LOCUS       NM_001100739            2971 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus synoviolin 1 (Syvn1), mRNA.
ACCESSION   NM_001100739 XM_001074153 XM_001075008 XM_341999
VERSION     NM_001100739.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2971)
  AUTHORS   Guo,L., Zhang,D., Ren,X. and Liu,D.
  TITLE     SYVN1 attenuates ferroptosis and alleviates spinal cord
            ischemia-reperfusion injury in rats by regulating the
            HMGB1/NRF2/HO-1 axis
  JOURNAL   Int Immunopharmacol 123, 110802 (2023)
   PUBMED   37591122
  REMARK    GeneRIF: SYVN1 attenuates ferroptosis and alleviates spinal cord
            ischemia-reperfusion injury in rats by regulating the
            HMGB1/NRF2/HO-1 axis.
REFERENCE   2  (bases 1 to 2971)
  AUTHORS   Sun,L., Ye,H., Tian,H., Xu,L., Cai,J., Zhang,C., Wang,R., Yang,H.,
            Zhao,S., Zhang,J. and Gao,S.
  TITLE     The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in
            Polycystic Ovary Syndrome by Regulating Mitochondrial Fission
  JOURNAL   Oxid Med Cell Longev 2022, 3639302 (2022)
   PUBMED   36193086
  REMARK    GeneRIF: The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role
            in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2971)
  AUTHORS   Liu,X., Zhou,N., Sui,X., Pei,Y., Liang,Z. and Hao,S.
  TITLE     Hrd1 induces cardiomyocyte apoptosis via regulating the degradation
            of IGF-1R by sema3a
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (12), 3615-3622 (2018)
   PUBMED   30248386
  REMARK    GeneRIF: Hrd1 might mediate the ubiquitination of IGF-1R through
            sema3a and then participate in the regulation of cardiomyocyte
            apoptosis.
REFERENCE   4  (bases 1 to 2971)
  AUTHORS   Tan,S.X., Jiang,D.X., Hu,R.C., Dai,A.G., Gan,G.X., Fu,D.Y.,
            Kong,C.C., Chen,Y.R., Wang,L.L. and Li,J.
  TITLE     Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type
            II Epithelial Cells from Apoptosis Induced by Cigarette Smoke
            Extract
  JOURNAL   Cell Physiol Biochem 43 (4), 1337-1345 (2017)
   PUBMED   28992619
  REMARK    GeneRIF: Endoplasmic reticulum stress induces HRD1 to protect
            alveolar type II epithelial cells from apoptosis induced by
            cigarette smoke extract.
REFERENCE   5  (bases 1 to 2971)
  AUTHORS   Hosokawa,N. and Wada,I.
  TITLE     Association of the SEL1L protein transmembrane domain with HRD1
            ubiquitin ligase regulates ERAD-L
  JOURNAL   FEBS J 283 (1), 157-172 (2016)
   PUBMED   26471130
REFERENCE   6  (bases 1 to 2971)
  AUTHORS   Omura,T., Kaneko,M., Okuma,Y., Orba,Y., Nagashima,K., Takahashi,R.,
            Fujitani,N., Matsumura,S., Hata,A., Kubota,K., Murahashi,K.,
            Uehara,T. and Nomura,Y.
  TITLE     A ubiquitin ligase HRD1 promotes the degradation of Pael receptor,
            a substrate of Parkin
  JOURNAL   J Neurochem 99 (6), 1456-1469 (2006)
   PUBMED   17059562
REFERENCE   7  (bases 1 to 2971)
  AUTHORS   Ye,Y., Shibata,Y., Kikkert,M., van Voorden,S., Wiertz,E. and
            Rapoport,T.A.
  TITLE     Recruitment of the p97 ATPase and ubiquitin ligases to the site of
            retrotranslocation at the endoplasmic reticulum membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14132-14138 (2005)
   PUBMED   16186510
REFERENCE   8  (bases 1 to 2971)
  AUTHORS   Yagishita,N., Ohneda,K., Amano,T., Yamasaki,S., Sugiura,A.,
            Tsuchimochi,K., Shin,H., Kawahara,K., Ohneda,O., Ohta,T.,
            Tanaka,S., Yamamoto,M., Maruyama,I., Nishioka,K., Fukamizu,A. and
            Nakajima,T.
  TITLE     Essential role of synoviolin in embryogenesis
  JOURNAL   J Biol Chem 280 (9), 7909-7916 (2005)
   PUBMED   15611074
REFERENCE   9  (bases 1 to 2971)
  AUTHORS   Kikkert,M., Doolman,R., Dai,M., Avner,R., Hassink,G., van
            Voorden,S., Thanedar,S., Roitelman,J., Chau,V. and Wiertz,E.
  TITLE     Human HRD1 is an E3 ubiquitin ligase involved in degradation of
            proteins from the endoplasmic reticulum
  JOURNAL   J Biol Chem 279 (5), 3525-3534 (2004)
   PUBMED   14593114
REFERENCE   10 (bases 1 to 2971)
  AUTHORS   Kaneko,M., Ishiguro,M., Niinuma,Y., Uesugi,M. and Nomura,Y.
  TITLE     Human HRD1 protects against ER stress-induced apoptosis through
            ER-associated degradation
  JOURNAL   FEBS Lett 532 (1-2), 147-152 (2002)
   PUBMED   12459480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166727.1.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_001074153.1, XM_341999.3, XM_001075008.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2971
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /note="synoviolin 1"
                     /db_xref="GeneID:361712"
                     /db_xref="RGD:1310488"
     exon            1..84
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            85..233
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1928
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /note="HRD1 protein; synovial apoptosis inhibitor 1,
                     synoviolin"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase synoviolin"
                     /protein_id="NP_001094209.1"
                     /db_xref="GeneID:361712"
                     /db_xref="RGD:1310488"
                     /translation="MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMA
                     VLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPR
                     FVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAY
                     HSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELF
                     TGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMSRRAIRNMNTLY
                     PDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCRMDVL
                     RASLPAQSPPPPEPADQGAPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFP
                     PVPPPPSSGEAAAPPSTSAATSRPSGAATTTAAGTSTSAPASGSVPGPEAGPAPGFPF
                     PPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLL
                     DAAMLQINQYLTVLASLGPPRPATSVNPTEETASTVVSATPSTSVPSSEAPAPSLGAS
                     PPIPEAEKPPVSTAEELPEDGEPDAAELRRRRLQKLESPVAH"
     exon            234..326
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            327..479
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            480..528
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            529..632
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            633..759
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            760..859
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            860..925
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1042
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1206
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1335
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1491
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1678
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1830
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2957
                     /gene="Syvn1"
                     /gene_synonym="RGD1310488"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcgcaggg ggtggggagt gttgttaacc ggagcggctg ccgcagtcgc ggtgattgag
       61 cgtgctcgcg gcgctgggct cctggtctct gggccagggc aatgttccgc accgcagtga
      121 tgatggcggc cagcctggcg ctgaccgggg cagtggtggc tcatgcctac tacctcaaac
      181 accagttcta ccccactgtc gtgtatttga ccaaatccag ccccagtatg gcagtcctgt
      241 acatccaggc ctttgtcctt gtcttcctct tgggcaaggt gatgggcaag gtgttttttg
      301 ggcagctgag ggcagcagaa atggagcacc tcttggaacg gtcctggtat gctgtcactg
      361 agacttgctt ggccttcacc gtttttcggg atgacttcag ccctcgcttt gtggcactct
      421 ttacactcct tctcttcctc aaatgtttcc attggttggc tgaagaccgt gtggacttta
      481 tggaacgcag ccccaacatc tcttggcttt tccactgccg cattgtctct cttatgttcc
      541 tcctgggcat cctggacttc ctctttgtca gccacgctta tcacagcatc ctgacccgag
      601 gggcgtctgt gcagctggtg tttggctttg agtatgccat tctgatgacc atggtgctca
      661 ccatcttcat caagtatgtg ctgcactccg tggacctcca gagtgagaat ccctgggaca
      721 acaaggccgt gtacatgctc tacacggagc tgtttacagg ctttatcaag gtcctgctgt
      781 acatggcctt tatgaccatc atgatcaagg tgcacacatt tccgctcttt gccattaggc
      841 ccatgtacct ggccatgagg cagttcaaga aagctgtgac agatgccatc atgtctcgca
      901 gagccatccg caacatgaac acactgtacc cggatgccac ccccgaggag ctccaggcaa
      961 tggataacgt ctgtatcatc tgcagagaag aaatggtgac cggtgctaag agattgcctt
     1021 gcaaccacat ctttcatacg agctgcctgc gctcctggtt ccagagacaa cagacctgcc
     1081 cgacatgccg tatggatgtt ctgcgggcat cattgccagc ccagtcacca ccaccccctg
     1141 agcctgctga ccaaggagcc ccccctgccc ctcatccccc accactgctg ccacagcccc
     1201 ctaatttccc ccagggcctc ctgcctcctt ttcctccggg catgttccca ctgtggccac
     1261 caatgggtcc ctttccacct gtcccacctc ccccaagctc aggagaggct gcagctcctc
     1321 cgtccaccag tgcagccact tctcgaccca gtggagcagc caccaccaca gctgctggca
     1381 cgagtacttc tgccccagca tctggctctg tacctggccc agaggctggt cctgcccctg
     1441 gcttcccttt ccctcctcct tggatgggta tgcctctgcc tccacctttt gccttccccc
     1501 cgatgcctgt gcctcctgcg ggctttgctg gcctaacccc agaggagctg cgggcactgg
     1561 agggccatga gcggcagcac ttggaggccc ggctacagag tctgcgcaac atacacacac
     1621 tactggacgc cgccatgctg caaatcaacc agtacctcac tgtcctggcc tccctgggcc
     1681 cccccaggcc agctacttca gtgaacccca ctgaagagac tgcctctaca gtggtatctg
     1741 ctaccccttc caccagcgtc cccagctctg aggctcctgc cccatccctg ggagcctccc
     1801 caccaattcc tgaagctgaa aagcctcctg tgagcactgc agaagagctt cctgaggatg
     1861 gagagcctga tgctgcagaa ctccgccggc gtcgcctgca gaagctcgag tctcccgttg
     1921 cccactgaca ctgcccagat ctggccctgc tctcttgagt agccctcact ggaacacgtc
     1981 ctgccaccaa gtgccagctc cctctctgtt tgcaccaggg agtagtaacc ccagttgaga
     2041 aagacttggc aggatctctg aggatcaagt gtctgggctt ccagttgatc caccccagtg
     2101 cccctggcag ccacgggggt gttggtcagt tctaaccttc ctcctctact tctgctatgt
     2161 tctactgggg ccttgaaagt agaagctgag cctctggcaa gcctctccca tgcttttagg
     2221 gagaaggtga agcccctcta agccctgctt gtgagtatgg gaccatgctg cagtgccgaa
     2281 cagtattagc ttctgttccc aagtgtggaa acccagaggg gctgaagaca gaccaggacc
     2341 ttgccccact ctctgccaag actggtacca gtctcttttc ctctacccat cttcccagaa
     2401 ccccctttgt gatggtggct gtgcccccta agccctgtgg catttccatg tcttactggc
     2461 aaccacacaa ctcagggaaa ggagtgcctg ggggtggggc acaggcgggc agcactgagg
     2521 gaccctgccc tgcccctccc cagcctcttt ccccatctca cccagcagcc actgcctggt
     2581 gggcctggct aagggtgtgc tgctccttaa accactgctc ccctgaaccc aaggcaggcc
     2641 acctccaacc tgtgggactt gagttcagga ttggaactat ttctgtacct agtggctttg
     2701 ggcttaaatt tgtctttcga atttgaatgc ttgaccccag gaaggagcag tatggggcta
     2761 ggtacctgga ctttccagtt tagaaaagct ctgggccagg aggggaccac ggagccaagg
     2821 cctagctgct gctttctttt ggttttgtgt tacaggagtt tctggagagt ttcagatgat
     2881 tatttaattt gtaaatattg tataaatttt aatagcttaa attgtatata cagctaaata
     2941 aaaccttgca ttaatgaaaa aaaaaaaaaa a
//
