LOCUS       NP_058805                579 aa            linear   ROD 27-MAR-2024
DEFINITION  synapsin-3 [Rattus norvegicus].
ACCESSION   NP_058805
VERSION     NP_058805.1
DBSOURCE    REFSEQ: accession NM_017109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Perlini,L.E., Szczurkowska,J., Ballif,B.A., Piccini,A.,
            Sacchetti,S., Giovedi,S., Benfenati,F. and Cancedda,L.
  TITLE     Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to
            regulate radial migration and orientation of pyramidal neurons in
            vivo
  JOURNAL   Cell Rep 11 (2), 234-248 (2015)
   PUBMED   25843720
  REMARK    GeneRIF: we show that SynIII phosphorylation at the CDK5 site is
            induced by activation of the semaphorin-3A (Sema3A) pathway, which
            is implicated in migration and orientation of cortical pyramidal
            neurons
REFERENCE   2  (residues 1 to 579)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   3  (residues 1 to 579)
  AUTHORS   Lam,P.P., Hyvarinen,K., Kauppi,M., Cosen-Binker,L., Laitinen,S.,
            Keranen,S., Gaisano,H.Y. and Olkkonen,V.M.
  TITLE     A cytosolic splice variant of Cab45 interacts with Munc18b and
            impacts on amylase secretion by pancreatic acini
  JOURNAL   Mol Biol Cell 18 (7), 2473-2480 (2007)
   PUBMED   17442889
REFERENCE   4  (residues 1 to 579)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   5  (residues 1 to 579)
  AUTHORS   Gitler,D., Xu,Y., Kao,H.T., Lin,D., Lim,S., Feng,J., Greengard,P.
            and Augustine,G.J.
  TITLE     Molecular determinants of synapsin targeting to presynaptic
            terminals
  JOURNAL   J Neurosci 24 (14), 3711-3720 (2004)
   PUBMED   15071120
REFERENCE   6  (residues 1 to 579)
  AUTHORS   Feng,J., Chi,P., Blanpied,T.A., Xu,Y., Magarinos,A.M., Ferreira,A.,
            Takahashi,R.H., Kao,H.T., McEwen,B.S., Ryan,T.A., Augustine,G.J.
            and Greengard,P.
  TITLE     Regulation of neurotransmitter release by synapsin III
  JOURNAL   J Neurosci 22 (11), 4372-4380 (2002)
   PUBMED   12040043
REFERENCE   7  (residues 1 to 579)
  AUTHORS   Jaffrey,S.R., Benfenati,F., Snowman,A.M., Czernik,A.J. and
            Snyder,S.H.
  TITLE     Neuronal nitric-oxide synthase localization mediated by a ternary
            complex with synapsin and CAPON
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 3199-3204 (2002)
   PUBMED   11867766
REFERENCE   8  (residues 1 to 579)
  AUTHORS   Hosaka,M. and Sudhof,T.C.
  TITLE     Homo- and heterodimerization of synapsins
  JOURNAL   J Biol Chem 274 (24), 16747-16753 (1999)
   PUBMED   10358015
REFERENCE   9  (residues 1 to 579)
  AUTHORS   Hosaka,M. and Sudhof,T.C.
  TITLE     Synapsin III, a novel synapsin with an unusual regulation by Ca2+
  JOURNAL   J Biol Chem 273 (22), 13371-13374 (1998)
   PUBMED   9593663
REFERENCE   10 (residues 1 to 579)
  AUTHORS   Kao,H.T., Porton,B., Czernik,A.J., Feng,J., Yiu,G., Haring,M.,
            Benfenati,F. and Greengard,P.
  TITLE     A third member of the synapsin gene family
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4667-4672 (1998)
   PUBMED   9539796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840105,
                              SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..579
                     /product="synapsin-3"
                     /note="regulated by Ca+2; synapsin-3-like"
                     /calculated_mol_wt=63218
     Region          1..29
                     /region_name="Synapsin_N"
                     /note="Synapsin N-terminal; pfam10581"
                     /db_xref="CDD:463155"
     Region          1..28
                     /region_name="A"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA and CaMK1.
                     /evidence=ECO:0000250|UniProtKB:Q8JZP2; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Region          15..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Region          28..90
                     /region_name="B, linker"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Region          91..398
                     /region_name="C, actin-binding and synaptic-vesicle
                     binding"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Region          92..190
                     /region_name="Synapsin"
                     /note="N-terminal domain; pfam02078"
                     /db_xref="CDD:460438"
     Region          192..394
                     /region_name="Synapsin_C"
                     /note="Synapsin, ATP binding domain; pfam02750"
                     /db_xref="CDD:308403"
     Region          <380..>530
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau; cl46901"
                     /db_xref="CDD:481241"
     Region          399..530
                     /region_name="J, Pro-rich linker"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Region          400..566
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Site            454
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8JZP2; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Site            461
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Site            469
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Site            474
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Site            480
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Site            483
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     Region          531..579
                     /region_name="E"
                     /note="propagated from UniProtKB/Swiss-Prot (O70441.1)"
     Site            540
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O70441.1)"
     CDS             1..579
                     /gene="Syn3"
                     /coded_by="NM_017109.2:295..2034"
                     /db_xref="GeneID:29130"
                     /db_xref="RGD:3799"
ORIGIN      
        1 mnflrrrlsd ssfvanlpng ympdlqrpes sssspaspat errhpqplaa sfsspgsslf
       61 ssfssamkqt pqaptglmep ptpvtpvvqr prillvidda htdwskyfhg kkvngdieir
      121 veqaefseln laayvtggcm vdmqvvrngt kivrsfkpdf ilvrqhaysm alaedyrslv
      181 iglqygglpa vnslysvynf cskpwvfsql ikifhslgpe kfplveqtff pnhkpmltap
      241 nfpvviklgh ahagmgkikv enqhdyqdit svvamaktya tteafidsky diriqkigsn
      301 ykaymrtsis gnwkantgsa mleqvamter yrlwvdscse mfggldicav kavhskngrd
      361 yiievmdssm pligehveed kqlmadlvvs kmsqllvpga svpsplrpwg pqtksakspg
      421 qgqlgpllgq pqprpppqgg prqaqspqpp rsrspsqqrl spqgqqpvsp qsgspqqqrs
      481 pgspqlsras ggsspnqask ptaslsshtr ppvqgrstsq qgeepqktas phphlnksqs
      541 ltnslstsdt shrgtpsede akaetirnlr ksfaslfsd
//
