LOCUS       NM_001113371            4985 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synaptojanin 2 (Synj2), transcript variant 1,
            mRNA.
ACCESSION   NM_001113371
VERSION     NM_001113371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4985)
  AUTHORS   Nemoto,Y., Wenk,M.R., Watanabe,M., Daniell,L., Murakami,T.,
            Ringstad,N., Yamada,H., Takei,K. and De Camilli,P.
  TITLE     Identification and characterization of a synaptojanin 2 splice
            isoform predominantly expressed in nerve terminals
  JOURNAL   J Biol Chem 276 (44), 41133-41142 (2001)
   PUBMED   11498538
REFERENCE   2  (bases 1 to 4985)
  AUTHORS   Nemoto,Y. and De Camilli,P.
  TITLE     Recruitment of an alternatively spliced form of synaptojanin 2 to
            mitochondria by the interaction with the PDZ domain of a
            mitochondrial outer membrane protein
  JOURNAL   EMBO J 18 (11), 2991-3006 (1999)
   PUBMED   10357812
REFERENCE   3  (bases 1 to 4985)
  AUTHORS   Kudo,M., Saito,S., Sakagami,H., Suzaki,H. and Kondo,H.
  TITLE     Localization of mRNAs for synaptojanin isoforms in the brain of
            developing and mature rats
  JOURNAL   Brain Res Mol Brain Res 64 (2), 179-185 (1999)
   PUBMED   9931483
REFERENCE   4  (bases 1 to 4985)
  AUTHORS   Khvotchev,M. and Sudhof,T.C.
  TITLE     Developmentally regulated alternative splicing in a novel
            synaptojanin
  JOURNAL   J Biol Chem 273 (4), 2306-2311 (1998)
   PUBMED   9442075
REFERENCE   5  (bases 1 to 4985)
  AUTHORS   Nemoto,Y., Arribas,M., Haffner,C. and DeCamilli,P.
  TITLE     Synaptojanin 2, a novel synaptojanin isoform with a distinct
            targeting domain and expression pattern
  JOURNAL   J Biol Chem 272 (49), 30817-30821 (1997)
   PUBMED   9388224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY034051.1, CK653289.1, U90312.1 and BI290811.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY034051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3768              AY034051.1         1-3768
            3769-4013           CK653289.1         403-647
            4014-4964           U90312.1           4083-5033
            4965-4985           BI290811.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..4985
                     /gene="Synj2"
                     /note="synaptojanin 2"
                     /db_xref="GeneID:84018"
                     /db_xref="RGD:69436"
     CDS             1..4491
                     /gene="Synj2"
                     /EC_number="3.1.3.36"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2"
                     /codon_start=1
                     /product="synaptojanin-2 isoform 1"
                     /protein_id="NP_001106842.1"
                     /db_xref="GeneID:84018"
                     /db_xref="RGD:69436"
                     /translation="MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAP
                     EEKEVIKGLYGKPTDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGT
                     EFYPLQEEAKEEDRLPALKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDCSEWGTSF
                     FWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARF
                     LTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRG
                     LEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMIN
                     FDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCLDR
                     TNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEG
                     KAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALL
                     GLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNL
                     LGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMW
                     GEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNK
                     GAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFW
                     CGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYK
                     YDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSP
                     GTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVIVNLQ
                     SPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMK
                     VKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGD
                     VLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALAKKKQHPTYKDDAD
                     LMTLKLELEVAGNFRHRSPSRSLSVPNRPRPPHPPQRPPPPTGLMVKKSASDASISSG
                     THGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGG
                     VPESAPGATPLRNQGSSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKPMLSEEQCE
                     QQPVHFTMASQEMNLETPPPITAPIPPVPKPRTFQPGRGVERRPSGGKPEPDDAPPVT
                     GAVELSSPEAPEAPSLAPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTCSSSSPSPPK
                     PDTPLLYPQMALGTSSAISPETDGPRVTEPEAASFHGDYPDPFWSLLHHPKLLNNNTW
                     LSKSSEPLDLGSRTPERTHTDSAQVNASVVERGLPPDHGGKDFSHWMAASNKDKRTTL
                     GV"
     exon            1..127
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..214
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            215..485
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..711
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..795
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..857
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..954
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1127
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1209
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1359
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1525
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1576
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1768
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1850
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1991
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2184
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2343
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2500
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2618
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2837
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2916
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3085
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3253
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3388
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3501
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3610
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3759
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..4982
                     /gene="Synj2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgctga gcaaagggct gcgactgctg gcgcggctgg accccaccgg cccgagcagc
       61 gtgctgctgg aggcgcgggg ccgcggcgac tgtctactct ttgaggccgg cgcggtggcc
      121 acgctggctc cggaagagaa ggaagtcatt aaaggactgt atgggaagcc gacggatgcc
      181 tatggctgcc tcggggagct gagtttaaaa tccggtggcg tccccttgag ctttctggtg
      241 ttggtgacag gctgcacgtc agtgggcaga attccagatg cagagatcta caaaatcact
      301 ggcactgagt tttaccccct gcaggaagag gccaaggaag aggaccgcct gccagccttg
      361 aagaaaatcc tgagttcagg ggtgttctat ttcgcatggc ccaatgatgg cgcctgcttc
      421 gatctgacca tcagggctca gaaacagggt gatgactgct ctgaatgggg gacctccttc
      481 ttctggaacc agctattgca tgtgcctctg cggcagcacc aggtgaactg tcatgactgg
      541 ttgctgaaag tcatctgtgg ggtggtgacc atccgcacgg tttatgcctc ccacaagcag
      601 gccaaggcct gtctcatctc tcgcatcagc tgtgaacgcg caggtgctcg cttcctcacc
      661 cggggtgtga acgacgatgg ccacgtgtcc aactttgtgg agacagagca ggcgatttac
      721 atggatgatg gagtgtcgtc ctttgtccag atccgaggct ccgttccgct gttctgggag
      781 cagccagggc tccaggttgg ctcccatcat ctgagactgc acagaggcct agaggccaac
      841 gcccctgctt ttgaaaggca catggtgctt ctgaaggagc agtacgggca gcaggtggtg
      901 gtgaacctgc tgggaagcag aggcggtgag gaggtgctca acagagcctt caagaagttg
      961 ctctgggctt cttgccacgc aggcgacacg cctatgataa attttgactt ccatcagttt
     1021 gccaaaggta ggaagctaga gaaattggag aacctgttga gacctcagtt aaaactacac
     1081 tgggatgact ttggcgtatt tgcgaagggc gagaatgtaa gtccacggtt tcagaaaggc
     1141 actctgcgga tgaactgtct cgactgtctg gacagaacca acactgtaca gtgcttcatt
     1201 gctcttgagg tgcttcatct gcagcttgag agcctagggc tgaattccaa gcccatcact
     1261 gaccgcttcg tggagtcctt caaagccatg tggtctctga atgggcatgg cctgagcaag
     1321 gtgttcacag ggagcagggc cctggaagga aaggccaagg tggggaagct gaaggatggg
     1381 gctagatcca tgtctcgtac catccagtcc aacttcttcg acggggtgaa gcaggaggcc
     1441 atcaagctac tgctagttgg agatgtctac aatgaagagt ctacagacaa aggcaggatg
     1501 ctgctggaca acacggccct tctgggtttg gggtcaaata aacaaaacag tctttcaggc
     1561 atgctggatg gaaaagcaac acccaggatc ctgaaggcca tgacagaacg ccagtcagaa
     1621 ttcacaaatt tcaagcggat ccagattgct atggggacct ggaatgtgaa cggaggaaaa
     1681 caattccgta gcaatctcct ggggaccact gaactcactg actggctcct ggatgcaccc
     1741 cagctctcag gagcagtgga ctctcaggac gatggcggtc ccgctgacat atttgccgtc
     1801 gggtttgagg agatggtgga gctgagtgca ggaaatattg tcaatgccag caccaccaac
     1861 aggaagatgt ggggtgagca gctccagaaa gccatctccc gatcccatcg gtacatcctc
     1921 ttgacctcag cacagctggt gggcgtctgt ctttacatct ttgtacgtcc gtaccacgtc
     1981 ccgttcatca gggatgtggc catcgacacc gtgaagaccg gtatgggggg aaaggcaggg
     2041 aataagggcg ccgtgggtat ccgctttcag ttccacagca ctagcttctg cttcatctgc
     2101 agtcacctga cggctgggca gtctcaggtg aaggagagga acgaagacta ccgggagatc
     2161 acgcacaagc tctccttccc ttcggggaga aacatatttt cacacgatta tgtgttttgg
     2221 tgtggcgatt tcaactaccg catcgatctt acttacgaag aagtcttcta ttttgttaaa
     2281 cgccaagact ggaagaaact tatggaattt gatcagttac agctacagaa atcaagtggg
     2341 aaaattttta aagactttca tgaaggaacc attaacttcg gacccaccta caagtatgac
     2401 gttggatcgg ctgcctatga cacaagtgac aagtgccgga ccccagcctg gacagacagg
     2461 gtgctgtggt ggaggaagaa gcatccgtac gataagacag ctggcgaact caaccttcta
     2521 gacagtgatc tagacggtga tgccaacatc agacatacct ggtctccggg cactctcaag
     2581 tactacggcc gtgccgagct gcaggcatct gatcacagac ctgtgctggc catcgtagag
     2641 gtggaggttc aagaggtcga tgtgggagcc cgggagagag tcttccagga agtgtcctct
     2701 gtccaaggcc cgctggacgc cactgttatt gtaaaccttc agtctccaac ccttgaagag
     2761 agaaatgaat ttccagagga cctgcgcaca gaacttatgc agactttggg gaattatggg
     2821 acgattattc tggtcaggat caaccaaggg cagatgctgg tgacatttgc agacagccac
     2881 tcagctctca gtgtgctgga tgtggatggt atgaaggtga aaggcagggc cgtgaagatt
     2941 cgaccaaaga ccaaagattg gctagaaggc ttgagagagg agctcattcg gaagcgggac
     3001 agcatggccc ctgtgtctcc caccgccaac tcctgcttgt tggaggagaa ctttgacttc
     3061 acaagtctgg actatgagtc agaaggggat gttcttgaag atgatgaaga ctacttagcg
     3121 gatgagtttg gtcagcctgt agtctcagac agtgagcttg gaggagacga ctcttctgat
     3181 accatgagcg cctcgacacc tgccagcaag tctcccgcac tggctaaaaa gaagcaacat
     3241 ccaacgtaca aagacgacgc tgacctgatg acgttaaagc tggagctgga agttgctggg
     3301 aattttcgcc accgttctcc gagcaggtcc ctgtctgtcc ccaataggcc tcggccacct
     3361 caccctccac aaagaccccc ccctccaact ggcttaatgg tgaagaagtc tgcctcagat
     3421 gcgtctatct cctccggaac ccacgggcaa tattccatct tgcagaccgc gaaacttctt
     3481 ccaggagcac ctcagcaacc gcccaaggct cgaactggaa taagtaaacc ttacaacgtc
     3541 aaacagatca aaaccaccaa tgctcaggag gcggaagcag ctatccggtg tctcctggaa
     3601 gctggcggag gtgtcccaga gtcagccccg ggtgccacgc ccctgagaaa ccaagggtct
     3661 tctaagccag aggcctccct ggggcctcca gtcctaccgc gccggcctgt tccaagggtt
     3721 cccactatga agaaaccaac tttgaggaga acaggaaagc ccatgttatc agaagaacag
     3781 tgtgaacagc agcctgtcca ttttacaatg gcttcccagg aaatgaacct tgagacccct
     3841 cctccaataa cagctcccat cccgcctgtt cccaaaccaa gaacatttca gcctgggaga
     3901 ggtgttgaga ggaggccgag tggtggcaag ccagaaccgg atgacgctcc tcctgtgaca
     3961 ggcgctgtgg agttatcgtc tccagaggcc ccagaggccc cgtccctggc tcccaaggtg
     4021 cctcctagga ggaagaagtc tgcaccagca gccttccacc tgcaggtcct gcagagcaac
     4081 agccaacttc tgcagggcct cacatgctcc agcagttctc cgtccccacc aaagcctgac
     4141 acccccctgc tctatccgca aatggcactt ggcacttcat ctgctataag tcccgaaact
     4201 gatggcccca gagtgacgga gcccgaggca gcctcttttc atggcgatta cccagatccc
     4261 ttctggagcc ttctccacca ccccaagctg ttgaataata atacctggct gtccaagagc
     4321 tctgagcctt tagacttggg gtccaggacc cctgagagga cacacacaga ctcagcgcag
     4381 gtcaatgcat cagtggttga gagggggctt ccaccagacc atgggggtaa agacttcagt
     4441 cactggatgg ccgccagtaa caaagacaag aggacaacat taggcgtttg acccacaggc
     4501 aagaacatgg cctgttggct ctgtagatgc tctcatttca aacgctcacc ttcctcatgt
     4561 gggcattgct tgacctggtc aaaagggatg ttgatgtaaa ggcacactga aaccctttgt
     4621 ttatctgtca ctctgtgtag tgaatgaaaa ctgtctccca ttcagtacag ttatccagcc
     4681 acccaaacgt tccattcaag gtctgtgcat tttaagcttg ctctcaggac actgggaaat
     4741 gtgctgttgc attcgggata tggattttaa agggaagaaa tctagattcc caagacgctc
     4801 tcatctgcgg aattttaagt ggttgttcaa tatatgtttg tgtgccattt gcttgttggt
     4861 tttgtttgtg tttttacaga tttgggataa gtggttaggt tcataaaaga tgacatcaaa
     4921 agcagtcggg accttaagag ctgttgtgac ccacttgaaa ccacattaag aaaaaaaaaa
     4981 aaaaa
//
