LOCUS       NM_019122               2096 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synaptotagmin 3 (Syt3), mRNA.
ACCESSION   NM_019122
VERSION     NM_019122.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Awasthi,A., Ramachandran,B., Ahmed,S., Benito,E., Shinoda,Y.,
            Nitzan,N., Heukamp,A., Rannio,S., Martens,H., Barth,J., Burk,K.,
            Wang,Y.T., Fischer,A. and Dean,C.
  TITLE     Synaptotagmin-3 drives AMPA receptor endocytosis, depression of
            synapse strength, and forgetting
  JOURNAL   Science 363 (6422) (2019)
   PUBMED   30545844
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Jensen,J.B., Ulhoi,B.P. and Jensen,K.M.
  TITLE     Lymph node mapping in patients with bladder cancer undergoing
            radical cystectomy and lymph node dissection to the level of the
            inferior mesenteric artery
  JOURNAL   BJU Int 106 (2), 199-205 (2010)
   PUBMED   20002670
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Bhalla,A., Chicka,M.C. and Chapman,E.R.
  TITLE     Analysis of the synaptotagmin family during reconstituted membrane
            fusion. Uncovering a class of inhibitory isoforms
  JOURNAL   J Biol Chem 283 (31), 21799-21807 (2008)
   PUBMED   18508778
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Lee,B.H., Min,X., Heise,C.J., Xu,B.E., Chen,S., Shu,H.,
            Luby-Phelps,K., Goldsmith,E.J. and Cobb,M.H.
  TITLE     WNK1 phosphorylates synaptotagmin 2 and modulates its membrane
            binding
  JOURNAL   Mol Cell 15 (5), 741-751 (2004)
   PUBMED   15350218
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Chapman,E.R., Desai,R.C., Davis,A.F. and Tornehl,C.K.
  TITLE     Delineation of the oligomerization, AP-2 binding, and synprint
            binding region of the C2B domain of synaptotagmin
  JOURNAL   J Biol Chem 273 (49), 32966-32972 (1998)
   PUBMED   9830048
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Fukuda,M., Kojima,T. and Mikoshiba,K.
  TITLE     Phospholipid composition dependence of Ca2+-dependent phospholipid
            binding to the C2A domain of synaptotagmin IV
  JOURNAL   J Biol Chem 271 (14), 8430-8434 (1996)
   PUBMED   8626542
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Li,C., Ullrich,B., Zhang,J.Z., Anderson,R.G., Brose,N. and
            Sudhof,T.C.
  TITLE     Ca(2+)-dependent and -independent activities of neural and
            non-neural synaptotagmins
  JOURNAL   Nature 375 (6532), 594-599 (1995)
   PUBMED   7791877
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Ullrich,B., Li,C., Zhang,J.Z., McMahon,H., Anderson,R.G.,
            Geppert,M. and Sudhof,T.C.
  TITLE     Functional properties of multiple synaptotagmins in brain
  JOURNAL   Neuron 13 (6), 1281-1291 (1994)
   PUBMED   7993622
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Mizuta,M., Inagaki,N., Nemoto,Y., Matsukura,S., Takahashi,M. and
            Seino,S.
  TITLE     Synaptotagmin III is a novel isoform of rat synaptotagmin expressed
            in endocrine and neuronal cells
  JOURNAL   J Biol Chem 269 (16), 11675-11678 (1994)
   PUBMED   8163462
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D28512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D28512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2096
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /note="synaptotagmin 3"
                     /db_xref="GeneID:25731"
                     /db_xref="RGD:3805"
     exon            1..82
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            83..253
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1869
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /note="sytIII; synaptotagmin III"
                     /codon_start=1
                     /product="synaptotagmin-3"
                     /protein_id="NP_061995.1"
                     /db_xref="GeneID:25731"
                     /db_xref="RGD:3805"
                     /translation="MSGDYEDDLCRRALILVSDLCARIRDADTNDRCQEFNELRIRGY
                     PRGPDADISVSLLSVIVTFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLA
                     PGVGLAGLVGGGGHHLGASLGGHPLLGGPHHHAHPAHHPPFAELLEPGGLGGSEPPEP
                     SYLDMDSYPEAAVASVVAAGVKPSQTSPELPSEGGTGSGLLLLPPSGGGLPSAQSHQQ
                     VTSLAPTTRYPALPRPLTQQTLTTQADPSSEERPPALPLPLPGGEEKAKLIGQIKPEL
                     YQGTGPGGRRTGGGSGEAGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSD
                     PYVKIYLLPDRKKKFQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSR
                     HDLIGQVVLDNLLELAEQPPDRPLWRDILEGGSEKADLGELNFSLCYLPTAGLLTVTI
                     IKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPES
                     VENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADPHGREHWAEMLANPRKPVEHWHQLV
                     EEKTLSSFTKGGKGLSEKENSE"
     exon            254..782
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1158
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1377
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1498
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1670
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1803
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1871
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2096
                     /gene="Syt3"
                     /gene_synonym="SIII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgtccac cctgcaaccc ccatgggcta ccgccccccg cctcctcggc tgccacccaa
       61 gacaaggcag ggataagcac agtgtaggat cacgtggcca ctatgtctgg ggactacgaa
      121 gatgacctct gtcggcgggc cctcatcctg gtttcagacc tctgtgcacg gatccgagat
      181 gctgatacca atgacaggtg tcaagagttc aacgaactgc gaatcagagg atatccccgg
      241 ggtccggatg cagacatttc cgtgagcctg ctgtcagtca tcgtgacgtt ctgtggcatc
      301 gtcctcttgg gtgtctctct cttcgtgtcc tggaagttgt gctgggtgcc ctggagggac
      361 aaagggggct cagcagtggg tggtggcccc ctgcgcaaag acttagcccc tggggttggg
      421 ctggcaggcc tggtaggagg tggtgggcac catctgggag ccagcctagg tggccatccc
      481 ctgctgggtg gtccgcacca tcatgcacac ccagcccacc atccaccatt tgctgaactg
      541 ctggaaccag gtggccttgg gggctctgag cctccagaac cttcctacct ggacatggac
      601 tcatatccag aggctgctgt ggcctctgtg gtagctgctg gggtcaaacc aagccagaca
      661 tcccctgagc tgccttctga gggtggaaca ggctctgggc tgctcctgct gcctcctagt
      721 ggtgggggct tgcccagtgc ccagtctcat cagcaggtca caagtctagc acccaccacc
      781 aggtacccag ccctgcctcg gcccctcacc cagcagaccc tgaccaccca agcagaccca
      841 agcagtgagg agcgaccacc tgcactgccc ttacccctgc caggcggaga ggagaaagcc
      901 aagctcatcg gtcagatcaa gccagagcta taccagggca ctggacctgg tggccggcga
      961 acgggcgggg gctctgggga ggcaggggca ccctgtggcc gcatcagttt tgcccttcgg
     1021 tacctctatg gctctgacca gctcgtggtg cggatccttc aggccctgga tctcccagca
     1081 aaggactcca atgggttctc agacccctac gtcaagatct acctgttgcc tgatcgcaaa
     1141 aagaagttcc agaccaaggt gcacaggaag acgctgaacc ctatcttcaa cgagacgttt
     1201 cagttttcgg tacccttggc cgagctggcg cagcgcaagc tgcacttcag tgtctatgac
     1261 ttcgacagat tctcgaggca cgatctcatc ggccaggtgg ttttggacaa cctgctggag
     1321 cttgctgaac agccccctga ccgtccactc tggagggaca tcctggaggg tggctcggaa
     1381 aaggcagatc ttggggagct caacttctca ctctgctacc tccccacggc cgggctcctc
     1441 accgtgacca tcatcaaagc ctctaacctc aaagcaatgg acctcactgg tttctcagac
     1501 ccctacgtga aggcctctct gatcagcgag gggcggcgtc tgaagaaacg gaagacctcc
     1561 attaagaaga acacgctgaa ccccacatac aacgaggccc tggtgttcga cgtggctccg
     1621 gagagcgtgg agaacgtggg tctcagtatc gcagtggtag actatgactg catcggccac
     1681 aatgaagtga tcggggtgtg ccgcgtgggc ccagaggccg ctgacccaca tggcagagaa
     1741 cactgggcag agatgctggc taaccctcgc aagcctgtgg agcactggca ccagctagtg
     1801 gaggagaaga ctctaagcag ctttaccaag ggcggcaaag gattgtcaga gaaagagaat
     1861 tcagagtgag ggtctggtct aggcctggga ttggaccagg cgccctcagg acccatccct
     1921 tcctgcccgg actgtgaact catctcgaag ccataatgtc cgagctgctg gtgcggggcg
     1981 gcctggacct gttcctcctt atcctggagg cgtgaggcta ggaggcagca ggcccagctc
     2041 cctgtttcag ggtgggaggt tctcggcctc cattgtctgt cttcttatcc ccagag
//
