LOCUS       NP_001100232             976 aa            linear   ROD 31-MAR-2024
DEFINITION  nesprin-3 [Rattus norvegicus].
ACCESSION   NP_001100232 XP_001069093 XP_001069144 XP_038968037
VERSION     NP_001100232.2
DBSOURCE    REFSEQ: accession NM_001106762.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 976)
  AUTHORS   Taranum,S., Sur,I., Muller,R., Lu,W., Rashmi,R.N., Munck,M.,
            Neumann,S., Karakesisoglou,I. and Noegel,A.A.
  TITLE     Cytoskeletal interactions at the nuclear envelope mediated by
            nesprins
  JOURNAL   Int J Cell Biol 2012, 736524 (2012)
   PUBMED   22518138
REFERENCE   2  (residues 1 to 976)
  AUTHORS   Morgan,J.T., Pfeiffer,E.R., Thirkill,T.L., Kumar,P., Peng,G.,
            Fridolfsson,H.N., Douglas,G.C., Starr,D.A. and Barakat,A.I.
  TITLE     Nesprin-3 regulates endothelial cell morphology, perinuclear
            cytoskeletal architecture, and flow-induced polarization
  JOURNAL   Mol Biol Cell 22 (22), 4324-4334 (2011)
   PUBMED   21937718
REFERENCE   3  (residues 1 to 976)
  AUTHORS   Gob,E., Schmitt,J., Benavente,R. and Alsheimer,M.
  TITLE     Mammalian sperm head formation involves different polarization of
            two novel LINC complexes
  JOURNAL   PLoS One 5 (8), e12072 (2010)
   PUBMED   20711465
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 976)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (residues 1 to 976)
  AUTHORS   Stewart-Hutchinson,P.J., Hale,C.M., Wirtz,D. and Hodzic,D.
  TITLE     Structural requirements for the assembly of LINC complexes and
            their function in cellular mechanical stiffness
  JOURNAL   Exp Cell Res 314 (8), 1892-1905 (2008)
   PUBMED   18396275
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Jul 19, 2021 this sequence version replaced
            XP_038968037.1, NP_001100232.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.37121.1,
                                           SRR26643295.26433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..976
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..976
                     /product="nesprin-3"
                     /calculated_mol_wt=112064
     Region          <170..>401
                     /region_name="PRK03918"
                     /note="DNA double-strand break repair ATPase Rad50"
                     /db_xref="CDD:235175"
     Region          <296..>759
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Region          578..742
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cl02488"
                     /db_xref="CDD:413338"
     Site            646..651
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          <947..976
                     /region_name="KASH"
                     /note="Nuclear envelope localization domain; pfam10541"
                     /db_xref="CDD:463142"
     CDS             1..976
                     /gene="Syne3"
                     /gene_synonym="RGD1304563"
                     /coded_by="NM_001106762.2:120..3050"
                     /db_xref="GeneID:299356"
                     /db_xref="RGD:1304563"
ORIGIN      
        1 mtqqpqedfd rsvedaqawm kavqeqlqvn dntkgpraal earlreteki cqlepegcik
       61 velvlraaea llatcqegqk peilarlrdi ksqweetvty mthchsriew vwlhwseyll
      121 aqdefyrwfq kmvvtleppv elqlglkekq wqlshaqvll hnvdnqavll drlleeagsl
      181 fsrigdpsvd eeaqkrmkae ydavkaraqh rvellaqvaq dheqyredvs efqlwlkalv
      241 ekvhgclgrn cklateprls vlqdiakdfp rgeeslnrle eqavgvirnt splgaerisg
      301 eleemrmvle klrvlwkeee grlqgllqsk gaceqqiqql evelgelkkv lqrlaqqgle
      361 ptvktatede lvahwrlfsg traalaseep rvdrlqtqlk elvifpdlqs lsdsvvaaiq
      421 eyqsmkgkna rlhnatrtel wqrsqrslnd lqlwkalaqr lldittslpd lasihtflpq
      481 ieaaltessr lkeqlsmlql ktdllgsifg qeraatlleq vtgsvrdrdl lhnsllqrks
      541 klqsllvqhk dfgvafdplh rklldlqari qaekglqrdl pgkqvqllrl qglqeegldl
      601 gtqieavrsl aqgnskyqhk vdqissdqqa lqrsledlvd rcqqnvrehc tfshrllelq
      661 lwitmatqtl eshqgdmrlw daesqeagle rllseipeke vqlsllqalg qlvmkksspe
      721 gaavvqeelr klmeswqalr lleesmlslm rneqlqrtev dtgkkqvftn nipkagflin
      781 pqdpiprrrh gvnppeehdl hedhpqllre feqwlqaens kllrittmrt atakdlrtre
      841 lklqeleari pegqilfenl lrhrpardps neledlryrw mlyksklkgs gdlltesspg
      901 eltafqksrq qkrwrspcsl lqkacrvalp lqlllllfll llfllpagee erscalannf
      961 arsfalmlry ngpppt
//
