LOCUS       NM_053553               1552 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus synaptogyrin 2 (Syngr2), mRNA.
ACCESSION   NM_053553
VERSION     NM_053553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Belfort,G.M., Bakirtzi,K. and Kandror,K.V.
  TITLE     Cellugyrin induces biogenesis of synaptic-like microvesicles in
            PC12 cells
  JOURNAL   J Biol Chem 280 (8), 7262-7272 (2005)
   PUBMED   15590695
  REMARK    GeneRIF: small conserved hydrophobic hairpins in the first luminal
            loop and the carboxyl terminus of cellugyrin were found to be
            critical for the formation of SLMVs
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Belfort,G.M. and Kandror,K.V.
  TITLE     Cellugyrin and synaptogyrin facilitate targeting of synaptophysin
            to a ubiquitous synaptic vesicle-sized compartment in PC12 cells
  JOURNAL   J Biol Chem 278 (48), 47971-47978 (2003)
   PUBMED   12928441
  REMARK    GeneRIF: Cellugyrin and synaptogyrin have roles in facilitating
            targeting of synaptophysin to a ubiquitous synaptic vesicle-sized
            compartment
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Sugita,S., Janz,R. and Sudhof,T.C.
  TITLE     Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells
  JOURNAL   J Biol Chem 274 (27), 18893-18901 (1999)
   PUBMED   10383386
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Janz,R. and Sudhof,T.C.
  TITLE     Cellugyrin, a novel ubiquitous form of synaptogyrin that is
            phosphorylated by pp60c-src
  JOURNAL   J Biol Chem 273 (5), 2851-2857 (1998)
   PUBMED   9446595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2020 this sequence version replaced NM_053553.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218897.1, FQ224907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000010.1  103528629-103528755
            128-365             JAXUCZ010000010.1  103531287-103531524
            366-505             JAXUCZ010000010.1  103531888-103532027
            506-1552            JAXUCZ010000010.1  103532121-103533167
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..1552
                     /gene="Syngr2"
                     /note="synaptogyrin 2"
                     /db_xref="GeneID:89815"
                     /db_xref="RGD:621334"
     exon            1..127
                     /gene="Syngr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..703
                     /gene="Syngr2"
                     /note="cellugyrin"
                     /codon_start=1
                     /product="synaptogyrin-2"
                     /protein_id="NP_446005.2"
                     /db_xref="GeneID:89815"
                     /db_xref="RGD:621334"
                     /translation="MESGAYGAANAGGSFDLRRYVSQPQVVTRLVSMVLALIVFSCIF
                     GEGYINLHSSDQLHCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAFFSQISNATDRK
                     YLVIGDLLFSALWTFLWFVGFCFLTNQWAATKPDDVLVGADSARAAITFSFFSIFSWG
                     VLASLAYQRYKAGVDAFIQNYVDPTPDPTTAYASYPSASVENYQQPPFTQNVETTEGY
                     QPPPVY"
     exon            128..365
                     /gene="Syngr2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..505
                     /gene="Syngr2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1552
                     /gene="Syngr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatccgcgg ctcggcggcg acggcgacat ggagagcggg gcctatggcg cggccaacgc
       61 gggcggctcc ttcgacctgc ggcgctatgt gtcccagcct caggtggtga cgcgcctcgt
      121 gagcatggtc ttggccttga tcgtattctc ctgcatcttc ggcgagggct acatcaacct
      181 tcactcatct gaccagctac actgtgtgtt caaccggaac gaagatgcct gccgctacgg
      241 cagtgccatt ggggtgctgg ccttcctggc ctcagccttc ttccttgtgg tggatgcgtt
      301 tttctctcag ataagcaatg ccactgaccg caagtatctg gtcattggtg acctgctctt
      361 ctcagctctc tggaccttcc tgtggtttgt cggtttctgc tttctgacca accagtgggc
      421 agccaccaaa cctgatgacg tgttggtggg agcagactca gcccgggctg ccatcacctt
      481 cagtttcttc tccatcttct cctggggtgt gctggcctcc ctggcctacc agcgttacaa
      541 ggctggagtg gatgccttca ttcagaacta tgtggacccc acgccggatc ccaccacagc
      601 ctacgcctcc taccctagtg cctcggtgga aaactaccag cagccgccct tcacccagaa
      661 tgtggagact actgagggct accagcctcc cccagtgtac tgagcagcca gggacaaaga
      721 ggcaggaggg tgcttggtgg ggctgcccct ccaccctgga cttctctcaa ggtttgctgt
      781 ccagaactgt agtcccttgg ctgttacagt tgacagcccg agtccatgcc tttctgcacc
      841 ccagcagcca gagcacacct gaagtgccca tgcccagagg ggcttcaccg ccacccgcct
      901 gaccctcaag ggcatctttg aggagagggt tttactaggc cttatccccc caccccagta
      961 ctgtaaatgg aacccagggc cttggatttg cttagccagc gctgccatcc agccgtacgc
     1021 tcagctccgc attgctttta ataacactga accccatcag agccagaagc aggtgcccgc
     1081 tgcagttttt gacacatgcc actttcccta cagctggagg ccttgggagc cccaactttt
     1141 ttttctccaa agacaaactt ggggatcctt gtgctacctg tctcctcagt gctcggctcc
     1201 ccacttcctc actcaggttc aggacccagc ttcgtctggg ttctatgctc actgctgtgt
     1261 cttctggggt caccactgtg ccaaccgtct ccaggctgcc tgcctgacag ctgtggggcg
     1321 ggcagaggga cgagatacca ctcctttctt gctcctaccc ctggcagaag gacagaactt
     1381 gcccggagac agcacctggc tttatgtaaa tattcccaag cagctgttag atactagtgg
     1441 ggagggcagg aacccctgca ctgaatgtac ggagacttgg tggggacagc cctgccctca
     1501 gttctgtaga ctagtttgga gatggaataa acgtttttct cagcctgttg ta
//
