LOCUS       NM_031666               7021 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus synaptotagmin 10 (Syt10), mRNA.
ACCESSION   NM_031666 XM_343316
VERSION     NM_031666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7021)
  AUTHORS   Cao,P., Maximov,A. and Sudhof,T.C.
  TITLE     Activity-dependent IGF-1 exocytosis is controlled by the
            Ca(2+)-sensor synaptotagmin-10
  JOURNAL   Cell 145 (2), 300-311 (2011)
   PUBMED   21496647
REFERENCE   2  (bases 1 to 7021)
  AUTHORS   Tucker,W.C., Edwardson,J.M., Bai,J., Kim,H.J., Martin,T.F. and
            Chapman,E.R.
  TITLE     Identification of synaptotagmin effectors via acute inhibition of
            secretion from cracked PC12 cells
  JOURNAL   J Cell Biol 162 (2), 199-209 (2003)
   PUBMED   12860971
REFERENCE   3  (bases 1 to 7021)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     A novel alternatively spliced variant of synaptotagmin VI lacking a
            transmembrane domain. Implications for distinct functions of the
            two isoforms
  JOURNAL   J Biol Chem 274 (44), 31428-31434 (1999)
   PUBMED   10531344
REFERENCE   4  (bases 1 to 7021)
  AUTHORS   Fukuda,M., Kanno,E. and Mikoshiba,K.
  TITLE     Conserved N-terminal cysteine motif is essential for homo- and
            heterodimer formation of synaptotagmins III, V, VI, and X
  JOURNAL   J Biol Chem 274 (44), 31421-31427 (1999)
   PUBMED   10531343
REFERENCE   5  (bases 1 to 7021)
  AUTHORS   Babity,J.M., Armstrong,J.N., Plumier,J.C., Currie,R.W. and
            Robertson,H.A.
  TITLE     A novel seizure-induced synaptotagmin gene identified by
            differential display
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2638-2641 (1997)
   PUBMED   9122248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000187.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_031666.3.
            
            On Oct 11, 2022 this sequence version replaced NM_031666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ437524.1, AF375463.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JACYVU010000187.1  7655079-7655362     c
            285-642             JACYVU010000187.1  7637003-7637360     c
            643-1210            JACYVU010000187.1  7624395-7624962     c
            1211-1331           JACYVU010000187.1  7605162-7605282     c
            1332-1503           JACYVU010000187.1  7603879-7604050     c
            1504-1633           JACYVU010000187.1  7600331-7600460     c
            1634-7021           JACYVU010000187.1  7592197-7597584     c
FEATURES             Location/Qualifiers
     source          1..7021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..7021
                     /gene="Syt10"
                     /note="synaptotagmin 10"
                     /db_xref="GeneID:60567"
                     /db_xref="RGD:62041"
     exon            1..284
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1705
                     /gene="Syt10"
                     /note="sytX; synaptotagmin X"
                     /codon_start=1
                     /product="synaptotagmin-10"
                     /protein_id="NP_113854.1"
                     /db_xref="GeneID:60567"
                     /db_xref="RGD:62041"
                     /translation="MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSG
                     QGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNVSTLPQSISS
                     APTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQR
                     QTTDPTSSSRHNSFRRHLPRQMNVSSVDFSMGTEPVLQRGETRTSIGRIKPELYKQKS
                     VDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLL
                     PDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVI
                     LDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKA
                     MDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCI
                     AVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSF
                     DSQGSCSSPRPPSTP"
     exon            285..642
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1210
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1331
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1503
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1633
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..7021
                     /gene="Syt10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagacctg gcagcagcgt ccgtcggcgc gcgccaccct cctgcgccct tgccaaccat
       61 ggggccaact cgcaactctt aaggctcagc ctcgggccaa gggaaatcag agaagctgcg
      121 agcagaagcc aagatgagtt tccgcaagga ggacggggtg agcagcctgt gccagaaggc
      181 gctgcacatc atcaccgagc tgtgcttcgc gggccaggtg gagtgggaca agtgttcggg
      241 catctttcca gccgatagga gcggccaggg cggaggtggc acagacattt cagtcagcct
      301 gttagcagtt gttgtaagct tctgtggcct ggccctgctg gttgtctccc ttttcgtctt
      361 ctggaagttg tgctggccct gctggaagag caagctcgtg gcccccaatg tcagtaccct
      421 tccgcagagc atctcaagtg ctccaactga ggtttttgag accgaagaga aaaaagaagt
      481 cgaagaaaat gaaaagccag caccaaaagc tattgagcct gcaataaaaa tcagccacac
      541 atcccccgac atcccagcag aagtgcaaac tgctttaaag gagcatttaa ttaaacatgc
      601 ccgtgtgcag aggcaaacga ccgatcctac atcttcatcc cgccacaatt ccttcaggag
      661 gcacctacca aggcaaatga acgtctccag tgttgacttt agcatgggca cggaacctgt
      721 cttacaaaga ggagaaacca gaaccagcat cgggaggata aaaccggaac tctataagca
      781 gaaatcagtt gactccgagg gcaacagaaa agacgacgtc aaaacctgtg ggaaacttaa
      841 ctttgcgctc cagtacgatt atgaaaatga actcctagtt gttaaaatta tcaaagctct
      901 agatctccca gctaaagatt tcacaggaac ttctgatcct tatgtgaaga tctatcttct
      961 tccggacagg aagaagaaat ttcagacccg tgtgcaccgg aagactttaa accctctgtt
     1021 cgatgagcta tttcagttcc cggtggttta cgatcagcta agcaaccgca aattacactt
     1081 tagtatatat gattttgaca gattttccag acacgacatg attggggaag tgattcttga
     1141 taatttattt gaagtctctg atctctccag ggaagccaca gtatggaaag atatccactg
     1201 tgcaaccaca gaaagcatag acctgggcga aatcatgttt tccctttgct atttgccaac
     1261 tgctggtcgc atgaccttga ctgtgatcaa gtgcagaaat ctgaaggcaa tggacattac
     1321 cggatcatca gatccttatg tcaaagtgtc tctgatgtgt gagggccgaa gacttaaaaa
     1381 aagaaaaaca actacaaaga aaaatactct caatcccgtg tacaatgaag ccattatttt
     1441 cgatatccct ccagaaaatg tggaccaggt cagcctgtgc attgcggtca tggattacga
     1501 cagggtggga cacaatgagg tcataggtgt gtgtcgaact ggactagacg ctgagggtct
     1561 tggaagagac cattggaatg aaatgctggc ctatcaccga aagccaatca cacactggca
     1621 ccccttgctg gagttacctg gccgagcaac cagttttgac agtcaaggat cctgctcttc
     1681 tcccaggcca ccgtccacac cataaaagcc tccaaataaa accacatcac agaaagacct
     1741 agaatcatgg gctcattgaa tcagaaacac atacacacag aaaacaccca tgcacaggac
     1801 atttggcttc ttcatttaaa atagacccat gataattaat aacttgatgc ataatttctt
     1861 ttggcttatg tgtttttaac tttgagttta ttaatacatt ctacttgagt actaatagtc
     1921 cttagttacc tatggcgttt aactttcatg tcttctctct actagcacag tgttttaata
     1981 tgttgtaatt ctttgcctaa gcaacaaaat aagatttttg agaagagaat ccacatgtat
     2041 gtaaaattaa atatagttta tgcctgtgtt gtgtgaaata gtgtaacgtg tcatctccaa
     2101 ccgtatatac atttctatct gaactttaat gtgcaaactt aaatcagttc aacagaatca
     2161 actccttcaa atcctaatta acatcacgtg tccaataata gtttttcttc catgatcagc
     2221 atttctgtca tcaaggtata tctctcaagc ttctgtttta gggacactca gctaagctgc
     2281 aaaatgaaga atcattttaa atataactgt acaacgtgac gttgagcgcc tggtaaacga
     2341 cgctatcagc ttccaatgtc ttaccattgc attagttaga ccggctgtac tgctgacgga
     2401 tagttttaaa acgcctagta atcttcacct ccagtgcagc ttgaggtatt cctaagtggc
     2461 tacagtcata agtttgtctt tcaaggttct ctagtactgt ggtgtgtctg tcctgtaact
     2521 tggagctgtc ctgcggctcc cgtgcttttg atggatcaca cttcatagaa accaaaggtc
     2581 cagtgaagct ctctgtgccc attgtccttt agatggacag gcgttgactc ctcccaccca
     2641 gaggctcatc actcatcgct agagctagac agactctcaa ggacaaaact tagatgcatg
     2701 ctataaacag tgcagctttc acgcttaata aaaataaatg catttcaaag gtccaaacag
     2761 tcagctcttt aatgaaagga aggattaatg atcagaccat tagaggttaa agaaaaaacc
     2821 caactatgca gatgcttttt ctttttacaa gatagaacgg tctttgaaat cagggcagct
     2881 ttttgctgtc tcgttttaag accctatcag aaggagccta agcagaatta taataacctt
     2941 gctttccagg tgtgcatatt taaagcttat tccacaataa ggtttctaaa agggaagaaa
     3001 atttatattt gaatttttaa aacaagttcg ttaggatgag aaagttttgt cacaaattat
     3061 gaaccttttt atatttgtaa aagtccctta tttcaaggga cttatatata tatataagaa
     3121 atatatattt aaagtcctgc aatttctctc ataaagattc agttgctgtt agccaggatg
     3181 ccagcacgtc tcattcatat ttatagcgta aactcagttc tacctaaagc tttgggataa
     3241 tggctgtgtc cagctaatga aaacatacta ctaaactttt tcttattaaa aataagagaa
     3301 acacatctga aaacacttga cagtcctgtc aaaacaaaac aaaataaccc tagacagtag
     3361 acatggatgt gtcatttctc aagtccacaa agtatgcatt ttcgctcaaa atgacatcat
     3421 acagacttac tccttgaaaa accacagcta atttcccaag gagaacaggc taaaccttct
     3481 taagcattta cgatgctgtg aaagaggtta aagagagtaa attcacaact gtctttcagt
     3541 taatatgtga gagacatttt ctcagagtga tgcacaaatt cattagaaca acagttcatt
     3601 gagagaaaat acactcctta cgggtcttac acagccacac acagaaattt ctctctgctt
     3661 gtgagctgtt aatctctcgg tgtttaaaat atggttccgt gttccagatc tgccgccctc
     3721 ccctcccccg actaacttgt ggaagggcac gtacgatgca ggtcaacgtg gcattcacta
     3781 aactgccaat gtcaaggatt cattcaggga cttaccacta tatgcatcta ggaaaaagat
     3841 tcagtgttgc cttgtgggcg ggacagcact gttgctaggt accgaatatg acagacacca
     3901 gtgtccggtg cccagtcatt tcagaaaacc agaagctgat tggtttagag tcttgatttt
     3961 cttcttcatt ggtgtcctac attggatttt agtccaaagg tccaggaatg atcactgctt
     4021 cctaatacac ttttcttaac agttcctgtt tcctttctca ggccaccctg tgttgctggc
     4081 actttacacg taaaactcac catagtcaga cacactcagt tcagtcgcaa atattaggac
     4141 aaatgacaga aaagtagtgg caggaagtgg agccaatcac atgcctacac gaagttcggc
     4201 gtgcactcgc tcgttactgc agggagctcg caaacgacta atactgtctc agggtttata
     4261 ttagagcaaa tgtatttgag ctacttggtt gcaatgttta agtgacattc acaactgtgc
     4321 ttactctcct ggtgtgttta ttcttttaaa agtttccagg gtcaataaag aactagcagt
     4381 ttcttgaagc ttaacagtta cttaacagtt cacttaacag ttacttcaga agttagaaaa
     4441 aaaatcaaaa tcccattctc atgcgaatcc tactatctat aaaacaaaat ataatttatt
     4501 ccaagatggg atgcccaagc agccaggaat tattacaata aagaagcata aaattataac
     4561 actgaacaca aatcaatttc ttctacctct tcaaaacaga cgacttgata tccttcttga
     4621 gcagaatttc tccgattttt gtcataatag ctgtgatatt actacaagtc agtttgtttg
     4681 caaatagtaa gaaaaccggg ttggtatggc tttaaaaaac cattaggttt agccattggt
     4741 taaatgtaaa gaaatgagac ctgtatcaca acttggtctt ctaacaatta cagatgttct
     4801 aagctgacat ggttggtttc agtgcttgta atttttagat taaaggaaga ctactgtcaa
     4861 caagtaggtt tttaaaagcc taagataatt taaataacca catatttatt ctaaaagata
     4921 ttaaagcata gaaaacaatc atatggagat gtaggaaaaa aaggaattcc ttcaaatttt
     4981 aactcttatt ggacagtaaa ttctcgaatg ttccaaaact ccatgactca gcatttaatc
     5041 gtcactcagt gacatagctc aggacatgat gtatatgaac ctgctgtgag gacctaatat
     5101 ttaggacaaa acgagtttaa tattttacac gagataaaga gccaactaaa taaaatactg
     5161 ttttcggaat gtaaatcctt ggtgttctct tagctaagaa ttttttcatt aaaagatcaa
     5221 tatttatcca atactatgtc agttaagatt aaggtaacta cttagcttcc actatgacaa
     5281 ttgactaaaa ccatacatat ttgaatagag gcattccata tttgatcaaa aatgtatttc
     5341 catcatagtg gttaaatcat tattttcttt tcttcctgtc tatcatgtaa ctaagtgaaa
     5401 gtttgctttg gtagcatgac agtgttacac tacagaaata gagaaatgca ctcagttaag
     5461 gaccaaggta agccttaatg ctttgcttaa agaaaacatt tgaatactaa aagtagtgac
     5521 tttaaaaaat aggtaaaaga tgtttaagag aaatgataat attttgtatg tctgagatga
     5581 ttaaatatac tcctcccagg ggaactattt ctataaatcc tatttttacc tctattgtga
     5641 caagaaatat gagctgctct tgataaattt atatggaagt gttttcatct caagcctatg
     5701 ataatttttg atgtagacta tgaaaccctt tccaaacagt gagactatgt ctgattttat
     5761 cacagagggt aaagtaaacc atggtcttct gacattttgt attttgttaa gttgcatcta
     5821 ctgtgtagag aattccctac ttgctgaaca taggattgag ttttagttat tcaacctcat
     5881 gaggtttttg tttcctgaaa ataatttctt gaatagcgat gcaaaactca ttaaggttaa
     5941 attagcttca atgctgcaaa gttaatgtgg gagggggggg gttagatttc ctgaggcttt
     6001 ccaaatagct tcttgtgtgc ctcatctgaa cactaaggaa atacgtttcc atgatttgct
     6061 gaaaattttg tgcaccccaa ataattctca tccccaagat tatgtaaaac aacaaaataa
     6121 tcattctgta gtaatattta tagaaaacat ttcatagata ggtttcatca agatttgctg
     6181 tttttcctgt aaagtccttt aagctttgca tttaaagaat atggtagtaa caatgtgaag
     6241 agttcactgc ataaagggga agcaggtaaa actcctatat gtaaaatatt tgcatttata
     6301 gcttcttcct taaacaaaga ggtacaacac ccaggttgtc aacattagct gtaattgacc
     6361 caacagagca atgactgggt tcacattcaa acatggagaa actacagagc attgaattca
     6421 gaatcaagat aagtcaatga gaaaagaatt gcctcccgtc ataaatgtga tgttcctcct
     6481 aactccttga caagtaggta gtcaccacat atactggtgg aaactgctaa cgttcttctc
     6541 gcagagcctc aggcaattta aatccatcat agttcatctt ctttggggta cttctaagtc
     6601 attgttctca gtgtaacctt ttaagtgaag ttcgtgattc acttcttagc cactgtttaa
     6661 atcagtacat tgacttctac tttctagaac agaaactgga gtcttgaaat ttgtgttcct
     6721 gacttttgta cggtgacagt cacttgtgaa ttttggcatc ttataatcat attacttaga
     6781 acagcttttc cgtaaaccct ctggaagatg tccgtgcatt gtgctttagc cttatttact
     6841 atgtcttctt tagagtgtac gaacacattc gtcaggatca gatgaattat gtaacaatga
     6901 aacctcaaag ctgttatgaa aggtagttca taattacttt tgtaaaagaa atggaaaagc
     6961 acttgaaata taattctact gtttcatatg tattttaaaa aaagaaataa agtcgttata
     7021 a
//
