LOCUS       NM_031667               4295 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus synaptotagmin 11 (Syt11), mRNA.
ACCESSION   NM_031667
VERSION     NM_031667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4295)
  AUTHORS   Shimojo,M., Madara,J., Pankow,S., Liu,X., Yates,J. 3rd, Sudhof,T.C.
            and Maximov,A.
  TITLE     Synaptotagmin-11 mediates a vesicle trafficking pathway that is
            essential for development and synaptic plasticity
  JOURNAL   Genes Dev 33 (5-6), 365-376 (2019)
   PUBMED   30808661
REFERENCE   2  (bases 1 to 4295)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
REFERENCE   3  (bases 1 to 4295)
  AUTHORS   Wang,C., Kang,X., Zhou,L., Chai,Z., Wu,Q., Huang,R., Xu,H., Hu,M.,
            Sun,X., Sun,S., Li,J., Jiao,R., Zuo,P., Zheng,L., Yue,Z. and
            Zhou,Z.
  TITLE     Synaptotagmin-11 is a critical mediator of parkin-linked
            neurotoxicity and Parkinson's disease-like pathology
  JOURNAL   Nat Commun 9 (1), 81 (2018)
   PUBMED   29311685
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4295)
  AUTHORS   Du,C., Wang,Y., Zhang,F., Yan,S., Guan,Y., Gong,X., Zhang,T.,
            Cui,X., Wang,X. and Zhang,C.X.
  TITLE     Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in
            microglia
  JOURNAL   Glia 65 (10), 1656-1667 (2017)
   PUBMED   28686317
REFERENCE   5  (bases 1 to 4295)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4295)
  AUTHORS   Yeo,H., Kim,H.W., Mo,J., Lee,D., Han,S., Hong,S., Koh,M.J., Sun,W.,
            Choi,S., Rhyu,I.J., Kim,H. and Lee,H.W.
  TITLE     Developmental expression and subcellular distribution of
            synaptotagmin 11 in rat hippocampus
  JOURNAL   Neuroscience 225, 35-43 (2012)
   PUBMED   22960622
REFERENCE   7  (bases 1 to 4295)
  AUTHORS   Cheng,Y., Sequeira,S.M., Malinina,L., Tereshko,V., Sollner,T.H. and
            Patel,D.J.
  TITLE     Crystallographic identification of Ca2+ and Sr2+ coordination sites
            in synaptotagmin I C2B domain
  JOURNAL   Protein Sci 13 (10), 2665-2672 (2004)
   PUBMED   15340165
  REMARK    GeneRIF: Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B
            domain were identified using high-resolution crystal structures.
            have identified
REFERENCE   8  (bases 1 to 4295)
  AUTHORS   Huynh,D.P., Scoles,D.R., Nguyen,D. and Pulst,S.M.
  TITLE     The autosomal recessive juvenile Parkinson disease gene product,
            parkin, interacts with and ubiquitinates synaptotagmin XI
  JOURNAL   Hum Mol Genet 12 (20), 2587-2597 (2003)
   PUBMED   12925569
REFERENCE   9  (bases 1 to 4295)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem J 354 (Pt 2), 249-257 (2001)
   PUBMED   11171101
REFERENCE   10 (bases 1 to 4295)
  AUTHORS   von Poser,C., Ichtchenko,K., Shao,X., Rizo,J. and Sudhof,T.C.
  TITLE     The evolutionary pressure to inactivate. A subclass of
            synaptotagmins with an amino acid substitution that abolishes Ca2+
            binding
  JOURNAL   J Biol Chem 272 (22), 14314-14319 (1997)
   PUBMED   9162066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and BC094518.1.
            
            On Mar 2, 2021 this sequence version replaced NM_031667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1109857.1,
                                           SRR26360194.394655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000002.1  176529725-176529775 c
            52-1836             BC094518.1         1-1785
            1837-4295           JAXUCZ010000002.1  176503845-176506303 c
FEATURES             Location/Qualifiers
     source          1..4295
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4295
                     /gene="Syt11"
                     /note="synaptotagmin 11"
                     /db_xref="GeneID:60568"
                     /db_xref="RGD:62042"
     exon            1..286
                     /gene="Syt11"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1542
                     /gene="Syt11"
                     /note="sytXI; synaptotagmin XI"
                     /codon_start=1
                     /product="synaptotagmin-11"
                     /protein_id="NP_113855.2"
                     /db_xref="GeneID:60568"
                     /db_xref="RGD:62042"
                     /translation="MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQA
                     EKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGL
                     LSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSL
                     TFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTL
                     DPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQL
                     TRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSDPYVKVNV
                     YYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVG
                     RLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY"
     exon            287..1110
                     /gene="Syt11"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1231
                     /gene="Syt11"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..4295
                     /gene="Syt11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaggcgg agcctatgtc tcatcaggac cagtctgact gcacctgcat ccttagctca
       61 gagcatccct ggagcatcta agagaaaaac gcagctagca accaaggatc gtactgtcgc
      121 aggagcagtc ggccatgcac cttcccctcc cttgatctgg aggtctacag ccggggcctc
      181 ggtactgatc gagatttcca aagttgtctg acctctgcaa aagtgtttct atcaacagcc
      241 tctgattaca acatggctga gatcacaaat atacgcccca gctttgatgt gtcaccagta
      301 gcggctggcc tcatcggcgc ctctgtgctg gtggtgtgtg tctctgtgac tgtctttgtg
      361 tggacatgct gccaccagca ggcggagaag aagcacaaga ccccaccgta caagtttatt
      421 catatgctga aaggcattag catctaccca gagaccctca gcaacaagaa gaaaatcatc
      481 aaagttcgga gggacaaaga tggttctcat agggaaagtg gacgagggaa cctgttagta
      541 aatgcggagt ctggcctgct gagccatgac agggatccca gagggcctag ccctgcatct
      601 tgtatagacc agttacccat caaaagagac tatggggaag aactgaggag ccccatgacc
      661 agcctgaccc ccggtgaaag caagcccacc tccccatcat cgccagagga agatgtgatg
      721 ctagggtccc ttaccttctc ggtggactac aactttccca agaaagctct ggtggtgaca
      781 atccaagagg cgcatgggct gccagtgatg gatggccaga cccagggctc cgatccctac
      841 atcaaaatga ccattcttcc tgacaagcgg catcgagtga agacccgggt gcttcgcaag
      901 accctggacc ccgtgtttga tgagaccttc accttctacg gcattcccta cagccagcta
      961 caggacctgg tgctgcactt ccttgtgctc agctttgatc gcttctctcg ggatgacgtc
     1021 atcggggagg tcatggtgcc cttggctgga gtggacccca gcacaggcaa ggttcagctg
     1081 accagggaca tcatcaagag gaacattcag aagtgcatta gcagagggga actccaggta
     1141 tctctgtcat accagcccgt cgcacagaga atgacagtgg tggtcctcaa agccagacac
     1201 ttgccgaaga tggatatcac cggtctctca gatccttatg tcaaggtgaa cgtctactac
     1261 ggcagaaaac gcattgccaa gaagaaaact catgtaaaga agtgcacttt gaaccccatc
     1321 ttcaatgagt ccttcatcta tgacatcccc accgatctcc tgcctgatat cagcatcgag
     1381 ttccttgtca ttgacttcga tcgtactact aagaatgagg tggtagggag gctgatcttg
     1441 ggggcacaca gtgtcacaac cagtggtgca gaacactgga gagaggtgtg cgagagtccc
     1501 cgcaagcctg tagccaagtg gcacagtctg agcgagtact aaccctgggg ccaggcgggg
     1561 aggcacacac ggggagaggt gacagagaag ctgactcaaa acctcatttt agtcgtagaa
     1621 gatttcttac agaacaaacc acacgaagaa cctcacactc cacacggctg cagattggtt
     1681 cttagcgtga ggattgcttt cttctctgca aggcactaga cgatcttttg ttttttaaaa
     1741 tgagggggga agagaaggga agaccccaag tctatatata acaatgtaac cttatacttg
     1801 catgtctaat acaaacaaga aattagccta acaatatcaa gttgcagatt ttaatccatg
     1861 aaaattgtgt tttgtgccga actgtatttg ctgatcccct gaaattggcc tctctttatc
     1921 aggcttctct gggttattcc agttttccat caccgcagga gaaaagtctg ctcttgtaaa
     1981 gccccatgtc cccatcatcc agtccctttt gctgtcacct ctcacatctc tgctctttgg
     2041 ctgagttaca aatcctgagg tctgtagtaa gtgaggaaat gagtggggtt tccaggagaa
     2101 agagtggttg agaatgggat gtgtgggtag taggcagcca gtgactagag attcccctga
     2161 tgagctcagg aggagtgggg ctggacttag gactctgatt tctccagaag gagcaatgga
     2221 gggttcacct agagcgaggt acctgtgaac agtaccagcg cgtcctgaaa gctgcttgca
     2281 ggtcagggga ccaggggatg aaataagatg tccatgtggc cctctgtggt gggctcttca
     2341 tcagtggtca gcagtcccag gtttgtaagg ttacactggc ttttactttt ccagaactgt
     2401 gccgggcgct caggcatctc ttcattatgt agccaacaca ggttgctttc tgtttcctaa
     2461 ggaaaacagg cctcagcccc tgagctttag agtggtggct cttaagaaag ccgagtgggg
     2521 ctgagttgta agaccgtatg aatgccttcc gagctccact ctcctcagca gaagctcacg
     2581 gctggagaac tgggagtctc cccacacagt gaagggtgga aaccaaagtt ccaccatgtc
     2641 tctgccactg caccagacag tgtagagctt gtgcatcgtc ctggagccca gacccaggtc
     2701 tccacgcgga gacttccaga ggaaacgagc ggtgagcttg gatgggcagt gcctattttg
     2761 acagcctgaa gaggacctca gtcaaataag agatagcttg atccagggcc tgaacaatta
     2821 gctgtaactg aagtgcccac ttccctgaag gccatcactt tctagcttgc ttctgagaag
     2881 gggtggacaa gctgactttc catggagagg gttggtgaca atgcctttgg tggttcccct
     2941 cgtgcttgtg gatctgaatc cactctgcgc cccccccacc ccacccccca acctctcatt
     3001 tgattttgtt tgcttggttt tgttcttttt ctgccgactc ttggcaaggc agagcagccc
     3061 tgtacagacg ggaaacccca ctgtactctt gctcctgtca gcccttaaat cccataatct
     3121 gactcagtgt ctcaccatca actgggatcg caccactagt ctccgtcctt taacccatgg
     3181 agtgtaaata gtgtatcata cgtagaagaa aatacttttt gttttctaaa aaggcatttt
     3241 gacatagttt aacgaaaacc cggcaggagc attctaagcc ccattaggga aaacgattga
     3301 aacggttcct cttcgtcgcc ttaatgtgta gagatcagaa gtcactgcgc aggccctgtc
     3361 tccttgggag aagggatgcg aagtgacagg tggagcctgg cctctgtccc gctgtgtgtg
     3421 cctctgtagc tccccctgag aagtctggga aacagcctca ccatgctcct cctccttccc
     3481 cgtgcccctg cagctcgatc ctttgcatcc tctgggtctg cggagcgcgg gtgctggtag
     3541 gggagcctgt acttccacag gctcggggct gccaagaaaa ggcaaagggg tgggcagtac
     3601 aggatccctc cctcctacct caggcctgat ccatcatgga cttggtatcc taacgcttct
     3661 tagcggactc tggctttcac acatgttctt cacagagctc acggctgtgg gcagaggcag
     3721 aacgcctctc cctggccatt gaaagacaag agagtcacat cctagctttt gcacaaggct
     3781 cttgtggtta ggaataggtt agggaaaggt cactcctgat ttcccagcag ccagtctgtc
     3841 tgtggagatt tcttgactcc ttggggactc tgagaactgt tcccaatatc agaagttccc
     3901 tcttgagttc tccttctttc agctctcggc atggccacag tgtgcgtctt ggtgggcagt
     3961 gccatgctgg agagcagatc tccgtgctgt ggggcccagg gggacctact taggagggga
     4021 tatgggagac tttattactg gtcatagtga cattgccctc accacaatcc ctctccaaag
     4081 tggtcgtctt tctttacctt gtgtcttctc ttgtaaaaat aaaactcaaa aataaaagtg
     4141 tcaaattaaa aagaaaaaaa aatggaaaaa gctaacacga actgtgtgaa gttgcataac
     4201 gctgtgacgc taacctgcaa tgtgtaatgc tatcttgtat gtggaccttg tcaatgcgcc
     4261 acacacgtgc agaataaaga ctgactcaga ctaaa
//
