LOCUS       NM_001191963            4092 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus synaptopodin 2 (Synpo2), mRNA.
ACCESSION   NM_001191963 XM_575030
VERSION     NM_001191963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4092)
  AUTHORS   Kai,F. and Duncan,R.
  TITLE     Prostate cancer cell migration induced by myopodin isoforms is
            associated with formation of morphologically and biochemically
            distinct actin networks
  JOURNAL   FASEB J 27 (12), 5046-5058 (2013)
   PUBMED   24005909
REFERENCE   2  (bases 1 to 4092)
  AUTHORS   Ulbricht,A., Eppler,F.J., Tapia,V.E., van der Ven,P.F., Hampe,N.,
            Hersch,N., Vakeel,P., Stadel,D., Haas,A., Saftig,P., Behrends,C.,
            Furst,D.O., Volkmer,R., Hoffmann,B., Kolanus,W. and Hohfeld,J.
  TITLE     Cellular mechanotransduction relies on tension-induced and
            chaperone-assisted autophagy
  JOURNAL   Curr Biol 23 (5), 430-435 (2013)
   PUBMED   23434281
REFERENCE   3  (bases 1 to 4092)
  AUTHORS   Kai,F., Tanner,K., King,C. and Duncan,R.
  TITLE     Myopodin isoforms alter the chemokinetic response of PC3 cells in
            response to different migration stimuli via differential effects on
            Rho-ROCK signaling pathways
  JOURNAL   Carcinogenesis 33 (11), 2100-2107 (2012)
   PUBMED   22915763
REFERENCE   4  (bases 1 to 4092)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 4092)
  AUTHORS   Linnemann,A., van der Ven,P.F., Vakeel,P., Albinus,B., Simonis,D.,
            Bendas,G., Schenk,J.A., Micheel,B., Kley,R.A. and Furst,D.O.
  TITLE     The sarcomeric Z-disc component myopodin is a multiadapter protein
            that interacts with filamin and alpha-actinin
  JOURNAL   Eur J Cell Biol 89 (9), 681-692 (2010)
   PUBMED   20554076
REFERENCE   6  (bases 1 to 4092)
  AUTHORS   Faul,C., Dhume,A., Schecter,A.D. and Mundel,P.
  TITLE     Protein kinase A, Ca2+/calmodulin-dependent kinase II, and
            calcineurin regulate the intracellular trafficking of myopodin
            between the Z-disc and the nucleus of cardiac myocytes
  JOURNAL   Mol Cell Biol 27 (23), 8215-8227 (2007)
   PUBMED   17923693
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575030.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.10032.1,
                                           SRR26643297.9434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000002.1  214055621-214055844 c
            225-376             JAXUCZ010000002.1  213948049-213948200 c
            377-1170            JAXUCZ010000002.1  213943971-213944764 c
            1171-3368           JAXUCZ010000002.1  213939414-213941611 c
            3369-4092           JAXUCZ010000002.1  213901685-213902408 c
FEATURES             Location/Qualifiers
     source          1..4092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4092
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /note="synaptopodin 2"
                     /db_xref="GeneID:499702"
                     /db_xref="RGD:1564779"
     exon            1..224
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..3908
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /note="myopodin"
                     /codon_start=1
                     /product="synaptopodin-2"
                     /protein_id="NP_001178892.1"
                     /db_xref="GeneID:499702"
                     /db_xref="RGD:1564779"
                     /translation="MGTGDFICISMTGGAPWGFRLQGGKEEKQPLQVAKIRSQSKASD
                     SGLCVGDEVVSINGNPCADLTYPEVIKLMESITDSLHLLIKRPTSGTSEALDSETENT
                     NHQHLPHGGPMESTTLQIQHAAKTQGKDFLLASVQTSAPRTEDQGNAWGYAECTTEDQ
                     VSQMPGSQEGHLVEEVILRKKPEAGQPGHVVELQLSLSKERQRCTSDPIVTLLGNEKF
                     KSPDPDWGTQHGRTVHINSIPAPEKADTSLTSGTTVQTSSGRELTVIQGRDPGGTGLP
                     QVEVILDCSDRLKAEECRLQAGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEQGEDQR
                     SGKDQGRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFK
                     KRRRRARKYTLVSYGTGELEREEEEEDQEAGDKDEISDLAFLGTSESEVDEELLSDVD
                     DNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEE
                     KTGGLAGGGSDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLGSVPQQNGFS
                     GVSETAGPQRMIPMNRTAKPFLGSVNQTAAPFSPTQSVTSPIPDFPAPPPYSAVSPPP
                     EAFSRGISSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEA
                     KRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGAGGDSGPEEDYLSLGAEACNF
                     MQSSAKQKTPPPVAPKPAVKTSSSSQPVAPVSPVWSPGVAPAQGPAFSTTNPPNPPQV
                     TAVSSIKIAQPTCPPARPASALNLAGPFKGPQAAVVSHNYTPKPSAPTPLVNAAPAGA
                     GGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSN
                     VRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNA
                     SLFTFQPPDSKDGLPQKSTVKVSSVAPAMKQALPPRQADIGSPTNAKASSVYSVPAYT
                     SQPNFFAEATSPVSASPVPVSVPTSPKQETTSTSYFVAPRPKFSAKKSGVTVQENWRS
                     LSLPGRAAPPIMSAPPWLCQPAYSYSSKPTLEQEKANKRPTPWEAAAKSPLGLVDEAF
                     RPRNIEESIVANVVSAARRKVFAGSQEDWKERLSFVPQTQKTSMSFSERREYNVPSPV
                     NSHVSSHSLYSSQLPYVCYRKESRNDLKAMSMDTRSEYCLPLGGYDYNPHPRGWRHQP
                     "
     exon            225..376
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1170
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..3368
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..4092
                     /gene="Synpo2"
                     /gene_synonym="RGD1564779"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggcagcc ttgcgtcctg cacgctccgc accagctaag cttaagacgc atcctctcct
       61 gcaccgcggc ttcgcctggc tttctcaagc tcttgatgct gcccagctga aaggagaaga
      121 tgggcaccgg agatttcatc tgcatttcca tgactggagg ggcgccctgg gggttcaggc
      181 tgcaaggagg caaggaggag aagcagccct tgcaagtggc aaagattcga agtcagagca
      241 aggcatcgga ctccgggctg tgtgttgggg atgaagtggt gtccatcaat ggtaaccctt
      301 gtgcagacct tacttaccct gaagtcatca aactcatgga aagcataacg gactccctcc
      361 atctgcttat taaaagaccc accagtggaa caagtgaggc tttggattct gaaacagaaa
      421 atacaaacca ccagcacctt ccacacgggg ggcccatgga aagtaccacc ctgcagatcc
      481 agcacgctgc caagacccag ggcaaagact tccttcttgc ttcagtccag actagtgctc
      541 cccgaactga ggaccaagga aatgcctggg gttatgcaga gtgtacaaca gaagaccaag
      601 tttcccagat gcctggctcc caagaaggac acttggtaga agaggtcatc ttaaggaaaa
      661 agccagaagc aggccagcca ggccatgtgg ttgagttaca gctgtccctc tcaaaggaaa
      721 gacagcgatg caccagtgac cctatagtga ctctcctggg aaatgaaaaa ttcaagtctc
      781 cagacccaga ctggggcacc caacacggga ggactgtcca cataaattca atccctgctc
      841 ctgagaaagc agacacttct ctgacgtccg gcaccacagt ccagacctcc agtggccggg
      901 agctgacagt gatccaggga agagacccag gaggcacagg gctgccccag gtggaagtga
      961 ttctagattg ctctgacagg ctgaaggctg aagagtgcag gctgcaggca ggaagggggt
     1021 gtgtggcttc tcccgtggaa ggagggcggt cagaagcacc tccttctctg gtctcctttg
     1081 cggtctcatc agaaggcacc gagcagggag aagatcaacg ctcgggaaag gaccagggca
     1141 gaccacacaa gcacagagcg aggcatgccc ggctcaggag gagtgaaagt ctgtctgaaa
     1201 agcaagtaaa agaagccaag tctaaatgca aaagcatcgc cctcctccta acggatgctc
     1261 ccaacccgaa ctccaagggg gtgttgatgt ttaagaagcg gaggcggaga gcccggaagt
     1321 acaccctagt cagttacggt actggagagc ttgagcgaga ggaggaagag gaggaccagg
     1381 aagcaggtga caaggacgag ataagtgacc ttgcatttct tggaaccagc gagtcggaag
     1441 tggatgaaga gttactgtct gacgtggacg acaacaccca agttgtgaac ttcgattggg
     1501 attctggact ggtggacatt gaaaagaggc tgaaccgagg cgacaagatg gagatgttgc
     1561 ccgacaccac aggcaaggga gcgctcatgt ttgccaagag gagagagagg atggaacagt
     1621 tcacagccca aaatgaagag gaaaagaccg gtgggctagc aggcggagga tcagatgccc
     1681 tacagacgga cggtctgaga accatgactt cttatcaaag aaaagaagaa tcggtgagaa
     1741 tgcagagctc tgtgagtgag agctccttcc agatgggacg cagtcttggc agtgtgccac
     1801 aacagaatgg cttcagtgga gtgtctgaga cagcagggcc ccagaggatg atccccatga
     1861 acagaaccgc caagcccttc ctgggatctg tgaaccagac agcggcccca ttctccccaa
     1921 cacagagtgt gacaagtccc atccctgact tccctgcgcc accaccatac tctgcagtct
     1981 cacctccacc agaagccttc tccaggggga tatcaagccc agttgctggc ccggcacagc
     2041 cccctccgtg gccccagcct gctccatggt cgcaaccagc cttctatgat tcttctgagc
     2101 aaatagcttc ccgcgatgag aggatcgcag tgccggccaa aagaacagga atactgcagg
     2161 aagccaaaag acgaggcaca acaaaaccca tgtttacttt caaagaaacc aaagtgagcc
     2221 ccaaccccga actcctgtcc cttcttcaaa atgcagaagg caagcgaggc actggagctg
     2281 gaggggactc cgggccagaa gaagactacc tcagtttagg cgcagaggct tgtaatttca
     2341 tgcagagttc tgccaaacaa aagacccctc ctcccgtcgc tccaaagcct gcagtcaaga
     2401 cctcctcttc ctcccaacca gtagcccctg tttctccagt ctggtctcca ggagtggctc
     2461 cagcccaggg tcctgccttc tctacaacaa acccaccaaa cccaccacag gtcactgctg
     2521 tgtcctccat caaaatagcc cagcctacct gccctccagc ccggcccgcg agtgcactga
     2581 acctggctgg tcctttcaaa ggtccccaag cagcagtagt cagtcataac tatacaccca
     2641 agccatcagc acccacacca ttagtaaatg ctgctcctgc tggtgccggg ggaccatcca
     2701 atgagcttcc tggaatgagt gggaaaggag cccaactctt cgctaaaagg cagtctagga
     2761 tggagaagta tgtggtagat tctgacacgg tgcaggccca cacagttcgg gcccagtctc
     2821 ctactccatc cctgcccgcc agttggaagt actcctccaa tgtccgagca ccgcctccgg
     2881 tggcctacaa tcctatccat tccccgtctt acccactggc tgctatcaag tctcagccac
     2941 cgggagccca ggcctccaaa acgagcaaga aaaagggcaa gaaacctctt aacactttgg
     3001 atgtcatgaa gcaccaacca tatcagctca acgcgtcttt gtttactttt caaccccccg
     3061 attcaaagga tggcctccct caaaagtcaa cagtcaaggt cagttcagta gcccctgcca
     3121 tgaagcaagc ccttcctccc cggcaggcgg atattggctc tcccacaaac gcgaaggctt
     3181 catctgtgta ttcagtcccg gcctatacct ctcagcccaa cttctttgcg gaggccacct
     3241 caccagtcag cgcatccccg gtgcctgtga gtgttcccac ctctccaaag caagaaacga
     3301 cctccacatc ctattttgtg gctccgaggc cgaagttctc agccaagaaa agtggtgtca
     3361 cagttcagga gaactggcgc tccctttctc tccccggaag agcagctccg cccatcatgt
     3421 ctgcacctcc ctggctgtgc cagcctgcct acagttactc cagcaaacca accctcgagc
     3481 aagagaaagc taacaagaga cctacacctt gggaggcggc ggccaagtcc cctctcggtc
     3541 tagtggatga ggccttcaga cccaggaaca tcgaggaatc cattgtggcg aatgtagtct
     3601 ctgcagctcg gaggaaggtg tttgcagggt cccaagagga ctggaaagag agactgtcct
     3661 ttgtccctca aactcagaag accagcatga gcttttctga aaggcgagag tataatgttc
     3721 catccccagt caacagccac gtgtctagcc actccttata tagctcccag ttgccatatg
     3781 tatgctacag gaaggagtcc agaaatgatt tgaaagcaat gtccatggac acgaggtctg
     3841 aatactgtct tccactaggt ggttatgact ataacccaca cccaaggggg tggagacacc
     3901 aaccatgaaa gcttgtgtga caaccgtgtg aattttgttg ttagtggcct ttgcagggtt
     3961 ctttacttta aaaatagact tcaatccact tttagtccta tgtggtcaca ggtcatttat
     4021 ctgagtgtac atgtgtgtaa acacacaagc gtggagcact tccttgtctg ctgatgccta
     4081 acgaactgct ag
//
