LOCUS       NM_138835               2071 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus synaptotagmin 12 (Syt12), mRNA.
ACCESSION   NM_138835
VERSION     NM_138835.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2071)
  AUTHORS   Kaeser-Woo,Y.J., Younts,T.J., Yang,X., Zhou,P., Wu,D.,
            Castillo,P.E. and Sudhof,T.C.
  TITLE     Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase
            is essential for hippocampal mossy fiber LTP
  JOURNAL   J Neurosci 33 (23), 9769-9780 (2013)
   PUBMED   23739973
REFERENCE   2  (bases 1 to 2071)
  AUTHORS   Maximov,A., Shin,O.H., Liu,X. and Sudhof,T.C.
  TITLE     Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates
            spontaneous neurotransmitter release
  JOURNAL   J Cell Biol 176 (1), 113-124 (2007)
   PUBMED   17190793
  REMARK    GeneRIF: These data suggest that spontaneous synaptic-vesicle
            exocytosis is selectively modulated by a Ca(2+)-independent
            synaptotagmin isoform, synaptotagmin-12, which is controlled by
            cyclic AMP-dependent phosphorylation.
REFERENCE   3  (bases 1 to 2071)
  AUTHORS   Thompson,C.C.
  TITLE     Thyroid hormone-responsive genes in developing cerebellum include a
            novel synaptotagmin and a hairless homolog
  JOURNAL   J Neurosci 16 (24), 7832-7840 (1996)
   PUBMED   8987811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U71294.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U71294.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132264 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2071
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2071
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /note="synaptotagmin 12"
                     /db_xref="GeneID:191595"
                     /db_xref="RGD:621876"
     exon            1..197
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..254
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1486
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /note="sytXII; synaptotagmin-related gene 1 protein;
                     synaptotagmin XII"
                     /codon_start=1
                     /product="synaptotagmin-12"
                     /protein_id="NP_620190.1"
                     /db_xref="GeneID:191595"
                     /db_xref="RGD:621876"
                     /translation="MAVDVTEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWT
                     SGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRVPPWNAQRTTTRGPPSRKGSLSIED
                     TFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSM
                     DYDGASHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFD
                     EKFSVPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQD
                     QNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQDGRKM
                     SKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPG
                     ASGMGTTHWNQMLATLRRPVSMWHPVRRN"
     exon            255..448
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..841
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1057
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1178
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1312
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2071
                     /gene="Syt12"
                     /gene_synonym="Srg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgttcga ccgccgggcc ccgcggagcc cccgatccgt gaggcgcggc tccagcgcga
       61 gacgagcgcg ccgctacact gcaggggtgg cgtagcagca ggcggctggg ctcctgagcg
      121 agccaactga gggaggccgg cgtgggagca gaggtagaac cgggagtcgg acctgcgtcc
      181 cctccgcgga acccgggtcc ctgtcactgc aggggacgtc atggccgtgg acgtgacaga
      241 atatcatttg agcgtcatca agagcccccc aggctgggag gtgggtgtct acgctgctgg
      301 ggccctggct ctgcttggca ttgcagctgt gagtctgtgg aagctctgga cgtcggggag
      361 tttccccagc ccctccccgt tccctaacta cgactacagg tacctgcagc aaaaatatgg
      421 agaggcctat gtggaggcta agctgaagcg agtccctcct tggaatgccc agcggaccac
      481 cactcgggga ccacccagcc gcaaaggcag cctcagtata gaagatacct ttgagagcat
      541 cagtgagcta ggacccctgg agctgatggg ccgggaactg gacttggctc cctatggtac
      601 tctccgcaag tcacagtcgg ctgactctct gaattccatc tcctctgtga gcaacacctt
      661 cggtcaggat ttcaccctgg gccaggtgga ggtgagcatg gactatgatg gagcttccca
      721 caccctccac gtggcggtgc tgcaaggcaa ggacctcctg gagcgcgagg aggccacctt
      781 cgagtcctgc ttcatgcgtg tcagtctgct gccagacgaa cagatcgtgg gcatctcccg
      841 gatccagagg aatgcctatt ccatcttctt cgatgagaag ttctctgtcc ccctggaccc
      901 cacagccctg gaggagaaga gtcttagatt ttctgtgttt ggcatcgatg aggatgagcg
      961 gaatgtgagc accggcgtgg tggagctgaa gctgtctgtt ctggacctcc cgctgcagcc
     1021 cttcagtggc tggctgtact tacaggacca gaataaggct gctgatgctg tgggagagat
     1081 cctgctgtcc ctcagttacc tgcccacagc ggagcggctg actgtggttg tggtgaaagc
     1141 caagaatctc atctggacca atgacaagac cacagcagac cccttcgtca aagtgtatct
     1201 gctgcaggat gggaggaaga tgagcaagaa gaagacggcg gtgaagaggg atgaccccaa
     1261 cccagtgttc aatgaagcca tgatcttctc agtaccagcc attgtgcttc aggacctgtc
     1321 tctccgagtg acagtggctg agagcagcag tgatggccgt ggggacaacg tgggccatgt
     1381 catcattggg ccaggggcca gcggcatggg caccacacac tggaaccaga tgctggccac
     1441 attgcgcagg cctgtgtcca tgtggcatcc agtccggcga aactaacagc cagggcaggc
     1501 caagtgggca gccgagcctc cagagcctcg caccatctca gttctaccca gcgatgccct
     1561 ctccatagtc agctggagct gtgaacacca gggcttcccc acctcccagg gggtcctcat
     1621 cagccatctt ggatcctctg tccagactgt catggaggaa tggctcttca tctggggacc
     1681 cagagtaatt tccccactga ggactacctg tagctggctg gggacctacc agactggcca
     1741 actgcgtatt gaagagtctt aggaagtatg tccattggcc tgcagaggga tgtgggcttc
     1801 agcactggcc aactcccctt ctgctattct cctagaggac agctgttaat aagtcttgag
     1861 ggatagctcc tgtaatgaca gggctaagat taacaagacg tagcactcag gatgctagga
     1921 actcaatatg cccctttccc atcctggttg attggctcag tgccaagtaa caacctgggc
     1981 agatgaactt agaaaggggc cctgaggtct ggggtaacag tgaggatctc tcagataagg
     2041 agcttcactt tgagggttgg agaaaaaaaa a
//
