LOCUS       NM_001034020            2653 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus synapsin II (Syn2), transcript variant 1, mRNA.
ACCESSION   NM_001034020
VERSION     NM_001034020.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   Williams,L.E. and Featherstone,D.E.
  TITLE     Regulation of hippocampal synaptic strength by glial xCT
  JOURNAL   J Neurosci 34 (48), 16093-16102 (2014)
   PUBMED   25429150
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Coleman,W.L. and Bykhovskaia,M.
  TITLE     Cooperative regulation of neurotransmitter release by Rab3a and
            synapsin II
  JOURNAL   Mol Cell Neurosci 44 (2), 190-200 (2010)
   PUBMED   20338242
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Kang,S.U., Zhang,M., Burgos,M. and Lubec,G.
  TITLE     Mass spectrometrical characterisation of mouse and rat synapsin
            isoforms 2a and 2b
  JOURNAL   Amino Acids 38 (4), 1131-1143 (2010)
   PUBMED   19609639
  REMARK    GeneRIF: study provided high sequence coverage information on
            synapsin 2a and 2b in mouse and rat, revealing highest identity
            between the species; phosphorylation sites were determined
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Hosaka,M. and Sudhof,T.C.
  TITLE     Homo- and heterodimerization of synapsins
  JOURNAL   J Biol Chem 274 (24), 16747-16753 (1999)
   PUBMED   10358015
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Hosaka,M. and Sudhof,T.C.
  TITLE     Synapsin III, a novel synapsin with an unusual regulation by Ca2+
  JOURNAL   J Biol Chem 273 (22), 13371-13374 (1998)
   PUBMED   9593663
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Rosahl,T.W., Spillane,D., Missler,M., Herz,J., Selig,D.K.,
            Wolff,J.R., Hammer,R.E., Malenka,R.C. and Sudhof,T.C.
  TITLE     Essential functions of synapsins I and II in synaptic vesicle
            regulation
  JOURNAL   Nature 375 (6531), 488-493 (1995)
   PUBMED   7777057
REFERENCE   9  (bases 1 to 2653)
  AUTHORS   Thiel,G., Sudhof,T.C. and Greengard,P.
  TITLE     Synapsin II. Mapping of a domain in the NH2-terminal region which
            binds to small synaptic vesicles
  JOURNAL   J Biol Chem 265 (27), 16527-16533 (1990)
   PUBMED   2118908
REFERENCE   10 (bases 1 to 2653)
  AUTHORS   Sudhof,T.C., Czernik,A.J., Kao,H.T., Takei,K., Johnston,P.A.,
            Horiuchi,A., Kanazir,S.D., Wagner,M.A., Perin,M.S., De Camilli,P.
            et al.
  TITLE     Synapsins: mosaics of shared and individual domains in a family of
            synaptic vesicle phosphoproteins
  JOURNAL   Science 245 (4925), 1474-1480 (1989)
   PUBMED   2506642
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 1, 2020 this sequence version replaced NM_001034020.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27925.1, SRR26643285.17429.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               JAXUCZ010000004.1  149858919-149859422
            505-562             JAXUCZ010000004.1  149968132-149968189
            563-654             JAXUCZ010000004.1  149969330-149969421
            655-811             JAXUCZ010000004.1  149972739-149972895
            812-901             JAXUCZ010000004.1  149977235-149977324
            902-964             JAXUCZ010000004.1  149987172-149987234
            965-1107            JAXUCZ010000004.1  149987598-149987740
            1108-1182           JAXUCZ010000004.1  149994656-149994730
            1183-1285           JAXUCZ010000004.1  149995182-149995284
            1286-1435           JAXUCZ010000004.1  149996454-149996603
            1436-1496           JAXUCZ010000004.1  150009143-150009203
            1497-1749           JAXUCZ010000004.1  150012985-150013237
            1750-2653           JAXUCZ010000004.1  150015942-150016845
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2653
                     /gene="Syn2"
                     /note="synapsin II"
                     /db_xref="GeneID:29179"
                     /db_xref="RGD:3798"
     exon            1..504
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1885
                     /gene="Syn2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synapsin-2"
                     /codon_start=1
                     /product="synapsin-2 isoform 1"
                     /protein_id="NP_001029192.2"
                     /db_xref="GeneID:29179"
                     /db_xref="RGD:3798"
                     /translation="MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPAPGPGTAT
                     ASAATSAASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLV
                     DAPAPSAASRKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADG
                     TYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLE
                     SIYNFCDKPWVFAQMVAIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHS
                     GMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISG
                     NWKTNTGSAMLEQIAMSDRYKLWVDACSEMFGGLDICAVKAVHGKDGKDYIFEVMDCS
                     MPLIGEHQVEDRQLITDLVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKEPDSSKTP
                     PQRPAPQGGPGQPQGMQPPGKVLPPRRLPSGPSLPPSSSSSSSSSSSSSAPQRPGGPT
                     TTHGDASSSSNSLAEAQAPQAAPPQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANED
                     EAKAETIRSLRKSFASLFSD"
     exon            505..562
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..654
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..811
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..901
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..964
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1107
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1182
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1285
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1435
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1496
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1749
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2653
                     /gene="Syn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccagag cgccgcggct gtctgctggg ctcacggaga cgcggaccac ctttggtcgc
       61 tccgcgccgt cctctccgcg ccgcctggcc cgccgcctcg agcgccctca gtccctcaag
      121 ccagatgatg aacttcctga ggcgccggct gtcggacagc agcttcattg ccaacctgcc
      181 caatggctac atgactgacc ttcagcgccc ggagccgcag cagcccccac ccgcccctgg
      241 ccccggtacc gctaccgcgt cggcggccac ctcagctgcc tcgcctggcc ccgagcgcag
      301 gccgccaccc gcccaggcac ccgcgccgca gccggcgccg cagcccgcgc cgacgccgtc
      361 ggtgggcagc agcttcttca gctcgctgtc gcaagccgtg aagcagacgg ccgcctccgc
      421 cggcctggtg gacgcgcccg cgccttcggc cgcttccagg aaggccaagg tgctgctggt
      481 ggtcgacgag ccgcacaccg actgggccaa gtgctttcgg ggcaaaaaaa tccttggaga
      541 ttatgacatc aaagtagaac aggcagaatt ttcagagctt aacctggtgg cccatgcgga
      601 tggaacctac gccgtggaca tgcaggtact ccggaatggc acaaaggttg tcaggtcctt
      661 caggccagac ttcgtgctca tccgacagca tgcatttggc atggcggaga atgaagactt
      721 ccgccacctg gtcattggca tgcagtatgc aggcctcccc agcatcaact cactggagtc
      781 catttacaac ttctgtgaca agccatgggt gtttgctcag atggtggcca tcttcaagac
      841 actgggaggg gagaaatttc cactcattga gcagacctac taccccaatc accgagagat
      901 gcttacactt cctacgtttc ctgtcgtggt gaagattggc catgctcact cgggcatggg
      961 caaggtcaaa gtggaaaatc actacgactt ccaggacatt gccagtgtgg tggccctcac
     1021 ccaaacctat gccacagcag aacccttcat tgacgccaag tatgacatcc gggttcagaa
     1081 gattggcaac aactacaagg cttacatgag gacatccatc tcagggaact ggaagacaaa
     1141 cactggctcc gcgatgctgg agcagatcgc catgtcagac cggtacaagc tctgggtcga
     1201 cgcctgctct gagatgtttg ggggcttgga catctgtgca gtcaaagctg tgcatggcaa
     1261 agatggcaaa gactacattt ttgaggtcat ggactgtagc atgccactga ttggggaaca
     1321 ccaagtggag gacagacaac tcatcactga tctagtcatc agcaagatga accagctatt
     1381 gtccaggact cctgccctgt ctccacagag acctttaacc acccaacagc cacagagtgg
     1441 aacacttaag gaaccggact ccagcaagac ccctcctcag cggccagccc cccaaggggg
     1501 ccctgggcaa ccccaaggaa tgcagccccc aggcaaggtg ctgcctccac gtcggctccc
     1561 ctcgggacca tcactgccac cttcttcctc ttcctcctcc tcttcctcct cctcttcctc
     1621 ggctcctcag aggccgggcg gccctaccac cacccacggt gatgcatcct ccagcagcaa
     1681 ctccctggca gaggcccagg cacctcaggc tgctccacca cagaagcccc agcctcaccc
     1741 acagctcaac aagtcgcagt ccctgacaaa tgcgttcagc ttctctgagt cctccttctt
     1801 ccggtcttca gccaatgaag atgaagccaa agcggagacc atccggagct tgaggaagtc
     1861 ctttgccagc ctcttttcag attagctctt cagatacacg agggcatccg gcccaaccag
     1921 gaaaggcatc taagacattc atcaacagca gtccgccatg tttggtggca atgtcccatg
     1981 acttgacatg tgtggcccct tcttctgttc ctttgtgctc agtaatttgt gcagcccaga
     2041 aatgaccatg tgatggtctc agggcaggtg gctaccctga gaaagacctg acagtagagg
     2101 aaagggctgt ttccctgtag tcttaagagc tttattctga agtcatcgtt gctgtgaatt
     2161 tagtggcctt attgtgacag agccatcgtg tcttactctt ccctgtgaag ccaggatctc
     2221 tgtaacgtag gactcctggc agcttaccta tctcagcata tcctagtagt cagtgctacc
     2281 tgtgggaaat atattcttac cttagaagta ttgttggctc taagttttag gagcttctcc
     2341 ccaaagctgg gtctcctgtg gtccctgttg aaagcacatt cacctgaccc tgcactccct
     2401 agactgctgt ggaggtcaag ttccttgtga ctgtttgaaa caagagaaca aggatccaca
     2461 gtgtctcctt tctcccctct ggagagcagt tctgttgtgt gagcatcagt aaccttgacc
     2521 tttcgaagct gtactgtaga agagaatgca tgccgctata acagcagtcc accaaccttt
     2581 gtgttcctca ccttatgaat gtcaagacct tggtgtaata aaagcagcag ctttaaccag
     2641 catttgattc agc
//
