LOCUS       NM_001399037            1878 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus synaptotagmin-like 1 (Sytl1), transcript variant
            1, mRNA.
ACCESSION   NM_001399037 XM_006239013
VERSION     NM_001399037.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Arimura,N., Kimura,T., Nakamuta,S., Taya,S., Funahashi,Y.,
            Hattori,A., Shimada,A., Menager,C., Kawabata,S., Fujii,K.,
            Iwamatsu,A., Segal,R.A., Fukuda,M. and Kaibuchi,K.
  TITLE     Anterograde transport of TrkB in axons is mediated by direct
            interaction with Slp1 and Rab27
  JOURNAL   Dev Cell 16 (5), 675-686 (2009)
   PUBMED   19460344
  REMARK    GeneRIF: Study shows that the Slp1/Rab27B/CRMP-2 complex directly
            links TrkB to Kinesin-1, and that this association is required for
            the anterograde transport of TrkB-containing vesicles in axons.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Holt,O., Kanno,E., Bossi,G., Booth,S., Daniele,T., Santoro,A.,
            Arico,M., Saegusa,C., Fukuda,M. and Griffiths,G.M.
  TITLE     Slp1 and Slp2-a localize to the plasma membrane of CTL and
            contribute to secretion from the immunological synapse
  JOURNAL   Traffic 9 (4), 446-457 (2008)
   PUBMED   18266782
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Synaptotagmin-like protein 1-3: a novel family of C-terminal-type
            tandem C2 proteins
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1226-1233 (2001)
   PUBMED   11243866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 30, 2021 this sequence version replaced XM_006239013.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1917247.1,
                                           SRR22582416.143838.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000005.1  150746763-150746840 c
            79-307              JAXUCZ010000005.1  150744448-150744676 c
            308-456             JAXUCZ010000005.1  150743000-150743148 c
            457-529             JAXUCZ010000005.1  150742695-150742767 c
            530-575             JAXUCZ010000005.1  150742574-150742619 c
            576-648             JAXUCZ010000005.1  150741089-150741161 c
            649-743             JAXUCZ010000005.1  150740749-150740843 c
            744-857             JAXUCZ010000005.1  150740472-150740585 c
            858-1024            JAXUCZ010000005.1  150740207-150740373 c
            1025-1121           JAXUCZ010000005.1  150739839-150739935 c
            1122-1280           JAXUCZ010000005.1  150739365-150739523 c
            1281-1359           JAXUCZ010000005.1  150739063-150739141 c
            1360-1459           JAXUCZ010000005.1  150738866-150738965 c
            1460-1665           JAXUCZ010000005.1  150736816-150737021 c
            1666-1878           JAXUCZ010000005.1  150736425-150736637 c
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1878
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /note="synaptotagmin-like 1"
                     /db_xref="GeneID:297872"
                     /db_xref="RGD:1310715"
     exon            1..78
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            79..307
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1805
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-like protein 1; exophilin-7"
                     /codon_start=1
                     /product="synaptotagmin-like protein 1 isoform 1"
                     /protein_id="NP_001385966.1"
                     /db_xref="GeneID:297872"
                     /db_xref="RGD:1310715"
                     /translation="MPQRGHPSQERLRALPSLPMAHGPGPEAEGLLDLSFLTEEEQEA
                     ISDVLKRDAHLRQLEEGRVSKLRASLADPWQLKILTGDWFQEARSQRHHHAHFGSDLV
                     RASIRRKKSSKGDQALGSDGDGEAAGEDTIEEAEPRVSIKVAAPETHTETQEPDFSSP
                     YVLTKVSSQEEEPQDQEAPGQGGVQVAEADPELDPEQEAEQESWPTPAQIKTTSKVLE
                     NGEETPGLGPSLDRMLSSSSSVSSLNSSTLSGSLKSLSGEAEAGPVQVRGSVLFSLRY
                     EPGTGELRVQVIQCQGLAAARRRRSDPYVKSYLLPDKQNKRKTSVKKRNLNPIFNETL
                     RHSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEATWLPLQPRIPTS
                     PDELPSRGLLSLSLKYIPAGSEGGGQPPSGELHFWIKEAQGLVPLRPGSLDTYIQCSV
                     LPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALASRQLG
                     GTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLLEQPCEWVDGLLPLRTNLVPRA"
     exon            308..456
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..529
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..575
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..648
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..743
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..857
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1024
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1121
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1280
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1359
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1459
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1665
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1878
                     /gene="Sytl1"
                     /gene_synonym="Slp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttttgtag tctctgaact gccttcctgg agagctggag ttgcctttga agttgtcctc
       61 cctactggac ccttacagga ggctacatat gcccaactgg ggcgcaaccc cagctgatgc
      121 cccagagagg ccacccatct caggagaggc ttcgggccct gccctccctc cccatggcac
      181 atggaccagg acctgaagct gagggattgc tggacctcag cttcttgaca gaggaggaac
      241 aggaggccat ctctgatgtc ctcaaacgag atgcccacct acgccagctg gaggaagggc
      301 gggtcagcaa gcttagggcc tcactggcag acccctggca gctaaagatc ctgacagggg
      361 actggttcca agaagcacgc tcccagcggc atcaccatgc ccattttggt tctgacctcg
      421 tccgggcttc tatccgaagg aagaagagct ctaaggggga ccaggctctg ggaagcgatg
      481 gtgatggaga ggctgctggg gaagacacca tagaagaggc agagcccagg gtctccatca
      541 aggtggctgc tccagagaca cacactgaga cccaagagcc tgatttctcc tcaccatatg
      601 tactcacaaa ggtttccagt caggaggagg agccccagga ccaggaagcc cctggccaag
      661 ggggtgtgca ggtggcagaa gcggacccag aactggatcc tgagcaggag gcggagcagg
      721 agtcgtggcc aactccagcc cagatcaaga cgacctccaa ggtcctggag aatggagaag
      781 agacccccgg gctcggcccc tctctcgacc gcatgctcag cagcagttcc tctgtgtcga
      841 gcctcaattc ttctacgctc agtggcagcc tgaagagctt gtcgggggag gcggaggcgg
      901 gcccggtgca ggtgcgcggc tctgtgctct tctccctgcg gtacgagcct ggcaccggcg
      961 agctgcgcgt acaagtgatc cagtgccagg gcctggccgc tgcccggcgt cgccgctccg
     1021 atccctacgt gaaaagctac ctcctcccgg ataagcagaa caagcgcaag acatcggtga
     1081 agaaacggaa tctgaacccg atcttcaacg agactctgcg gcactctgtc cagcaggccg
     1141 atctcccagg acgcgtgctg agcctgtccg tgtggcaccg tgaaagtctg ggtcgcaaca
     1201 tctttctggg agaggtggaa gtgcccctag acacgtggaa ctgggactct gaggctacct
     1261 ggctccccct gcagcctcgg attcccacat ctccagacga gctccccagc cgtggactgc
     1321 tgtctctgtc cctcaagtat atccctgccg gctcagaggg aggagggcag cctccaagtg
     1381 gggagctaca tttctggata aaggaagctc agggcctcgt accactgcgg ccaggatcct
     1441 tggataccta cattcaatgc tcagtgctgc ccgatgacag tcgggccagc cgccaacgca
     1501 caagagtggt tcgacgaagt ctcagccctg tgttcaacca caccatggtt tatgatggct
     1561 ttgggcctgc tgacctacgc caggcctgtg ctgagctctc cttgtgggat catggggccc
     1621 tggccagtcg acagttgggg ggcacgcgtc tcagccttgg tactggcagt agttatgggc
     1681 ttcaggtgcc ctggatggac tccacacctg aggagaagca gctatggcag acactcctgg
     1741 agcagccctg tgagtgggtg gatggccttc tgcccctcag aaccaacctg gtccctaggg
     1801 catagccttg tcaaacccct ctgtggatcc ccacctgaag cacacccatc gccagagtca
     1861 ataaagtctg tttacaga
//
