LOCUS       NM_001024239            1870 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus syncytin b (Synb), mRNA.
ACCESSION   NM_001024239 XM_224362
VERSION     NM_001024239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1870)
  AUTHORS   Wu,D.M., Yan,Y.E., Ma,L.P., Liu,H.X., Qu,W. and Ping,J.
  TITLE     Intrauterine growth retardation-associated syncytin b
            hypermethylation in maternal rat blood revealed by DNA methylation
            array analysis
  JOURNAL   Pediatr Res 82 (4), 704-711 (2017)
   PUBMED   28604758
  REMARK    GeneRIF: Hypermethylated Synb in maternal blood could reflect
            placental dysfunction and the occurrence of intrauterine growth
            retardation.
REFERENCE   2  (bases 1 to 1870)
  AUTHORS   Redelsperger,F., Raddi,N., Bacquin,A., Vernochet,C., Mariot,V.,
            Gache,V., Blanchard-Gutton,N., Charrin,S., Tiret,L., Dumonceaux,J.,
            Dupressoir,A. and Heidmann,T.
  TITLE     Genetic Evidence That Captured Retroviral Envelope syncytins
            Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice
  JOURNAL   PLoS Genet 12 (9), e1006289 (2016)
   PUBMED   27589388
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1870)
  AUTHORS   Dupressoir,A., Vernochet,C., Harper,F., Guegan,J., Dessen,P.,
            Pierron,G. and Heidmann,T.
  TITLE     A pair of co-opted retroviral envelope syncytin genes is required
            for formation of the two-layered murine placental
            syncytiotrophoblast
  JOURNAL   Proc Natl Acad Sci U S A 108 (46), E1164-E1173 (2011)
   PUBMED   22032925
REFERENCE   4  (bases 1 to 1870)
  AUTHORS   Dupressoir,A., Marceau,G., Vernochet,C., Benit,L.,
            Kanellopoulos,C., Sapin,V. and Heidmann,T.
  TITLE     Syncytin-A and syncytin-B, two fusogenic placenta-specific murine
            envelope genes of retroviral origin conserved in Muridae
  JOURNAL   Proc Natl Acad Sci U S A 102 (3), 725-730 (2005)
   PUBMED   15644441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000015.1.
            
            On Feb 27, 2015 this sequence version replaced NM_001024239.1.
            
            Summary: Many different endogenous retrovirus families are
            expressed in normal placental tissue at high levels, suggesting
            that endogenous retroviruses are functionally important in
            reproduction. This gene is part of an endogenous retrovirus
            provirus that has inactivating mutations in the gag and pol genes.
            This gene is the envelope glycoprotein gene which appears to have
            been selectively preserved. The gene's protein product plays a
            major role in placental development and trophoblast fusion. The
            protein has the characteristics of a typical retroviral envelope
            protein, including a cleavage site that separates the surface (SU)
            and transmembrane (TM) proteins which form a heterodimer. [provided
            by RefSeq, Apr 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            endogenous retrovirus  :: PMID: 15644441
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1870              JAXUCZ010000015.1  50993279-50995148   c
FEATURES             Location/Qualifiers
     source          1..1870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     gene            1..1870
                     /gene="Synb"
                     /gene_synonym="RGD1566115"
                     /note="syncytin b"
                     /db_xref="GeneID:290348"
                     /db_xref="RGD:1566115"
     exon            1..1870
                     /gene="Synb"
                     /gene_synonym="RGD1566115"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..1854
                     /gene="Synb"
                     /gene_synonym="RGD1566115"
                     /codon_start=1
                     /product="syncytin b precursor"
                     /protein_id="NP_001019410.2"
                     /db_xref="GeneID:290348"
                     /db_xref="RGD:1566115"
                     /translation="MTHLWVLCFVLFPSSLSYPESWMPLINLTHHILRDANSSLFPNC
                     WVCLSTQTQRSLAVPAPLSTWTDTPMKLHLTYSVKAFPGSFPISDLERRLRLFHPLIA
                     SYPFHNPERRAITFLQLVSSTGIFRIITRITSVIYPEKDRFFESAQRPLWGPLFTETV
                     LRSQAPLCISRFFKVSAYATFVGNLSASLCNYTLRISPSTSHENLDLSITHPFKQAMK
                     RPNAKWKNPLRFSGPPSLIFSKPSYHPCPADKYCHTSPATPWMRCPHAPSSTCYNLTL
                     FESDNLTHPVTMSVDSTHFKAKLQGRRDPYPLSHYQPIPGAALSGQYSVWENEITIQE
                     NWGVTSNIFSHLLSFSYIFCLNSSGVFFLCGTSTYVCLPANWSGVCTLVFQYPDIELL
                     PNNQTVPVPLFASVLSSASVLRPKRSPHLLPFLAGLGISSALGTGIAGLASSTLYFQR
                     LSKALSETLEEIAASITTLQNQIDSLAGVVLQNRRALDLITAEKGGTCLFLQEECCFY
                     VNQSGIVRDAARKLRERASELSQHSDSWGQWPDPGRWLPWLTPFLGPLLFIFFLLTFG
                     SCLLNCLTRFVSQRLGSFVQDTAKMQVDSILQNFQYKKLPQDSQDEDTIPM"
ORIGIN      
        1 atgacacacc tttgggtcct ctgttttgtc cttttccctt cctccttgtc ctatcccgag
       61 agctggatgc cccttataaa cctcactcac cacatcctac gggatgccaa ctcttccctg
      121 tttcccaact gctgggtctg cttgtccacc caaacccaac ggtccctggc agtcccagcc
      181 ccactgtcca cttggacaga cacacccatg aagcttcacc ttacctactc agtcaaggcc
      241 ttccctggct cttttcccat tagcgacctt gaaagacgcc tccgtctctt ccacccactg
      301 attgcctcct atcccttcca caatcctgag agaagggcga tcacttttct tcaactcgtc
      361 agctcaacag gcatatttcg gatcatcacc cggataacct ctgtgatata tcctgagaag
      421 gaccgtttct tcgaatctgc ccagcgccct ctctggggac cactctttac tgagaccgtc
      481 ctcaggtcac aggccccact ctgcatatcc cgcttcttca aggtctcagc ttatgccact
      541 tttgtaggca acctctctgc ttctctctgc aactacaccc ttcgtatttc accttctacc
      601 agccatgaaa acctagatct ttccatcacc catccattca aacaggcaat gaaaaggccc
      661 aatgccaaat ggaaaaaccc actccgtttc tccgggcccc cctccctaat cttctcaaag
      721 ccctcttacc atccctgccc agcagacaaa tactgccaca cctccccggc cactccctgg
      781 atgcgctgtc ctcacgcccc ctctagcacc tgctataacc ttaccttatt tgaatcagat
      841 aacttaaccc atcctgtcac catgtcagtg gactctaccc atttcaaggc caaactccag
      901 gggcgcagag acccttatcc tctctcccat tatcagccta tcccgggagc tgccctgtct
      961 ggacagtatt cagtctggga gaatgagatc actatccaag aaaactgggg agtcacctcc
     1021 aacattttct cacatctgct cagcttctcg tacatcttct gtctcaactc ttcaggagtt
     1081 ttcttcctct gcggaacatc gacttatgtc tgcctcccag ccaattggtc cggtgtctgt
     1141 acccttgtct tccaataccc ggatattgaa ctcctcccca ataaccaaac ggtgcctgtc
     1201 cccctttttg cttcagttct ttcctcggcc tcagttcttc gtccaaagag gtctccacac
     1261 ctcctcccct tccttgcagg cctgggcatc tcttctgccc ttggtacggg tatagctggc
     1321 ttggcctcct caactctata tttccaacgg ctttctaagg ctctctcaga aaccctggaa
     1381 gaaatagctg cctctattac taccctccag aaccaaatag actcgcttgc gggcgttgtt
     1441 ctccaaaacc gcagagctct ggacctcatc accgccgaaa aggggggcac ctgtctcttc
     1501 ctccaggaag agtgctgctt ctatgtaaac cagtctggaa tagtccggga tgcggcaagg
     1561 aaactccgag aacgagcatc tgaactcagc cagcattctg actcttgggg acagtggcct
     1621 gaccctggac gctggctgcc ctggctgact ccctttctgg gacctcttct cttcatcttc
     1681 ttcctactga catttgggtc ttgtcttctg aattgtctaa cccgttttgt gtcgcagaga
     1741 cttggctcct ttgtccagga cactgccaaa atgcaggtgg acagcatcct ccaaaatttc
     1801 caatataaaa aactgcctca agactcccaa gatgaggaca ctattcctat gtaacaggaa
     1861 gaagttgtga
//
