LOCUS       NP_445928               1332 aa            linear   ROD 31-MAR-2024
DEFINITION  synaptojanin-1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_445928 XP_001073290 XP_573256
VERSION     NP_445928.3
DBSOURCE    REFSEQ: accession NM_053476.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1332)
  AUTHORS   Hunn,B.H., Cragg,S.J., Bolam,J.P., Spillantini,M.G. and
            Wade-Martins,R.
  TITLE     Impaired intracellular trafficking defines early Parkinson's
            disease
  JOURNAL   Trends Neurosci 38 (3), 178-188 (2015)
   PUBMED   25639775
  REMARK    Review article
REFERENCE   2  (residues 1 to 1332)
  AUTHORS   Drouet,V. and Lesage,S.
  TITLE     Synaptojanin 1 mutation in Parkinson's disease brings further
            insight into the neuropathological mechanisms
  JOURNAL   Biomed Res Int 2014, 289728 (2014)
   PUBMED   25302295
  REMARK    Review article
REFERENCE   3  (residues 1 to 1332)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1332)
  AUTHORS   Cossec,J.C., Lavaur,J., Berman,D.E., Rivals,I., Hoischen,A.,
            Stora,S., Ripoll,C., Mircher,C., Grattau,Y., Olivomarin,J.C., de
            Chaumont,F., Lecourtois,M., Antonarakis,S.E., Veltman,J.A.,
            Delabar,J.M., Duyckaerts,C., Di Paolo,G. and Potier,M.C.
  TITLE     Trisomy for synaptojanin1 in Down syndrome is functionally linked
            to the enlargement of early endosomes
  JOURNAL   Hum Mol Genet 21 (14), 3156-3172 (2012)
   PUBMED   22511594
REFERENCE   5  (residues 1 to 1332)
  AUTHORS   Milosevic,I., Giovedi,S., Lou,X., Raimondi,A., Collesi,C., Shen,H.,
            Paradise,S., O'Toole,E., Ferguson,S., Cremona,O. and De Camilli,P.
  TITLE     Recruitment of endophilin to clathrin-coated pit necks is required
            for efficient vesicle uncoating after fission
  JOURNAL   Neuron 72 (4), 587-601 (2011)
   PUBMED   22099461
REFERENCE   6  (residues 1 to 1332)
  AUTHORS   Ringstad,N., Nemoto,Y. and De Camilli,P.
  TITLE     The SH3p4/Sh3p8/SH3p13 protein family: binding partners for
            synaptojanin and dynamin via a Grb2-like Src homology 3 domain
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8569-8574 (1997)
   PUBMED   9238017
REFERENCE   7  (residues 1 to 1332)
  AUTHORS   de Heuvel,E., Bell,A.W., Ramjaun,A.R., Wong,K., Sossin,W.S. and
            McPherson,P.S.
  TITLE     Identification of the major synaptojanin-binding proteins in brain
  JOURNAL   J Biol Chem 272 (13), 8710-8716 (1997)
   PUBMED   9079704
REFERENCE   8  (residues 1 to 1332)
  AUTHORS   Ramjaun,A.R. and McPherson,P.S.
  TITLE     Tissue-specific alternative splicing generates two synaptojanin
            isoforms with differential membrane binding properties
  JOURNAL   J Biol Chem 271 (40), 24856-24861 (1996)
   PUBMED   8798761
REFERENCE   9  (residues 1 to 1332)
  AUTHORS   McPherson,P.S., Garcia,E.P., Slepnev,V.I., David,C., Zhang,X.,
            Grabs,D., Sossin,W.S., Bauerfeind,R., Nemoto,Y. and De Camilli,P.
  TITLE     A presynaptic inositol-5-phosphatase
  JOURNAL   Nature 379 (6563), 353-357 (1996)
   PUBMED   8552192
REFERENCE   10 (residues 1 to 1332)
  AUTHORS   McPherson,P.S., Takei,K., Schmid,S.L. and De Camilli,P.
  TITLE     p145, a major Grb2-binding protein in brain, is co-localized with
            dynamin in nerve terminals where it undergoes activity-dependent
            dephosphorylation
  JOURNAL   J Biol Chem 269 (48), 30132-30139 (1994)
   PUBMED   7982917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Dec 20, 2022 this sequence version replaced NP_445928.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U45479.2, SRR26360176.709055.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     Protein         1..1332
                     /product="synaptojanin-1 isoform 1"
                     /EC_number="3.1.3.36"
                     /note="synaptic inositol 1,4,5-trisphosphate 5-phosphatase
                     1"
                     /calculated_mol_wt=147255
     Region          100..520
                     /region_name="COG5329"
                     /note="Phosphoinositide polyphosphatase (Sac family)
                     [Signal transduction mechanisms]"
                     /db_xref="CDD:227637"
     Region          573..908
                     /region_name="INPP5c_Synj1"
                     /note="Catalytic inositol polyphosphate 5-phosphatase
                     (INPP5c) domain of synaptojanin 1; cd09098"
                     /db_xref="CDD:197332"
     Site            order(581,583,631,708..709,729,732..733,770,772,774,
                     824..825,840,846,898..899)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:197332"
     Site            order(581,631,729,770,772,846,898..899)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197332"
     Site            order(583,631,898)
                     /site_type="other"
                     /note="Mg binding site [ion binding]"
                     /db_xref="CDD:197332"
     Site            order(631,708..709,729,732..733,774,824..825,840,898)
                     /site_type="other"
                     /note="putative PI/IP binding site [chemical binding]"
                     /db_xref="CDD:197332"
     Site            order(729,772,899)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197332"
     Region          907..1049
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          <1067..1301
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..1332
                     /gene="Synj1"
                     /coded_by="NM_053476.4:229..4227"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:85238"
                     /db_xref="RGD:69434"
ORIGIN      
        1 mrkswtcwsg sdasggcsgg gcgrrrrrsr rkraaseerr mafskgfriy hkldpppfsl
       61 ivetrhkeec lmfesgavav lssaekeaik gtyakvlday gllgvlrlnl gdtmlhylvl
      121 vtgcmsvgki qesevfrvts tefislrvda sdedrisevr kvlnsgnfyf awsasgvsld
      181 lslnahrsmq ehttdnrffw nqslhlhlkh ygvncddwll rlmcggveir tiyaahkqak
      241 aclisrlsce ragtrfnvrg tnddghvanf veteqviyld dcvssfiqir gsvplfweqp
      301 glqvgshrvr msrgfeanap afdrhfrtlk dlygkqivvn llgskegehm lskafqshlk
      361 asehasdihm vsfdyhqmvk ggkaeklhsv lkpqvqkfld ygffyfdgsa vqrcqsgtvr
      421 tncldcldrt nsvqaflgle mlakqlealg laekpqlvtr fqevfrsmws vngdsiskiy
      481 agtgalegka klkdgarsvt rtiqnnffds skqeaidvll lgntlnsdla dkarallttg
      541 slrvseqtlq sasskvlknm cenfykyskp kkirvcvgtw nvnggkqfrs iafknqtltd
      601 wlldapklag iqefqdkrsk ptdifaigfe emvelnagni vnasttnqkl wavelqktis
      661 rdnkyvllas eqlvgvclfv firpqhapfi rdvavdtvkt gmggatgnkg avairmlfht
      721 tslcfvcshf aagqsqvker nedfveiark lsfpmgrmlf shdyvfwcgd fnyridlpne
      781 evkelirqqn wdsliagdql inqknagqif rgflegkvtf aptykydlfs edydtsekcr
      841 tpawtdrvlw rrrkwpfdrs aedldllnas fqdeskilyt wtpgtllhyg raelktsdhr
      901 pvvalididi feveaeerqk iykeviavqg ppdgtvlvsi kssaqentff ddalidellq
      961 qfahfgevil irfvedkmwv tflegssaln vlslngkell nrtititlks pdwiktleee
     1021 mslekisvtl psstsstllg edaevsadfd megdvddysa eveellpqhl qpssssglgt
     1081 spsssprtsp cqsptapeys apslpirpsr apsrtpgpls sqgapvdtqp aaqkessqti
     1141 epkrpppprp vapparpapp qrppppsgar spaparkefg apkspgtark dnigrnqpsp
     1201 qaglagpgps gygaarptip aragvisapq sqarvsagrl tpesqskple tskgpavlpe
     1261 plkpqaafpp qpslptpaqk lqdplvpiaa pmppsipqsn letpplpppr srssqslpsd
     1321 sspqlqqeqp tg
//
