LOCUS       NM_001395651            3119 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synaptotagmin binding, cytoplasmic RNA
            interacting protein (Syncrip), transcript variant 4, mRNA.
ACCESSION   NM_001395651 XM_006243513
VERSION     NM_001395651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Tratnjek,L., Zivin,M. and Glavan,G.
  TITLE     Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in
            the rat brain and co-localize in Purkinje neurons
  JOURNAL   J Chem Neuroanat 79, 12-21 (2017)
   PUBMED   27771350
  REMARK    GeneRIF: Both SYNCRIP (and SYT7) were expressed and partially
            co-localized in somata of Purkinje neurons in the cerebellar
            cortex.
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Ban,B.K., Jun,M.H., Ryu,H.H., Jang,D.J., Ahmad,S.T. and Lee,J.A.
  TITLE     Autophagy negatively regulates early axon growth in cortical
            neurons
  JOURNAL   Mol Cell Biol 33 (19), 3907-3919 (2013)
   PUBMED   23918799
  REMARK    GeneRIF: Data indicate that atg7, RhoA and hnRNP-Q1 are involved in
            autophagy negatively regulates early axon growth in cortical
            neurons.
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Arif,A., Chatterjee,P., Moodt,R.A. and Fox,P.L.
  TITLE     Heterotrimeric GAIT complex drives transcript-selective translation
            inhibition in murine macrophages
  JOURNAL   Mol Cell Biol 32 (24), 5046-5055 (2012)
   PUBMED   23071094
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Bannai,H., Fukatsu,K., Mizutani,A., Natsume,T., Iemura,S.,
            Ikegami,T., Inoue,T. and Mikoshiba,K.
  TITLE     An RNA-interacting protein, SYNCRIP (heterogeneous nuclear
            ribonuclear protein Q1/NSAP1) is a component of mRNA granule
            transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA
            in neuronal dendrites
  JOURNAL   J Biol Chem 279 (51), 53427-53434 (2004)
   PUBMED   15475564
  REMARK    GeneRIF: SYNCRIP is transported within the dendrite as a component
            of mRNA granules
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Sampath,P., Mazumder,B., Seshadri,V., Gerber,C.A., Chavatte,L.,
            Kinter,M., Ting,S.M., Dignam,J.D., Kim,S., Driscoll,D.M. and
            Fox,P.L.
  TITLE     Noncanonical function of glutamyl-prolyl-tRNA synthetase:
            gene-specific silencing of translation
  JOURNAL   Cell 119 (2), 195-208 (2004)
   PUBMED   15479637
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 28, 2021 this sequence version replaced XM_006243513.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.635864.1,
                                           SRR26360186.2447320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-507               JAXUCZ010000008.1  98314880-98315386   c
            508-667             JAXUCZ010000008.1  98313424-98313583   c
            668-786             JAXUCZ010000008.1  98312608-98312726   c
            787-894             JAXUCZ010000008.1  98312381-98312488   c
            895-1008            JAXUCZ010000008.1  98310019-98310132   c
            1009-1185           JAXUCZ010000008.1  98309744-98309920   c
            1186-1321           JAXUCZ010000008.1  98296911-98297046   c
            1322-1527           JAXUCZ010000008.1  98295126-98295331   c
            1528-1677           JAXUCZ010000008.1  98294467-98294616   c
            1678-1799           JAXUCZ010000008.1  98293921-98294042   c
            1800-3119           JAXUCZ010000008.1  98288558-98289877   c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..3119
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /note="synaptotagmin binding, cytoplasmic RNA interacting
                     protein"
                     /db_xref="GeneID:363113"
                     /db_xref="RGD:1305683"
     exon            1..507
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            508..667
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..2391
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /note="isoform 4 is encoded by transcript variant 4;
                     heterogeneous nuclear ribonucleoprotein Q; hnRNP-Q; liver
                     regeneration-related protein LRRG077"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein Q
                     isoform 4"
                     /protein_id="NP_001382580.1"
                     /db_xref="GeneID:363113"
                     /db_xref="RGD:1305683"
                     /translation="MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLD
                     EIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTY
                     RQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSV
                     GTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQE
                     AVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILY
                     HQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVM
                     AKVKVLFVRNLANTVTEEILEKSFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMN
                     GKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG
                     RGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAP
                     SRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRK
                     ADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENEEFYQDTFGQQWK"
     exon            668..786
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            787..894
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1008
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1185
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1321
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1527
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1677
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1799
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..3119
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcacgtca gcgcgggaga gagaaagagc gactcggcag ggactgggga cgggccgaga
       61 gagctagcga gggagggcgt gagccagaga gccagcgagg agaagggcgg ccactcgtgc
      121 ttgagcggcc gcggacggga gtgggaaagc tgggggagga ggtgcaggga aggaaggacg
      181 aagaccgaga ggacagggcg gcccacggcc ggcagaggtg gcaaggggag aaggaggagc
      241 tgtaggaggg caggggctga gggagtgagt gagagaagcg gacgcgccag ggaggggagg
      301 gaaggggggt cacgcggggg cgcgcgcgcg cactgggagc gcgctcggag gcgagtggaa
      361 ctggatcggg tttgctgcca gcggcgtgag cttcggccgc cattttacaa cagctccact
      421 cgcgccggac acagggagca gcgagcacgc gttccccgcc acccgacccg gtcggacagg
      481 attcctcggc cccagccccg cggggagatc tctggaaaca tggctacaga acatgttaat
      541 ggaaatggta ctgaagagcc catggatact acttcagcag ttatccattc agaaaatttt
      601 cagacattgc ttgatgctgg tttaccacag aaagttgctg aaaaactaga tgaaatttac
      661 gttgcagggc tagttgcaca tagtgattta gatgagagag ctatcgaagc tttaaaagag
      721 ttcaatgaag acggcgcatt ggcagtgctt caacagttca aagacagtga tctctctcat
      781 gttcagaaca aaagtgcctt tttatgtgga gtcatgaaga cttacaggca gagagagaaa
      841 caagggacca aagtagcaga ctctagtaaa ggaccagatg aggcgaagat taaggcactt
      901 ttggaaagaa caggctacac tcttgatgtg actacaggtc agaggaagta tggggggcca
      961 cctccagatt ctgtttattc aggtcagcag ccttctgttg gcactgagat atttgtgggg
     1021 aagatcccca gagatctgtt tgaagatgag cttgttccat tgtttgagaa agctggacct
     1081 atatgggatc ttcgtttaat gatggatcca cttactggtc tcaacagagg ttatgccttt
     1141 gtcacttttt gtacaaaaga agcagcacaa gaggctgtta aactgtataa taatcatgaa
     1201 attcgttccg ggaaacatat tggtgtctgc atctcagttg ccaacaatag gctttttgtg
     1261 ggctctattc ctaagagtaa aaccaaggaa cagattcttg aagaatttag taaagtgaca
     1321 gagggtctca cagatgtcat tttataccac caacctgatg acaagaaaaa aaacagaggc
     1381 ttttgctttc ttgaatatga agatcataaa acagctgccc aggcaaggcg taggctaatg
     1441 agtggtaaag ttaaagtctg gggaaatgtt ggaactgttg aatgggctga tcctattgaa
     1501 gatcctgatc ctgaagttat ggcaaaggta aaagtgctgt ttgtacgcaa ccttgccaac
     1561 actgtaacag aagaaatttt agaaaagtcg tttagtcagt ttgggaaact ggaacgagtg
     1621 aagaagctaa aagattatgc tttcattcat tttgatgaga gagatggtgc tgtcaaggct
     1681 atggaagaaa tgaatggtaa agacttggag ggagaaaaca ttgaaattgt ttttgctaag
     1741 ccaccagatc agaagaggaa agaaagaaaa gctcagaggc aagcagcaaa gaatcaaatg
     1801 tatgatgatt actactatta tggtccacct catatgcccc ctccaacaag aggtcgaggg
     1861 cgtggaggta gaggtggcta tggatatcct ccagattatt atggatacga agattattat
     1921 gattattatg gttatgatta ccataactat cgtggtggat atgaagatcc atattatggt
     1981 tatgaagatt ttcaagttgg agctagagga aggggtggta gaggagcaag gggtgctgct
     2041 ccatccagag gtcgcggggc tgctcctccc cgtggtagag ccggttattc acagagagga
     2101 ggccctggat cagcaagagg cgttcgtggt gcgagaggag gtgcccaaca acaaagaggc
     2161 cgcggggtac gtggtgcaag gggtggccgc ggtggaaatg taggaggaaa gcgcaaagct
     2221 gatgggtaca accagccaga ttccaagcgg cgccagacca ataatcagaa ctggggctcc
     2281 caacccattg ctcagcaacc gctccaaggt ggtgatcatt ctggtaacta tggttacaaa
     2341 tctgaaaacg aggagtttta tcaggatact tttgggcaac agtggaagta gaacaggagg
     2401 gcatctgtaa aattagagac tgataggttg atcagaaatt gggcctaaat ctgaacgggt
     2461 gccgctataa tttgagacat ctggcaagat tttcccttta tgtatatatt ttaacaaccc
     2521 gcttggacat gaacaaagtc acacttctgc ttctggcgaa ttgattttat ttttactttt
     2581 aatttttttc caataaacgt attattagaa gatatgaaag aaatagttaa tgagtttgca
     2641 ttccttctta agaatttggc tcggggttgg ggatttagct cagtggtaga gcgcttgcct
     2701 aggaagcgca aggccctggg ttcggtcccc agctccgaaa aaaagaacca aaaaaaaaat
     2761 ggctcatttg gctgtttgtg tgtgtgtata catatatgca tatgtgtaca tatatatata
     2821 tatatgtata tgtatgtata tacacacaaa cacacgtgtc tgggtagtat ttagacttgg
     2881 tgtcttgaaa aggtagttga ttaaaaactt gagtatgtct ttaatatctt gtatcagaac
     2941 aactatttgt atgttaccaa cttaaattgc tagaataagg taaattggta cacaactgct
     3001 atttttaatt tagaactttg acctaattgg gttttcaaaa ccatttggct acttgtatta
     3061 tttatgctgt tgttaatttc aataaaaaaa attcacacct aaatgtatac ttactaaaa
//
