LOCUS       NM_012758               5311 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus spleen associated tyrosine kinase (Syk), mRNA.
ACCESSION   NM_012758
VERSION     NM_012758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5311)
  AUTHORS   Li,S., Liu,R., Xue,M., Qiao,Y., Chen,Y., Long,G., Tian,X., Hu,Y.,
            Zhou,P., Dong,X., Qi,Z., Cui,Y. and Shen,Y.
  TITLE     Spleen tyrosine kinase-induced JNK-dependent NLRP3 activation is
            involved in diabetic cardiomyopathy
  JOURNAL   Int J Mol Med 43 (6), 2481-2490 (2019)
   PUBMED   30942391
  REMARK    GeneRIF: It was demonstrated in the present study that Syk was
            markedly activated in the development of Diabetic cardiomyopathy,
            subsequently promoting NLRP3 inflammasome activation through the
            phosphorylation of JNK, leading to the cleavage of pro-caspase-1
            and maturation of IL-1beta, and finally contributing to diabetic
            cardiac dysfunction.
REFERENCE   2  (bases 1 to 5311)
  AUTHORS   Qiao,Y., Tian,X., Men,L., Li,S., Chen,Y., Xue,M., Hu,Y., Zhou,P.,
            Long,G., Shi,Y., Liu,R., Liu,Y., Qi,Z., Cui,Y. and Shen,Y.
  TITLE     Spleen tyrosine kinase promotes NLR family pyrin domain containing
            3 inflammasome-mediated IL-1beta secretion via c-Jun N-terminal
            kinase activation and cell apoptosis during diabetic nephropathy
  JOURNAL   Mol Med Rep 18 (2), 1995-2008 (2018)
   PUBMED   29901140
  REMARK    GeneRIF: present results determined that high glucoseinduced
            activation of the NLRP3 inflammasome is mediated by Syk/JNK
            activation, which subsequently increased the protein expression
            level of IL1beta and mature IL1beta. The present study identified
            that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in
            the pathogenesis ofdiabetic nephropathy.
REFERENCE   3  (bases 1 to 5311)
  AUTHORS   Buyanravjikh,S., Han,S., Lee,S., Jeong,A.L., Ka,H.I., Park,J.Y.,
            Boldbaatar,A., Lim,J.S., Lee,M.S. and Yang,Y.
  TITLE     Cryptotanshinone inhibits IgE-mediated degranulation through
            inhibition of spleen tyrosine kinase and tyrosine-protein kinase
            phosphorylation in mast cells
  JOURNAL   Mol Med Rep 18 (1), 1095-1103 (2018)
   PUBMED   29845271
  REMARK    GeneRIF: Cryptotanshinone inhibits IgEmediated degranulation
            through inhibition of spleen tyrosine kinase and tyrosineprotein
            kinase phosphorylation in mast cells.
            Erratum:[Mol Med Rep. 2021 Sep;24(3):644. doi:
            10.3892/mmr.2021.12283.. PMID: 34278499]
REFERENCE   4  (bases 1 to 5311)
  AUTHORS   Knoll,M., Winther,S., Natarajan,A., Yang,H., Jiang,M., Thiru,P.,
            Shahsafaei,A., Chavarria,T.E., Lamming,D.W., Sun,L., Hansen,J.B.
            and Lodish,H.F.
  TITLE     SYK kinase mediates brown fat differentiation and activation
  JOURNAL   Nat Commun 8 (1), 2115 (2017)
   PUBMED   29235464
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5311)
  AUTHORS   Honjoh,C., Chihara,K., Yoshiki,H., Yamauchi,S., Takeuchi,K.,
            Kato,Y., Hida,Y., Ishizuka,T. and Sada,K.
  TITLE     Association of C-Type Lectin Mincle with FcepsilonRIbetagamma
            Subunits Leads to Functional Activation of RBL-2H3 Cells through
            Syk
  JOURNAL   Sci Rep 7, 46064 (2017)
   PUBMED   28393919
  REMARK    GeneRIF: mast cells contribute to Mincle-mediated immunity through
            Syk activation triggered by association with the
            FcepsilonRIbetagamma complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5311)
  AUTHORS   Katagiri,T., Ogimoto,M., Hasegawa,K., Mizuno,K. and Yakura,H.
  TITLE     Selective regulation of Lyn tyrosine kinase by CD45 in immature B
            cells
  JOURNAL   J Biol Chem 270 (47), 27987-27990 (1995)
   PUBMED   7499277
REFERENCE   7  (bases 1 to 5311)
  AUTHORS   Cheng,A.M., Rowley,B., Pao,W., Hayday,A., Bolen,J.B. and Pawson,T.
  TITLE     Syk tyrosine kinase required for mouse viability and B-cell
            development
  JOURNAL   Nature 378 (6554), 303-306 (1995)
   PUBMED   7477353
REFERENCE   8  (bases 1 to 5311)
  AUTHORS   Turner,M., Mee,P.J., Costello,P.S., Williams,O., Price,A.A.,
            Duddy,L.P., Furlong,M.T., Geahlen,R.L. and Tybulewicz,V.L.
  TITLE     Perinatal lethality and blocked B-cell development in mice lacking
            the tyrosine kinase Syk
  JOURNAL   Nature 378 (6554), 298-302 (1995)
   PUBMED   7477352
REFERENCE   9  (bases 1 to 5311)
  AUTHORS   Sillman,A.L. and Monroe,J.G.
  TITLE     Association of p72syk with the src homology-2 (SH2) domains of PLC
            gamma 1 in B lymphocytes
  JOURNAL   J Biol Chem 270 (20), 11806-11811 (1995)
   PUBMED   7744830
REFERENCE   10 (bases 1 to 5311)
  AUTHORS   Benhamou,M., Ryba,N.J., Kihara,H., Nishikata,H. and Siraganian,R.P.
  TITLE     Protein-tyrosine kinase p72syk in high affinity IgE receptor
            signaling. Identification as a component of pp72 and association
            with the receptor gamma chain after receptor aggregation
  JOURNAL   J Biol Chem 268 (31), 23318-23324 (1993)
   PUBMED   7693687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 1, 2020 this sequence version replaced NM_012758.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21684.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000017.1  12813152-12813273   c
            123-265             JAXUCZ010000017.1  12801366-12801508   c
            266-722             JAXUCZ010000017.1  12798772-12799228   c
            723-883             JAXUCZ010000017.1  12797606-12797766   c
            884-1022            JAXUCZ010000017.1  12786904-12787042   c
            1023-1104           JAXUCZ010000017.1  12785250-12785331   c
            1105-1136           JAXUCZ010000017.1  12784755-12784786   c
            1137-1205           JAXUCZ010000017.1  12783222-12783290   c
            1206-1293           JAXUCZ010000017.1  12776796-12776883   c
            1294-1471           JAXUCZ010000017.1  12775484-12775661   c
            1472-1681           JAXUCZ010000017.1  12768411-12768620   c
            1682-1871           JAXUCZ010000017.1  12766260-12766449   c
            1872-2012           JAXUCZ010000017.1  12765120-12765260   c
            2013-2125           JAXUCZ010000017.1  12763914-12764026   c
            2126-5311           JAXUCZ010000017.1  12756493-12759678   c
FEATURES             Location/Qualifiers
     source          1..5311
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..5311
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /note="spleen associated tyrosine kinase"
                     /db_xref="GeneID:25155"
                     /db_xref="RGD:3796"
     exon            1..122
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            123..265
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            266..722
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..2198
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /EC_number="2.7.10.2"
                     /function="tyrosine kinase"
                     /note="spleen tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase SYK"
                     /protein_id="NP_036890.2"
                     /db_xref="GeneID:25155"
                     /db_xref="RGD:3796"
                     /translation="MAGNAVDNANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSR
                     NYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLL
                     KKPFNRPPGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATT
                     AHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRID
                     RDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPV
                     TWSPGGIISRIKSYSFPKPGHKKPPPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREA
                     LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDNELGSGNFGTVKKGYYQMKKVVKT
                     VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPL
                     NKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG
                     LSKALRADENYYKAQTHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKP
                     YRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY
                     YDVVN"
     exon            723..883
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1022
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1104
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1136
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1205
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1293
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1471
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1681
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1871
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2012
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2125
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..5311
                     /gene="Syk"
                     /gene_synonym="p72syk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctccttc cctccgtctc tgtggccacc cccattttta agcctgccag tttggtcctt
       61 tccacgctcc atgctgcctg gtgcccggga gcccaggcca tctgcgactc caggacagga
      121 agtcagaaga ggggagctca gacatgacag gcaagccaca tggctggtac aatgagtacc
      181 atggaacctg aaggagcgca tgtgtttgat agtgttggct cttcaagagg cagcagctat
      241 ggaagtgcca agggtgtgta caagagtact tctccacata cctcccagag ctctgaaggg
      301 gtgcagacat ggcgggcaat gctgtggaca atgccaacca cctgacctac ttttttggca
      361 acatcacccg ggaagaggcc gaagactacc tggtccaggg aggcatgacc gatgggctct
      421 acctgctacg ccagagccgc aattacctgg gtggttttgc tttgtcggtg gcacacaaca
      481 ggaaggcaca ccactacact atcgagagag aacttaacgg cacctacgcc atctccgggg
      541 gcagggccca tgccagcccg gcagacctct gccattacca ctcccaggaa cccgaaggcc
      601 ttgtctgcct cctcaagaag cccttcaacc ggcccccggg ggtacagccc aagactggac
      661 cctttgagga cctgaaggag aacctcatca gggaatatgt gaaacagacc tggaaccttc
      721 agggccaggc tctggagcaa gccatcatca gtcagaagcc ccaactggag aagttgatcg
      781 ccacgacggc tcatgagaag atgccctggt tccatggcaa catctccaga gacgagtcag
      841 agcagacggt cctcataggg tcaaagacca acggaaaatt cctgatcagg gccagagaca
      901 acaacggctc ctttgcactg tgcctgctgc acgaagggaa ggtattacac tatcgcatcg
      961 acagggacaa gaccgggaag ctttccatcc ccgaggggaa gaagtttgac accctctggc
     1021 agctagtgga acattactct tacaagccag atgggctatt aagagtcctc acggtaccat
     1081 gtcaaaagat tggcgtgcag atgggccacc caggaagttc aaatgcccat cctgtgactt
     1141 ggtcaccagg tggaataatc tcaagaatca aatcctactc cttcccaaag cctggccaca
     1201 aaaagcctcc cccaccccaa gggagccgtc cggagagcac cgtgtccttc aatccctatg
     1261 agccaacggg aggggcctgg ggcccagaca gaggccttca gagagaagcc ctgcccatgg
     1321 acactgaggt atatgagagt ccttacgctg accctgaaga gatccggccc aaagaggtct
     1381 acctggacag gaaactgctg accctggagg acaatgaact gggctctggc aacttcggga
     1441 ctgtgaaaaa gggatactac caaatgaaaa aagttgtaaa aacagtggct gtgaaaatcc
     1501 tgaagaatga ggccaacgac ccggctctga aggacgagct gctggcggag gccaacgtca
     1561 tgcagcagct ggacaacccc tacattgtgc gcatgatcgg aatctgtgag gcggagtcgt
     1621 ggatgctggt gatggagatg gcggagctgg ggcccctcaa caagtacctg cagcagaaca
     1681 ggcacatcaa ggataagaac atcatcgagc tggttcacca ggtttccatg ggaatgaagt
     1741 atttggagga gagcaatttt gtgcacagag atctggccgc gaggaacgtg cttctggtca
     1801 cccagcacta cgccaagatc agtgacttcg gtctttccaa agccctccgt gctgatgaaa
     1861 actactacaa ggcccagacc cacgggaagt ggccggtgaa gtggtacgcc cccgaatgca
     1921 tcaactactt taagttctcc agtaagagtg atgtctggag cttcggagtc ctgatgtggg
     1981 aagcgttctc ctacgggcag aagccataca gagggatgaa agggagcgaa gtgactgcca
     2041 tgctggagaa aggagagcgg atggggtgcc ctccaggatg cccgagagag atgtacgact
     2101 tgatgaacct atgctggact tacgatgtgg agaacaggcc aggattcgcg gctgtggaac
     2161 tgcggcttcg caattactac tacgacgtgg ttaactaaga gcttgggtgc ctgtccgcgg
     2221 ccacctcgaa ttctcaagcg atcgcaggaa atttattcag atgaactggc tctcagagtt
     2281 tcatctccct ctgcccagag ggagagctaa ccaagcaaag ctaggaactc actctcgcaa
     2341 cagttctggt cccaaaagac agacaagcag caagcccgcg ggacctgagg acttgtctgt
     2401 ctggcttttg tttccatctg tgtggttttc gtcttgggtc acgttccggg aaccatttcc
     2461 aaattcgctt gacgtcattc cgttgctctg gggccaggat ttcagtgtcg ccccctgcag
     2521 gtcagaaaga gaagtgcttc gccatttcag caaaggactg agagaaacct caccaatgcc
     2581 gttggcaagg cggaagacgg ttaaggaaaa tgacagactc aggcactgct tttgctctca
     2641 gcactgagac tgaaacacca cgtgaatggg atgctgagac atgctggctt ggcttgcacg
     2701 cccctggagt ccgcctcctt gtagaatgac ttgaagtccg ctgttgtgtg cttacaggag
     2761 gaggcgtgaa tagcattctg catgaaggct gccaggcagg gtgggctccc atgatcctct
     2821 gcgactgagc caagtgtatc aggcatgggt cagagtccct ttctctgcag aaggaatgaa
     2881 tgcatccagg actccttgtt gcggccacaa tacctgacca gcaacctcag ggaggaaacg
     2941 cttgtttggg ctcacaggcc atcatggtgg caaagacttt acaacaggca ggaaagactt
     3001 gagggcatga acaagaagct gtaaggtcac gtggtatcca cactgaggaa gcgaagaatg
     3061 aacaggaagt aggaccaggc tataaggccc caaagcccac ccaccccacc ccacccccca
     3121 tcccccaccc cccgtgaccc actttccttc agcaagaccc cacttcccaa aggttccaca
     3181 ggtctctcag acagtgaatg ccaacagctg gggaccaagt gttcaaatat acgagcctct
     3241 gtggggagcc tttcacattc aaactgcaag aggttccatc cattttctga tgctatgact
     3301 gaacacctag atagggtggt gtacaaagag aagcaatgta tctcttagct gtacatccct
     3361 ctccaagggt cggaactgcc cccagtgaga tgcagtgcca ggcagcagcc ttcctgaatg
     3421 tcacagggtg atatcccgac agagggggga agccttctca ggtgtgtcct tctcttatga
     3481 gcccctgata ccgtcccaga gcctcctcag gaccccactt cttcttaacc atcccccaag
     3541 gtcccatctc caaacaccat gctgtgaacc taggcactaa gtcttcaaca catgagccct
     3601 gaggggacac attcatacta gagcagacgg caacacagtg accaggacca cctcaggatg
     3661 agctcgcgga tggaatttta attcagaata aaaccagaga ggtgaccttc cccacaagta
     3721 agccttgcta agtgtgactt tgagctctat cctcctgact tgcataaggt tcggctaact
     3781 accgaccaca caccaagtgt cacctgtcca tagcacagtt gctgaggaca taaaagttac
     3841 aaaggctgca tagccttccg tctaggtcta ggggaatgta caaaggaagc atctcatcct
     3901 cacccctgag acactgacaa acacagccag ggacggcatg ggaggcccca ctggcggcgg
     3961 gttcgatgaa cagagccggt gaaatgggtt cccctcttta gaccagtagt tctcaaccga
     4021 gaccctccag tacagttcct agtgctgtga tgacccccaa tcatcaagtt actttgtggc
     4081 tacttcataa ctgtaatttt gctactgtta tgaatcatag tgtgaatatc tgttgatatg
     4141 caggatatgc aatgtgcatc ccccaaggag ggcacaccca caggttggga accactgcct
     4201 ttgatatgga ggcgctacac ttagaagcta tgggtgtgtc ttggaactgt gctagtaggt
     4261 cagtcgccct gttgggggcg agatccctgt gtgttgctgg ctgagtgggc ctgcagaaca
     4321 cctccttggt gaggaaatcc cgtgggtcac tgcctgattg agtcaaggga ggaagagaca
     4381 ctgtgttggt tatggagaca ggaccgtcta gtctgaggaa gaagctctct gctgagctcc
     4441 tggcctacct tcccctgtcc tcagggtagg gctattaaaa ggccaccttg aaggtctggg
     4501 ggtggttgtg cgagaaccct atggaggcct ctgtcttttt ccagtcttgt ttgctttctg
     4561 gcctctctag tagtgcctct cctttccagg gggttgggac tgaccattcg ttatcgggat
     4621 gtgaccaagc agaacggagg gagacacggc tttgtctccc ttcagaaggt cgaaactggc
     4681 tcctggacgc agaagtcatg tgtggctatt gtccagggct ctcatctgtt gaaaactgtg
     4741 tcttgctgtc aagattaatt ctctcccctg gggccacaga ggagggcgga tggagagagg
     4801 atcctccctg gagggtttag attctgaatg caccataaat ttgcaaggtc ggaaacaagg
     4861 tccttctcag gcgtctatac ttggcctagg tctgctcaca agctgcctct ggtgctccga
     4921 atcccttctg cctggccgct gggctcactg tgtgccttca cctatgaccc tttaatcagc
     4981 agagcacacg gagcacctaa tctgcctcgc cacatcccac tgacctcgcc acaccacata
     5041 cctcatgcag aaccgaatgt ctctccagta aacgcccaag ccagccattc ataaaaacct
     5101 gtctctgtgt gcactggaac atgtcctccc tgtacccaaa cccactttgt gtgccagaca
     5161 gtgactccac agggacgcca ggcctgtgat cgcattgctc gttgcagagg gaagccccgg
     5221 gttgtccgtc tcagggatta ctcccaccca gagcagcaca cagtgttccc ctgttatttc
     5281 agaaattatt tttaataaag atctactatt a
//
