LOCUS       NP_001382580             623 aa            linear   ROD 03-APR-2024
DEFINITION  heterogeneous nuclear ribonucleoprotein Q isoform 4 [Rattus
            norvegicus].
ACCESSION   NP_001382580 XP_006243575
VERSION     NP_001382580.1
DBSOURCE    REFSEQ: accession NM_001395651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 623)
  AUTHORS   Tratnjek,L., Zivin,M. and Glavan,G.
  TITLE     Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in
            the rat brain and co-localize in Purkinje neurons
  JOURNAL   J Chem Neuroanat 79, 12-21 (2017)
   PUBMED   27771350
  REMARK    GeneRIF: Both SYNCRIP (and SYT7) were expressed and partially
            co-localized in somata of Purkinje neurons in the cerebellar
            cortex.
REFERENCE   2  (residues 1 to 623)
  AUTHORS   Ban,B.K., Jun,M.H., Ryu,H.H., Jang,D.J., Ahmad,S.T. and Lee,J.A.
  TITLE     Autophagy negatively regulates early axon growth in cortical
            neurons
  JOURNAL   Mol Cell Biol 33 (19), 3907-3919 (2013)
   PUBMED   23918799
  REMARK    GeneRIF: Data indicate that atg7, RhoA and hnRNP-Q1 are involved in
            autophagy negatively regulates early axon growth in cortical
            neurons.
REFERENCE   3  (residues 1 to 623)
  AUTHORS   Arif,A., Chatterjee,P., Moodt,R.A. and Fox,P.L.
  TITLE     Heterotrimeric GAIT complex drives transcript-selective translation
            inhibition in murine macrophages
  JOURNAL   Mol Cell Biol 32 (24), 5046-5055 (2012)
   PUBMED   23071094
REFERENCE   4  (residues 1 to 623)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (residues 1 to 623)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (residues 1 to 623)
  AUTHORS   Bannai,H., Fukatsu,K., Mizutani,A., Natsume,T., Iemura,S.,
            Ikegami,T., Inoue,T. and Mikoshiba,K.
  TITLE     An RNA-interacting protein, SYNCRIP (heterogeneous nuclear
            ribonuclear protein Q1/NSAP1) is a component of mRNA granule
            transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA
            in neuronal dendrites
  JOURNAL   J Biol Chem 279 (51), 53427-53434 (2004)
   PUBMED   15475564
  REMARK    GeneRIF: SYNCRIP is transported within the dendrite as a component
            of mRNA granules
REFERENCE   7  (residues 1 to 623)
  AUTHORS   Sampath,P., Mazumder,B., Seshadri,V., Gerber,C.A., Chavatte,L.,
            Kinter,M., Ting,S.M., Dignam,J.D., Kim,S., Driscoll,D.M. and
            Fox,P.L.
  TITLE     Noncanonical function of glutamyl-prolyl-tRNA synthetase:
            gene-specific silencing of translation
  JOURNAL   Cell 119 (2), 195-208 (2004)
   PUBMED   15479637
REFERENCE   8  (residues 1 to 623)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (residues 1 to 623)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   10 (residues 1 to 623)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 28, 2021 this sequence version replaced XP_006243575.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.635864.1,
                                           SRR26360186.2447320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..623
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     Protein         1..623
                     /product="heterogeneous nuclear ribonucleoprotein Q
                     isoform 4"
                     /note="heterogeneous nuclear ribonucleoprotein Q; hnRNP-Q;
                     liver regeneration-related protein LRRG077"
                     /calculated_mol_wt=69489
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:O60506; propagated from
                     UniProtKB/Swiss-Prot (Q7TP47.1)"
     Region          23..107
                     /region_name="NURR_hnRNPQ"
                     /note="NURR (N-terminal unit for RNA recognition) domain
                     found in heterogeneous nuclear ribonucleoprotein Q
                     (hnRNPQ) and similar proteins; cd21066"
                     /db_xref="CDD:410954"
     Region          103..615
                     /region_name="hnRNP-R-Q"
                     /note="heterogeneous nuclear ribonucleoprotein R, Q
                     family; TIGR01648"
                     /db_xref="CDD:273732"
     CDS             1..623
                     /gene="Syncrip"
                     /gene_synonym="Ab2-339; hnRNP Q"
                     /coded_by="NM_001395651.1:520..2391"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:363113"
                     /db_xref="RGD:1305683"
ORIGIN      
        1 matehvngng teepmdttsa vihsenfqtl ldaglpqkva ekldeiyvag lvahsdlder
       61 aiealkefne dgalavlqqf kdsdlshvqn ksaflcgvmk tyrqrekqgt kvadsskgpd
      121 eakikaller tgytldvttg qrkyggpppd svysgqqpsv gteifvgkip rdlfedelvp
      181 lfekagpiwd lrlmmdpltg lnrgyafvtf ctkeaaqeav klynnheirs gkhigvcisv
      241 annrlfvgsi pksktkeqil eefskvtegl tdvilyhqpd dkkknrgfcf leyedhktaa
      301 qarrrlmsgk vkvwgnvgtv ewadpiedpd pevmakvkvl fvrnlantvt eeileksfsq
      361 fgklervkkl kdyafihfde rdgavkamee mngkdlegen ieivfakppd qkrkerkaqr
      421 qaaknqmydd yyyygpphmp pptrgrgrgg rggygyppdy ygyedyydyy gydyhnyrgg
      481 yedpyygyed fqvgargrgg rgargaapsr grgaapprgr agysqrggpg sargvrgarg
      541 gaqqqrgrgv rgarggrggn vggkrkadgy nqpdskrrqt nnqnwgsqpi aqqplqggdh
      601 sgnygyksen eefyqdtfgq qwk
//
