LOCUS       NM_053324               1506 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synaptotagmin 9 (Syt9), mRNA.
ACCESSION   NM_053324
VERSION     NM_053324.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Gautam,V., D'Avanzo,C., Berezovska,O., Tanzi,R.E. and Kovacs,D.M.
  TITLE     Synaptotagmins interact with APP and promote Abeta generation
  JOURNAL   Mol Neurodegener 10, 31 (2015)
   PUBMED   26202512
  REMARK    GeneRIF: Syt-9 regulates endogenous APP-CTF and Abeta levels in
            PC12 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Zhang,Z., Wu,Y., Wang,Z., Dunning,F.M., Rehfuss,J., Ramanan,D.,
            Chapman,E.R. and Jackson,M.B.
  TITLE     Release mode of large and small dense-core vesicles specified by
            different synaptotagmin isoforms in PC12 cells
  JOURNAL   Mol Biol Cell 22 (13), 2324-2336 (2011)
   PUBMED   21551071
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Matsuoka,H., Harada,K., Nakamura,J., Fukuda,M. and Inoue,M.
  TITLE     Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat
            adrenal chromaffin cells
  JOURNAL   Cell Tissue Res 344 (1), 41-50 (2011)
   PUBMED   21287204
  REMARK    GeneRIF: In contrast to PC12 cells and the pancreatic beta cell
            line INS-1, Syt9 was not immunodetected in large dense-core
            vesicles in rat chromaffin cells.
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Zhang,Z., Hui,E., Chapman,E.R. and Jackson,M.B.
  TITLE     Regulation of exocytosis and fusion pores by synaptotagmin-effector
            interactions
  JOURNAL   Mol Biol Cell 21 (16), 2821-2831 (2010)
   PUBMED   20573977
  REMARK    GeneRIF: Data show that Syt I produced more rapid dilation of
            fusion pores than syt VII or syt IX, consistent with its role in
            synchronous synaptic release.
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Gauthier,B.R. and Wollheim,C.B.
  TITLE     Synaptotagmins bind calcium to release insulin
  JOURNAL   Am J Physiol Endocrinol Metab 295 (6), E1279-E1286 (2008)
   PUBMED   18713958
  REMARK    Review article
REFERENCE   6  (bases 1 to 1506)
  AUTHORS   Fukuda,M.
  TITLE     RNA interference-mediated silencing of synaptotagmin IX, but not
            synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12
            cells
  JOURNAL   Biochem J 380 (Pt 3), 875-879 (2004)
   PUBMED   15015935
REFERENCE   7  (bases 1 to 1506)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   8  (bases 1 to 1506)
  AUTHORS   Fukuda,M., Kowalchyk,J.A., Zhang,X., Martin,T.F. and Mikoshiba,K.
  TITLE     Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells
  JOURNAL   J Biol Chem 277 (7), 4601-4604 (2002)
   PUBMED   11751925
REFERENCE   9  (bases 1 to 1506)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
REFERENCE   10 (bases 1 to 1506)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF375461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF375461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1506
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /note="synaptotagmin 9"
                     /db_xref="GeneID:60564"
                     /db_xref="RGD:621169"
     CDS             1..1476
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /note="sytIX; synaptotagmin 5; synaptotagmin V;
                     synaptogamin V; synaptotagmin IX"
                     /codon_start=1
                     /product="synaptotagmin-9"
                     /protein_id="NP_445776.1"
                     /db_xref="GeneID:60564"
                     /db_xref="RGD:621169"
                     /translation="MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPR
                     LRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLFSGSKDNNQEPLNYT
                     DTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQPGGQDNCAHAVRVQRQVTE
                     PTPSARHNSIRRQLNLSNPDFNIQQLQRQEQLTGIGRIKPELYKQRSLDNDDGRRSNS
                     KACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKV
                     HRKTLNPVFDEVFLFPVHYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFFDLADFP
                     RECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYV
                     KVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDRVGHN
                     EVIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLLEKR"
     exon            1..145
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            146..497
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1044
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1165
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1337
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1467
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1506
                     /gene="Syt9"
                     /gene_synonym="Sytv"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccgggg ccagggacgc gctctgtcac caggcgctgc agctgctggc cgagctctgt
       61 gcccgagggg ccctggagca cgacagctgc caagatttca tctaccacct gcgggaccgt
      121 gccagacccc ggctccgcga cccagatatc tctgtgagcc tgctaactct cgtggttacc
      181 gcctgtggtc ttgccctctt tggtgtctct cttttcgtgt cttggaaact gtgctgggtt
      241 ccgtggcgag agcgaggcct gttctctggt agcaaagaca acaaccaaga gcctcttaac
      301 tacactgata cagagacaaa tgagcaggag aacagcgagg acttcctaga cccacccaca
      361 ccctgcccgg actcctccat gaagatcagc cacacttccc ccgacattcc cctctccacc
      421 cagccaggtg gccaggacaa ctgtgcccat gccgtccgtg tacagcgaca agtcacagag
      481 ccaacgccgt cagctcggca taactcaatc cgaagacaac tcaacctgtc aaacccggac
      541 tttaatatcc aacagcttca gaggcaggag cagttgactg ggattggtag aattaagcca
      601 gagttatata aacagaggtc actggacaac gacgatggga ggagaagtaa cagcaaagcc
      661 tgcgggaaac tgaacttcat cttaaaatac gactgcgact tggaacagct catcgtgaag
      721 atccacaaag ccgtcaatct gcccgccaag gacttctctg ggacgtcaga tccttatgtc
      781 aagatctact tgcttcctga ccggaaaaca aaacaccaga ctaaggttca caggaagacc
      841 ctgaaccctg tgtttgacga ggtgttttta tttcctgtgc actacaatga ccttgaagct
      901 cggaagcttc acttctccgt gtatgacttt gacaggttct ctcgccatga cttgattggt
      961 caagtggtgg tggaccactt cttcgacttg gctgacttcc ccagggagtg catcctttgg
     1021 aaggatatcg agtatgtcac caacgataat gtggacctgg gtgagcttat gttttcgctc
     1081 tgctatcttc caacagccgg caggctgacc atcaccatca tcaaagcaag gaatttaaag
     1141 gcaatggaca ttacgggagc gtcagatccg tacgtgaaag tctcactgat gtgtgatggc
     1201 cggagactga agaagaggaa aacatccacc aagaggaaca cgcttaaccc tgtttacaat
     1261 gaagccatag tcttcgatgt ccctcctgag agcattgatc agatccactt gtccatagct
     1321 gtcatggact atgaccgtgt aggtcacaat gaggtcatcg gcgtgtgcca agtaggcaac
     1381 gaggctgagc ggctgggcag agaccactgg agtgagatgc tgtcatatcc ccgaaagccc
     1441 atcgcacact ggcactctct gctggagaaa cgatgattgt ggataggaag actgcttttg
     1501 ccaagg
//
