LOCUS       NM_022599               5811 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus synaptojanin 2 binding protein (Synj2bp), mRNA.
ACCESSION   NM_022599
VERSION     NM_022599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5811)
  AUTHORS   Adam,M.G., Berger,C., Feldner,A., Yang,W.J., Wustehube-Lausch,J.,
            Herberich,S.E., Pinder,M., Gesierich,S., Hammes,H.P., Augustin,H.G.
            and Fischer,A.
  TITLE     Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1
            and DLL4 and inhibits sprouting angiogenesis
  JOURNAL   Circ Res 113 (11), 1206-1218 (2013)
   PUBMED   24025447
REFERENCE   2  (bases 1 to 5811)
  AUTHORS   Serasinghe,M.N. and Yoon,Y.
  TITLE     The mitochondrial outer membrane protein hFis1 regulates
            mitochondrial morphology and fission through self-interaction
  JOURNAL   Exp Cell Res 314 (19), 3494-3507 (2008)
   PUBMED   18845145
  REMARK    Erratum:[Exp Cell Res. 2009 Mar 10;315(5):899]
REFERENCE   3  (bases 1 to 5811)
  AUTHORS   Liu,Z.H., Tsuchida,K., Matsuzaki,T., Bao,Y.L., Kurisaki,A. and
            Sugino,H.
  TITLE     Characterization of isoforms of activin receptor-interacting
            protein 2 that augment activin signaling
  JOURNAL   J Endocrinol 189 (2), 409-421 (2006)
   PUBMED   16648306
REFERENCE   4  (bases 1 to 5811)
  AUTHORS   Cestra,G., Toomre,D., Chang,S. and De Camilli,P.
  TITLE     The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of
            multiple regulatory mechanisms converging on the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 102 (5), 1731-1736 (2005)
   PUBMED   15659545
REFERENCE   5  (bases 1 to 5811)
  AUTHORS   Matsuzaki,T., Hanai,S., Kishi,H., Liu,Z., Bao,Y., Kikuchi,A.,
            Tsuchida,K. and Sugino,H.
  TITLE     Regulation of endocytosis of activin type II receptors by a novel
            PDZ protein through Ral/Ral-binding protein 1-dependent pathway
  JOURNAL   J Biol Chem 277 (21), 19008-19018 (2002)
   PUBMED   11882656
REFERENCE   6  (bases 1 to 5811)
  AUTHORS   Nemoto,Y., Wenk,M.R., Watanabe,M., Daniell,L., Murakami,T.,
            Ringstad,N., Yamada,H., Takei,K. and De Camilli,P.
  TITLE     Identification and characterization of a synaptojanin 2 splice
            isoform predominantly expressed in nerve terminals
  JOURNAL   J Biol Chem 276 (44), 41133-41142 (2001)
   PUBMED   11498538
REFERENCE   7  (bases 1 to 5811)
  AUTHORS   Nemoto,Y. and De Camilli,P.
  TITLE     Recruitment of an alternatively spliced form of synaptojanin 2 to
            mitochondria by the interaction with the PDZ domain of a
            mitochondrial outer membrane protein
  JOURNAL   EMBO J 18 (11), 2991-3006 (1999)
   PUBMED   10357812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF260258.1 and JAXUCZ010000006.1.
            
            On Oct 14, 2005 this sequence version replaced NM_022599.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, Sprague-Dawley and BN/SsNHsdMCW, because no
            single transcript from the same strain was available for the full
            length of the gene.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF260258.1, SRR26643294.26152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1058              AF260258.1         1-1058
            1059-5811           JAXUCZ010000006.1  106920970-106925722 c
FEATURES             Location/Qualifiers
     source          1..5811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..5811
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /note="synaptojanin 2 binding protein"
                     /db_xref="GeneID:64531"
                     /db_xref="RGD:69400"
     exon            1..148
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..522
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /note="NPW16; mitochondrial outer membrane protein 25"
                     /codon_start=1
                     /product="synaptojanin-2-binding protein"
                     /protein_id="NP_072121.2"
                     /db_xref="GeneID:64531"
                     /db_xref="RGD:69400"
                     /translation="MNGRVDYLVSEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYV
                     SRIKEDGAAARDGRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLPV
                     QNGPIVHRGDGEPSGVPVAVVLLPVFALTLVAVWAFVRYRKQL"
     exon            149..285
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /inference="alignment:Splign:2.1.0"
     exon            286..381
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /inference="alignment:Splign:2.1.0"
     exon            382..5811
                     /gene="Synj2bp"
                     /gene_synonym="Omp25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggcgg cacggagctt gattcacctt cacctgcgcc gggcacccgc tgaccccggg
       61 tttccgcccg gagagcagtc agatatgaac ggacgggtgg attatttagt ctccgaggaa
      121 gagatcaacc tgaccagagg accctcgggg ctgggcttca acatcgtcgg tgggacagat
      181 caacagtatg tctccaatga cagtggcatc tacgtcagcc gcatcaaaga ggatggggct
      241 gcggcccggg atgggcggct ccaggagggt gataagatcc tctcggtaaa tggccaagac
      301 ctgaagaacc tgttgcacca agatgccgta gacctcttcc gtaatgcagg atatgccgtg
      361 tccctgagag tgcagcacag gttaccagtg cagaatggac ctatagttca tcgaggcgac
      421 ggagagccga gtggagttcc tgtagctgtg gtgctgctgc cagtgtttgc ccttaccctg
      481 gtagcagttt gggccttcgt gagataccga aagcagctct gagatgcctg ttgtcttcca
      541 gtgtgtccga tgagctaact atctctctca ctcaccatct cgacatcctc ccctagtctt
      601 ccttcccaca tagccaacac atgatttaaa gtgactgctt atcacccgaa accttgctgt
      661 tcaaaatctc caagacttca cattctaatg gaagagtaaa gagattattt gaagaaagct
      721 gggggtgggg agagccttgc ttagaataaa tgagaagtta catattttac tagaactgcc
      781 aataaaaatt cagctatcag ccaaagagga gaagcttgct cttcctgtct ccatggacga
      841 caccttttgc ttagctggtg tgctttgaag gctagctgtg ctatgtgaaa ggaggagctg
      901 attttttaaa tactttttct tgggaagtat ttgtggcctt taatttgtaa ctatatactt
      961 agatgcctat attggacata ggcgaatgaa tttttttctt ttcttagaaa agaaaataca
     1021 tatatacact aacacacaca cacacacaca cacacacagc ataaaactga tgccttatgg
     1081 agagttaaag aggtgagaaa actactggtt cttggatttc tagtggacaa gttttgggaa
     1141 ctagggggtc atattccttt atatataatc aaaactcata ttaaagaatg agttctggat
     1201 tgtaaagaga acttactttt tccacttgtc tgtaagtctt tgtccacaag ttaaaaacat
     1261 acacagtcct aagggctgat cataactgaa acacttcaaa aattattggc agagaaggta
     1321 taacggggat ggaaaagtta gctttaaaag agaatgctca gtcagtggca ttaggaaaat
     1381 aatgactgaa gcaattagtt gaaaactgta gaacaactag tgttccaggg tagctacagt
     1441 gatgtgggaa attgtggcaa agcagttctt ctcaagtcaa tttgtttaaa agactttggg
     1501 gtgtaaagat gagtcctgac agtctctgaa tgaccttagt gactgttgta ctatgtgaaa
     1561 ggatccattg gcatggagat gagaagtagg agggccaaat aaaccatcaa gacaactgaa
     1621 aaaagatcat acctcagggt ggcacttgaa ccctcaaagt gctcaccaac tttcagtttc
     1681 tagtatcagg caaagcctaa gggaagggac tgctttcctg gcagggtgga ccccaaatca
     1741 gcctgcttct gatagagtta cgatgagaag gcccaaattg atgtaggctt tctttttgtg
     1801 tatttttccc aaagctataa gcactagttt tggttttaat aaggtaatgg accatttttt
     1861 cagaaaaagg ggaaggaata aggtttgttt gtttatagag ggtgcaagga agtttagtga
     1921 gcatttctga ggaaagcctg agcacacaga gtagattaac tatgccagag aatagccagg
     1981 gatattgggg ggtggggggt agtggagctg tcctgtttat gtagcatcaa agttggtttt
     2041 agagtactga ggatagttga accaagccta attttttttt tcactttaac aaaataattt
     2101 ccgtcttttc aataaattgg ccagactatt ttgacctaag attataaaga gttttcctga
     2161 caacctagca gtcacttaac agatgtcgat tgcacattag ttttgtcaag acacctttat
     2221 aacaaaggga aatgcacaca cttcatccaa aaggacattg tggttacagt taggaagaaa
     2281 acacttaaga tggaattatc catgtaagtg taagttgttt atattacaga caacaaaaga
     2341 aaatagctcc caagctttga gcactgaaga tctcagagga aggactcctt aggtgccaat
     2401 cgtctagcaa gcatgcatac ataggggaca agttaagagt cttaccgggt tgagtaagaa
     2461 aaggaaacta ttgccatgcg agacagagca cgatgcagca atgtggagga tgagcagaca
     2521 gctagcatgt tgtaaggagc tcagaacggg agagccttcc tgcagtggca tcgggggaga
     2581 atgcaaagga aagtcttgaa cagtccagtg agcctttgcc tctggataaa ctgttgatac
     2641 agggagacat ttgctttaaa cagtcttcac ataaccaagc cattcagtac ttcttgaaac
     2701 tgacttcata acaggagtca ttgtaagttc cacagaaagc aagacgtatg tatttcagtt
     2761 cttgtcttga ccagcagcac tccggaggcc cagtgtccgg tgccctcctt gtatctgaag
     2821 caggggtaac agctctgctg tgggcctgtt tccctctagt atttacctca aggcttggaa
     2881 atgtattttg aaagaccttc agtcaaacga agtaaagcaa atgtcaagaa ggataaacca
     2941 ctgttgtgtg ttgatgtgtg gtgtattgtg atataaataa aaaatatcgt tgaagtttta
     3001 ctttgtaaag attctggtaa cacttgggtc tccttgggaa agaaacaaca cttgaccaaa
     3061 gcatttaagt tttaggcaaa ttccataata tttcactctt agttataaaa ttatcataca
     3121 tgagatgttg aggatctata tagattattc agattttata ttccttatag attgactcaa
     3181 atattcctta aaagattata tatgatgctc ctatggcata aattgtaatg tttaatgttt
     3241 tgaaaattgg ttataggtat tttttaagtt cccataaagt gtttcttgta tttgtcattg
     3301 tgaattatat gtaattctaa tagatattgt ttgctttagt catttttgtc tccttttcct
     3361 atagtttcct gtgtgagtga ttccatgtaa ttaattggac tgtctagcca caggcaacaa
     3421 atagaagtag tatttgtaat tgcagcctgt gccagggact gtgttagact gattagtaac
     3481 actatgaatc acccgagatc ttaagtattg ctataaagag aagactgaag atgagagagt
     3541 aaagtatttt cctgggatta tatagttggt aaaaaagaat catgatttaa actctggact
     3601 ttggataaaa gtatcagtaa ttttcctcat tgctagcagt cctcatgcaa ggtctctgga
     3661 ctaaagcgat gtattacctg caaatgcttg agtttcatcc catacttatg gcgtgaggtg
     3721 agtgtggcag ccagcatctc tgtcctccta ggtaactggt tagtgctgaa cctcgagatt
     3781 caccactgtc aggagctgtc tctgcttaga atcacctgga cagctggctg tcaacccacg
     3841 ttaagtaaga acatgtggga ctagaattca gtcaacaata aaagctttca tcaggtggct
     3901 aaaatgtgca gactctgttt gtactggcat gttggccatc actcacagat gcaactctag
     3961 ccagaatcaa gaatggggca gatccagagc ccagctcgct gagcttctgc cccagatttc
     4021 agaggcagag taagaagtgg aacagtgttt tcctcccagg tgctcaggac aggctggtca
     4081 acttccagtc acatatgcca tttagtaagt gcttcggcct gtgcagccat tagtaaccaa
     4141 atcatgggat agtgaatcta aaatactctt ggataaaatt tgtattagaa ttaaaaaaaa
     4201 atgagggtca gaaaggtgaa ctaactccaa cttagatgcc cctccccttt attttggtct
     4261 caaatctgtt ttaatgtgtc cacaacatta atcaaaaact gtattttttt tttcggagct
     4321 ggggactgaa cccagggcct tgcgcttgct aggcaagcgc tctaccactg agctaaatcc
     4381 ccaaccccca aaactgtatt ttaaaaatca gttcactttc atcttttttt ccttgggttt
     4441 tcagtaaaga ccagaaggac tgacagacag ctagagaggt tgtgtagaca tccagatggg
     4501 gagagtgcat tggacaatct gagaaatcta ttcaggtgct gcctaattcc attagcttta
     4561 agttagatac aagctgtttg tagtattttg ggttttattg tgcaaataaa caatagaggc
     4621 ctttagtccc agcgttagga tgcagaggca gaagaaggca gatctctgag aaggaagcca
     4681 gaaatggatc tctgtctccc cctcccttct ctcccctccc ctccctccct ctgtgtgtga
     4741 gtataatcaa taaggatttt atcctaccta ctttcaatgg aacgtatctt tttgcagata
     4801 ctgttttttt tcttcattga taactatcaa cactagtaga gaaaatacaa agataaaatt
     4861 tagtcactga gctgaaatag cttagcatct gagagtgggt gatctttaat gtatcttttg
     4921 aacatcactg aagaagtaaa gtgtttgagt tcttaagctc tctcaaagta gattcagggt
     4981 tgactgttat cctaggctaa tccttctttg ctgttccttt taactgcaga acttttattg
     5041 agaccaaccc tcacctcaca gtgcagttat gattttttta ataaaagaca atcttttaaa
     5101 gaattttgcc cagtgggcat gagattctga actgccatta actcttgtgt tgataactgt
     5161 atagagaata cacagcactc gactacctga tgcacttaat acaaagtttg tcagaaagca
     5221 ttgctgatga aaagtctagc attctgaaat gccagtgcct ctaactaaat tcccctcatc
     5281 gttccctcat tacacgggag aaagggaggg gaagaggact agtaaaggct ttcagtgcag
     5341 ttttgttact tgtcagcaga gtgatttgca aaagaacttc gtaatgtatt gactagtcac
     5401 aggaaaatgg gatgatcctc ttcagtgttg gcaggtttgc acgtgaagac acggcactga
     5461 gtccagtttt aacgctgtgt ttctaatcct gcttgaacat gagtttgtta ttactggatt
     5521 cttgtacacc ttcgaggctt ttcagttctt ggaacattat tttcgtgaag taccttatgt
     5581 tgtttccttt ctgctctgat tcttatgtcc ccttgcatcc ctgtatgtaa acagtcactg
     5641 tttcacaggt tagatgcctg agagctactt ggaaatcaag taaaaatcaa tcacatttgc
     5701 taggaattat catcaccaat gcatcagtga tcctgtttca agctcactga taccagtgtg
     5761 tccagatttg cctcttgaac tatgacattc aataaagacc tgttgaactt g
//
