LOCUS       NP_113855                429 aa            linear   ROD 30-MAR-2024
DEFINITION  synaptotagmin-11 [Rattus norvegicus].
ACCESSION   NP_113855
VERSION     NP_113855.2
DBSOURCE    REFSEQ: accession NM_031667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 429)
  AUTHORS   Shimojo,M., Madara,J., Pankow,S., Liu,X., Yates,J. 3rd, Sudhof,T.C.
            and Maximov,A.
  TITLE     Synaptotagmin-11 mediates a vesicle trafficking pathway that is
            essential for development and synaptic plasticity
  JOURNAL   Genes Dev 33 (5-6), 365-376 (2019)
   PUBMED   30808661
REFERENCE   2  (residues 1 to 429)
  AUTHORS   Stucchi,R., Plucinska,G., Hummel,J.J.A., Zahavi,E.E., Guerra San
            Juan,I., Klykov,O., Scheltema,R.A., Altelaar,A.F.M. and
            Hoogenraad,C.C.
  TITLE     Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM
            Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to
            Postsynaptic Sites
  JOURNAL   Cell Rep 24 (3), 685-700 (2018)
   PUBMED   30021165
REFERENCE   3  (residues 1 to 429)
  AUTHORS   Wang,C., Kang,X., Zhou,L., Chai,Z., Wu,Q., Huang,R., Xu,H., Hu,M.,
            Sun,X., Sun,S., Li,J., Jiao,R., Zuo,P., Zheng,L., Yue,Z. and
            Zhou,Z.
  TITLE     Synaptotagmin-11 is a critical mediator of parkin-linked
            neurotoxicity and Parkinson's disease-like pathology
  JOURNAL   Nat Commun 9 (1), 81 (2018)
   PUBMED   29311685
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 429)
  AUTHORS   Du,C., Wang,Y., Zhang,F., Yan,S., Guan,Y., Gong,X., Zhang,T.,
            Cui,X., Wang,X. and Zhang,C.X.
  TITLE     Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in
            microglia
  JOURNAL   Glia 65 (10), 1656-1667 (2017)
   PUBMED   28686317
REFERENCE   5  (residues 1 to 429)
  AUTHORS   Bento,C.F., Ashkenazi,A., Jimenez-Sanchez,M. and Rubinsztein,D.C.
  TITLE     The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate
            autophagy via a common pathway
  JOURNAL   Nat Commun 7, 11803 (2016)
   PUBMED   27278822
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 429)
  AUTHORS   Yeo,H., Kim,H.W., Mo,J., Lee,D., Han,S., Hong,S., Koh,M.J., Sun,W.,
            Choi,S., Rhyu,I.J., Kim,H. and Lee,H.W.
  TITLE     Developmental expression and subcellular distribution of
            synaptotagmin 11 in rat hippocampus
  JOURNAL   Neuroscience 225, 35-43 (2012)
   PUBMED   22960622
REFERENCE   7  (residues 1 to 429)
  AUTHORS   Cheng,Y., Sequeira,S.M., Malinina,L., Tereshko,V., Sollner,T.H. and
            Patel,D.J.
  TITLE     Crystallographic identification of Ca2+ and Sr2+ coordination sites
            in synaptotagmin I C2B domain
  JOURNAL   Protein Sci 13 (10), 2665-2672 (2004)
   PUBMED   15340165
  REMARK    GeneRIF: Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B
            domain were identified using high-resolution crystal structures.
            have identified
REFERENCE   8  (residues 1 to 429)
  AUTHORS   Huynh,D.P., Scoles,D.R., Nguyen,D. and Pulst,S.M.
  TITLE     The autosomal recessive juvenile Parkinson disease gene product,
            parkin, interacts with and ubiquitinates synaptotagmin XI
  JOURNAL   Hum Mol Genet 12 (20), 2587-2597 (2003)
   PUBMED   12925569
REFERENCE   9  (residues 1 to 429)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem J 354 (Pt 2), 249-257 (2001)
   PUBMED   11171101
REFERENCE   10 (residues 1 to 429)
  AUTHORS   von Poser,C., Ichtchenko,K., Shao,X., Rizo,J. and Sudhof,T.C.
  TITLE     The evolutionary pressure to inactivate. A subclass of
            synaptotagmins with an amino acid substitution that abolishes Ca2+
            binding
  JOURNAL   J Biol Chem 272 (22), 14314-14319 (1997)
   PUBMED   9162066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and BC094518.1.
            
            On Apr 20, 2007 this sequence version replaced NP_113855.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1109857.1,
                                           SRR26360194.394655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..429
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..429
                     /product="synaptotagmin-11"
                     /note="sytXI; synaptotagmin XI"
                     /calculated_mol_wt=48081
     Site            16..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08835.2)"
     Region          132..154
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08835.2)"
     Site            133
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9R0N3; propagated from
                     UniProtKB/Swiss-Prot (O08835.2)"
     Region          157..282
                     /region_name="C2A_Synaptotagmin-4-11"
                     /note="C2A domain first repeat present in Synaptotagmins 4
                     and 11; cd08388"
                     /db_xref="CDD:176034"
     Region          291..427
                     /region_name="C2B_Synaptotagmin-4"
                     /note="C2 domain second repeat present in Synaptotagmin 4;
                     cd08404"
                     /db_xref="CDD:176049"
     Site            order(321,327,381,383,388)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:176049"
     CDS             1..429
                     /gene="Syt11"
                     /coded_by="NM_031667.3:253..1542"
                     /db_xref="GeneID:60568"
                     /db_xref="RGD:62042"
ORIGIN      
        1 maeitnirps fdvspvaagl igasvlvvcv svtvfvwtcc hqqaekkhkt ppykfihmlk
       61 gisiypetls nkkkiikvrr dkdgshresg rgnllvnaes gllshdrdpr gpspascidq
      121 lpikrdygee lrspmtsltp geskptspss peedvmlgsl tfsvdynfpk kalvvtiqea
      181 hglpvmdgqt qgsdpyikmt ilpdkrhrvk trvlrktldp vfdetftfyg ipysqlqdlv
      241 lhflvlsfdr fsrddvigev mvplagvdps tgkvqltrdi ikrniqkcis rgelqvslsy
      301 qpvaqrmtvv vlkarhlpkm ditglsdpyv kvnvyygrkr iakkkthvkk ctlnpifnes
      361 fiydiptdll pdisieflvi dfdrttknev vgrlilgahs vttsgaehwr evcesprkpv
      421 akwhslsey
//
