LOCUS       NM_133417               1273 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus SYF2 pre-mRNA-splicing factor (Syf2), mRNA.
ACCESSION   NM_133417 XM_001068998
VERSION     NM_133417.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1273)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 1273)
  AUTHORS   Sang,A., Yang,X., Chen,H., Qin,B., Zhu,M., Dai,M., Zhu,R. and
            Liu,X.
  TITLE     Upregulation of SYF2 Relates to Retinal Ganglion Cell Apoptosis and
            Retinal Glia Cell Proliferation After Light-Induced Retinal Damage
  JOURNAL   J Mol Neurosci 56 (2), 480-490 (2015)
   PUBMED   25944718
  REMARK    GeneRIF: SYF2 protein expression was dramatically upregulated after
            retinal damage.
REFERENCE   3  (bases 1 to 1273)
  AUTHORS   Zhou,Z., Liu,Y., Nie,X., Cao,J., Zhu,X., Yao,L., Zhang,W., Yu,J.,
            Wu,G., Liu,Y. and Yang,H.
  TITLE     Involvement of upregulated SYF2 in Schwann cell differentiation and
            migration after sciatic nerve crush
  JOURNAL   Cell Mol Neurobiol 34 (7), 1023-1036 (2014)
   PUBMED   24962097
  REMARK    GeneRIF: the upregulation of SYF2 was associated with Schwann cell
            differentiation and migration following sciatic nerve crush.
REFERENCE   4  (bases 1 to 1273)
  AUTHORS   Xu,W., Cao,M., Zheng,H., Tan,X., Li,L., Cui,G., Xu,J., Cao,J.,
            Ke,K. and Wu,Q.
  TITLE     Upregulation of SYF2 is associated with neuronal apoptosis caused
            by reactive astrogliosis to neuroinflammation
  JOURNAL   J Neurosci Res 92 (3), 318-328 (2014)
   PUBMED   24301298
  REMARK    GeneRIF: This study shows that SYF2 was significantly increased in
            the rat cerebral cortex after LPS injection, suggesting that SYF2
            might be involved in the pathological processes of astrocyte
            proliferation and neuronal apoptosis.
REFERENCE   5  (bases 1 to 1273)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   6  (bases 1 to 1273)
  AUTHORS   Chen,C.H., Chu,P.C., Lee,L., Lien,H.W., Lin,T.L., Fan,C.C., Chi,P.,
            Huang,C.J. and Chang,M.S.
  TITLE     Disruption of murine mp29/Syf2/Ntc31 gene results in embryonic
            lethality with aberrant checkpoint response
  JOURNAL   PLoS One 7 (3), e33538 (2012)
   PUBMED   22448250
REFERENCE   7  (bases 1 to 1273)
  AUTHORS   Whitehouse,C.J., Huckle,J.W., Demarchez,M., Reynolds,A.J. and
            Jahoda,C.A.
  TITLE     Genes that are differentially expressed in rat vibrissa follicle
            germinative epithelium in vivo show altered expression patterns
            after extended organ culture
  JOURNAL   Exp Dermatol 11 (6), 542-555 (2002)
   PUBMED   12473062
REFERENCE   8  (bases 1 to 1273)
  AUTHORS   Chang,M.S., Chen,C.Y., Yeh,H.I., Fan,C.C., Huang,C.J. and Yang,Y.C.
  TITLE     Cloning, expression, and genomic organization of mouse mp29 gene
  JOURNAL   Biochem Biophys Res Commun 299 (2), 241-246 (2002)
   PUBMED   12437976
REFERENCE   9  (bases 1 to 1273)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 1273)
  AUTHORS   Chang,M.S., Chang,C.L., Huang,C.J. and Yang,Y.C.
  TITLE     p29, a novel GCIP-interacting protein, localizes in the nucleus
  JOURNAL   Biochem Biophys Res Commun 279 (2), 732-737 (2000)
   PUBMED   11118353
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_133417.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF366369.1, BC097289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000005.1  152440171-152440213
            44-148              JAXUCZ010000005.1  152440376-152440480
            149-274             JAXUCZ010000005.1  152443175-152443300
            275-392             JAXUCZ010000005.1  152443861-152443978
            393-483             JAXUCZ010000005.1  152444491-152444581
            484-582             JAXUCZ010000005.1  152445577-152445675
            583-1273            JAXUCZ010000005.1  152447404-152448094
FEATURES             Location/Qualifiers
     source          1..1273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1273
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /note="SYF2 pre-mRNA-splicing factor"
                     /db_xref="GeneID:170933"
                     /db_xref="RGD:621592"
     exon            1..43
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..748
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /note="GCIP-interacting protein p29; SYF2 homolog, RNA
                     splicing factor"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SYF2"
                     /protein_id="NP_596908.2"
                     /db_xref="GeneID:170933"
                     /db_xref="RGD:621592"
                     /translation="MAAVTEVVVPADGAEARPLAAEELAAQKREQRLRKFRELHLKRN
                     EARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEI
                     SAEDAERWERRKKKKNPDLGFSDYAAAQLRQYHRLTKQIKPDMESYERQREKHGEDFF
                     PTSNSLLHGTHVPSSEEIDRMVLDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFN
                     KKAERFYGKYTAEIKQNLERGTAV"
     exon            44..148
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            149..274
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            275..392
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            393..483
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            484..582
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
     exon            583..1273
                     /gene="Syf2"
                     /gene_synonym="Gcipip; P29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagtggag gaggctgtaa tggcggctgt gactgaagtt gtggtacccg cggacggcgc
       61 ggaagccagg cccttggcgg ccgaggagct ggcggcgcag aagcgagagc agagactgcg
      121 caagttccgt gagctgcatc tgaagcggaa tgaagctcgt aagttaaatc accaggaagt
      181 tgtggaagaa gacaaaagac ttaagctgcc tgctaactgg gaagccaaga aagcacgtct
      241 ggagtgggaa ctccaggaag aagaaaagaa gaaggagtgt gcagctcgag gggaagacta
      301 cgagaaggtg aaactgctgg agatcagtgc ggaggacgct gagaggtggg agaggaggaa
      361 gaagaagaag aaccctgact tggggttttc agattatgct gctgcccaat tgcgccagta
      421 tcaccggctg accaagcaga tcaaacctga catggaaagc tacgagcgac agagagaaaa
      481 gcatggagaa gattttttcc cgacatccaa cagtcttctc catgggacgc atgtgccttc
      541 ctcagaggaa attgacagaa tggttttaga tctggaaaag caaattgaaa agagagacaa
      601 atacagccga agacgtcctt acaatgacga tgccgacatc gactacatta atgagaggaa
      661 cgccaagttc aacaagaaag cagagaggtt ctacgggaag tacacggctg agatcaagca
      721 gaacctggag agaggaacag ctgtgtgagc ctgccctcgg gagcagtaca ggagctggga
      781 aggggttgga ggtggccgca ggcaaattca aactcccatg tgggactatt tcctttactt
      841 acccctgcct ccccgagggc cttctgaaat aaatgtcttt tctcacctct cttcaacatg
      901 cacatgtcca cattttcctg cttggataga ccatgtattt cttgtagtga gtgatgtttt
      961 gtaaaaatct aatttgtata aatcctaatt attatttttc tatgtatttt aaatgtgcat
     1021 gaccatatat ccttgaatta ctggggcgta gatggttgtg tacacagtgc agtcactgct
     1081 gctttgagtg ttcttaggaa gtagaagcta cagtcgggct ttggggctgt ccaggaaagg
     1141 actaggaagc agaggctgtc aagacagatg ctcctggagt tctggcactg tcttcccggg
     1201 ctggagtcag aggccatggc tgtgagcctc tcacactctc tttttaaaga acaataaagt
     1261 gctttggaat aga
//
