LOCUS       NM_001415786            4037 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus symplekin scaffold protein (Sympk), mRNA.
ACCESSION   NM_001415786 XM_008758908
VERSION     NM_001415786.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4037)
  AUTHORS   Bratkowski,M., Unarta,I.C., Zhu,L., Shubbar,M., Huang,X. and Liu,X.
  TITLE     Structural dissection of an interaction between transcription
            initiation and termination factors implicated in
            promoter-terminator cross-talk
  JOURNAL   J Biol Chem 293 (5), 1651-1665 (2018)
   PUBMED   29158257
REFERENCE   2  (bases 1 to 4037)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   3  (bases 1 to 4037)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   4  (bases 1 to 4037)
  AUTHORS   Xiang,K., Nagaike,T., Xiang,S., Kilic,T., Beh,M.M., Manley,J.L. and
            Tong,L.
  TITLE     Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide
            complex
  JOURNAL   Nature 467 (7316), 729-733 (2010)
   PUBMED   20861839
REFERENCE   5  (bases 1 to 4037)
  AUTHORS   Xing,H., Mayhew,C.N., Cullen,K.E., Park-Sarge,O.K. and Sarge,K.D.
  TITLE     HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with
            symplekin
  JOURNAL   J Biol Chem 279 (11), 10551-10555 (2004)
   PUBMED   14707147
REFERENCE   6  (bases 1 to 4037)
  AUTHORS   Hilditch-Maguire,P., Trettel,F., Passani,L.A., Auerbach,A.,
            Persichetti,F. and MacDonald,M.E.
  TITLE     Huntingtin: an iron-regulated protein essential for normal nuclear
            and perinuclear organelles
  JOURNAL   Hum Mol Genet 9 (19), 2789-2797 (2000)
   PUBMED   11092755
REFERENCE   7  (bases 1 to 4037)
  AUTHORS   Keon,B.H., Schafer,S., Kuhn,C., Grund,C. and Franke,W.W.
  TITLE     Symplekin, a novel type of tight junction plaque protein
  JOURNAL   J Cell Biol 134 (4), 1003-1018 (1996)
   PUBMED   8769423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 30, 2022 this sequence version replaced XM_008758908.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.822.1,
                                           SRR26643429.1075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000001.1  87800416-87800506
            92-215              JAXUCZ010000001.1  87803329-87803452
            216-281             JAXUCZ010000001.1  87803598-87803663
            282-335             JAXUCZ010000001.1  87806119-87806172
            336-409             JAXUCZ010000001.1  87806255-87806328
            410-536             JAXUCZ010000001.1  87808821-87808947
            537-786             JAXUCZ010000001.1  87810142-87810391
            787-957             JAXUCZ010000001.1  87811253-87811423
            958-1197            JAXUCZ010000001.1  87812488-87812727
            1198-1352           JAXUCZ010000001.1  87814713-87814867
            1353-1503           JAXUCZ010000001.1  87815206-87815356
            1504-1708           JAXUCZ010000001.1  87817133-87817337
            1709-1859           JAXUCZ010000001.1  87817831-87817981
            1860-2095           JAXUCZ010000001.1  87819116-87819351
            2096-2177           JAXUCZ010000001.1  87819768-87819849
            2178-2291           JAXUCZ010000001.1  87819984-87820097
            2292-2439           JAXUCZ010000001.1  87820626-87820773
            2440-2600           JAXUCZ010000001.1  87821362-87821522
            2601-2709           JAXUCZ010000001.1  87822431-87822539
            2710-2810           JAXUCZ010000001.1  87822791-87822891
            2811-2901           JAXUCZ010000001.1  87823256-87823346
            2902-3003           JAXUCZ010000001.1  87823999-87824100
            3004-3191           JAXUCZ010000001.1  87826453-87826640
            3192-3368           JAXUCZ010000001.1  87827372-87827548
            3369-3464           JAXUCZ010000001.1  87827682-87827777
            3465-3824           JAXUCZ010000001.1  87828048-87828407
            3825-4037           JAXUCZ010000001.1  87828515-87828727
FEATURES             Location/Qualifiers
     source          1..4037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4037
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /note="symplekin scaffold protein"
                     /db_xref="GeneID:292683"
                     /db_xref="RGD:1306735"
     exon            1..91
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            92..215
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3953
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /note="hepatocyte nuclear factor 3 gamma"
                     /codon_start=1
                     /product="symplekin"
                     /protein_id="NP_001402715.1"
                     /db_xref="GeneID:292683"
                     /db_xref="RGD:1306735"
                     /translation="MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAA
                     LITNDSKITVLKQVQELIINKDPTLLDNFLDEIIAFQADKSTEVRKFVIGFIEEACKR
                     DIELLLKLIANLNMLLRDENVNVVKKAILTMTQLYKVALQWMVKSRVISDLQEACWDM
                     VSSMAAEIILLLDSDNDGIRTHAIKFVEGLIVTLSPRMADSEVPRRQEHDISLDRIPR
                     DHPYIQYNVLWEEGKAALEQLLKFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQ
                     AYETLHANLPPTLAKSQVSSVRKNLKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAE
                     IARNMPSSKDSRKRPRDDTESTLKKMKLEPNLGEDDEDKDLEPGPSGTSKASAQISGQ
                     SDTDITAEFLQPLLTPDNVANLVLISMVYLPETMPASFQAIYTPVESAGTEAQIKHLA
                     RLMATQMTAAGLGPGVEQTKQCKEEPKEEKVVKPESVLIKRRLSVQGQAISVVGSQST
                     MSPLEEEVPQAKRRPEPIIPVTQPRLAGAGGRKKIFRLSDVLKPLTDAQVEAMKLGAV
                     KRILRAEKAVACSGAAQVRIKILASLVTQFDSGFKAEVLSFILEDVRARLDLAFAWLY
                     QEYNAYLAAGPSGTLDKYEDCLICLLSGLQEKPDQKDGIFTKVVLEAPLITESALEVI
                     RKYCEDESRAYLGMSTLGDLIFKRPSRQFQYLHVLLDLSSHEKDRVRSQALLFIKRMY
                     EKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAAPWTEETVKQCLYLYLALL
                     PQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPELLLLVENCPKGAETLV
                     TRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEKKEVIQALPKLIKLN
                     PIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMKSIIKATNLCFAE
                     RNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNILARLIMKQVWK
                     YPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQA
                     HIPNSIMTILEASGKQEPEVKEAPSGSLEEDDLEPLALALAPALAPAPAPRPPQDLIG
                     LRLAQEKALKRQLEEEQKQKPTGVGAPTSSVSSTPLVGPAARAGPTPAEEVMEYREEG
                     PECETPAIFISMDDDSGLAETTLLDSSLEGPLPKEAAAVGPSSKDERSPQNLSHAVEE
                     ALKTSSPEAREPESKGNS"
     exon            216..281
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            282..335
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            336..409
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            410..536
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            537..786
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            787..957
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1197
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1352
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1503
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1708
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1859
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2095
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2177
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2291
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2439
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2600
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2709
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2810
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2901
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3003
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3191
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3368
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3464
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3824
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..4037
                     /gene="Sympk"
                     /gene_synonym="Hfn3g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtcacggc ggcgggcgga agatggcggc ggcagcgtct gtggagaggc gctgctgagg
       61 gggcgcgagg gggacggagg ccggagccgc gggagaacct gacagcagtc atggcaagcg
      121 gcagcgggga cagtgtcacc cgccggagtg tggcatcaca gtttttcaca caagaagaag
      181 ggccaggcat tgatggcatg accacttctg aaagggtggt agatctcctg aaccaggctg
      241 cgctgatcac caatgactca aagatcacag tgctcaaaca ggtccaagag ctgatcatca
      301 acaaggaccc caccctgctt gacaacttcc tggacgagat catcgctttc caagcagaca
      361 agtccactga agtgcgcaag tttgtcattg gcttcatcga ggaggcatgc aagcgggaca
      421 ttgagctgct gctaaaactg atcgccaacc tcaacatgct attgcgggat gaaaacgtga
      481 atgtggtaaa gaaggccatc ctcaccatga cccagctcta caaggtggcc ctgcagtgga
      541 tggtgaagtc tcgggtcatc agcgacctcc aggaggcctg ctgggacatg gtgtcctcca
      601 tggctgcaga aatcatactg ctcttggatt ctgacaatga tggcatccgt acacatgcca
      661 ttaagtttgt ggagggcctc attgtcactc tgtcaccccg aatggctgac tcagaggtcc
      721 cccgacgcca ggagcatgac atcagtctgg accgcatccc tcgagatcac ccctacatcc
      781 agtacaatgt cctatgggaa gaaggcaagg cagctctgga gcagcttctc aagttcatgg
      841 tgcaccccgc catctcctcc atcaacctga ccacagcgct cggctccctt gccaacatcg
      901 cccgccagag acccatgttc atgtctgagg tgatccaggc ctatgagact ctgcatgcca
      961 acctgccccc aacactggcc aagtcccagg tgagcagcgt gcgtaagaac ctcaagctgc
     1021 acttgctgag cgtgctcaag caccctgcct ccttggagtt ccaggcccag atcaccaccc
     1081 tgctggtgga cctgggcacg ccccaggccg agattgcccg taacatgcct agcagcaagg
     1141 actcccgcaa gcggccccgg gacgatacag aatccacgct caagaagatg aagctggagc
     1201 ccaacctggg agaagatgat gaggacaaag acttggagcc tggcccatcg gggacatcaa
     1261 aggcctcagc ccagatctca ggccagtcag acacagacat cactgctgag ttcttgcagc
     1321 ctctgctgac acctgacaat gtggccaatc tggtcctcat cagcatggtg tacctgcccg
     1381 agaccatgcc tgcctccttc caagccattt acacccccgt ggagtcagca ggcacagaag
     1441 cccagatcaa gcacctggca cggctcatgg ccacacagat gacagctgcg ggactgggtc
     1501 ctggtgtgga acagacgaaa cagtgcaagg aggagcccaa ggaggagaag gtggtaaagc
     1561 cggagagcgt cctgatcaaa cggcgcctgt cagtgcaggg ccaggccatc tctgtggtgg
     1621 gctctcagag caccatgtcc cccttggagg aggaagtacc ccaggccaag aggaggccag
     1681 aacccatcat tcctgtcaca cagccacggc tggcaggcgc tggtgggcgc aagaagatct
     1741 tccgtctgag cgatgtgctg aagcccctga cagatgccca ggtggaagcc atgaagctgg
     1801 gagctgtgaa gcggatcctg agggctgaga aggctgtagc ctgcagtggg gcggcccagg
     1861 tgcgcatcaa gatcctggcc agcctcgtga cacagttcga ctccggattc aaggcagagg
     1921 tgctgtcctt tatcctggaa gacgtccggg cccgtctgga cctggctttt gcctggctct
     1981 accaggagta caatgcctac ctggcagcgg ggccctctgg cactctggac aagtatgaag
     2041 actgccttat ctgcctgctc tctggacttc aagagaaacc agaccagaaa gatgggatct
     2101 ttaccaaggt ggttttggag gccccgctga tcactgagag tgctttggag gtgatacgga
     2161 agtactgtga ggatgagagt cgcgcctacc tgggcatgtc gacacttgga gacctgatct
     2221 tcaagcgccc ttctcgccaa ttccagtatc tgcacgttct cctcgacctc agctctcacg
     2281 agaaggacag ggtgcgctcc caggccctgc tcttcattaa gcgcatgtat gagaaggagc
     2341 agcttcgaga atatgtggag aaatttgccc tcaactacct gcagctcctg gtccacccca
     2401 acccaccctc agtgctgttt ggagctgaca aggacacaga ggtggctgcg ccctggacag
     2461 aggaaacagt gaagcagtgt ttgtacctat atctggctct cctgcctcag aaccacaagc
     2521 tgatccatga gctggcagca gtgtacacgg aggccatcgc cgacatcaag cggacagtgc
     2581 tgagagtcat tgagcaaccg atccgaggga tgggcatgaa ctcaccagag ttgctgctgc
     2641 tggtggaaaa ctgtcccaag ggggcagaga cgctggtcac ccgctgcctg cacagcctca
     2701 ctgacaaagt gccaccatcc ccagaactgg tgaagcgggt ccgggacctg taccacaagc
     2761 ggctgcctga cgtgcgcttc ctcatccctg tgctcaacgg cttggagaag aaagaggtga
     2821 tccaggccct gcctaagctc atcaaactca accccattgt ggtgaaggag gtcttcaacc
     2881 gcctgctagg cacccagcat ggtgagggga actctgccct gtcccccctg aatccgggag
     2941 agctgctgat tgcattgcac aatattgact ctgtaaagtg tgacatgaag tccatcatca
     3001 aagccaccaa cctgtgtttt gcggagcgga atgtgtacac atcggaagtg ctggctgtgg
     3061 tgatgcagca gctgatggag caaagccctc tgcccatgct gctcatgcgg accgtcatcc
     3121 agtccctgac catgtacccc cgcctggggg gcttcgtcat gaacatcctg gcccggctca
     3181 tcatgaagca ggtatggaag taccccaagg tatgggaggg cttcatcaag tgctgccagc
     3241 gcaccaagcc ccagagtttc caggtcatcc tgcagctacc tccacagcag cttggcgcag
     3301 tctttgacaa gtgccctgag ctccgggagc cactgttggc ccatgtgcgc tccttcaccc
     3361 cccaccagca agcacacatc cccaactcca tcatgacaat cctggaggcc agtggcaagc
     3421 aggagccgga agtcaaggaa gcaccttcag ggtccctgga agaggatgac ctggagccct
     3481 tggctctggc cttggccccg gctttggccc cggcccctgc cccacggccc cctcaggacc
     3541 tcatcggcct tcgattggct caggagaagg ccttgaagcg gcagctcgaa gaagaacaga
     3601 agcagaagcc cacaggcgtc ggagcgccca cttcctcagt gtcctcgaca cccttggtgg
     3661 ggccagcagc ccgagctggt cccaccccgg ctgaggaggt tatggaatac cgggaggaag
     3721 gtcctgaatg cgagaccccg gccatcttca tcagcatgga cgacgactca gggctggccg
     3781 aaaccacact tctggactct agtctcgagg gacccctgcc taaggaggca gcagcagtcg
     3841 gaccgagctc caaggacgag cggagccccc agaacctcag ccatgctgtg gaagaagcct
     3901 tgaagacctc cagcccagag gccagggaac ccgagagcaa ggggaacagc tgacaactgc
     3961 gggagtttgg ggggaggggc gggatggggc ctcctagagc tttgccttaa cacaaataaa
     4021 ggaggtggcg ctcaggg
//
