LOCUS       NM_021695               2678 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synaptopodin (Synpo), mRNA.
ACCESSION   NM_021695
VERSION     NM_021695.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2678)
  AUTHORS   Ribeiro,P.C., Lojudice,F.H., Fernandes-Charpiot,I.M.M.,
            Baptista,M.A.S.F., de Almeida Araujo,S., Mendes,G.E.F.,
            Sogayar,M.C., Abbud-Filho,M. and Caldas,H.C.
  TITLE     Therapeutic potential of human induced pluripotent stem cells and
            renal progenitor cells in experimental chronic kidney disease
  JOURNAL   Stem Cell Res Ther 11 (1), 530 (2020)
   PUBMED   33298161
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2678)
  AUTHORS   Konietzny,A., Gonzalez-Gallego,J., Bar,J., Perez-Alvarez,A.,
            Drakew,A., Demmers,J.A.A., Dekkers,D.H.W., Hammer,J.A. 3rd,
            Frotscher,M., Oertner,T.G., Wagner,W., Kneussel,M. and
            Mikhaylova,M.
  TITLE     Myosin V regulates synaptopodin clustering and localization in the
            dendrites of hippocampal neurons
  JOURNAL   J Cell Sci 132 (16) (2019)
   PUBMED   31371487
  REMARK    GeneRIF: Myosin V regulates synaptopodin clustering and
            localization in the dendrites of hippocampal neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2678)
  AUTHORS   Ji,C., Tang,M., Zeidler,C., Hohfeld,J. and Johnson,G.V.
  TITLE     BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau
            degradation via autophagy in neuronal processes
  JOURNAL   Autophagy 15 (7), 1199-1213 (2019)
   PUBMED   30744518
  REMARK    GeneRIF: The study provides evidence of a novel role for the
            co-chaperone BAG3 in synapses. In cooperation with SYNPO, it
            functions as part of a surveillance complex that facilitates the
            autophagic clearance of MAPT p-Ser262, and possibly other MAPT
            species at the post-synapse.
REFERENCE   4  (bases 1 to 2678)
  AUTHORS   Dorval,G., Kuzmuk,V., Gribouval,O., Welsh,G.I., Bierzynska,A.,
            Schmitt,A., Miserey-Lenkei,S., Koziell,A., Haq,S., Benmerah,A.,
            Mollet,G., Boyer,O., Saleem,M.A. and Antignac,C.
  TITLE     TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic
            Syndrome via Defective Trafficking Pathways
  JOURNAL   Am J Hum Genet 104 (2), 348-355 (2019)
   PUBMED   30661770
REFERENCE   5  (bases 1 to 2678)
  AUTHORS   Wang,L., Dumoulin,A., Renner,M., Triller,A. and Specht,C.G.
  TITLE     The Role of Synaptopodin in Membrane Protein Diffusion in the
            Dendritic Spine Neck
  JOURNAL   PLoS One 11 (2), e0148310 (2016)
   PUBMED   26840625
  REMARK    GeneRIF: Using single particle tracking we have identified a
            specific effect of synaptopodin on the diffusion of metabotropic
            mGluR5 receptors in the spine neck.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2678)
  AUTHORS   Asanuma,K., Kim,K., Oh,J., Giardino,L., Chabanis,S., Faul,C.,
            Reiser,J. and Mundel,P.
  TITLE     Synaptopodin regulates the actin-bundling activity of alpha-actinin
            in an isoform-specific manner
  JOURNAL   J Clin Invest 115 (5), 1188-1198 (2005)
   PUBMED   15841212
  REMARK    Erratum:[J Clin Invest. 2012 Feb 1;122(2):781]
REFERENCE   7  (bases 1 to 2678)
  AUTHORS   Deller,T., Korte,M., Chabanis,S., Drakew,A., Schwegler,H.,
            Stefani,G.G., Zuniga,A., Schwarz,K., Bonhoeffer,T., Zeller,R.,
            Frotscher,M. and Mundel,P.
  TITLE     Synaptopodin-deficient mice lack a spine apparatus and show
            deficits in synaptic plasticity
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10494-10499 (2003)
   PUBMED   12928494
REFERENCE   8  (bases 1 to 2678)
  AUTHORS   Yamazaki,M., Matsuo,R., Fukazawa,Y., Ozawa,F. and Inokuchi,K.
  TITLE     Regulated expression of an actin-associated protein, synaptopodin,
            during long-term potentiation
  JOURNAL   J Neurochem 79 (1), 192-199 (2001)
   PUBMED   11595771
REFERENCE   9  (bases 1 to 2678)
  AUTHORS   Deller,T., Merten,T., Roth,S.U., Mundel,P. and Frotscher,M.
  TITLE     Actin-associated protein synaptopodin in the rat hippocampal
            formation: localization in the spine neck and close association
            with the spine apparatus of principal neurons
  JOURNAL   J Comp Neurol 418 (2), 164-181 (2000)
   PUBMED   10701442
REFERENCE   10 (bases 1 to 2678)
  AUTHORS   Mundel,P., Heid,H.W., Mundel,T.M., Kruger,M., Reiser,J. and Kriz,W.
  TITLE     Synaptopodin: an actin-associated protein in telencephalic
            dendrites and renal podocytes
  JOURNAL   J Cell Biol 139 (1), 193-204 (1997)
   PUBMED   9314539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB769636.1, CB794090.1, AB013130.1, DY313339.1 and EV779156.1.
            
            On Oct 16, 2007 this sequence version replaced NM_021695.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN12840113 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               CB769636.1         57-355
            300-683             CB794090.1         42-425
            684-1418            AB013130.1         210-944
            1419-2115           DY313339.1         37-733
            2116-2366           EV779156.1         495-745
            2367-2678           AB013130.1         1893-2204
FEATURES             Location/Qualifiers
     source          1..2678
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2678
                     /gene="Synpo"
                     /note="synaptopodin"
                     /db_xref="GeneID:60324"
                     /db_xref="RGD:620668"
     exon            1..195
                     /gene="Synpo"
                     /inference="alignment:Splign:2.1.0"
     exon            196..2678
                     /gene="Synpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..2609
                     /gene="Synpo"
                     /codon_start=1
                     /product="synaptopodin"
                     /protein_id="NP_067727.2"
                     /db_xref="GeneID:60324"
                     /db_xref="RGD:620668"
                     /translation="MEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHL
                     SQNRETQQSSPNPPETEEVPSPAADINQNPSSPNATLTTAASNSHHNQPTADVNQNPP
                     ATITPVQQNSSETQCSPNGTLDSKPNTPSADDGQRPVPAEEVRSSILLIDKVSAPPSA
                     ASPFSREATPLSSSGPPAADLMSSSLLIGMQPSTLVASAEQEVSGHAAVTTPTKVYSE
                     VHLTLAKPASVVNRTARPFGMQSPGTTSQIEQSPMMGRRHFGEKAWAPPASSMADRSP
                     QPQRHIMARSPMVERRLVGQRSPVVERRPLGNFTPPPTYAETLSTAPVASQVRSPPSY
                     STLYPSSDPKPPHLKGQVVPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDL
                     VQTADEKRRQRDQGEVGMEDEPFALGAEASNFQQEPIARDRSGPAAAEETVPEWASCL
                     KSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSL
                     PSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPHQMRPSLYA
                     LSPVKEPAKISSRATSSRASSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPS
                     RSSPGLYNAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEA
                     QVWKPSFCFK"
ORIGIN      
        1 tgcccgccca gcgcccgcgg ctcccgcttg ggtccccttc agcctctagc ggctaggacc
       61 tcgcttaggg cgctgagtgg gcgccgccgc tgggcggggt gcagggatct cggggcgggg
      121 ctcacgcatg gacgtagcca ggtgagccaa ggcggcggcg cccgggagct cggggaccgc
      181 gcacggctgc tggagctttg ggccggagca ccagcttcac agaaaaggat ctgaaggagg
      241 ccaaggagag gagccagcgg attgcagccc agctcaccac ccctcccagc tccaactccc
      301 gaggggtcca gctcttcaac aggcgcaggc agagggtgaa cgagttcacc ttggagagcc
      361 gaggccagag gtcaccaaag ctcagccaag aggcccttca aacagggcat ccttccagcc
      421 ccataggcca tgccccaggg cttagtgtga atcctacctc tccatcgaag ccaggctctc
      481 caaagcactc cagctcccaa agccccagcc gaggggtccc tggccacatc atggaggggt
      541 actcagagga agccagtctg ctgcggcacc tggagaaggt tgccagtgag gaggaagaag
      601 taccattggt agtttactta aaggagaatg cagccctgct gacagctaat ggactgcacc
      661 tgtcccagaa ccgagagacc cagcagtcct caccaaaccc tcctgaaacg gaggaagtgc
      721 ccagcccagc tgcagatatc aaccagaacc cctcctctcc caatgccacg ctcaccacag
      781 cagcctctaa cagccaccac aaccaaccca ccgctgatgt caatcaaaac cccccagcca
      841 ctatcacccc tgtccaacaa aattcatctg agacacagtg ttccccgaat ggcacgcttg
      901 attccaaacc caacactcca agcgctgatg atgggcagcg cccggtgcca gcagaggaag
      961 tgaggtccag cattctcctg attgacaagg tgtccgctcc accatctgcc gccagcccct
     1021 tctctagaga agctactccc ctctccagct ctgggccacc agctgcagat ctcatgtcca
     1081 gctctctgct cattggcatg cagcctagca ccctagtggc atcagcagaa caagaggtgt
     1141 ctggacatgc agctgtcacc acgcccacta aggtgtatag tgaagtacat ctcacactag
     1201 ccaagcctgc atccgtggtc aacaggaccg ccaggccatt tgggatgcag tcgccaggga
     1261 ctaccagcca gatagagcaa agtcccatga tgggaagacg acattttgga gagaaggcct
     1321 gggctccccc agctagcagt atggcggata ggagtcccca gccacagagg cacataatgg
     1381 cccgcagtcc catggtagaa aggaggctgg ttgggcagcg aagcccggtt gtagagagac
     1441 gccccttagg aaactttacc ccacccccca cctatgcgga gactttgtca acagcccccg
     1501 tggcttccca ggttaggtct cctccctctt attctactct gtatcccagc tctgacccca
     1561 agcctcccca tttgaagggc caggtagttc ctgccaacaa gacaggaatt ttggaagaat
     1621 ctatggcacg ccgaggcagc cggaaatcaa tgttcacgtt cgtggagaag cctaaggtga
     1681 cgccgaatcc agacttgctg gacctcgtgc agacagctga tgagaagcgg aggcagagag
     1741 accaagggga ggtgggcatg gaagacgagc cctttgccct gggagctgag gcctccaact
     1801 tccagcagga gccaatagct cgggacaggt ccggccctgc ggcagctgag gagactgtcc
     1861 ctgaatgggc ttcctgcctc aagtcacccc gtatccaggc taagccgaag cccaaaccca
     1921 accagaatct ctcagaggcc tcagggaagg gggctgagct ctatgcccgc cgccagtcac
     1981 ggatggagaa atacgtcata gagtcgtcag gccatgcgga attggctcgc tgcccttcac
     2041 ctactatgtc attgccttca tcctggaagt acaccactaa tgcccctggg ggcttccgag
     2101 tggcgtcctt aagcccagcg cggactccgc ctgcctctct ctaccacggc tatctgccag
     2161 agaatggagt cctgcgccca gagcctacca agcagcagcc acaccagatg aggccttcac
     2221 tctatgctct gtcgccggtc aaggaacctg ccaagatctc atcacgtgcc acctcgtcac
     2281 gcgcttcgtc acgcactgtc tcacctcgtg ctgcctcccc ggccaagcct agctccctgg
     2341 acctggtgcc caacctgccc agagcaggcc tcccaccgtc tcctgcgctt cctcggcctt
     2401 cccgctcctc cccaggcctc tacaatgccc cagtccagga cagcctccag cccactgccg
     2461 tgagccccac ctacagcagt gatatctccc ccgtgtctcc ctccagggcg tggtctcctc
     2521 gagccaagca ggcccccagg ccttccttct ccacccggaa tgctgggatc gaggcccagg
     2581 tgtggaaacc ttccttctgc ttcaagtaac acatcccagt gcctgtcttg tccccccttt
     2641 cggagggcca gagagaagat gtggcaggat ctagctca
//
