), 1266-1278 (2013)
   PUBMED   23072560
  REMARK    GeneRIF: The different functionality of rat Taar subtypes 1 and 4
            mainly correlates with receptor's cell surface expression rather
            than with specific amino acid residues involved in ligand binding
            specificity.
REFERENCE   6  (bases 1 to 999)
  AUTHORS   Miller,G.M.
  TITLE     The emerging role of trace amine-associated receptor 1 in the
            functional regulation of monoamine transporters and dopaminergic
            activity
  JOURNAL   J Neurochem 116 (2), 164-176 (2011)
   PUBMED   21073468
  REMARK    GeneRIF: Overview focuses on recent studies which reveal a role for
            TAAR1 in the functional regulation of monoamine transporters and
            the neuronal regulatory mechanisms that modulate dopaminergic
            activity. [review]
            Review article
REFERENCE   7  (bases 1 to 999)
  AUTHORS   Kitahama,K., Araneda,S., Geffard,M., Sei,H. and Okamura,H.
  TITLE     Tyramine-immunoreactive neuronal structures in the rat brain:
            abundance in the median eminence of the mediobasal hypothalamus
  JOURNAL   Neurosci Lett 383 (3), 215-219 (2005)
   PUBMED   15955414
  REMARK    GeneRIF: The Tyramine highly concentrated in the median eminence of
            the mediobasal hypothalamus, in which its physiological function on
            prolactin release has been demonstrated.
REFERENCE   8  (bases 1 to 999)
  AUTHORS   Lindemann,L., Ebeling,M., Kratochwil,N.A., Bunzow,J.R., Grandy,D.K.
            and Hoener,M.C.
  TITLE     Trace amine-associated receptors form structurally and functionally
            distinct subfamilies of novel G protein-coupled receptors
  JOURNAL   Genomics 85 (3), 372-385 (2005)
   PUBMED   15718104
REFERENCE   9  (bases 1 to 999)
  AUTHORS   Bunzow,J.R., Sonders,M.S., Arttamangkul,S., Harrison,L.M.,
            Zhang,G., Quigley,D.I., Darland,T., Suchland,K.L., Pasumamula,S.,
            Kennedy,J.L., Olson,S.B., Magenis,R.E., Amara,S.G. and Grandy,D.K.
  TITLE     Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid
            diethylamide, and metabolites of the catecholamine
            neurotransmitters are agonists of a rat trace amine receptor
  JOURNAL   Mol Pharmacol 60 (6), 1181-1188 (2001)
   PUBMED   11723224
REFERENCE   10 (bases 1 to 999)
  AUTHORS   Borowsky,B., Adham,N., Jones,K.A., Raddatz,R., Artymyshyn,R.,
            Ogozalek,K.L., Durkin,M.M., Lakhlani,P.P., Bonini,J.A.,
            Pathirana,S., Boyle,N., Pu,X., Kouranova,E., Lichtblau,H.,
            Ochoa,F.Y., Branchek,T.A. and Gerald,C.
  TITLE     Trace amines: identification of a family of mammalian G
            protein-coupled receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 8966-8971 (2001)
   PUBMED   11459929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF421352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF421352.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /note="trace-amine-associated receptor 1"
                     /db_xref="GeneID:113914"
                     /db_xref="RGD:621621"
     CDS             1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /codon_start=1
                     /product="trace amine-associated receptor 1"
                     /protein_id="NP_599155.1"
                     /db_xref="GeneID:113914"
                     /db_xref="RGD:621621"
                     /translation="MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVI
                     ISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTD
                     IMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFL
                     ELNLEGVEEQYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKG
                     QARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGY
                     VIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL"
     exon            1..999
                     /gene="Taar1"
                     /gene_synonym="taR-1; Tar1; Trar1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcatcttt gccacaatag cgcgaatatt tcccacacga acagcaactg gtcaagggat
       61 gtccgtgctt cactgtacag cttaatatca ctcataattc taaccactct ggttggcaac
      121 ttaatagtaa tcatttcgat atcccacttc aagcaacttc acacgcccac aaattggctc
      181 cttcattcca tggccgttgt cgactttctg ctgggctgtc tggtcatgcc ctacagcatg
      241 gtgagaacag ttgagcactg ctggtacttt ggggaactct tctgcaaact tcacaccagc
      301 actgatatca tgctgagctc ggcatccatt ctccacctag ccttcatttc cattgaccgc
      361 tactatgctg tgtgcgaccc tttaagatac aaagccaaga tcaatctcgc cgccattttt
      421 gtgatgatcc tcattagctg gagccttcct gctgtttttg catttgggat gatcttcctg
      481 gagctgaact tagaaggagt tgaggagcag tatcacaatc aggtcttctg cctgcgcggc
      541 tgttttccct tcttcagtaa agtatctggg gtactggcat tcatgacgtc tttctatata
      601 cctggatctg ttatgttatt tgtttactat agaatatatt tcatagctaa aggacaagcg
      661 aggtcaatta atcgtgcaaa tcttcaagtt ggattggaag gggaaagcag agcgccacaa
      721 agcaaggaaa caaaagccgc aaaaacctta gggatcatgg tgggcgtttt cctcctgtgc
      781 tggtgcccgt tctttttctg catggtcctg gaccctttcc tgggctatgt tatcccaccc
      841 actctgaatg acacactgaa ttggttcggg tacctgaact ctgccttcaa cccgatggtt
      901 tatgcctttt tctatccctg gttcagaaga gcgttgaaga tggttctctt cggtaaaatt
      961 ttccaaaaag attcatctag gtctaagtta tttttgtaa
//
