LOCUS       NM_001025020            2055 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus synapse differentiation inducing 1 (Syndig1),
            mRNA.
ACCESSION   NM_001025020 XM_342541
VERSION     NM_001025020.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Matt,L., Kirk,L.M., Chenaux,G., Speca,D.J., Puhger,K.R.,
            Pride,M.C., Qneibi,M., Haham,T., Plambeck,K.E., Stern-Bach,Y.,
            Silverman,J.L., Crawley,J.N., Hell,J.W. and Diaz,E.
  TITLE     SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and
            Plasticity Underlying Cognitive Function
  JOURNAL   Cell Rep 22 (9), 2246-2253 (2018)
   PUBMED   29490264
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Lovero,K.L., Blankenship,S.M., Shi,Y. and Nicoll,R.A.
  TITLE     SynDIG1 promotes excitatory synaptogenesis independent of AMPA
            receptor trafficking and biophysical regulation
  JOURNAL   PLoS One 8 (6), e66171 (2013)
   PUBMED   23785483
  REMARK    GeneRIF: SynDIG1 is not a typical auxiliary subunit to AMPA
            receptors, but instead is a protein critical to excitatory
            synaptogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Diaz,E.
  TITLE     SynDIG1 regulation of excitatory synapse maturation
  JOURNAL   J Physiol 590 (1), 33-38 (2012)
   PUBMED   21878521
  REMARK    GeneRIF: An interesting aspect of SynDIG1 is that its distribution
            at excitatory synapses is regulated by activity, suggesting that
            SynDIG1 might also play a role in synaptic plasticity.
            Review article
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Kalashnikova,E., Lorca,R.A., Kaur,I., Barisone,G.A., Li,B.,
            Ishimaru,T., Trimmer,J.S., Mohapatra,D.P. and Diaz,E.
  TITLE     SynDIG1: an activity-regulated, AMPA- receptor-interacting
            transmembrane protein that regulates excitatory synapse development
  JOURNAL   Neuron 65 (1), 80-93 (2010)
   PUBMED   20152115
  REMARK    GeneRIF: Results describe SynDIG1 as an activity-regulated
            transmembrane protein that regulates AMPA receptor content and
            excitatory synapse development.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092131.1.
            
            On Jun 25, 2005 this sequence version replaced XM_342541.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2055
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /note="synapse differentiation inducing 1"
                     /db_xref="GeneID:362235"
                     /db_xref="RGD:1310753"
     exon            1..83
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     exon            84..169
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     exon            170..727
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1024
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /note="transmembrane protein 90B; dispanin subfamily C
                     member 2"
                     /codon_start=1
                     /product="synapse differentiation-inducing gene protein 1"
                     /protein_id="NP_001020191.1"
                     /db_xref="GeneID:362235"
                     /db_xref="RGD:1310753"
                     /translation="MDGIVEQKSVLVHSKIGDAGKRNGLINTRNFMAESRDGLVSVYP
                     APQYQSHRLVASAAPGSLEGGRSDPVQQLLDPNTLQQSVDSHYRPNIILYSDGVLRSW
                     GDGVATDCCETTFIEDRSPTKDSLEYPDGKFIDLSGDDIKIHTLSYDVEEEEELQELE
                     SDYSSDTESEDNFLMMPPRDHLGLSVFSMLCCFWPLGIAAFYLSHETNKAVAKGDFHQ
                     ASTSSRRALFLAVLSITIGTGIYVGVAVALIAYLSKNNHL"
     exon            728..865
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
     exon            866..2027
                     /gene="Syndig1"
                     /gene_synonym="DSPC2; RGD1310753; Tmem90b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgcgcc ccgcacgctc cctggctctc gagacgcgcg ggcgacagcc tgggcgcacc
       61 agccgggtca ccttgtccca gaggttctgg tggcttgatg cctggccact tccttctttc
      121 acctgttcgt gagagataat ctggactgcc tattaagacc cttttacagg gaaatgggtc
      181 ctatggggct tgtgtgacct gtgaatacag cctgctagcc tgacgccaag cagggaggga
      241 gtctatcatg gatggcatcg ttgagcagaa gagtgttctg gtacacagta agatcggtga
      301 tgctggcaaa aggaatggct taattaacac cagaaacttc atggctgaga gcagggatgg
      361 tctggtgtct gtttacccag caccgcagta ccagagccac aggctagtgg ccagtgcggc
      421 accaggcagc ctggaaggag gcagaagtga tcctgtgcag cagctgctgg acccaaacac
      481 actgcagcag tccgtggact cccactatcg tcccaacatc attctatact cagatggtgt
      541 gctccgatcc tggggggatg gtgtagccac tgactgctgt gagaccacct tcattgagga
      601 ccggtcaccc accaaagaca gcctggagta ccccgatggg aaattcatcg acctctcagg
      661 ggatgacatc aaaatccaca ccctgtctta tgatgtggag gaagaggagg agttacagga
      721 gctggagagt gactactcta gcgacacaga gagtgaggac aacttcctca tgatgcctcc
      781 acgggatcac ctgggactca gtgtcttctc catgctctgc tgcttctggc ctttgggcat
      841 cgcggccttc tacttgtccc atgagacaaa caaagctgtg gccaaaggag acttccatca
      901 ggccagcacc agctcccgga gggccctatt tctggcagtg ctgtccatta cgattggaac
      961 tggcatctat gtgggtgtag ctgttgccct cattgcctac ctctccaaaa acaaccacct
     1021 gtgagctttc caaaggctgg catgaaggag ggggagctga gccagatgta tgagggcaga
     1081 gaagagacat ctgtgtgtta ctgtacagta caagggattg ccggacaact ccatgatgcc
     1141 ctggaatctt ctactcctgg acttcctttg tttttatcct tcaacttcat cttcagcact
     1201 gtgcagagca ccaggcagcc aggaatgctg attcttcctc atggaagttc caaagattcc
     1261 atcccagtgg ctgcccctgg ataaagtcta ctggatggat gacaagccag ctctgtagcc
     1321 tgccagtgcc tggactaaca ccccattagc aatatacaaa cagtcaaaat atgtttattt
     1381 tttatggaat atggtgcaat aggcagaatg cagaagacat gtcatcacta gcttgtggcc
     1441 cgcttaaatt ctctgtgtgt accccatctt tgtggcttcc ttgtcagaaa taagtggggc
     1501 tgagaaagaa aggaaagcaa ctgctgggag atcttctgtc tctctgtcca cagatggatc
     1561 ctgtctgaga atgcagaatt agaggagcat aatgcctacc ctggccttgc tcagtcccag
     1621 cacgctgcct cagcttggag catcaggctt cttgcagata cccagcaata cacagttctg
     1681 gggcctcact aatcttaaag gagaggaaac cacagctcct ctcaaaaaca aacccagtgt
     1741 tttccccggg agcctgaggg aaaggaactg tgaagacaca ccaggtgttt aactcctgga
     1801 tgttcatcct ggtcatgagc ttcaatgttg gagatcccgg aaatgagatg ggccttattc
     1861 tgtccactaa atgaatggct attttcttgt cattttttaa gtgcaactct tgcttcatgc
     1921 tgcttcagtt gccagatgaa tgctgagaaa taagtaatca cagatgtttt aataccatgt
     1981 cattgctgtt ttacgagtgt tcattattta acaaaaatta tcttttaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaa
//
