LOCUS       NM_138849               2623 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus synaptotagmin 17 (Syt17), mRNA.
ACCESSION   NM_138849 XM_017588771 XM_346552
VERSION     NM_138849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2623)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   2  (bases 1 to 2623)
  AUTHORS   Han,K.H., Lee,U.Y., Jang,Y.S., Cho,Y.M., Jang,Y.M., Hwang,I.A.,
            Ghee,J.Y., Lim,S.W., Kim,W.Y., Yang,C.W., Kim,J. and Kwon,O.J.
  TITLE     Differential regulation of B/K protein expression in proximal and
            distal tubules of rat kidneys with ischemia-reperfusion injury
  JOURNAL   Am J Physiol Renal Physiol 292 (1), F100-F106 (2007)
   PUBMED   16896191
  REMARK    GeneRIF: B/K protein is closely associated with cell death in
            proximal tubules, which are vulnerable to ischemia-reperfusion
            injury in the kidney
REFERENCE   3  (bases 1 to 2623)
  AUTHORS   Jang,Y.S., Lee,M.Y., Choi,S.H., Kim,M.Y., Chin,H., Jeong,S.W.,
            Kim,I.K. and Kwon,O.J.
  TITLE     Expression of B/K protein in the hippocampus of kainate-induced rat
            seizure model
  JOURNAL   Brain Res 999 (2), 203-211 (2004)
   PUBMED   14759499
  REMARK    GeneRIF: Induction of both B/K protein expression and ER stress
            response in hippocampus of a rat kainate seizure model and ER
            stress-induced expression of B/K strongly suggest the possible role
            of B/K protein in epileptogenesis or epilepsy-induced neuronal
            damage
REFERENCE   4  (bases 1 to 2623)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     The N-terminal cysteine cluster is essential for membrane targeting
            of B/K protein
  JOURNAL   Biochem J 360 (Pt 2), 441-448 (2001)
   PUBMED   11716773
REFERENCE   5  (bases 1 to 2623)
  AUTHORS   Kwon,O.J., Gainer,H., Wray,S. and Chin,H.
  TITLE     Identification of a novel protein containing two C2 domains
            selectively expressed in the rat brain and kidney
  JOURNAL   FEBS Lett 378 (2), 135-139 (1996)
   PUBMED   8549819
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XM_017588771.1, NM_138849.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U30831.1, SRR26643287.2020.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840116, SAMN16676811
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000001.1  182195689-182195788 c
            101-118             JAXUCZ010000001.1  182191383-182191400 c
            119-267             JAXUCZ010000001.1  182190645-182190793 c
            268-416             JAXUCZ010000001.1  182184629-182184777 c
            417-1036            JAXUCZ010000001.1  182182302-182182921 c
            1037-1157           JAXUCZ010000001.1  182158237-182158357 c
            1158-1313           JAXUCZ010000001.1  182156369-182156524 c
            1314-2623           JAXUCZ010000001.1  182129496-182130805 c
FEATURES             Location/Qualifiers
     source          1..2623
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2623
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /note="synaptotagmin 17"
                     /db_xref="GeneID:192189"
                     /db_xref="RGD:708576"
     exon            1..100
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1510
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /note="sytXVII; protein B/K; brain and kidney protein; B/K
                     protein; synaptotagmin XVII"
                     /codon_start=1
                     /product="synaptotagmin-17"
                     /protein_id="NP_620204.1"
                     /db_xref="GeneID:192189"
                     /db_xref="RGD:708576"
                     /translation="MAYIQLEPLNEGFLSRISDVLLCGWTCQHCCQRCYESSCCQSSE
                     DEVEILGPFPAQTPPWLMASRSNDKDGDSVHTASDVPLTPRTNSPDGRRSSSDTSKST
                     YSLTRRISSLDSRRPSSPLIDIKPIEFGVLSAKKEPIQPSVLRRTYTPDDYFRKFEPR
                     LYSLDSNLDDVDSLTDEEIMSKYQLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHD
                     GSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLL
                     TVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQNEVELGELLLSLNYLPS
                     AGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESF
                     SFKVPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSESNHWRRMLNTHRTA
                     VEQWHSLRSRAECDRVSPASLEVT"
     exon            101..118
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            119..267
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            268..416
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1036
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1157
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1313
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2623
                     /gene="Syt17"
                     /gene_synonym="Bk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgtgcca cctcgccgga ccggcgaggg caaaggggct gtggcgacgc catgcccggg
       61 ccggagtgag tgagcgcggg cgaagatggc gtacatccag ttggaaccac tgaacgaggg
      121 ctttctttcc agaatctctg atgtgctgct gtgtggatgg acttgtcaac actgctgtca
      181 gaggtgctat gagtccagct gctgccagtc tagtgaagat gaagtggaga tcttgggacc
      241 tttccctgcc cagactcctc catggctgat ggccagccgg agcaatgaca aggatggtga
      301 ctctgtgcac acagccagcg atgttccttt gaccccaagg accaactccc ctgatgggag
      361 acgctcatcc tcagacacat ccaagtccac atacagcctg actcggagaa tctccagtct
      421 ggattcccgg cgccccagct ccccactcat tgacatcaaa cctattgagt tcggtgttct
      481 cagtgccaag aaggagccca tccagccatc tgtgctgcgc cgaacctaca cccctgatga
      541 ctacttcagg aagtttgagc cccgacttta ctcccttgac tcgaatcttg atgacgtaga
      601 ctctctgacc gatgaggaga taatgtccaa gtaccagctg ggcatgctgc acttcagcac
      661 ccagtatgac ctgctgcaca accacctcac cgtgagggtg atcgaggccc gggacctgcc
      721 gcctccaatc tcccatgatg gctcccgcca ggacatggcc cattccaacc cctacgtcaa
      781 gatctgcctc ctgcctgacc agaagaactc caagcagacg ggagtcaaac gcaagaccca
      841 gaagcctgtg tttgaggaac gctacacctt cgagatcccc ttcctagaag cccagaggag
      901 gaccctgctg ctcactgtgg tggattttga caaattctcc cgccactgtg tgattgggaa
      961 agtagcggtg cctttgtgtg aggtggactt ggtgaagggc ggccactggt ggaaagctct
     1021 gatccccagc tctcagaatg aagtggagct gggagagctg ctgctttctc taaactatct
     1081 cccaagtgct ggcagactga atgtggacat cattcgagcc aagcaactcc tgcagacaga
     1141 tgtgagccag ggttcagacc catttgtgaa aatccagctg gtacacggac tcaagcttgt
     1201 gaaaactaag aagacatcat tcttacgagg cacaatcgat cctttctaca atgaatcctt
     1261 cagcttcaaa gttccccagg aagaactaga aaacgccagc ctagtattca cagtgttcgg
     1321 tcacaacatg aaaagcagca acgacttcat cgggaggatc gtcatcggcc agtattcctc
     1381 cggcccctcg gaatccaacc actggcggcg aatgctcaac acgcaccgca ctgctgtgga
     1441 acagtggcat agcctgaggt cccgggctga gtgtgaccga gtgtctccgg cctcgctgga
     1501 ggtgacctga tcgccataag gaaggcaacc ttcatttgtt aaaaaaagag gaaaaaaatg
     1561 tgtcacataa atattcagcc cacacctacg tatactttca cacatgtgca cgtgcataca
     1621 caacgccctc tctgtaccga gagccagctg acagttgatc atgaaacagc caccctcatt
     1681 gagggaagct tgtgaagttt ccagacactc cattcatgca taaatcacaa gcctggtaga
     1741 ctctgctgtg ggacttacta gcagtgccta ctcttatcca cacctatgtc ccaaaatgta
     1801 ctttcaaccc tcaggccaga gaaaggaggc cttcctagga agagcctgac tcagtttacc
     1861 aagagttcag ctgttatttg gggggcttga ttccccactt caaaaccata tcttccagga
     1921 aagttctgaa caggccactg ttaactgggg tcccttctcc aacggtgtaa gtatctttat
     1981 tttctcctta gcaaatatga taaatagatt agaccctttg gagagaccaa agggtagcaa
     2041 aagacagtaa gttcgtgtca ggagcacact ctcagctgct ttgtccttgt gttaacttat
     2101 tgctgggact ccctgtgggt gtgtgtgtgt tattgtgagt gtgccctcac gggtaagtac
     2161 atgtgtgcct gttcatccca ttagacagca aggcagtagc caggacctcc atccatgaag
     2221 ctctcttacc tctgcctttt atccaatgca agtttacccc atatcctctc acacatcaga
     2281 gacccaacct gaggtagtga tagttcacat atgtccataa tagggttttg atagagcaga
     2341 ggtaacatgt ctgactgaat tgtggtggtt ataacccatt gggggtttgg catggggacg
     2401 agaatggtac tacatccctc caccatgacc tctccccaaa accagactcc agtgatcctt
     2461 ctgtgtttct gtgtgcacca cagtcatgtc tcatgtgcta aggctttagt gtagttagaa
     2521 tagagttccc tcacaggatg cttctgtatc tttctccaca gcgtattgtc ctctgtgatg
     2581 gggagttatc tgttgttgaa ataaaagatt atttatttgt gac
//
