LOCUS       NM_001108492            8184 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus synaptotagmin-like 2 (Sytl2), mRNA.
ACCESSION   NM_001108492 XM_001061661 XM_008759652 XM_008774622 XM_341882
VERSION     NM_001108492.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8184)
  AUTHORS   Yasuda,T. and Fukuda,M.
  TITLE     Slp2-a controls renal epithelial cell size through regulation of
            Rap-ezrin signaling independently of Rab27
  JOURNAL   J Cell Sci 127 (Pt 3), 557-570 (2014)
   PUBMED   24284068
REFERENCE   2  (bases 1 to 8184)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   3  (bases 1 to 8184)
  AUTHORS   Menasche,G., Menager,M.M., Lefebvre,J.M., Deutsch,E., Athman,R.,
            Lambert,N., Mahlaoui,N., Court,M., Garin,J., Fischer,A. and de
            Saint Basile,G.
  TITLE     A newly identified isoform of Slp2a associates with Rab27a in
            cytotoxic T cells and participates to cytotoxic granule secretion
  JOURNAL   Blood 112 (13), 5052-5062 (2008)
   PUBMED   18812475
REFERENCE   4  (bases 1 to 8184)
  AUTHORS   Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
            Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
  TITLE     Slp1 and Slp2-a localize to the plasma membrane of CTL and
            contribute to secretion from the immunological synapse
  JOURNAL   Traffic 9 (4), 446-457 (2008)
   PUBMED   18266782
REFERENCE   5  (bases 1 to 8184)
  AUTHORS   Yu,M., Kasai,K., Nagashima,K., Torii,S., Yokota-Hashimoto,H.,
            Okamoto,K., Takeuchi,T., Gomi,H. and Izumi,T.
  TITLE     Exophilin4/Slp2-a targets glucagon granules to the plasma membrane
            through unique Ca2+-inhibitory phospholipid-binding activity of the
            C2A domain
  JOURNAL   Mol Biol Cell 18 (2), 688-696 (2007)
   PUBMED   17182843
REFERENCE   6  (bases 1 to 8184)
  AUTHORS   Saegusa,C., Tanaka,T., Tani,S., Itohara,S., Mikoshiba,K. and
            Fukuda,M.
  TITLE     Decreased basal mucus secretion by Slp2-a-deficient gastric surface
            mucous cells
  JOURNAL   Genes Cells 11 (6), 623-631 (2006)
   PUBMED   16716193
REFERENCE   7  (bases 1 to 8184)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   8  (bases 1 to 8184)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and CK842035.1.
            
            On or before Aug 30, 2019 this sequence version replaced
            XM_008759652.2, XM_008774622.1, NM_001108492.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               JAXUCZ010000001.1  153685886-153686316
            432-903             JAXUCZ010000001.1  153728960-153729431
            904-1055            JAXUCZ010000001.1  153738232-153738383
            1056-1188           JAXUCZ010000001.1  153740079-153740211
            1189-1270           JAXUCZ010000001.1  153751203-153751284
            1271-1385           JAXUCZ010000001.1  153752562-153752676
            1386-2186           JAXUCZ010000001.1  153755347-153756147
            2187-5876           JAXUCZ010000001.1  153759473-153763162
            5877-5978           JAXUCZ010000001.1  153764939-153765040
            5979-6032           JAXUCZ010000001.1  153767350-153767403
            6033-6080           JAXUCZ010000001.1  153768605-153768652
            6081-6175           JAXUCZ010000001.1  153772228-153772322
            6176-6295           JAXUCZ010000001.1  153775111-153775230
            6296-6465           JAXUCZ010000001.1  153776510-153776679
            6466-6568           JAXUCZ010000001.1  153780394-153780496
            6569-6739           JAXUCZ010000001.1  153782333-153782503
            6740-6818           JAXUCZ010000001.1  153783945-153784023
            6819-6918           JAXUCZ010000001.1  153786567-153786666
            6919-7124           JAXUCZ010000001.1  153789665-153789870
            7125-8168           JAXUCZ010000001.1  153790714-153791757
            8169-8184           CK842035.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..8184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..8184
                     /gene="Sytl2"
                     /note="synaptotagmin-like 2"
                     /db_xref="GeneID:361604"
                     /db_xref="RGD:1307647"
     exon            1..431
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..903
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             803..7270
                     /gene="Sytl2"
                     /codon_start=1
                     /product="synaptotagmin-like protein 2"
                     /protein_id="NP_001101962.2"
                     /db_xref="GeneID:361604"
                     /db_xref="RGD:1307647"
                     /translation="MIDLSFLTEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQ
                     QLKNMSGQWFYEAKAKRHKDKIHGADIIRASMRRKRLPAAAEQKKDTAMRTKESWVNN
                     VNKDASLPPELAVVEEPADDTGPAGPSSSVVDPASSAIERSQENTRTPAVSLPKQRKN
                     PFDSLETPEDLSSQQTKTKQSKTGKAGLFQISKEGGLSESKEKPSIPDMSCQKSEKPK
                     QPVSMETENASLIKAPIPKARKLIYKSNDLKNDDYLSFAGQRRDSLNARGTPRGILKR
                     NSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEHSLDDDSCTNSLEPLKHVR
                     FSAVKNDLPQSPRPVLGQEVGEFTVLESDRLQNGTEDTGDIDEFQDHPEFSHRKPLSL
                     YQSVTNPRISERETEQPMSSGSIPSEEISCHSDILPTRPQCVESSSIISEQDKSSHFT
                     KLQSEMSKSPEDELTQCVEPEPSQTSDHSFRDHRQGKPLLTALTDQTASPVGPCATEI
                     RKTTDDSISKVLDWFNRSSHTEDSTSTLQHLQGLDLREQTDSRAQISNTLMTDNMSLK
                     GDDTKVPASTTTKVKPVRPDSTFQEEGDVLASESCRDSDALLKSNSEDLSQQGTLKKG
                     PDTLQRFERYRIPSHKNENMGDSQGSESTGEGVGTLPADSDYLLRPLKRSDSEEAPWN
                     TTHPSSLGKGKTKFHVPQKSKRNTHINADSSVIFLDSILKDDAERKSKTRNISFLKPS
                     LETENSGLPPGATDSGSSWRKPEDQEEVGEEPKNQVLREKYKRVSDRISFWEGGKAGA
                     KLKAPQPASSCSQESSSTKAYQPVKSQVMSLGSLSLGQSDYSQVTAKHGVFDGDDQTP
                     RLASSSSSNKPETTGSPISGLSKNHPSGNQFGKVTLPQTMENETHPSLEKDRFLIDKS
                     NGNFKVLSLRERMDERNTEHVYSHSQFENLRKFWGLGADGNSKHSDGNNTATNKQTSV
                     PSNRQKSKEFNTVNLSSEKTPEVEEGRHLRQGNVGAAEEMEKLNLKCRLPAPPDETKF
                     PQKTPQKFTYPLVGNEPSKEDVGKNTECLVTPVTEKACSDQEIQESIVKTSVLPKVST
                     DTFKDRVQKLVAEATSPAGQTSGKEVHEQQALKVGASENGAWPQNKSFVKDEEELTGV
                     KKSTKELQRRIPQDCSVDKLLKEATGTPSSPLQSLQEPVMTRPSSPPKEDLLFKKWIR
                     ENHSPSADQRERTAPSPQGVETLAGTDFTSKAKHCNTEGMLQLTAEGSPPLAQPSQSF
                     EGVSSPPADVSLSWNAPLLSQDSTLSSQREISEAIEKVVLPSKPAMTDINAVLQKLLR
                     EAGEVDTKLPERPLSPQRVSSVWAAPDPVGPNEDSHSSYPVPDTTHEGRSARMAPSAH
                     ATTSPTYTVTRYGQELLQEVAETVRETIIQPKPECPEFRAALEKLRKETLQTSLSKDD
                     KNTVTISPSALTGSCETSHQLAFEFHPTEIQETVEKAEAPSVTESIFDVGLEKLLKEM
                     SEGPRQLQLTRDILEKQTSQAEQAGLMGETPHPFLDDSGASKMNFASSGLESQVSPCD
                     KQLGGDEAVTGQLIDVQGYAGGFGVSECPQPYEDHKREDVETVLFVEDKGREKVIAEA
                     TRAPQKPGFEEAPKEMRVSRNKRSIVLLETKGKATETSTVKSELATAYKRQEKEQGPE
                     ACSESEFSDGNTSSNRESWRNTSSSEEEHSPVLKTLERRAARKIPSKSLEDIPSDSSN
                     QAKVDNLPEELVRSAEDDQKADQDPDTNECIPGISTVPSLPDNPFSHPDKLKRMSKSV
                     PAFLQDESDDRETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSG
                     DFGNLEVKGSVQFAIDYVESLKELHVFVAQCKDLAAADAKKQRSDPYVKTYLLPDKGK
                     MGKKKTLVVKKTLNPVYNEILRYKIERQVLKTQKLNLSVWHRDTFKRNSFLGEVELDL
                     ETWDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPEPSPGKKLPTTGEVH
                     IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTSNPVFNHTMVYDGFR
                     PEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEAALWEKMV
                     NSPNTWVEAMLPLRMLLIAKISK"
     exon            904..1055
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1188
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1270
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1385
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2186
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..5876
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5877..5978
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            5979..6032
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6033..6080
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6175
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6176..6295
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6296..6465
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6466..6568
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6569..6739
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6740..6818
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6819..6918
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            6919..7124
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
     exon            7125..8169
                     /gene="Sytl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagccct gtgctccggg aaggtcctgc gctgccctcc cctccgccct ccccaaacag
       61 cagcgggtga cacctgggcg gcgcaacagg ctgccagcgc cgggcggcag agagaggctg
      121 gcagctccaa ggaggtacag agggctctgg caacggccag ggaggttggg gggagacgcg
      181 gcgcgctctg ggtgtgactt ttctgcacac tgacggtgtc accgggacta ctttctggtc
      241 ctgctccggg tcttggtgta gttggaggag ttggtgtaga gagatatttt tgttgtcctt
      301 gctattctga ctgctacaac gtgaaccgcc ggtgttggca actgacaagc ttcgctcctc
      361 agtttctcct ttagttaaga gtgacttctg ctgccctcgc cgctgtgtgt cagctaagct
      421 agggacacca ggtcgaggat gcaccaagga gtctgctgct caagatggtg atgagcatgg
      481 agagagactg tgtctaagac aggtccagag agggtgcact gaagaaattc tgctgaaggc
      541 gtatacaagg catgcagcat cctcctgaga cctgttcatc ccatagacca ctgctacctc
      601 aaggaacctt gctcttatga ttttgatgtc atctgcctaa aacttttgtg gattccagtc
      661 aagactttta ctaccaaata agataccatt taattttgca tcctgtaatc atcctggctg
      721 tggtctcagc tctttttccc tgagaacctc aagctacatt tgtttgttac aattgttcct
      781 tttgtgtaaa ttgtgctcca aaatgatcga cttaagtttc ctgacagagg aggaacaaga
      841 tgccatctta aaggttctgc agagggatgc tgccctgaag agggctgaag aggagagggt
      901 cagacacttg cctgaaaaaa ttaaggatga ccaacaacta aagaacatga gtggccaatg
      961 gttttatgaa gctaaggcaa aaagacacaa ggacaaaatc catggtgctg acatcatcag
     1021 agcatccatg agaaggaaga gactcccagc ggcagctgag cagaagaagg acacagcaat
     1081 gaggacaaag gagagctggg tgaataatgt caacaaagac gcttcccttc ccccagagct
     1141 agctgttgtg gaagagccag cagatgacac aggtccagca ggcccaagtt ccagtgtggt
     1201 ggatccagct tccagtgcga ttgaaaggtc ccaggaaaat acgaggactc cagctgtgtc
     1261 tctgcccaag caaaggaaga atccattcga cagcctcgag acgccagaag atctctcatc
     1321 gcaacaaacc aaaaccaagc agtcaaaaac tggaaaagct ggtttatttc agatttcaaa
     1381 agagggtggg ttgtcagaat caaaagaaaa gccatctatt ccagatatgt catgtcaaaa
     1441 gtcagagaaa ccaaagcaac ctgtatccat ggagacagaa aatgcgtctc ttatcaaagc
     1501 tccaatcccc aaagccagaa aactgatcta caaatcaaat gacttaaaga acgacgatta
     1561 cctgtctttt gctggacaaa ggagggactc cctgaatgcg agagggactc caagagggat
     1621 cctaaagcgc aactccagtt ccagtagcac ggactcagag actctccgtt taaattacaa
     1681 cttggatccg aaaagcaaaa tcctatcacc tggcctcacc atccatgaga gaatttctga
     1741 aaaggaacat tctttagatg atgactcttg cacaaactca cttgagccct taaagcatgt
     1801 gagattctct gccgtgaaga atgaccttcc acagagtcct agacctgtcc ttggccagga
     1861 agtaggagaa tttactgttt tagaatctga caggttgcaa aatggaactg aagatacagg
     1921 ggacatagat gagtttcagg atcacccaga gttctcccac agaaaacctt tgtctcttta
     1981 tcagtcagtg acaaacccaa gaatttcgga aagggaaaca gaacagccga tgtcttctgg
     2041 gtctattcca agtgaggaga tctcttgcca ttcagacatt ctacccacaa gacctcagtg
     2101 tgtggagagt tcatccatca tcagtgaaca agataaatca tcacatttta caaagcttca
     2161 atcagaaatg tccaaaagcc ctgaggatga actgactcag tgtgttgagc ctgagccatc
     2221 ccagacatca gaccacagtt ttagagacca tcggcaaggt aagcctcttc tcacggctct
     2281 cactgatcag acagcctcac ccgtgggtcc atgtgctaca gagataagga agacaactga
     2341 tgattccata tctaaagtcc tagactggtt taatcgaagt tctcatacag aggacagtac
     2401 atcaactctc caacatcttc aaggactaga tctcagagag caaacagact cgagagcaca
     2461 gattagcaat accttgatga cagacaacat gtctctgaag ggagacgaca caaaggtccc
     2521 agcatccact acaactaagg tgaagcctgt gaggcctgac tcaacatttc aagaagaggg
     2581 agatgtgctg gcttctgaaa gttgccgaga cagtgacgca cttctcaagt ctaactctga
     2641 ggatttgtcc caacaaggca ccctcaagaa aggtccagat acactgcaac gatttgaaag
     2701 atacagaatc ccaagtcaca agaatgaaaa catgggtgat agccaaggtt cagagagtac
     2761 aggagaagga gttgggaccc ttcctgcaga cagtgactac ctgctcagac ctctgaaaag
     2821 atctgattca gaggaagccc catggaacac tacgcatccc agcagcttag gtaaagggaa
     2881 aaccaagttc catgtacctc aaaaaagtaa gaggaacaca catataaatg ctgactcttc
     2941 agtaattttc ctagattcca ttttgaaaga cgatgcagag aggaaaagca aaaccagaaa
     3001 tatctccttc ctaaaacctt ctctagagac agagaatagt gggttgcccc ctggggctac
     3061 tgacagtgga tcttcttgga ggaagcctga ggaccaagaa gaagttggtg aggaacccaa
     3121 gaaccaagtg ctgagagaga aatacaaacg ggtgagcgac agaatatctt tttgggaagg
     3181 aggcaaagct ggtgctaagt taaaggcacc acagcccgca tcttcttgta gccaggagtc
     3241 atcttcaact aaagcatacc agcccgtgaa gtcacaagtc atgtccctgg gcagtttatc
     3301 tttaggccag agtgactata gtcaagtcac agctaaacat ggggtctttg atggggatga
     3361 ccaaacacct cgtctcgcta gttcttcttc ctcaaataaa cctgaaacaa ccgggtcccc
     3421 aatatcaggt ctatccaaaa accacccttc aggtaaccag ttcggtaaag taactctacc
     3481 tcaaactatg gagaatgaaa cacacccttc tttggagaaa gacagatttc tgattgataa
     3541 atcaaatggc aacttcaaag ttctgtctct aagagaaagg atggatgaac gcaatacaga
     3601 acacgtctat agtcactctc agtttgagaa tctgaggaag ttttggggcc tgggagctga
     3661 cggaaacagt aaacatagcg atgggaataa tactgctaca aacaaacaaa cgtctgtgcc
     3721 gtcgaacaga cagaaatcca aggagtttaa caccgtgaac ttatcaagtg aaaagacccc
     3781 tgaagtagaa gaaggaagac atttaaggca gggaaatgtt ggagctgcag aagagatgga
     3841 gaaattaaac ttaaagtgca ggcttccagc accaccagac gaaaccaaat ttccacagaa
     3901 aacaccccaa aagttcactt atccgttggt aggaaatgag ccttcgaagg aagatgtagg
     3961 aaaaaataca gaatgcttgg ttaccccagt gactgaaaag gcttgctcgg atcaagagat
     4021 tcaagaatcc atagtgaaaa caagtgtttt gcctaaagtc tctacagaca cgttcaagga
     4081 cagggtacag aagttagtgg cagaagccac atcaccagca ggccagactt ctggcaagga
     4141 agttcatgag cagcaagcgc tcaaagtcgg tgcttctgaa aatggggcat ggcctcaaaa
     4201 caaaagtttt gtcaaggatg aggaggaact cacaggggtc aagaagagca ccaaagagct
     4261 ccaaagaagg attccacagg actgtagtgt ggacaaactc ctgaaggaag caactggaac
     4321 tccgtcgagt cccttgcaat ctctgcagga accggttatg actagaccct cctccccacc
     4381 taaagaggac ctattgttta aaaagtggat aagagagaat cacagtcctt cagcagatca
     4441 gagagagaga acagctcctt ccccacaggg tgttgaaact ttggcaggta cagatttcac
     4501 ctcgaaggcc aaacattgta acacagaagg gatgcttcag ttgactgcag aagggtctcc
     4561 tccattggct cagccttccc agtcttttga gggagtttcc agtcctccag cagatgtgtc
     4621 tttatcttgg aatgctcctc ttctgtccca ggatagcacc ttgtcttctc agagggaaat
     4681 ttctgaggct atagagaaag ttgttcttcc ctccaaacca gcaatgaccg atataaatgc
     4741 tgtattgcag aagctactta gagaagctgg agaagtagac accaagctcc ctgaaagacc
     4801 cttaagccct cagagagtga gttctgtgtg ggctgctcca gaccctgttg gtccaaatga
     4861 ggactcccat tcttcttacc cggttcctga tacaactcat gaaggcagat ctgctagaat
     4921 ggcaccatca gcacatgcca ctacgtcacc tacttatact gtgactcggt atggtcagga
     4981 gctacttcag gaagtggcag agacagtgag ggagacgatc attcagccta agccagagtg
     5041 ccctgaattc agggctgcct tggaaaaact acgaaaggaa acactgcaaa cttccctgtc
     5101 aaaagacgac aagaatacag tgactatttc cccatcagcc ttaacaggta gttgtgagac
     5161 gtcccatcag cttgcttttg aattccatcc tacagaaata caagaaactg tagagaaggc
     5221 tgaggctcca tcagttactg agagcatttt tgatgttggt cttgagaaac ttcttaaaga
     5281 gatgtccgaa gggcctcgtc agctccagct gacaagagac attttggaga agcagacttc
     5341 acaggcagag caagcagggc tcatgggaga aacaccccat ccttttttgg atgactcagg
     5401 agcctctaaa atgaactttg caagtagtgg tttggaatct caagtcagcc cgtgtgataa
     5461 acaattagga ggagatgaag ctgtcactgg tcaattgata gatgtccagg gttacgcagg
     5521 tgggtttggg gtctctgaat gcccccaacc ttatgaagac cataaaagag aggacgttga
     5581 aactgtgcta tttgtagagg acaaaggcag agaaaaggtt attgcagaag caacacgggc
     5641 tccccagaaa ccaggctttg aagaagctcc taaagaaatg agggtgtcca gaaataagcg
     5701 ctccattgtt ctcctggaaa caaaaggaaa ggctacagaa acaagcacag ttaaatccga
     5761 actagcaaca gcatataaga gacaagagaa agaacaagga ccagaggcat gctctgaatc
     5821 tgagttttca gatgggaaca ccagctctaa cagggagagc tggagaaata cctccagttc
     5881 agaagaagaa cacagccctg ttttgaaaac tttggaaagg agagctgcta ggaaaatacc
     5941 ttccaaaagt ctggaagaca ttccatcaga ttcatcaaat caagcaaaag tagataatct
     6001 gcctgaagaa ttagtccgta gtgctgaaga tgatcaaaaa gcagaccagg acccagatac
     6061 aaatgaatgt ataccaggaa tttccacagt gccttcactg cctgataatc cgttttccca
     6121 ccctgacaaa ctcaaaagga tgagcaagtc cgtgccagca tttcttcaag atgagagcga
     6181 tgacagagaa acagacacag catcagagag cagctaccag ctcaggagat acaagaagag
     6241 ccccagctca ttaaccaatc ttagcagctc ctctggcatg acgtccttgt cctctgcgag
     6301 tggcagtgtg atgagcgttt acagcggaga ctttggcaac ctggaagtga aaggaagtgt
     6361 gcagtttgca atcgactacg tggagtccct gaaagagcta catgtgtttg tggcccagtg
     6421 taaggactta gcagcagcag atgctaagaa acagcgctca gacccatatg taaagaccta
     6481 tcttctacca gacaaaggca aaatgggcaa gaagaagacc cttgtagtga agaagacctt
     6541 gaatcctgta tacaacgaga tattgcggta taaaattgaa aggcaagtct taaagacaca
     6601 gaagttgaac ctgtctgttt ggcatcggga tacgtttaag cgcaacagct ttctggggga
     6661 ggtagaactt gacctcgaaa catgggactg ggacagcaaa cagaacaaac aactgaagtg
     6721 gtacccgctg aagaggaaga cagcaccagt tgcccttgag acagaaaaca gaggtgaaat
     6781 gaagctagct ctccaatatg ttccggagcc aagccctggc aaaaagcttc ctactactgg
     6841 agaagtgcac atctgggtga aggaatgcct tgacctccca ctgctgaggg ggagccacct
     6901 aaattctttt gttaagtgta ccatccttcc agataccagt agaaaaagtc gccagaagac
     6961 aagagctgta ggaaaaacca gcaaccccgt cttcaaccat accatggtgt atgatgggtt
     7021 caggcctgaa gatctgatgg aagcctgtgt agaactcaca gtctgggacc attataaact
     7081 aaccaaccag tttctgggag gtctccggat cggctttgga acagggaaaa gctacgggac
     7141 tgaagtggat tggatggact ctacctctga ggaagctgct ctctgggaga agatggtaaa
     7201 ctctcccaac acttgggttg aagcaatgct gcccctcagg atgcttctca tcgccaagat
     7261 ttccaagtga tcttagtcag cggattccac catcaaaagc tactccccgg ggggagctac
     7321 tccccggggg gatctgaact tgagctgacg tcgtgcacag atatcctctc ccatcgtcac
     7381 taatgacaac tatgaagcat gctcaactta atctgcacgc attcctttgc ttgcatggct
     7441 caagggaact aaaccatgac aagatgtaca gcccagaagt gcgatgtgat gccaacattc
     7501 acggagacaa ctgaacgagc taggaaaact gaactgttgc tcccacacca aagaaaaagc
     7561 tagctttaca tgtttcgtac cacaatctgt gttgcagttc aggcctgcct tttggttatt
     7621 aaaatgcttg ctgggcatat aaataggaag gttacgagca aaaggacaag gatactcctg
     7681 ggctggggca gagagaggaa ggacagaggt gatgacaacg acctacataa tatgacaact
     7741 atttacttag taacctctaa tgaaacattg aattccatct cagggcagta agactgactt
     7801 cactgctcat aaatctgcct tgagaaaccc ccacacaccc cgactcctat aacgtcacct
     7861 ttctcagtct caaacggact ttggtgccac ctactggctg catatggaat tcagctcttg
     7921 gcttattttg gcttcatttt tgctaaaacg ggtggcaagt gtgtatttta taagactatg
     7981 ctaaaatatt gcatataatg atggtttttc ttatgatttt actatacgga aacagcataa
     8041 tagtcacaga tatgctttgc tacaaagttt taatcgaaat ataaattgct caactgtatt
     8101 gaacttccta tgtataattt tcagaaggta ttttgtaaaa acccttagaa taaattatca
     8161 tgacttaaaa aaaaaaaaaa aaaa
//
