LOCUS       NM_019133               3184 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus synapsin I (Syn1), transcript variant 1, mRNA.
ACCESSION   NM_019133
VERSION     NM_019133.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3184)
  AUTHORS   Ma,W., Lu,K., Liang,H.M. and Zhang,J.Y.
  TITLE     Synapsin 1 Ameliorates Cognitive Impairment and Neuroinflammation
            in Rats with Alzheimer's Disease: An Experimental and
            Bioinformatics Study
  JOURNAL   Curr Alzheimer Res 20 (9), 648-659 (2023)
   PUBMED   38213171
  REMARK    GeneRIF: Synapsin 1 Ameliorates Cognitive Impairment and
            Neuroinflammation in Rats with Alzheimer's Disease: An Experimental
            and Bioinformatics Study.
REFERENCE   2  (bases 1 to 3184)
  AUTHORS   Yang,H.J., Chen,P.C., Huang,C.T., Cheng,T.L., Hsu,S.P., Chen,C.Y.,
            Lu,J.C. and Wang,C.T.
  TITLE     The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core
            Vesicle Release
  JOURNAL   J Neurosci 41 (13), 2828-2841 (2021)
   PUBMED   33632727
  REMARK    GeneRIF: The Phosphoprotein Synapsin Ia Regulates the Kinetics of
            Dense-Core Vesicle Release.
REFERENCE   3  (bases 1 to 3184)
  AUTHORS   Zhang,S., Yan,M.L., Yang,L., An,X.B., Zhao,H.M., Xia,S.N., Jin,Z.,
            Huang,S.Y., Qu,Y. and Ai,J.
  TITLE     MicroRNA-153 impairs hippocampal synaptic vesicle trafficking via
            downregulation of synapsin I in rats following chronic cerebral
            hypoperfusion
  JOURNAL   Exp Neurol 332, 113389 (2020)
   PUBMED   32580014
  REMARK    GeneRIF: MicroRNA-153 impairs hippocampal synaptic vesicle
            trafficking via downregulation of synapsin I in rats following
            chronic cerebral hypoperfusion.
REFERENCE   4  (bases 1 to 3184)
  AUTHORS   Tao-Cheng,J.H.
  TITLE     Immunogold labeling of synaptic vesicle proteins in developing
            hippocampal neurons
  JOURNAL   Mol Brain 13 (1), 9 (2020)
   PUBMED   31959215
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3184)
  AUTHORS   Liu,X., Zhang,R., Wu,Z., Si,W., Ren,Z., Zhang,S., Zhou,J. and
            Chen,D.
  TITLE     miR-134-5p/Foxp2/Syn1 is involved in cognitive impairment in an
            early vascular dementia rat model
  JOURNAL   Int J Mol Med 44 (5), 1729-1740 (2019)
   PUBMED   31545395
  REMARK    GeneRIF: The miR1345p/Foxp2/Syn1 axis was found to contribute to
            cognitive impairment in a chronic ischemiainduced early VD model,
            which may enable the development of new therapeutic strategies for
            the prevention and treatment of VD.
REFERENCE   6  (bases 1 to 3184)
  AUTHORS   Li,L., Chin,L.S., Shupliakov,O., Brodin,L., Sihra,T.S., Hvalby,O.,
            Jensen,V., Zheng,D., McNamara,J.O., Greengard,P. et al.
  TITLE     Impairment of synaptic vesicle clustering and of synaptic
            transmission, and increased seizure propensity, in synapsin
            I-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9235-9239 (1995)
   PUBMED   7568108
REFERENCE   7  (bases 1 to 3184)
  AUTHORS   Cho,K.O., Hunt,C.A. and Kennedy,M.B.
  TITLE     The rat brain postsynaptic density fraction contains a homolog of
            the Drosophila discs-large tumor suppressor protein
  JOURNAL   Neuron 9 (5), 929-942 (1992)
   PUBMED   1419001
REFERENCE   8  (bases 1 to 3184)
  AUTHORS   Sudhof,T.C., Czernik,A.J., Kao,H.T., Takei,K., Johnston,P.A.,
            Horiuchi,A., Kanazir,S.D., Wagner,M.A., Perin,M.S., De Camilli,P.
            et al.
  TITLE     Synapsins: mosaics of shared and individual domains in a family of
            synaptic vesicle phosphoproteins
  JOURNAL   Science 245 (4925), 1474-1480 (1989)
   PUBMED   2506642
  REMARK    Review article
REFERENCE   9  (bases 1 to 3184)
  AUTHORS   McCaffery,C.A. and DeGennaro,L.J.
  TITLE     Determination and analysis of the primary structure of the nerve
            terminal specific phosphoprotein, synapsin I
  JOURNAL   EMBO J 5 (12), 3167-3173 (1986)
   PUBMED   3028773
REFERENCE   10 (bases 1 to 3184)
  AUTHORS   Huttner,W.B., Schiebler,W., Greengard,P. and De Camilli,P.
  TITLE     Synapsin I (protein I), a nerve terminal-specific phosphoprotein.
            III. Its association with synaptic vesicles studied in a highly
            purified synaptic vesicle preparation
  JOURNAL   J Cell Biol 96 (5), 1374-1388 (1983)
   PUBMED   6404912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ084192.1, M27812.1, CO401107.1, JAXUCZ010000021.1 and BG378858.1.
            
            On Sep 5, 2012 this sequence version replaced NM_019133.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27812.1, X04655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               FQ084192.1         118-368
            252-2217            M27812.1           234-2199
            2218-2251           CO401107.1         428-461
            2252-2418           M27812.1           2233-2399
            2419-2574           JAXUCZ010000021.1  3780189-3780344
            2575-3184           BG378858.1         1-610               c
FEATURES             Location/Qualifiers
     source          1..3184
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..3184
                     /gene="Syn1"
                     /note="synapsin I"
                     /db_xref="GeneID:24949"
                     /db_xref="RGD:3797"
     exon            1..475
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2213
                     /gene="Syn1"
                     /note="isoform a is encoded by transcript variant 1;
                     synapsin-1"
                     /codon_start=1
                     /product="synapsin-1 isoform a"
                     /protein_id="NP_062006.1"
                     /db_xref="GeneID:24949"
                     /db_xref="RGD:3797"
                     /translation="MNYLRRRLSDSNFMANLPNGYMTDLQRPQPPPPPPSAASPGATP
                     GSAAASAERASTAAPVASPAAPSPGSSGGGGFFSSLSNAVKQTTAAAAATFSEQVGGG
                     SGGAGRGGAAARVLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGG
                     FSVDMEVLRNGVKVVRSLKPDFVLIRQHAFSMARNGDYRSLVIGLQYAGIPSVNSLHS
                     VYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSG
                     MGKVKVDNQHDFQDIASVVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGN
                     WKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVEALHGKDGRDHIIEVVGSSM
                     PLIGDHQDEDKQLIVELVVNKMTQALPRQRDASPGRGSHSQTPSPGALPLGRQTSQQP
                     AGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPS
                     PTAAPQQSASQATPMTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQAS
                     ISGPAPPKVSGASPGGQQRQGPPQKPPGPAGPIRQASQAGPGPRTGPPTTQQPRPSGP
                     GPAGRPTKPQLAQKPSQDVPPPIIAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLS
                     QDEVKAETIRSLRKSFASLFSD"
     exon            476..533
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..625
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..782
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..872
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..935
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1078
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1153
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1256
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1397
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1485
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..2077
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..3170
                     /gene="Syn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccagaga gcgccgccgt gctcctgagc cccttgcgct ccgcccccgc ggcccaccga
       61 cccactgccc cttggatccc ctgccccaag ctgccaccat gaactacctg cggcgccgcc
      121 tgtcggacag caacttcatg gccaatctgc ctaatgggta tatgacagac ctgcagcgcc
      181 cgcaaccacc tccgccgccg ccctcagccg ccagccctgg ggccactccc ggatccgctg
      241 ctgcctctgc cgagagggcc tccacagctg ctccagtggc ctctccagca gcccctagtc
      301 ccgggtcctc ggggggcggt ggcttcttct cctcgctgtc taacgcggtc aaacagacca
      361 cagcagctgc agccgccacc ttcagtgagc aggtgggcgg tggctctggg ggcgcaggcc
      421 gcgggggcgc cgccgccagg gtgctgctgg tcatcgacga gccgcacacc gactgggcaa
      481 aatacttcaa agggaagaag atccatggag aaattgacat taaagtagag caagctgaat
      541 tctccgatct caatcttgtg gctcatgcca atggtggatt ctccgtggac atggaagttc
      601 ttcggaatgg ggtcaaagtt gtgaggtctc tgaagccaga ctttgtgctg atccgccagc
      661 atgccttcag catggcacgt aatggagact accgcagttt ggtcattggg ctgcagtatg
      721 ctgggatccc cagtgttaac tctttgcatt ctgtctacaa cttttgtgac aaaccctggg
      781 tgtttgccca gatggttcga ctacacaaga agcttggaac agaggaattc cctctgattg
      841 atcagacttt ctatcccaat cataaagaga tgctcagcag cacaacatac cctgtagttg
      901 tgaagatggg ccacgcacac tctgggatgg gcaaggtcaa ggtagacaac caacatgact
      961 tccaggatat tgcaagtgtt gtggcactga ctaagacata tgccactgct gagcccttca
     1021 ttgatgctaa atacgatgtg cgtgtccaga agattgggca gaactacaag gcctacatga
     1081 ggacatcagt gtcagggaac tggaagacca atacaggctc tgctatgctt gagcagattg
     1141 ctatgtctga caggtacaag ttgtgggtag acacgtgctc agagattttt gggggacttg
     1201 acatctgcgc agtggaagca ctgcatggca aggacggaag ggatcacatt attgaggtgg
     1261 tgggctcctc catgccactc attggggatc accaggatga agacaagcag ctcatcgtgg
     1321 aacttgtggt caacaagatg actcaggctc tgcctcggca gcgggatgct tcccctggca
     1381 ggggttccca cagccagact ccatccccag gagccctgcc cttgggccgc cagacctccc
     1441 agcagcctgc aggacctcct gctcaacaac gacccccacc ccagggaggc cctccacaac
     1501 caggcccagg acctcagcgc cagggacccc cgctgcaaca gcgcccaccc ccacaaggcc
     1561 agcaacatct ttctggcctt ggacccccag ctggcagccc tctgccccag cgcctaccaa
     1621 gtcccacagc agcacctcag cagtccgcct ctcaggccac accaatgacc cagggtcaag
     1681 gccgccagtc acggccagtg gcaggaggcc ccggagcacc tccagcagcc cgcccgccgg
     1741 cctccccatc tccacagcgt caggcagggc ccccacaggc tacccgtcag gcatctatct
     1801 ctggtccagc tccaccgaag gtctcaggag cctcacccgg agggcagcag cgccaaggcc
     1861 ctccccagaa acccccaggc cctgctggtc ccattcgtca ggccagccag gcaggtcccg
     1921 gacctcgcac tgggccaccc accacacagc agccccggcc cagcggccca ggtcctgctg
     1981 gacgtcccac caaaccacag ctggctcaga aacccagcca ggatgtgcca ccacccatca
     2041 ttgctgctgc cgggggaccc ccgcaccccc agctcaacaa atcccagtct ctgaccaatg
     2101 ccttcaacct tccagagcca gccccgccca ggcccagcct tagccaggat gaggtgaaag
     2161 ctgagaccat ccgcagcctg aggaagtctt tcgccagcct cttctccgac tgacacccta
     2221 ctctgagaac ccctaaaccc ctagacaacc ctctctgggt cctgagtcca tttctcacct
     2281 ttggaatctc caaatccctt gagaacccct ctctcctggt tctacatccc acttctcatt
     2341 cctcaagatg tcccttgaga aacgtggtcc taaatccagt tctcacattg ggaatcccca
     2401 agtccattta gaatcctgtt cccagtcacc tccagatctg ttttagaatc tccaaattcc
     2461 tgaagacctc tacttctgat atctctaaag ggtgatttcc tccctggaag ttcctgaatg
     2521 gcagaacctg tttctgacct aatacatcct ctcctggagc tctggaattc ctggaaaacc
     2581 ctattctact cttggtcctg aatctctcca gcacaccttg ctcctaatca gaagtttcaa
     2641 attccaaaag aagcccctat ccttaaatct cttcctagat tatctctctg gagagccacc
     2701 tcttcaaatg ccacctacta tccaccaacc agtccctcaa ggacttcctt tcacctcttc
     2761 cctcaacccc attcaacata ctggaagttc cttccacttc taggacccct aagttccttc
     2821 ctccagaaac ctcctcccca atctcctgcc tctgacagct gtctttaaat atgcaaactc
     2881 tacccatcct ctcagaatcc tttgcacaag ggaggcctaa ggtctcccac cactccccca
     2941 cctttgccaa tgtttgtgtc tgtgactgac ttggcctcct tttgtgccat gctaggcata
     3001 tgtggtcctc attcgtgctg cctgtggtaa tgtgtacagt ggcgctgttt gtgtggtccg
     3061 catcttcctc caacctccac tccttgcctg gacttgcccc acccctcagt ggctctgaac
     3121 cccaagagaa gagtcgggaa gcaaaataaa caagcaaagg cccagcagaa aaaaaaaaaa
     3181 aaaa
//
