LOCUS       NM_019350               1900 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus synaptotagmin 5 (Syt5), mRNA.
ACCESSION   NM_019350 XM_001071181
VERSION     NM_019350.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Qiu,X., Ge,J., Gao,Y., Teng,M. and Niu,L.
  TITLE     Structural analysis of Ca2+-binding pocket of synaptotagmin 5 C2A
            domain
  JOURNAL   Int J Biol Macromol 95, 946-953 (2017)
   PUBMED   27793683
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Lynch,K.L. and Martin,T.F.
  TITLE     Synaptotagmins I and IX function redundantly in regulated
            exocytosis but not endocytosis in PC12 cells
  JOURNAL   J Cell Sci 120 (Pt 4), 617-627 (2007)
   PUBMED   17264148
  REMARK    GeneRIF: Syt1 and Syt5 function redundantly in regulated exocytosis
            but not endocytosis in PC12 cells.
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Fukuda,M.
  TITLE     Distinct developmental expression of synaptotagmin I and IX in the
            mouse brain
  JOURNAL   Neuroreport 17 (2), 179-182 (2006)
   PUBMED   16407767
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Haberman,Y., Ziv,I., Gorzalczany,Y., Fukuda,M. and
            Sagi-Eisenberg,R.
  TITLE     Classical protein kinase C(s) regulates targeting of synaptotagmin
            IX to the endocytic recycling compartment
  JOURNAL   J Cell Sci 118 (Pt 8), 1641-1649 (2005)
   PUBMED   15784685
  REMARK    GeneRIF: We show that targeting of Syt IX to the ERC involves
            constitutive trafficking to the plasma membrane followed by
            internalization and transport to the ERC.
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Zhang,Q., Fukuda,M., Van Bockstaele,E., Pascual,O. and Haydon,P.G.
  TITLE     Synaptotagmin IV regulates glial glutamate release
  JOURNAL   Proc Natl Acad Sci U S A 101 (25), 9441-9446 (2004)
   PUBMED   15197251
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     A novel alternatively spliced variant of synaptotagmin VI lacking a
            transmembrane domain. Implications for distinct functions of the
            two isoforms
  JOURNAL   J Biol Chem 274 (44), 31428-31434 (1999)
   PUBMED   10531344
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Fukuda,M., Kojima,T. and Mikoshiba,K.
  TITLE     Phospholipid composition dependence of Ca2+-dependent phospholipid
            binding to the C2A domain of synaptotagmin IV
  JOURNAL   J Biol Chem 271 (14), 8430-8434 (1996)
   PUBMED   8626542
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Hudson,A.W. and Birnbaum,M.J.
  TITLE     Identification of a nonneuronal isoform of synaptotagmin
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5895-5899 (1995)
   PUBMED   7597049
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Craxton,M. and Goedert,M.
  TITLE     Synaptotagmin V: a novel synaptotagmin isoform expressed in rat
            brain
  JOURNAL   FEBS Lett 361 (2-3), 196-200 (1995)
   PUBMED   7698322
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092198.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001071181.1, NM_019350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092198.1, U26402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1900
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /note="synaptotagmin 5"
                     /db_xref="GeneID:54309"
                     /db_xref="RGD:3806"
     exon            1..258
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            259..400
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1482
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /note="synaptotagmin IX; sytV; synaptotagmin V"
                     /codon_start=1
                     /product="synaptotagmin-5"
                     /protein_id="NP_062223.1"
                     /db_xref="GeneID:54309"
                     /db_xref="RGD:3806"
                     /translation="MFPEPPTPGSPAPETPPDSSRIRQGAVPAWVLATILLGSGLLVF
                     SSCFCLYRKRCRRRMGKKSQAQAQVHLQEVKELGRSYIDKVQPEIEELDPSPSMPGQQ
                     VLDKHQLGRLQYSLDYDFQTGQLLVGILQAEGLAALDLGGSSDPYVSVYLLPDKRRRH
                     ETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVN
                     LGRPVQAWRELQVAPKEEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSD
                     PYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKL
                     GKNEAIGRVAVGTAVGGAGLRHWADMLANPRRPIAQWHSLRPPDRARPIPAP"
     exon            401..573
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            574..693
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            694..861
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1029
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1147
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1281
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1820
                     /gene="Syt5"
                     /gene_synonym="SytIX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggccgagg ggcggagcag ggcgttctcc tttctccagg gcagaacacg cacgcacata
       61 tatgcacaca tacactcgcg cgcgcgcgcg cgctcccaca caggggcgca gacatagcct
      121 ggctaggctc agccgcgccc ccacactgcc aagctgtgtg atcagcacac aagggacagc
      181 gccatcaccc acgtgctggg ggcggggtcc cggcagccca cagcacctcc agaagggtcc
      241 tgtccagcca cctagcagga gtggggtggg ggatagggta cttgggtacc tctgcaggaa
      301 gcaccgcagg aacccgacgc catgttcccg gaacccccga ccccggggtc tccagcgcct
      361 gagacacctc cagactccag ccgcatcagg cagggggcag tgcctgcctg ggtcctggct
      421 accatcttgc tgggctcagg cctcctggtc ttcagcagct gtttctgtct ctaccggaag
      481 cgctgtcgga gacggatggg caaaaagagt caggcccaag cccaagtcca tcttcaggaa
      541 gtgaaggagc tgggccggag ttacatagat aaggttcagc ctgaaataga ggaactggac
      601 ccctcaccat ccatgccagg acagcaggta ttggacaagc accagttagg ccgactgcag
      661 tattcactgg attatgactt ccagactggc cagctcctgg taggcatctt gcaagctgag
      721 ggactggcag cgttggacct aggaggttcc tcagacccct atgttagtgt ctatctgctg
      781 ccagacaagc ggaggcgaca tgagaccaag gtgcatcggc agaccctgaa tccacacttt
      841 ggagagacct ttgccttcaa ggtcccatac gtggaactag gaggtagagt gctggtcatg
      901 gcggtgtatg acttcgatcg cttctcccgc aacgatgcca tcggagaggt gcgggtgcct
      961 atgagttcag tgaacctggg gcggccagtg caggcctggc gagagctgca ggtggctccc
     1021 aaagaggagc aggagaaact gggggatatc tgcttctctc tccggtatgt ccccacggcc
     1081 gggaagctca ccgtcattgt cctggaagct aaaaacctga agaaaatgga tgtaggagga
     1141 ctctcagacc cttatgtcaa ggtgcacctg ctccagggag gtaaaaaggt tcggaagaag
     1201 aaaaccacca ttaagaagaa caccctgaac ccctattaca acgaggcctt cagctttgag
     1261 gtgccctgtg accaggtgca gaaagtccag gtggagctga ccgttttgga ctatgacaaa
     1321 ctggggaaga atgaggccat cgggagagtg gcggtgggca cagcagttgg tggggctggc
     1381 ctacggcact gggctgacat gttggccaac cctaggcggc ccattgccca gtggcactct
     1441 ctgcggcccc ctgacagagc caggccaata cctgcaccct gattcctgtc aagcaagcac
     1501 ctgaccccag atcctttgct ccctgtccct tacctctctc cccacatgac tctccctact
     1561 ccccaaacat tgcattcatt cctacctcca cattggaaat gtttccgact tccagtacca
     1621 ctcctatacc cagaaaccac agtggtcctg cggggaggtg gagaagttgg gaaagtctgg
     1681 catcccctgc cccagagtcc taccctctgc tttgacaatc agctgtgaag cctctgatct
     1741 cctttctccc agtctctgag ctcttcccac acagcttgac ccctgtgctg ctcctggggc
     1801 caaataaata ctcaacagct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
